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2019

Age differences in outcome after mild traumatic brain injury: results from the HeadSMART study

Richey, L. N., Rao, V., Roy, D., Narapareddy, B. R., Wigh, S., Bechtold, K. T., Sair, H. I., Van Meter, T. E., Falk, H., Leoutsakos, J. M., Yan, H., Lyketsos, C. G., Korley, F. K. & Peters, M. E., Jan 1 2019, (Accepted/In press) In : International Review of Psychiatry.

Research output: Contribution to journalArticle

Brain Concussion
Post-Concussion Syndrome
Logistic Models
Glasgow Outcome Scale
Craniocerebral Trauma

Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging

Kapogiannis, D., Mustapic, M., Shardell, M. D., Berkowitz, S. T., Diehl, T. C., Spangler, R. D., Tran, J., Lazaropoulos, M. P., Chawla, S., Gulyani, S., Eitan, E., An, Y., Huang, C. W., Oh, E., Lyketsos, C. G., Resnick, S. M., Goetzl, E. J. & Ferrucci, L., Jan 1 2019, In : JAMA Neurology.

Research output: Contribution to journalArticle

Baltimore
Longitudinal Studies
Alzheimer Disease
Biomarkers
Insulin Receptor Substrate Proteins

Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (Nature Genetics, (2019), 51, 3, (414-430), 10.1038/s41588-019-0358-2)

Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE) & Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), Sep 1 2019, In : Nature genetics. 51, 9, p. 1423-1424 2 p.

Research output: Contribution to journalComment/debate

Open Access
Meta-Analysis
Immunity
Alzheimer Disease
Lipids

Automated generation of radiologic descriptions on brain volume changes from T1-weighted MR images: Initial assessment of feasibility

The Alzheimer's Disease Neuroimaging Initiative, Jan 1 2019, In : Frontiers in Neurology. 10, JAN, 7.

Research output: Contribution to journalArticle

Open Access
Magnetic Resonance Spectroscopy
Brain
Atlases
Atrophy
Reading

Caregiver-Care Recipient Relationship Closeness is Associated With Neuropsychiatric Symptoms in Dementia

Vernon, E. K., Cooley, B., Rozum, W., Rattinger, G. B., Behrens, S., Matyi, J., Fauth, E., Lyketsos, C. G. & Tschanz, J. A. T., Jan 1 2019, (Accepted/In press) In : American Journal of Geriatric Psychiatry.

Research output: Contribution to journalArticle

Caregivers
Dementia
Aggression
Psychotic Disorders
Linear Models

Cloud-Based Brain Magnetic Resonance Image Segmentation and Parcellation System for Individualized Prediction of Cognitive Worsening

and Alzheimer's Disease Neuroimaging Initiative ADNI, Jan 1 2019, In : Journal of Healthcare Engineering. 2019, 9507193.

Research output: Contribution to journalArticle

Open Access
Magnetic resonance
Image segmentation
Brain
Magnetic Resonance Spectroscopy
Neuroimaging

Comment on “Personality Changes During the Transition from Cognitive Health to Mild Cognitive Impairment”

Agϋera-Ortiz, L., Lyketsos, C. G. & Ismail, Z., Jan 1 2019, In : Journal of the American Geriatrics Society. 67, 1, p. 190-191 2 p.

Research output: Contribution to journalLetter

Health Transition
Personality
Cognitive Dysfunction

Comparing proxy rated quality of life of people living with dementia in care homes

Robertson, S., Cooper, C., Hoe, J., Lord, K., Rapaport, P., Marston, L., Cousins, S., Lyketsos, C. G. & Livingston, G., Jan 1 2019, (Accepted/In press) In : Psychological Medicine. p. 1-10 10 p.

Research output: Contribution to journalArticle

Proxy
Home Care Services
Dementia
Quality of Life
Spouses
Citalopram
Multicenter Studies
Alzheimer Disease
Randomized Controlled Trials
Research Personnel

Fornix-region deep brain stimulation–induced memory flashbacks in Alzheimer’s disease

Deeb, W., Salvato, B., Almeida, L., Foote, K. D., Amaral, R., Germann, J., Rosenberg, P. B., Tang-Wai, D. F., Wolk, D. A., Burke, A. D., Salloway, S., Sabbagh, M. N., Chakravarty, M. M., Smith, G., Lyketsos, C. G., Lozano, A. M. & Okun, M. S., Aug 22 2019, In : New England Journal of Medicine. 381, 8, p. 783-785 3 p.

