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2019

Acclimation to a thermoneutral environment abolishes age-associated alterations in heart rate and heart rate variability in conscious, unrestrained mice

Axsom, J. E., Nanavati, A. P., Rutishauser, C. A., Bonin, J. E., Moen, J. M. & Lakatta, E. G., Jan 1 2019, (Accepted/In press) In : GeroScience.

Research output: Contribution to journalArticle

Open Access
Acclimatization
Heart Rate
Temperature
Cardiovascular Models
Controlled Environment

Acute salt loading and cardiotonic steroids in resistant hypertension

Emelyanov, I. V., Konradi, A. O., Lakatta, E., Fedorova, O. V. & Bagrov, A. Y., Jan 1 2019, Current Topics in Membranes. Academic Press Inc., (Current Topics in Membranes).

Research output: Chapter in Book/Report/Conference proceedingChapter

Cardiac Glycosides
Pulse Wave Analysis
Vascular Stiffness
Salts
Hypertension

Age-related changes of the retinal microvasculature

Orlov, N. V., Coletta, C., van Asten, F., Qian, Y., Ding, J., AlGhatrif, M., Lakatta, E., Chew, E., Wong, W., Swaroop, A., Fiorillo, E., Delitala, A., Marongiu, M., Goldberg, I. G. & Schlessinger, D., May 1 2019, In : PloS one. 14, 5, e0215916.

Research output: Contribution to journalArticle

Open Access
Blood pressure
Microvessels
Fractals
Blood Pressure
photographs

Aging, MicroRNAs, and Heart Failure

Florio, M. C., Magenta, A., Beji, S., Lakatta, E. G. & Capogrossi, M. C., Jan 1 2019, (Accepted/In press) In : Current Problems in Cardiology.

Research output: Contribution to journalArticle

MicroRNAs
Heart Failure
Small Untranslated RNA
Untranslated RNA
Blood Vessels

Cardiotonic Steroids Induce Vascular Fibrosis Via Pressure-Independent Mechanism in NaCl-Loaded Diabetic Rats

Fedorova, O. V., Fadeev, A. V., Grigorova, Y. N., Marshall, C. A., Zernetkina, V., Kolodkin, N. I., Agalakova, N. I., Konradi, A. O., Lakatta, E. G. & Bagrov, A. Y., Nov 1 2019, In : Journal of cardiovascular pharmacology. 74, 5, p. 436-442 7 p.

Research output: Contribution to journalArticle

Cardiac Glycosides
Blood Vessels
Fibrosis
Pressure
Transforming Growth Factors

Complexities in cardiovascular rhythmicity: perspectives on circadian normality, ageing and disease

Monfredi, O. & Lakatta, E. G., Sep 1 2019, In : Cardiovascular research. 115, 11, p. 1576-1595 20 p.

Research output: Contribution to journalArticle

Open Access
Periodicity
Health
Solar System
Brain Stem
Retina

Discoidin domain Receptor 2: A determinant of metabolic syndrome-associated arterial fibrosis in non-human primates

Ushakumary, M. G., Wang, M., Harikrishnan, V., Titus, A. S., Zhang, J., Liu, L., Monticone, R., Wang, Y., Mattison, J. A., De Cabo, R., Lakatta, E. G. & Kailasam, S., Jan 1 2019, In : PloS one. 14, 12, e0225911.

Research output: Contribution to journalArticle

Open Access
metabolic syndrome
Collagen Type I
fibrosis
Primates
collagen

Impact of Stiffer Arteries on the Response to Antihypertensive Treatment: A Longitudinal Study of the SardiNIA Cohort

Lakatta, E. G., AlunniFegatelli, D., Morrell, C. H., Fiorillo, E., Orru, M., Delitala, A., Marongiu, M., Schlessinger, D., Cucca, F. & Scuteri, A., Jan 1 2019, (Accepted/In press) In : Journal of the American Medical Directors Association.

