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  • Ted M Dawson
2020

PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency

Pirooznia, S. K., Yuan, C., Khan, M. R., Karuppagounder, S. S., Wang, L., Xiong, Y., Kang, S. U., Lee, Y., Dawson, V. L. & Dawson, T. M., Mar 5 2020, In : Molecular neurodegeneration. 15, 1, 17.

Research output: Contribution to journalArticle

Open Access

Poly (ADP-ribose) (PAR)-dependent cell death in neurodegenerative diseases

Park, H., Kam, T. I., Dawson, T. M. & Dawson, V. L., Jan 1 2020, (Accepted/In press) International Review of Cell and Molecular Biology. Elsevier Inc., (International Review of Cell and Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingChapter

2019

A comprehensive screening of copy number variability in dementia with Lewy bodies

Kun-Rodrigues, C., Orme, T., Carmona, S., Hernandez, D. G., Ross, O. A., Eicher, J. D., Shepherd, C., Parkkinen, L., Darwent, L., Heckman, M. G., Scholz, S. W., Troncoso, J. C., Pletnikova, O., Dawson, T. M., Rosenthal, L. I. S., Ansorge, O., Clarimon, J., Lleo, A., Morenas-Rodriguez, E., Clark, L. & 48 others, Honig, L. S., Marder, K., Lemstra, A., Rogaeva, E., St. George-Hyslop, P., Londos, E., Zetterberg, H., Barber, I., Braae, A., Brown, K., Morgan, K., Troakes, C., Al-Sarraj, S., Lashley, T., Holton, J., Compta, Y., Van Deerlin, V., Serrano, G. E., Beach, T. G., Lesage, S., Galasko, D., Masliah, E., Santana, I., Pastor, P., Diez-Fairen, M., Aguilar, M., Tienari, P. J., Myllykangas, L., Oinas, M., Revesz, T., Lees, A., Boeve, B. F., Petersen, R. C., Ferman, T. J., Escott-Price, V., Graff-Radford, N., Cairns, N. J., Morris, J. C., Pickering-Brown, S., Mann, D., Halliday, G. M., Hardy, J., Trojanowski, J. Q., Dickson, D. W., Singleton, A., Stone, D. J., Guerreiro, R. & Bras, J., Mar 1 2019, In : Neurobiology of Aging. 75, p. 223.e1-223.e10

Research output: Contribution to journalArticle

Assessment of APOE in atypical parkinsonism syndromes

Sabir, M. S., Blauwendraat, C., Ahmed, S., Serrano, G. E., Beach, T. G., Perkins, M., Rice, A. C., Masliah, E., Morris, C. M., Pihlstrom, L., Pantelyat, A., Resnick, S. M., Cookson, M. R., Hernandez, D. G., Albert, M., Dawson, T. M., Rosenthal, L. I. S., Houlden, H., Pletnikova, O., Troncoso, J. C. & 1 others, Scholz, S. W., Jul 1 2019, In : Neurobiology of Disease. 127, p. 142-146 5 p.

Research output: Contribution to journalArticle

Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia

Panicker, N., Sarkar, S., Harischandra, D. S., Neal, M., Kam, T-I., Jin, H., Saminathan, H., Langley, M., Charli, A., Samidurai, M., Rokad, D., Ghaisas, S., Pletnikova, O., Dawson, V., Dawson, T. M., Anantharam, V., Kanthasamy, A. G. & Kanthasamy, A., Jun 3 2019, In : The Journal of experimental medicine. 216, 6, p. 1411-1430 20 p.

Research output: Contribution to journalArticle

Open Access

Glial pathology and retinal neurotoxicity in the anterior visual pathway in experimental autoimmune encephalomyelitis

Jin, J., Smith, M. D., Kersbergen, C. J., Kam, T. I., Viswanathan, M., Martin, K., Dawson, T. M., Dawson, V. L., Zack, D. J., Whartenby, K. & Calabresi, P. A., Jul 31 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Open Access

Heritability and genetic variance of dementia with Lewy bodies

for the International Parkinson's Disease Genomics Consortium, Jul 1 2019, In : Neurobiology of Disease. 127, p. 492-501 10 p.