Research output: Contribution to journalLetter

Deep Brain Stimulation
Alzheimer Disease

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Alzheimer Disease Genetics Consortium (ADGC), The European Alzheimer’s Disease Initiative (EADI), Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE), & Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES), Mar 1 2019, In : Nature genetics. 51, 3, p. 414-430 17 p.

Research output: Contribution to journalArticle

Meta-Analysis
Immunity
Alzheimer Disease
Lipids
Serum Amyloid A Protein

History of traumatic brain injury interferes with accurate diagnosis of Alzheimer’s dementia: a nation-wide case-control study

Pradeep, T., Bray, M. J. C., Arun, S., Richey, L. N., Jahed, S., Bryant, B. R., LoBue, C., Lyketsos, C. G., Kim, P. & Peters, M. E., Jan 1 2019, (Accepted/In press) In : International Review of Psychiatry.

Research output: Contribution to journalArticle

Case-Control Studies
Alzheimer Disease
Diagnostic Errors
Dementia
National Institute on Aging (U.S.)

Loss of consciousness and altered mental state predicting depressive and post-concussive symptoms after mild traumatic brain injury

Roy, D., Peters, M., Everett, A. D., Leoutsakos, J-M. S., Yan, H., Rao, V. A., Kortte, K. B., Sair, H., Van Meter, T. E., Falk, H., Vassila, A., Hall, A., Ofoche, U., Akbari, F., Lyketsos, C. G. & Korley, F., Jan 1 2019, In : Brain Injury.

Research output: Contribution to journalArticle

Post-Concussion Syndrome
Brain Concussion
Unconsciousness
Depression
Wounds and Injuries
Equipment and Supplies
Dementia
Alzheimer Disease
Anxiety
Cognitive Dysfunction

Neuropsychiatric symptoms in patients with dementia and the longitudinal costs of informal care in the Cache County population

Rattinger, G. B., Sanders, C. L., Vernon, E., Schwartz, S., Behrens, S., Lyketsos, C. G. & Tschanz, J. A. T., Jan 1 2019, In : Alzheimer's and Dementia: Translational Research and Clinical Interventions. 5, p. 81-88 8 p.

Research output: Contribution to journalArticle

Open Access
Dementia
Patient Care
Costs and Cost Analysis
Population
Apathy
Baltimore
Sex Characteristics
Divorce
Psychological Stress
Dementia
Open Access
Neurobehavioral Manifestations
Dementia
Volunteers
Focus Groups
Healthy Volunteers
Dementia
Healthy Volunteers
Equipment and Supplies
Proportional Hazards Models
Volunteers
Open Access
Antipsychotic Agents
Dementia
Behavioral Symptoms
Psychology
Hunger
2018

Abnormal CSF amyloid-β42 and tau levels in hip fracture patients without dementia

Oh, E., Blennow, K., Bigelow, G., Inouye, S. K., Marcantonio, E. R., Neufeld, K. J., Rosenberg, P. B., Troncoso, J. C., Wang, N. Y., Zetterberg, H., Sieber, F. & Lyketsos, C. G., Sep 1 2018, In : PLoS One. 13, 9, e0204695.

Research output: Contribution to journalArticle

hip fractures
Cerebrospinal fluid
dementia
Hip Fractures
cerebrospinal fluid

Advancing Research on Care Needs and Supportive Approaches for Persons With Dementia: Recommendations and Rationale

Kolanowski, A., Fortinsky, R. H., Calkins, M., Devanand, D. P., Gould, E., Heller, T., Hodgson, N. A., Kales, H. C., Kaye, J., Lyketsos, C. G., Resnick, B., Schicker, M. & Zimmerman, S., Jan 1 2018, (Accepted/In press) In : Journal of the American Medical Directors Association.

Research output: Contribution to journalArticle

Dementia
Research
Behavioral Symptoms
Developmental Disabilities
Social Environment

A Precision Medicine Model for Targeted NSAID Therapy in Alzheimer's Disease

O'Bryant, S. E., Zhang, F., Johnson, L. A., Hall, J., Edwards, M., Grammas, P., Oh, E., Lyketsos, C. G. & Rissman, R. A., Jan 1 2018, In : Journal of Alzheimer's disease : JAD. 66, 1, p. 97-104 8 p.