Research output: Contribution to journalArticle

Pulse Wave Analysis
Antihypertensive Agents
Italy
Longitudinal Studies
Arteries

Monoclonal Antibody to Marinobufagenin Downregulates TGFβ Profibrotic Signaling in Left Ventricle and Kidney and Reduces Tissue Remodeling in Salt-Sensitive Hypertension

Zhang, Y., Wei, W., Shilova, V., Petrashevskaya, N. N., Zernetkina, V. I., Grigorova, Y. N., Marshall, C. A., Fenner, R. C., Lehrmann, E., Wood, W. H., Becker, K. G., Lakatta, E. G., Bagrov, A. Y. & Fedorova, O. V., Oct 15 2019, In : Journal of the American Heart Association. 8, 20, p. e012138

Research output: Contribution to journalArticle

Open Access
Heart Ventricles
Inbred Dahl Rats
Down-Regulation
Salts
Monoclonal Antibodies

Overexpression of a neuronal type adenylyl cyclase (type 8) in sinoatrial node markedly impacts heart rate and rhythm

Moen, J. M., Matt, M. G., Ramirez, C., Tarasov, K. V., Chakir, K., Tarasova, Y. S., Lukyanenko, Y., Tsutsui, K., Monfredi, O., Morrell, C. H., Tagirova, S., Yaniv, Y., Huynh, T., Pacak, K., Ahmet, I. & Lakatta, E. G., Jan 1 2019, In : Frontiers in Neuroscience. 13, JUN, 00615.

Research output: Contribution to journalArticle

Open Access
Sinoatrial Node
Heart Rate
Adenylyl Cyclases
G-Protein-Coupled Receptor Kinase 5
Catecholamines
Open Access
Independent Living
Ankle Brachial Index
Population
Pulse Wave Analysis
Baltimore

To help aging populations, classify organismal senescence

Calimport, S. R. G., Bentley, B. L., Stewart, C. E., Pawelec, G., Scuteri, A., Vinciguerra, M., Slack, C., Chen, D., Harries, L. W., Marchant, G., Alexander Fleming, G., Conboy, M., Antebi, A., Small, G. W., Gil, J., Lakatta, E. G., Richardson, A., Rosen, C., Nikolich, K., Wyss-Coray, T. & 5 others, Steinman, L., Montine, T., de Magalhães, J. P., Campisi, J. & Church, G., Nov 1 2019, In : Science. 366, 6465, p. 576-578 3 p.

Research output: Contribution to journalArticle

2018

A coupled-clock system drives the automaticity of human sinoatrial nodal pacemaker cells

Tsutsui, K., Monfredi, O. J., Sirenko-Tagirova, S. G., Maltseva, L. A., Bychkov, R., Kim, M. S., Ziman, B. D., Tarasov, K. V., Tarasova, Y. S., Zhang, J., Wang, M., Maltsev, A. V., Brennan, J. A., Efimov, I. R., Stern, M. D., Maltsev, V. A. & Lakatta, E., Jun 12 2018, In : Science Signaling. 11, 534, eaap7608.

Research output: Contribution to journalArticle

Pacemakers
Clocks
Action Potentials
Sinoatrial Node
Animals

Adipocytokine correlations with thyroid function and autoimmunity in euthyroid sardinians

Delitala, A. P., Steri, M., Fiorillo, E., Marongiu, M., Lakatta, E., Schlessinger, D. & Cucca, F., Nov 1 2018, In : Cytokine. 111, p. 189-193 5 p.

Research output: Contribution to journalArticle

Adipokines
Adiponectin
Leptin
Autoimmunity
Thyroid Gland

Aldosterone, inactive matrix gla-protein, and large artery stiffness in hypertension

Chirinos, J. A., Sardana, M., Syed, A. A., Koppula, M. R., Varakantam, S., Vasim, I., Oldland, H. G., Phan, T. S., Drummen, N. E. A., Vermeer, C., Townsend, R. R., Akers, S. R., Wei, W., Lakatta, E. & Fedorova, O. V., Jan 1 2018, (Accepted/In press) In : Journal of the American Society of Hypertension.