Research output: Contribution to journalArticle

Open Access

Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease

Brahmachari, S., Lee, S., Kim, S., Yuan, C., Karuppagounder, S., Ge, P., Shi, R., Kim, E. J., Liu, A., Kim, D., Quintin, S., Jiang, H., Kumar, M., Yun, S. P., Kam, T-I., Mao, X., Lee, Y., Swing, D. A., Tessarollo, L., Ko, H. S. & 2 others, Dawson, V. & Dawson, T. M., Aug 1 2019, In : Brain : a journal of neurology. 142, 8, p. 2380-2401 22 p.

Research output: Contribution to journalArticle

Promising disease-modifying therapies for Parkinson’s disease

Dawson, V. L. & Dawson, T. M., Nov 27 2019, In : Science translational medicine. 11, 520, eaba1659.

Research output: Contribution to journalArticle

SQSTM1/p62 promotes mitochondrial ubiquitination independently of PINK1 and PRKN/parkin in mitophagy

Yamada, T., Dawson, T. M., Yanagawa, T., Iijima, M. & Sesaki, H., Nov 1 2019, In : Autophagy. 15, 11, p. 2012-2018 7 p.

Research output: Contribution to journalArticle

The A1 astrocyte paradigm: New avenues for pharmacological intervention in neurodegeneration

Hinkle, J. T., Dawson, V. & Dawson, T. M., Jul 1 2019, In : Movement Disorders. 34, 7, p. 959-969 11 p.

Research output: Contribution to journalArticle

Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease

Kim, S., Kwon, S. H., Kam, T-I., Panicker, N., Karuppagounder, S., Lee, S., Lee, J. H., Kim, W. R., Kook, M., Foss, C., Shen, C., Lee, H., Kulkarni, S., Pasricha, P. J., Lee, G., Pomper, M. G., Dawson, V., Dawson, T. M. & Ko, H. S., Aug 21 2019, In : Neuron. 103, 4, p. 627-641.e7

Research output: Contribution to journalArticle

2018

A homozygous ATAD1 mutation impairs postsynaptic AMPA receptor trafficking and causes a lethal encephalopathy

Piard, J., Umanah, G., Harms, F. L., Abalde-Atristain, L., Amram, D., Chang, M., Chen, R., Alawi, M., Salpietro, V., Rees, M. I., Chung, S. K., Houlden, H., Verloes, A., Dawson, T. M., Dawson, V., Van Maldergem, L. & Kutsche, K., Mar 1 2018, In : Brain. 141, 3, p. 651-661 11 p.

Research output: Contribution to journalArticle

Animal models of neurodegenerative diseases

Dawson, T. M., Golde, T. E. & Lagier-Tourenne, C., Oct 1 2018, In : Nature Neuroscience. 21, 10, p. 1370-1379 10 p.

Research output: Contribution to journalReview article

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease

Yun, S. P., Kam, T-I., Panicker, N., Kim, S., Oh, Y., Park, J. S., Kwon, S. H., Park, Y. J., Karuppagounder, S., Park, H., Kim, S., Oh, N., Kim, N. A., Lee, S., Brahmachari, S., Mao, X., Lee, J. H., Kumar, M., An, D., Kang, S. & 13 others, Lee, Y., Lee, K. C., Na, D. H., Kim, D., Lee, S. H., Roschke, V. V., Liddelow, S. A., Mari, Z., Barres, B. A., Dawson, V., Lee, S., Dawson, T. M. & Ko, H. S., Jul 1 2018, In : Nature Medicine. 24, 7, p. 931-938 8 p.