Research output: Contribution to journalArticle

Precision Medicine
Non-Steroidal Anti-Inflammatory Agents
Alzheimer Disease
Naproxen
Proteomics

Association of a Care Coordination Model With Health Care Costs and Utilization: The Johns Hopkins Community Health Partnership (J-CHiP)

Johns Hopkins Community Health Partnership (J-CHiP) Team, Nov 2 2018, In : JAMA Network Open. 1, 7, p. e184273

Research output: Contribution to journalArticle

Open Access
Patient Acceptance of Health Care
Health Care Costs
Medicaid
Medicare
Health

Characterization of 3 novel tau radiopharmaceuticals,11C-RO-963,11C-RO-643, and18F-RO-948, in healthy controls and in Alzheimer subjects

Wong, D. F., Comley, R. A., Kuwabara, H., Rosenberg, P. B., Resnick, S. M., Ostrowitzki, S., Vozzi, C., Boess, F., Oh, E., Lyketsos, C. G., Honer, M., Gobbi, L., Klein, G., George, N., Gapasin, L., Kitzmiller, K., Roberts, J., Sevigny, J., Nandi, A., Brasic, J. R. & 7 others, Mishra, C., Thambisetty, M., Mogekar, A., Mathur, A., Albert, M., Dannals, R. F. & Borroni, E., Dec 1 2018, In : Journal of Nuclear Medicine. 59, 12, p. 1869-1876 8 p.

Research output: Contribution to journalArticle

Radiopharmaceuticals
Alzheimer Disease
Whole Body Imaging
Brain
Temporal Lobe

Deep Brain Stimulation Targeting the Fornix for Mild Alzheimer Dementia (the ADvance Trial): A Two Year Follow-up Including Results of Delayed Activation

Leoutsakos, J-M. S., Yan, H., Anderson, W. S., Asaad, W. F., Baltuch, G., Burke, A., Chakravarty, M. M., Drake, K. E., Foote, K. D., Fosdick, L., Giacobbe, P., Mari, Z., McAndrews, M. P., Munro, C., Oh, E., Okun, M. S., Pendergrass, J. C., Ponce, F. A., Rosenberg, P. B., Sabbagh, M. N. & 7 others, Salloway, S., Tang-Wai, D. F., Targum, S. D., Wolk, D., Lozano, A. M., Smith, G. & Lyketsos, C. G., Jan 1 2018, In : Journal of Alzheimer's Disease. 64, 2, p. 597-606 10 p.

Research output: Contribution to journalArticle

Deep Brain Stimulation
Alzheimer Disease
Safety
Therapeutics
Electrodes

Effect of the WeCareAdvisor™ on family caregiver outcomes in dementia: A pilot randomized controlled trial

Kales, H. C., Gitlin, L. N., Stanislawski, B., Myra Kim, H., Marx, K., Turnwald, M., Chiang, C. & Lyketsos, C. G., May 10 2018, In : BMC Geriatrics. 18, 1, 113.

Research output: Contribution to journalArticle

Caregivers
Dementia
Randomized Controlled Trials
Behavioral Symptoms
Control Groups

Erratum: Going beyond clinical care to reduce health care spending: Findings from the J-CHiP community-based population health management program evaluation (Medical Care (2018) 56 (603-609) DOI: 10.1097/MLR.0000000000000934)

Andon, L., Bailey, J., Baumgartner, W., Bellantoni, M., Beranek, E., Blum, R., Boonyasai, R. T., Brown, P. M. C., Brotman, D. J., Colmers, J., Deutschendorf, A., Durso, S. C., Erdman, S., Everett, A., Filbert, L., Fingerhood, M., Ford, D., Greene, P., Haldeman, D., Hellmann, D. & 22 others, Hickman, D., Howell, E. E., Kachur, S., Kravet, S., Langley, A., Lepley, D., Leung, C., Lyketsos, C. G., Mandell, S., Myers, M., Novak, T., Parker, D., Petinga, M., Proctor, L. H., Purnell, L., Reel, S., Reitz, J., Richardson, M., Rothman, P. B., Sylvester, C., Truant, V. & Young, H., Dec 1 2018, In : Medical Care. 56, 12, 1 p.