Research output: Contribution to journalArticle

Aldosterone
Arteries
Hypertension
Pulse Wave Analysis
Thigh

Antibody to marinobufagenin reverses placenta-induced fibrosis of umbilical arteries in preeclampsia

Fedorova, O. V., Ishkaraeva, V. V., Grigorova, Y. N., Reznik, V. A., Kolodkin, N. I., Zazerskaya, I. E., Zernetkina, V., Agalakova, N. I., Tapilskaya, N. I., Adair, C. D., Lakatta, E. & Bagrov, A. Y., Aug 13 2018, In : International Journal of Molecular Sciences. 19, 8, 2377.

Research output: Contribution to journalArticle

fibrosis
Umbilical Arteries
Blood pressure
arteries
blood pressure

Association of arginine vasopressin with low atrial natriuretic peptide levels, left ventricular remodelling, and outcomes in adults with and without heart failure

Chirinos, J. A., Sardana, M., Oldland, G., Ansari, B., Lee, J., Hussain, A., Mustafa, A., Akers, S. R., Wei, W., Lakatta, E. & Fedorova, O. V., Oct 1 2018, In : ESC heart failure. 5, 5, p. 911-919 9 p.

Research output: Contribution to journalArticle

Ventricular Remodeling
Arginine Vasopressin
Atrial Natriuretic Factor
Heart Failure
Confidence Intervals

Basal Spontaneous Firing of Rabbit Sinoatrial Node Cells Is Regulated by Dual Activation of PDEs (Phosphodiesterases) 3 and 4

Vinogradova, T. M., Sirenko, S., Lukyanenko, Y. O., Yang, D., Tarasov, K. V., Lyashkov, A. E., Varghese, N. J., Li, Y., Chakir, K., Ziman, B. & Lakatta, E., Jun 1 2018, In : Circulation: Arrhythmia and Electrophysiology. 11, 6, e005896.

Research output: Contribution to journalArticle

Type 4 Cyclic Nucleotide Phosphodiesterase
Sinoatrial Node
Rabbits
Phosphoric Diester Hydrolases
Ryanodine Receptor Calcium Release Channel

Calorie restriction curbs proinflammation that accompanies arterial aging, preserving a youthful phenotype

Wang, M., Zhang, L., Zhu, W., Zhang, J., Kim, S. H., Wang, Y., Ni, L., Telljohann, R., Monticone, R. E., McGraw, K., Liu, L., de Cabo, R. & Lakatta, E., Sep 1 2018, In : Journal of the American Heart Association. 7, 18, e009112.

Research output: Contribution to journalArticle

Platelet-Derived Growth Factor
Phenotype
Vascular Smooth Muscle
Smooth Muscle Myocytes
Aorta

Characteristics of healthy vascular ageing in pooled population-based cohort studies: the global Metabolic syndrome and Artery REsearch Consortium

Metabolic syndrome, Arteries REsearch (MARE) Consortium, Dec 1 2018, In : Journal of Hypertension. 36, 12, p. 2340-2349 10 p.

Research output: Contribution to journalArticle

Blood Vessels
Cohort Studies
Arteries
Pulse Wave Analysis
Research

Dietary sodium restriction reduces arterial stiffness, vascular TGF-β-dependent fibrosis and marinobufagenin in young normotensive rats

Grigorova, Y. N., Wei, W., Petrashevskaya, N., Zernetkina, V., Juhasz, O., Fenner, R., Gilbert, C., Lakatta, E., Shapiro, J. I., Bagrov, A. Y. & Fedorova, O. V., Oct 15 2018, In : International Journal of Molecular Sciences. 19, 10, 3168.

Research output: Contribution to journalArticle

Dietary Sodium
beta factor
fibrosis
Vascular Stiffness
Transforming Growth Factor beta

Dual activation of phosphodiesterases 3 and 4 regulates basal spontaneous beating rate of cardiac pacemaker cells: Role of compartmentalization?