Research output: Contribution to journalArticle

DISC1 regulates lactate metabolism in astrocytes: Implications for psychiatric disorders

Jouroukhin, Y., Kageyama, Y., Misheneva, V., Shevelkin, A., Andrabi, S., Prandovszky, E., Yolken, R. H., Dawson, V., Dawson, T. M., Aja, S. M., Sesaki, H. & Pletnikov, M., Dec 1 2018, In : Translational Psychiatry. 8, 1, 76.

Research output: Contribution to journalArticle

Dopamine transporter availability reflects gastrointestinal dysautonomia in early Parkinson disease

Hinkle, J. T., Perepezko, K., Mills, K., Mari, Z., Butala, A., Dawson, T. M., Pantelyat, A., Rosenthal, L. I. S. & Pontone, G. M., Jan 1 2018, (Accepted/In press) In : Parkinsonism and Related Disorders.

Research output: Contribution to journalArticle

Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration

Jeong, G. R., Jang, E. H., Bae, J. R., Jun, S., Kang, H. C., Park, C. H., Shin, J. H., Yamamoto, Y., Tanaka-Yamamoto, K., Dawson, V., Dawson, T. M., Hur, E. M. & Lee, B. D., Feb 13 2018, In : Molecular Neurodegeneration. 13, 1, 8.

Research output: Contribution to journalArticle

Excitotoxic programmed cell death involves caspase-independent mechanisms

Dawson, T. M. & Dawson, V., Jan 1 2018, Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death Mechanisms: Second Edition. Springer International Publishing, p. 3-17 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Finding useful biomarkers for Parkinson s disease

Chen-Plotkin, A. S., Albin, R., Alcalay, R., Babcock, D., Bajaj, V., Bowman, D., Buko, A., Cedarbaum, J., Chelsky, D., Cookson, M. R., Dawson, T. M., Dewey, R., Foroud, T., Frasier, M., German, D., Gwinn, K., Huang, X., Kopil, C., Kremer, T., Lasch, S. & 20 others, Marek, K., Marto, J. A., Merchant, K., Mollenhauer, B., Naito, A., Potashkin, J., Reimer, A., Rosenthal, L. I. S., Saunders-Pullman, R., Scherzer, C. R., Sherer, T., Singleton, A., Sutherland, M., Thiele, I., Van Der Brug, M., Keuren-Jensen, K. V., Vaillancourt, D., Walt, D., West, A. & Zhang, J., Aug 15 2018, In : Science Translational Medicine. 10, 454, eaam6003.

Research output: Contribution to journalReview article

GBA1 deficiency negatively affects physiological α-synuclein tetramers and related multimers

Kim, S., Yun, S. P., Lee, S., Umanah, G., Bandaru, V. V. R., Yin, X., Rhee, P., Karuppagounder, S., Kwon, S. H., Lee, H., Mao, X., Kim, D., Pandey, A., Lee, G., Dawson, V., Dawson, T. M. & Ko, H. S., Jan 23 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 4, p. 798-803 6 p.

Research output: Contribution to journalArticle

Genetic analysis of neurodegenerative diseases in a pathology cohort

Blauwendraat, C., Pletnikova, O., Geiger, J. T., Murphy, N. A., Abramzon, Y., Rudow, G., Mamais, A., Sabir, M. S., Crain, B., Ahmed, S., Rosenthal, L. I. S., Bakker, C. C., Faghri, F., Chia, R., Ding, J., Dawson, T. M., Pantelyat, A., Albert, M., Nalls, M. A., Resnick, S. M. & 5 others, Ferrucci, L., Cookson, M. R., Hillis-Trupe, A., Troncoso, J. C. & Scholz, S. W., Jan 1 2018, (Accepted/In press) In : Neurobiology of Aging.