Research output: Contribution to journalComment/debate

Melissa
Corylus
Program Evaluation
Delivery of Health Care
Health

Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease

International Genomics of Alzheimer's Project (IGAP), ARUK Consortium & GERAD/PERADES, CHARGE, ADGC, EADI, Jan 1 2018, In : Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 10, p. 595-598 4 p.

Research output: Contribution to journalArticle

Cholesterol Ester Transfer Proteins
HDL Cholesterol
Alzheimer Disease
Genes
Single Nucleotide Polymorphism

Home is where the future is: The BrightFocus Foundation consensus panel on dementia care

Samus, Q. M., Black, B. E., Bovenkamp, D., Buckley, M., Callahan, C., Davis, K., Gitlin, L. N., Hodgson, N., Johnston, D. M., Kales, H. C., Karel, M., Kenney, J. J., Ling, S. M., Panchal, M., Reuland, M., Willink, A. & Lyketsos, C. G., Jan 1 2018, In : Alzheimer's and Dementia. 14, 1, p. 104-114 11 p.

Research output: Contribution to journalShort survey

Dementia
Consensus
Safety Management
Continuity of Patient Care
Reward

Identifying Better Outcome Measures to Improve Treatment of Agitation in Dementia: A Report from the EU/US/CTAD Task Force

Sano, M., Soto, M., Carrillo, M., Cummings, J., Hendrix, S., Mintzer, J., Porsteinsson, A., Rosenberg, P., Schneider, L., Touchon, J., Aisen, P., Vellas, B. & Lyketsos, C., Jan 1 2018, In : The journal of prevention of Alzheimer's disease. 5, 2, p. 98-102 5 p.

Research output: Contribution to journalArticle

Advisory Committees
Caregivers
Dementia
Outcome Assessment (Health Care)
Clinical Trials

Implementation of a comprehensive program to improve coordination of care in an urban academic health care system

on behalf of the J-CHiP program, Aug 20 2018, In : Journal of Health Organization and Management. 32, 5, p. 638-657 20 p.

Research output: Contribution to journalArticle

Urban Health
Delivery of Health Care
Skilled Nursing Facilities
Patient Transfer
Primary Health Care

Influence of study population definition on the effect of age on outcomes after blunt head trauma

Peters, M., Hsu, M., Rao, V. A., Roy, D., Narapareddy, B. R., Kortte, K. B., Sair, H., Van Meter, T. E., Falk, H., Hall, A. J., Lyketsos, C. G. & Korley, F., Jan 1 2018, (Accepted/In press) In : Brain Injury.

Research output: Contribution to journalArticle

United States Department of Veterans Affairs
Craniocerebral Trauma
Post-Concussion Syndrome
Population
Depression

Management of behavioral and psychological symptoms in people with Alzheimer's disease: An international Delphi consensus

Kales, H. C., Lyketsos, C. G., Miller, E. M. & Ballard, C., Jan 1 2018, (Accepted/In press) In : International Psychogeriatrics.

Research output: Contribution to journalArticle

Behavioral Symptoms
Dementia
Consensus
Alzheimer Disease
Psychology
Home Care Services
Caregivers
Dementia
Long-Term Care
Quality of Life

New Clues to Preclinical Alzheimer’s Disease

Rosenberg, P. B. & Lyketsos, C. G., Jun 1 2018, In : American Journal of Psychiatry. 175, 6, p. 493-494 2 p.

Research output: Contribution to journalEditorial

Alzheimer Disease

Nutritional Status is Associated with Severe Dementia and Mortality: The Cache County Dementia Progression Study

Sanders, C. L., Wengreen, H. J., Schwartz, S., Behrens, S. J., Corcoran, C., Lyketsos, C. G. & Tschanz, J. T., Jan 1 2018, (Accepted/In press) In : Alzheimer Disease and Associated Disorders.

Research output: Contribution to journalArticle

Nutritional Status
Dementia
Mortality
Nutrition Assessment
Malnutrition

Population Neuroscience: Dementia Epidemiology Serving Precision Medicine and Population Health

Ganguli, M., Albanese, E., Seshadri, S., Bennett, D. A., Lyketsos, C. G., Kukull, W. A., Skoog, I. & Hendrie, H. C., Jan 1 2018, In : Alzheimer Disease and Associated Disorders. 32, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Precision Medicine
Neurosciences
Dementia
Epidemiology
Health

Recommendations for the Nomenclature of Cognitive Change Associated With Anaesthesia and Surgery-2018

Nomenclature Consensus Working Group, Nov 1 2018, In : Anesthesia and Analgesia. 127, 5, p. 1189-1195 7 p.