Vinogradova, T. M., Kobrinsky, E. & Lakatta, E., Oct 9 2018, In : Frontiers in Physiology. 9, OCT, 1301.

Research output: Contribution to journalReview article

Type 4 Cyclic Nucleotide Phosphodiesterase
Phosphoric Diester Hydrolases
Cyclic AMP
Cyclic AMP-Dependent Protein Kinases
Ryanodine Receptor Calcium Release Channel
Ions
Rabbits
Sinoatrial Node
Cell Size
Names
Blood Pressure

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

the Million Veteran Program, Oct 1 2018, In : Nature Genetics. 50, 10, p. 1412-1425 14 p.

Research output: Contribution to journalArticle

Blood Pressure
Cardiovascular Diseases
Genetic Association Studies
Life Style
Hypertension

Heterogeneity of calcium clock functions in dormant, dysrhythmically and rhythmically firing single pacemaker cells isolated from SA node

Kim, M. S., Maltsev, A. V., Monfredi, O., Maltseva, L. A., Wirth, A., Florio, M. C., Tsutsui, K., Riordon, D. R., Parsons, S. P., Tagirova, S., Ziman, B. D., Stern, M. D., Lakatta, E. & Maltsev, V. A., Sep 1 2018, In : Cell Calcium. 74, p. 168-179 12 p.

Research output: Contribution to journalArticle

Sinoatrial Node
Calcium
Adrenergic Receptors
Action Potentials
Diastole

Positive Feedback Mechanisms among Local Ca Releases, NCX, and ICaL Ignite Pacemaker Action Potentials

Lyashkov, A. E., Beahr, J., Lakatta, E., Yaniv, Y. & Maltsev, V. A., Mar 13 2018, In : Biophysical Journal. 114, 5, p. 1176-1189 14 p.

Research output: Contribution to journalArticle

Action Potentials
Membrane Potentials
Ryanodine Receptor Calcium Release Channel
Sarcoplasmic Reticulum
Noise

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

van Setten, J., Brody, J. A., Jamshidi, Y., Swenson, B. R., Butler, A. M., Campbell, H., Del Greco, F. M., Evans, D. S., Gibson, Q., Gudbjartsson, D. F., Kerr, K. F., Krijthe, B. P., Lyytikäinen, L. P., Müller, C., Müller-Nurasyid, M., Nolte, I. M., Padmanabhan, S., Ritchie, M. D., Robino, A., Smith, A. V. & 106 others, Steri, M., Tanaka, T., Teumer, A., Trompet, S., Ulivi, S., Verweij, N., Yin, X., Arnar, D. O., Asselbergs, F. W., Bader, J. S., Barnard, J., Bis, J., Blankenberg, S., Boerwinkle, E., Bradford, Y., Buckley, B. M., Chung, M. K., Crawford, D., den Hoed, M., Denny, J. C., Dominiczak, A. F., Ehret, G. B., Eijgelsheim, M., Ellinor, P. T., Felix, S. B., Franco, O. H., Franke, L., Harris, T. B., Holm, H., Ilaria, G., Iorio, A., Kähönen, M., Kolcic, I., Kors, J. A., Lakatta, E., Launer, L. J., Lin, H., Lin, H. J., Loos, R. J. F., Lubitz, S. A., Macfarlane, P. W., Magnani, J. W., Leach, I. M., Meitinger, T., Mitchell, B. D., Munzel, T., Papanicolaou, G. J., Peters, A., Pfeufer, A., Pramstaller, P. P., Raitakari, O. T., Rotter, J. I., Rudan, I., Samani, N. J., Schlessinger, D., Silva Aldana, C. T., Sinner, M. F., Smith, J. D., Snieder, H., Soliman, E. Z., Spector, T. D., Stott, D. J., Strauch, K., Tarasov, K. V., Thorsteinsdottir, U., Uitterlinden, A. G., Van Wagoner, D. R., Völker, U., Völzke, H., Waldenberger, M., Jan Westra, H., Wild, P. S., Zeller, T., Alonso, A., Avery, C. L., Bandinelli, S., Benjamin, E. J., Cucca, F., Dörr, M., Ferrucci, L., Gasparini, P., Gudnason, V., Hayward, C., Heckbert, S. R., Hicks, A. A., Jukema, J. W., Kääb, S., Lehtimäki, T., Liu, Y., Munroe, P. B., Parsa, A., Polasek, O., Psaty, B. M., Roden, D. M., Schnabel, R. B., Sinagra, G., Stefansson, K., Stricker, B. H., van der Harst, P., van Duijn, C. M., Wilson, J. F., Gharib, S. A., de Bakker, P. I. W., Isaacs, A., Arking, D. & Sotoodehnia, N., Dec 1 2018, In : Nature Communications. 9, 1, 2904.