Research output: Contribution to journalArticle

Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease

Yamada, T., Murata, D., Adachi, Y., Itoh, K., Kameoka, S., Igarashi, A., Kato, T., Araki, Y., Huganir, R. L., Dawson, T. M., Yanagawa, T., Okamoto, K., Iijima, M. & Sesaki, H., Jan 1 2018, (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., Annicchiarico-Petruzzelli, M., Antonov, A. V., Arama, E., Baehrecke, E. H., Barlev, N. A., Bazan, N. G., Bernassola, F., Bertrand, M. J. M., Bianchi, K., Blagosklonny, M. V. & 149 others, Blomgren, K., Borner, C., Boya, P., Brenner, C., Campanella, M., Candi, E., Carmona-Gutierrez, D., Cecconi, F., Chan, F. K. M., Chandel, N. S., Cheng, E. H., Chipuk, J. E., Cidlowski, J. A., Ciechanover, A., Cohen, G. M., Conrad, M., Cubillos-Ruiz, J. R., Czabotar, P. E., D'Angiolella, V., Dawson, T. M., Dawson, V., De Laurenzi, V., De Maria, R., Debatin, K. M., Deberardinis, R. J., Deshmukh, M., Di Daniele, N., Di Virgilio, F., Dixit, V. M., Dixon, S. J., Duckett, C. S., Dynlacht, B. D., El-Deiry, W. S., Elrod, J. W., Fimia, G. M., Fulda, S., García-Sáez, A. J., Garg, A. D., Garrido, C., Gavathiotis, E., Golstein, P., Gottlieb, E., Green, D. R., Greene, L. A., Gronemeyer, H., Gross, A., Hajnoczky, G., Hardwick, J. M., Harris, I. S., Hengartner, M. O., Hetz, C., Ichijo, H., Jäättelä, M., Joseph, B., Jost, P. J., Juin, P. P., Kaiser, W. J., Karin, M., Kaufmann, T., Kepp, O., Kimchi, A., Kitsis, R. N., Klionsky, D. J., Knight, R. A., Kumar, S., Lee, S. W., Lemasters, J. J., Levine, B., Linkermann, A., Lipton, S. A., Lockshin, R. A., López-Otín, C., Lowe, S. W., Luedde, T., Lugli, E., MacFarlane, M., Madeo, F., Malewicz, M., Malorni, W., Manic, G., Marine, J. C., Martin, S. J., Martinou, J. C., Medema, J. P., Mehlen, P., Meier, P., Melino, S., Miao, E. A., Molkentin, J. D., Moll, U. M., Muñoz-Pinedo, C., Nagata, S., Nuñez, G., Oberst, A., Oren, M., Overholtzer, M., Pagano, M., Panaretakis, T., Pasparakis, M., Penninger, J. M., Pereira, D. M., Pervaiz, S., Peter, M. E., Piacentini, M., Pinton, P., Prehn, J. H. M., Puthalakath, H., Rabinovich, G. A., Rehm, M., Rizzuto, R., Rodrigues, C. M. P., Rubinsztein, D. C., Rudel, T., Ryan, K. M., Sayan, E., Scorrano, L., Shao, F., Shi, Y., Silke, J., Simon, H. U., Sistigu, A., Stockwell, B. R., Strasser, A., Szabadkai, G., Tait, S. W. G., Tang, D., Tavernarakis, N., Thorburn, A., Tsujimoto, Y., Turk, B., Vanden Berghe, T., Vandenabeele, P., Vander Heiden, M. G., Villunger, A., Virgin, H. W., Vousden, K. H., Vucic, D., Wagner, E. F., Walczak, H., Wallach, D., Wang, Y., Wells, J. A., Wood, W., Yuan, J., Zakeri, Z., Zhivotovsky, B., Zitvogel, L., Melino, G. & Kroemer, G., Mar 1 2018, In : Cell Death and Differentiation. 25, 3, p. 486-541 56 p.