Research output: Contribution to journalArticle

Terminology
Anesthesia
Research
Preoperative Period
Perioperative Period

Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery—2018

The Nomenclature Consensus Working Group, Nov 1 2018, In : Acta Anaesthesiologica Scandinavica. 62, 10, p. 1473-1480 8 p.

Research output: Contribution to journalArticle

Terminology
Anesthesia
Research
Preoperative Period
Perioperative Period

Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery—2018

The Nomenclature Consensus Working Group, Jan 1 2018, (Accepted/In press) In : British Journal of Anaesthesia.

Research output: Contribution to journalArticle

Terminology
Anesthesia
Research
Preoperative Period
Perioperative Period

Sex Differences in the Neuropsychiatric Symptoms of Patients With Alzheimer’s Disease

Tao, Y., Peters, M., Drye, L. T., Devanand, D. P., Mintzer, J. E., Pollock, B. G., Porsteinsson, A. P., Rosenberg, P. B., Schneider, L. S., Shade, D., Weintraub, D., Yesavage, J., Lyketsos, C. G., Munro, C. & for the CitAD Research Group, T. CD. R. G., Jan 1 2018, (Accepted/In press) In : American Journal of Alzheimer's Disease and other Dementias.

Research output: Contribution to journalArticle

Sex Characteristics
Alzheimer Disease
Equipment and Supplies
Citalopram
Multicenter Studies

Sex-specific association of apolipoprotein e with cerebrospinal fluid levels of tau

Alzheimer's Disease Genetics Consortium and the Alzheimer's Disease Neuroimaging Initiative, Aug 1 2018, In : JAMA Neurology. 75, 8, p. 989-998 10 p.

Research output: Contribution to journalArticle

Apolipoproteins
Apolipoproteins E
Cerebrospinal Fluid
Alzheimer Disease
Neurofibrillary Tangles

Sex-specific genetic predictors of Alzheimer’s disease biomarkers

Alzheimer’s Disease Neuroimaging Initiative (ADNI) & The Alzheimer Disease Genetics Consortium (Adgc), Jul 2 2018, (Accepted/In press) In : Acta Neuropathologica. p. 1-16 16 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Biomarkers
Genome-Wide Association Study
Amyloid
Endophenotypes

Special Issue on mild behavioral impairment and non-cognitive prodromes to dementia

Mortby, M. E., Lyketsos, C. G., Geda, Y. E. & Ismail, Z., Feb 1 2018, In : International Psychogeriatrics. 30, 2, p. 167-169 3 p.

Research output: Contribution to journalReview article

Neurobehavioral Manifestations
Dementia
Cognitive Dysfunction
Observational Studies
Dementia
Medicare
Education
Fee-for-Service Plans

Use of FDA approved medications for Alzheimer's disease in mild dementia is associated with reduced informal costs of care

Behrens, S., Rattinger, G. B., Schwartz, S., Matyi, J., Sanders, C., DeBerard, M. S., Lyketsos, C. G. & Tschanz, J. A. T., Mar 21 2018, (Accepted/In press) In : International Psychogeriatrics. p. 1-9 9 p.

Research output: Contribution to journalArticle

Dementia
Patient Care
Alzheimer Disease
Costs and Cost Analysis
Salaries and Fringe Benefits
2017

A randomized trial of a web-based platform to help families manage dementia-related behavioral symptoms: The WeCareAdvisor™

Gitlin, L. N., Kales, H. C., Marx, K., Stanislawski, B. & Lyketsos, C. G., Nov 1 2017, In : Contemporary Clinical Trials. 62, p. 27-36 10 p.

Research output: Contribution to journalArticle

Behavioral Symptoms
Dementia
Caregivers
Interviews
Therapeutics

Characterizing Highly Benefited Patients in Randomized Clinical Trials

Charu, V., Rosenberg, P. B., Schneider, L. S., Drye, L. T., Rein, L., Shade, D., Lyketsos, C. G. & Frangakis, C., 2017, In : International Journal of Biostatistics. 13, 1, 20160045.

Research output: Contribution to journalArticle

Randomized Clinical Trial
Randomized Controlled Trials
Randomized Controlled Trial
Predictors
Covariates
Home Care Services
Dementia
Delivery of Health Care
Medicare
Medicaid