Research output: Contribution to journalArticle

genome
Genome-Wide Association Study
loci
Atrial Fibrillation
Meta-Analysis

Reduced vasorin enhances angiotensin II signaling within the aging arterial wall

Pintus, G., Giordo, R., Wang, Y., Zhu, W., Kim, S. H., Zhang, L., Ni, L., Zhang, J., Telljohann, R., McGraw, K. R., Monticone, R. E., Ferris, C., Liu, L., Wang, M. & Lakatta, E., Jun 1 2018, In : Oncotarget. 9, 43, p. 27117-27132 16 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Angiotensin II
Smooth Muscle Myocytes
Transforming Growth Factor beta1
Matrix Metalloproteinases

Segment-specific associations between local haemodynamic and imaging markers of early atherosclerosis at the carotid artery: an in vivo human study

Gallo, D., Bijari, P. B., Morbiducci, U., Qiao, Y., Xie, Y. J., Etesami, M., Habets, D., Lakatta, E., Wasserman, B. A. & Steinman, D. A., Oct 10 2018, In : Journal of the Royal Society, Interface. 15, 147

Research output: Contribution to journalArticle

Common Carotid Artery
Hemodynamics
Carotid Arteries
Shear stress
Atherosclerosis

TGFβ1 reinforces arterial aging in the vascular smooth muscle cell through a long-range regulation of the cytoskeletal stiffness

Zhu, W., Kim, B. C., Wang, M., Huang, J., Isak, A., Bexiga, N. M., Monticone, R., Ha, T., Lakatta, E. & An, S., Dec 1 2018, In : Scientific Reports. 8, 1, 2668.

Research output: Contribution to journalArticle

Transforming Growth Factors
Vascular Smooth Muscle
Smooth Muscle Myocytes
Thoracic Aorta
Actin Cytoskeleton

The reality of getting old

Lakatta, E., Sep 1 2018, In : Nature Reviews Cardiology. 15, 9, p. 499-500 2 p.

Research output: Contribution to journalComment/debate

Life Expectancy
Cardiology
Research

Unique Ca2+-cycling protein abundance and regulation sustains local Ca2+ releases and spontaneous firing of rabbit sinoatrial node cells

Vinogradova, T. M., Sirenko, S. T. & Lakatta, E., Aug 1 2018, In : International Journal of Molecular Sciences. 19, 8, 2173.

Research output: Contribution to journalReview article

sarcoplasmic reticulum
Sinoatrial Node
rabbits
Depolarization
Sarcoplasmic Reticulum
2017

Arterial Stiffness and Risk of Overall Heart Failure, Heart Failure with Preserved Ejection Fraction, and Heart Failure with Reduced Ejection Fraction: The Health ABC Study (Health, Aging, and Body Composition)

Pandey, A., Khan, H., Newman, A. B., Lakatta, E., Forman, D. E., Butler, J. & Berry, J. D., Feb 1 2017, In : Hypertension. 69, 2, p. 267-274 8 p.

Research output: Contribution to journalArticle

Vascular Stiffness
Pulse Wave Analysis
Body Composition
Thigh
Heart Failure

Causal effect of plasminogen activator inhibitor type 1 on coronary heart disease

CHARGE Consortium Hemostatic Factor Working Group, ICBP Consortium & CHARGE Consortium Subclinical Working Group, Jun 1 2017, In : Journal of the American Heart Association. 6, 6, e004918.