Research output: Contribution to journalReview article

Onset and Remission of Psychosis in Parkinson's Disease: Pharmacologic and Motoric Markers

Hinkle, J. T., Perepezko, K., Bakker, C. C., Broen, M. P. G., Chin, K., Dawson, T. M., Johnson, V., Mari, Z., Marvel, C. L., Mills, K. A., Pantelyat, A., Pletnikova, O., Rosenthal, L. S., Shepard, M. D., Stevens, D. A., Troncoso, J. C., Wang, J. & Pontone, G. M., Jan 1 2018, In : Movement Disorders Clinical Practice. 5, 1, p. 31-38 8 p.

Research output: Contribution to journalArticle

Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy

Kaji, S., Maki, T., Kinoshita, H., Uemura, N., Ayaki, T., Kawamoto, Y., Furuta, T., Urushitani, M., Hasegawa, M., Kinoshita, Y., Ono, Y., Mao, X., Quach, T. H., Iwai, K., Dawson, V., Dawson, T. M. & Takahashi, R., Jan 1 2018, (Accepted/In press) In : Stem Cell Reports.

Research output: Contribution to journalArticle

Poly(ADP-ribose) drives pathologic a-synuclein neurodegeneration in Parkinson’s disease

Kam, T-I., Mao, X., Park, H., Chou, S. C., Karuppagounder, S., Umanah, G., Yun, S. P., Brahmachari, S., Panicker, N., Chen, R., Andrabi, S. A., Qi, C., Poirier, G. G., Pletnikova, O., Troncoso, J. C., Bekris, L. M., Leverenz, J. B., Pantelyat, A., Ko, H. S., Rosenthal, L. I. S. & 2 others, Dawson, T. M. & Dawson, V., Nov 2 2018, In : Science. 362, 6414, eaat8407.

Research output: Contribution to journalArticle

Reply: ATAD1 encephalopathy and stiff baby syndrome: A recognizable clinical presentation

Piard, J., Umanah, G., Harms, F. L., Abalde-Atristain, L., Amram, D., Chang, M., Chen, R., Alawi, M., Salpietro, V., Rees, M. I., Chung, S. K., Houlden, H., Verloes, A., Dawson, T. M., Dawson, V., Van Maldergem, L. & Kutsche, K., Jun 1 2018, In : Brain. 141, 6, p. e50

Research output: Contribution to journalLetter

Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice

Xiong, Y., Neifert, S., Karuppagounder, S., Liu, Q., Stankowski, J. N., Lee, B. D., Ko, H. S., Lee, Y., Grima, J. C., Mao, X., Jiang, H., Kang, S., Swing, D. A., Iacovitti, L., Tessarollo, L., Dawson, T. M. & Dawson, V., Feb 13 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 7, p. 1635-1640 6 p.

Research output: Contribution to journalArticle

Sex differences in progression to mild cognitive impairment and dementia in Parkinson's disease

Cholerton, B., Johnson, C. O., Fish, B., Quinn, J. F., Chung, K. A., Peterson-Hiller, A. L., Rosenthal, L. I. S., Dawson, T. M., Albert, M., Hu, S. C., Mata, I. F., Leverenz, J. B., Poston, K. L., Montine, T. J., Zabetian, C. P. & Edwards, K. L., Jan 1 2018, (Accepted/In press) In : Parkinsonism and Related Disorders.

Research output: Contribution to journalArticle

Synthetic mRNAs Drive Highly Efficient iPS Cell Differentiation to Dopaminergic Neurons

Xue, Y., Zhan, X., Sun, S., Karuppagounder, S., Xia, S., Dawson, V., Dawson, T. M., Laterra, J. J., Zhang, J. & Ying, M., Jan 1 2018, (Accepted/In press) In : Stem cells translational medicine.