Research output: Contribution to journalArticle

Plasminogen Activator Inhibitor 1
Coronary Disease
Odds Ratio
Mendelian Randomization Analysis
Genome-Wide Association Study

Computer algorithms for automated detection and analysis of local Ca2+ releases in spontaneously beating cardiac pacemaker cells

Maltsev, A. V., Parsons, S. P., Kim, M. S., Tsutsui, K., Stern, M. D., Lakatta, E., Maltsev, V. A. & Monfredi, O., Jul 1 2017, In : PLoS One. 12, 7, e0179419.

Research output: Contribution to journalArticle

Pacemakers
calcium
cells
Noise
Affine transforms

Hemodynamic determinants of the short-term blood pressure variability: Differential roles of arterial stiffness and wave reflection

Hsu, P. F., Cheng, H. M., Sung, S. H., Chuang, S. Y., Lakatta, E., Yin, F. C. P., Chou, P. & Chen, C. H., 2017, In : American Journal of Hypertension. 30, 3, p. 256-263 8 p.

Research output: Contribution to journalArticle

Vascular Stiffness
Pulse Wave Analysis
Hemodynamics
Thigh
Blood Pressure

Longitudinal Association between Serum Uric Acid and Arterial Stiffness: Results from the Baltimore Longitudinal Study of Aging

Canepa, M., Viazzi, F., Strait, J. B., Ameri, P., Pontremoli, R., Brunelli, C., Studenski, S., Ferrucci, L., Lakatta, E. & AlGhatrif, M., Feb 1 2017, In : Hypertension. 69, 2, p. 228-235 8 p.

Research output: Contribution to journalArticle

Baltimore
Vascular Stiffness
Uric Acid
Longitudinal Studies
Serum

Lower mitochondrial energy production of the thigh muscles in patients with low-normal ankle-brachial index

AlGhatrif, M., Zane, A., Oberdier, M., Canepa, M., Studenski, S., Simonsick, E. M., Spencer, R. G., Fishbein, K., Reiter, D., Lakatta, E., McDermott, M. M. & Ferrucci, L., Sep 1 2017, In : Journal of the American Heart Association. 6, 9, e006604.

Research output: Contribution to journalArticle

Ankle Brachial Index
Thigh
Muscles
Phosphocreatine
Exercise

Mammalian γ2 AMPK regulates intrinsic heart rate

Yavari, A., Bellahcene, M., Bucchi, A., Sirenko, S., Pinter, K., Herring, N., Jung, J. J., Tarasov, K. V., Sharpe, E. J., Wolfien, M., Czibik, G., Steeples, V., Ghaffari, S., Nguyen, C., Stockenhuber, A., Clair, J. R. S., Rimmbach, C., Okamoto, Y., Yang, D., Wang, M. & 44 others, Ziman, B. D., Moen, J. M., Riordon, D. R., Ramirez, C., Paina, M., Lee, J., Zhang, J., Ahmet, I., Matt, M. G., Tarasova, Y. S., Baban, DI., Sahgal, N., Lockstone, H., Puliyadi, R., De Bono, J., Siggs, O. M., Gomes, J., Muskett, H., Maguire, M. L., Beglov, Y., Kelly, M., Dos Santos, P. P. N., Bright, N. J., Woods, A., Gehmlich, K., Isackson, H., Douglas, G., Ferguson, D. J. P., Schneider, J. E., Tinker, A., Wolkenhauer, O., Channon, K. M., Cornall, R. J., Sternick, E. B., Paterson, D. J., Redwood, C. S., Carling, D., Proenza, C., David, R., Baruscotti, M., DIfrancesco, D., Lakatta, E., Watkins, H. & Ashrafian, H., Dec 1 2017, In : Nature Communications. 8, 1, 1258.

Research output: Contribution to journalArticle

heart rate
AMP-Activated Protein Kinases
bradycardia
Heart Rate
homeostasis

Prognostic utility of morning blood pressure surge for 20-year all- cause and cardiovascular mortalities: Results of a community-based study

Cheng, H. M., Wu, C. L., Sung, S. H., Lee, J. C., Kario, K., Chiang, C. E., Huang, C. J., Hsu, P. F., Chuang, S. Y., Lakatta, E., Yin, F. C. P., Chou, P. & Chen, C. H., Dec 1 2017, In : Journal of the American Heart Association. 6, 12, e007667.

Research output: Contribution to journalArticle

Sleep
Blood Pressure
Mortality
Confidence Intervals
Proportional Hazards Models

Spontaneous, local diastolic subsarcolemmal calcium releases in single, isolated guinea-pig sinoatrial nodal cells

Sirenko, S. G., Yang, D., Maltseva, L. A., Kim, M. S., Lakatta, E. & Maltsev, V. A., Sep 1 2017, In : PLoS One. 12, 9, e0185222.

Research output: Contribution to journalArticle

guinea pigs
Guinea Pigs
Calcium
calcium
cells

The Pressure of Aging

AlGhatrif, M., Wang, M., Fedorova, O. V., Bagrov, A. Y. & Lakatta, E., Jan 1 2017, In : Medical Clinics of North America. 101, 1, p. 81-101 21 p.

Research output: Contribution to journalReview article

Blood Pressure
Pressure
Pulse Wave Analysis
Hemodynamics
Hypertension

The Systematic Evaluation of Identifying the Infarct Related Artery Utilizing Cardiac Magnetic Resonance in Patients Presenting with ST-Elevation Myocardial Infarction

Hamo, C. E., Klem, I., Rao, S. V., Songco, V., Najjar, S., Lakatta, E., Raman, S. V., Harrington, R. A. & Heitner, J. F., Jan 1 2017, In : PLoS One. 12, 1, e0169108.

Research output: Contribution to journalArticle

infarction
myocardial infarction
Magnetic resonance
arteries
Magnetic Resonance Spectroscopy
2016

52 Genetic Loci Influencing Myocardial Mass

van der Harst, P., van Setten, J., Verweij, N., Vogler, G., Franke, L., Maurano, M. T., Wang, X., Mateo Leach, I., Eijgelsheim, M., Sotoodehnia, N., Hayward, C., Sorice, R., Meirelles, O., Lyytikäinen, L. P., Polašek, O., Tanaka, T., Arking, D., Ulivi, S., Trompet, S., Müller-Nurasyid, M. & 140 others, Smith, A. V., Dörr, M., Kerr, K. F., Magnani, J. W., Del Greco M., F., Zhang, W., Nolte, I. M., Silva, C. T., Padmanabhan, S., Tragante, V., Esko, T., Abecasis, G. R., Adriaens, M. E., Andersen, K., Barnett, P., Bis, J. C., Bodmer, R., Buckley, B. M., Campbell, H., Cannon, M. V., Chakravarti, A., Chen, L. Y., Delitala, A., Devereux, R. B., Doevendans, P. A., Dominiczak, A. F., Ferrucci, L., Ford, I., Gieger, C., Harris, T. B., Haugen, E., Heinig, M., Hernandez, D. G., Hillege, H. L., Hirschhorn, J. N., Hofman, A., Hubner, N., Hwang, S. J., Iorio, A., Kähönen, M., Kellis, M., Kolcic, I., Kooner, I. K., Kooner, J. S., Kors, J. A., Lakatta, E., Lage, K., Launer, L. J., Levy, D., Lundby, A., Macfarlane, P. W., May, D., Meitinger, T., Metspalu, A., Nappo, S., Naitza, S., Neph, S., Nord, A. S., Nutile, T., Okin, P. M., Olsen, J. V., Oostra, B. A., Penninger, J. M., Pennacchio, L. A., Pers, T. H., Perz, S., Peters, A., Pinto, Y. M., Pfeufer, A., Pilia, M. G., Pramstaller, P. P., Prins, B. P., Raitakari, O. T., Raychaudhuri, S., Rice, K. M., Rossin, E. J., Rotter, J. I., Schafer, S., Schlessinger, D., Schmidt, C. O., Sehmi, J., Silljé, H. H. W., Sinagra, G., Sinner, M. F., Slowikowski, K., Soliman, E. Z., Spector, T. D., Spiering, W., Stamatoyannopoulos, J. A., Stolk, R. P., Strauch, K., Tan, S. T., Tarasov, K. V., Trinh, B., Uitterlinden, A. G., van den Boogaard, M., van Duijn, C. M., van Gilst, W. H., Viikari, J. S., Visscher, P. M., Vitart, V., Völker, U., Waldenberger, M., Weichenberger, C. X., Westra, H. J., Wijmenga, C., Wolffenbuttel, B. H., Yang, J., Bezzina, C. R., Munroe, P. B., Snieder, H., Wright, A. F., Rudan, I., Boyer, L. A., Asselbergs, F. W., van Veldhuisen, D. J., Stricker, B. H., Psaty, B. M., Ciullo, M., Sanna, S., Lehtimäki, T., Wilson, J. F., Bandinelli, S., Alonso, A., Gasparini, P., Jukema, J. W., Kääb, S., Gudnason, V., Felix, S. B., Heckbert, S. R., de Boer, R. A., Newton-Cheh, C., Hicks, A. A., Chambers, J. C., Jamshidi, Y., Visel, A., Christoffels, V. M., Isaacs, A., Samani, N. J. & de Bakker, P. I. W., Sep 27 2016, In : Journal of the American College of Cardiology. 68, 13, p. 1435-1448 14 p.