Research output: Contribution to journalArticle

The AAA + ATPase Thorase is neuroprotective against ischemic injury

Zhang, J., Yang, J., Wang, H., Sherbini, O., Keuss, M. J., Umanah, G., Pai, E. L. L., Chi, Z., Paldanius, K. M. A., He, W., Wang, H., Andrabi, S. A., Dawson, T. M. & Dawson, V., Jan 1 2018, (Accepted/In press) In : Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journalArticle

α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism

Yun, S. P., Kim, D., Kim, S., Kim, S., Karuppagounder, S., Kwon, S. H., Lee, S., Kam, T-I., Lee, S., Ham, S., Park, J. H., Dawson, V., Dawson, T. M., Lee, Y. & Ko, H. S., Jan 8 2018, In : Molecular Neurodegeneration. 13, 1, 1.

Research output: Contribution to journalArticle

2017

Activation mechanisms of the E3 ubiquitin ligase parkin

Panicker, N., Dawson, V. & Dawson, T. M., Sep 15 2017, In : Biochemical Journal. 474, 18, p. 3075-3086 12 p.

Research output: Contribution to journalReview article

Augmentation of poly(ADP-ribose) polymerase-dependent neuronal cell death by acidosis

Zhang, J., Li, X., Kwansa, H., Kim, Y. T., Yi, L., Hong, G., Andrabi, S. A., Dawson, V., Dawson, T. M., Koehler, R. C. & Yang, Z. J., Jun 1 2017, In : Journal of Cerebral Blood Flow and Metabolism. 37, 6, p. 1982-1993 12 p.

Research output: Contribution to journalArticle

C-Abl and Parkinson's Disease: Mechanisms and Therapeutic Potential

Brahmachari, S., Karuppagounder, S., Ge, P., Lee, S., Dawson, V., Dawson, T. M. & Ko, H. S., 2017, In : Journal of Parkinson's Disease. 7, 4, p. 589-601 13 p.

Research output: Contribution to journalReview article

Cell death mechanisms of neurodegeneration

Fan, J., Dawson, T. M. & Dawson, V., 2017, Advances in Neurobiology. Springer New York LLC, Vol. 15. p. 403-425 23 p. (Advances in Neurobiology; vol. 15).

Research output: Chapter in Book/Report/Conference proceedingChapter

Domain-specific cognitive impairment in non-demented Parkinson's disease psychosis

Hinkle, J. T., Perepezko, K., Bakker, C. C., Dawson, T. M., Johnson, V., Mari, Z., Marvel, C. L., Mills, K. A., Pantelyat, A., Pletnikova, O., Rosenthal, L. S., Shepard, M. D., Stevens, D. A., Troncoso, J. C., Wang, J. & Pontone, G. M., 2017, (Accepted/In press) In : International Journal of Geriatric Psychiatry.

Research output: Contribution to journalArticle

Heterozygous PINK1 p.G411S increases risk of Parkinson's disease via a dominant-negative mechanism

Puschmann, A., Fiesel, F. C., Caulfield, T. R., Hudec, R., Ando, M., Truban, D., Hou, X., Ogaki, K., Heckman, M. G., James, E. D., Swanberg, M., Jimenez-Ferrer, I., Hansson, O., Opala, G., Siuda, J., Boczarska-Jedynak, M., Friedman, A., Koziorowski, D., Aasly, J. O., Lynch, T. & 12 others, Mellick, G. D., Mohan, M., Silburn, P. A., Sanotsky, Y., Vilariño-Güell, C., Farrer, M. J., Chen, L., Dawson, V. L., Dawson, V., Dawson, T. M., Ross, O. A. & Springer, W., Jan 1 2017, In : Brain : a journal of neurology. 140, p. 98-117 20 p.

Research output: Contribution to journalArticle

Markers of impaired motor and cognitive volition in Parkinson's disease: Correlates of dopamine dysregulation syndrome, impulse control disorder, and dyskinesias

Hinkle, J. T., Perepezko, K., Rosenthal, L. I. S., Mills, K., Pantelyat, A., Mari, Z., Tochen, L., Bang, J. Y., Gudavalli, M., Yoritomo, N., Butala, A., Bakker, C. C., Johnson, V., Moukheiber, E., Dawson, T. M. & Pontone, G. M., Jan 1 2017, (Accepted/In press) In : Parkinsonism and Related Disorders.