Research output: Contribution to journalArticle

Genetic Loci
Cardiomegaly
Meta-Analysis
Myocardium
Histone Code

AGE-RAGE signal generates a specific NF-Κ B RelA "barcode" that directs collagen i expression

Peng, Y., Kim, J. M., Park, H-S., Yang, A., Islam, C., Lakatta, E. & Lin, L., Jan 5 2016, In : Scientific Reports. 6, 18822.

Research output: Contribution to journalArticle

Collagen
NF-kappa B
Advanced Glycosylation End Products
Post Translational Protein Processing
Phosphorylation

Aortic Fibrosis, Induced by High Salt Intake in the Absence of Hypertensive Response, Is Reduced by a Monoclonal Antibody to Marinobufagenin

Grigorova, Y. N., Juhasz, O., Zernetkina, V., Fishbein, K. W., Lakatta, E., Fedorova, O. V. & Bagrov, A. Y., May 1 2016, In : American Journal of Hypertension. 29, 5, p. 641-646 6 p.

Research output: Contribution to journalArticle

Fibrosis
Salts
Monoclonal Antibodies
Nitroprusside
Blood Pressure

A rat carotid balloon injury model to test anti-vascular remodeling therapeutics

Petrasheskaya, N., Tae, H. J., Ahmet, I., Talan, M. I., Lakatta, E. & Lin, L., Sep 19 2016, In : Journal of Visualized Experiments. 2016, 115, e53777.

Research output: Contribution to journalArticle

Balloons
Rats
Wounds and Injuries
Pharmaceutical Preparations
Ultrasonography

Ca2 +/calmodulin-activated phosphodiesterase 1A is highly expressed in rabbit cardiac sinoatrial nodal cells and regulates pacemaker function

Lukyanenko, Y. O., Younes, A., Lyashkov, A. E., Tarasov, K. V., Riordon, D. R., Lee, J., Sirenko, S. G., Kobrinsky, E., Ziman, B., Tarasova, Y. S., Juhaszova, M., Sollott, S. J., Graham, D. & Lakatta, E., Sep 1 2016, In : Journal of Molecular and Cellular Cardiology. 98, p. 73-82 10 p.

Research output: Contribution to journalArticle

Type 1 Cyclic Nucleotide Phosphodiesterases
Rabbits
Calmodulin
Adenylyl Cyclases
Lipids