Research output: Contribution to journalArticle

Mitochondrial mechanisms of neuronal cell death: Potential the rapeutics

Dawson, T. M. & Dawson, V., Jan 6 2017, In : Annual Review of Pharmacology and Toxicology. 57, p. 437-454 18 p.

Research output: Contribution to journalReview article

Models of LRRK2-associated parkinson’s disease

Xiong, Y., Dawson, T. M. & Dawson, V., Apr 1 2017, Advances in Neurobiology. Springer New York LLC, Vol. 14. p. 163-191 29 p. (Advances in Neurobiology; vol. 14).

Research output: Chapter in Book/Report/Conference proceedingChapter

Neurotoxic reactive astrocytes are induced by activated microglia

Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W. S., Peterson, T. C., Wilton, D. K., Frouin, A., Napier, B. A., Panicker, N., Kumar, M., Buckwalter, M. S., Rowitch, D. H., Dawson, V., Dawson, T. M., Stevens, B. & 1 others, Barres, B. A., Jan 26 2017, In : Nature. 541, 7638, p. 481-487 7 p.

Research output: Contribution to journalArticle

Nitric Oxide Signaling in Neurodegeneration and Cell Death

Dawson, T. M. & Dawson, V., 2017, (Accepted/In press) In : Advances in Pharmacology.

Research output: Contribution to journalArticle

Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases

Berger, N. A., Besson, V. C., Boulares, A. H., Bürkle, A., Chiarugi, A., Clark, R. S., Curtin, N. J., Cuzzocrea, S., Dawson, T. M., Dawson, V., Haskó, G., Liaudet, L., Moroni, F., Pacher, P., Radermacher, P., Salzman, A. L., Snyder, S. H., Soriano, F. G., Strosznajder, R. P., Sümegi, B. & 2 others, Swanson, R. A. & Szabo, C., 2017, (Accepted/In press) In : British Journal of Pharmacology.

Research output: Contribution to journalArticle

Overexpression of Parkinson’s disease-associated mutation LRRK2 G2019S in mouse forebrain induces behavioral deficits and α-synuclein pathology

Xiong, Y., Neifert, S., Karuppagounder, S., Stankowski, J. N., Lee, B. D., Grima, J. C., Chen, G., Ko, H. S., Lee, Y., Swing, D., Tessarollo, L., Dawson, T. M. & Dawson, V., 2017, In : eNeuro. 4, 2, e0004.

Research output: Contribution to journalArticle

Parkinson's disease biomarkers: Perspective from the NINDS Parkinson's Disease Biomarkers Program

Gwinn, K., David, K. K., Swanson-Fischer, C., Albin, R., Hillaire-Clarke, C. S., Sieber, B. A., Lungu, C., Bowman, F. D., Alcalay, R. N., Babcock, D., Dawson, T. M., Dewey, R. B., Foroud, T., German, D., Huang, X., Petyuk, V., Potashkin, J. A., Saunders-Pullman, R., Sutherland, M., Walt, D. R. & 6 others, West, A. B., Zhang, J., Chen-Plotkin, A., Scherzer, C. R., Vaillancourt, D. E. & Rosenthal, L. I. S., Jun 1 2017, In : Biomarkers in Medicine. 11, 6, p. 451-473 23 p.

Research output: Contribution to journalReview article

PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival

Lee, Y., Stevens, D. A., Kang, S., Jiang, H., Lee, Y. I., Ko, H. S., Scarffe, L. A., Umanah, G., Kang, H., Ham, S., Kam, T-I., Allen, K., Brahmachari, S., Kim, J. W., Neifert, S., Yun, S. P., Fiesel, F. C., Springer, W., Dawson, V., Shin, J. H. & 1 others, Dawson, T. M., Jan 24 2017, In : Cell Reports. 18, 4, p. 918-932 15 p.

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