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  • Paul F Worley
2019

Arc Oligomerization Is Regulated by CaMKII Phosphorylation of the GAG Domain: An Essential Mechanism for Plasticity and Memory Formation

Zhang, W., Chuang, Y. A., Na, Y., Ye, Z., Yang, L., Lin, R., Zhou, J., Wu, J., Qiu, J., Savonenko, A., Leahy, D. J., Huganir, R., Linden, D. J. & Worley, P. F., Jul 11 2019, In : Molecular cell. 75, 1, p. 13-25.e5

Research output: Contribution to journalArticle

Increased alcohol-drinking induced by manipulations of mGlu5 phosphorylation within the bed nucleus of the stria terminalis

Campbell, R. R., Domingo, R. D., Williams, A. R., Wroten, M. G., McGregor, H. A., Waltermire, R. S., Greentree, D. I., Goulding, S. P., Thompson, A. B., Lee, K. M., Quadir, S. G., Chavez, C. L. J., Coelho, M. A., Gould, A. T., Von Jonquieres, G., Klugmann, M., Worley, P. F., Kippin, T. E. & Szumlinski, K. K., Apr 3 2019, In : Journal of Neuroscience. 39, 14, p. 2745-2761 17 p.

Research output: Contribution to journalArticle

Input-Specific Metaplasticity in the Visual Cortex Requires Homer1a-Mediated mGluR5 Signaling

Chokshi, V., Gao, M., Grier, B. D., Owens, A., Wang, H., Worley, P. F. & Lee, H. K., Nov 20 2019, In : Neuron. 104, 4, p. 736-748.e6

Research output: Contribution to journalArticle

Synaptic biomarkers in CSF aid in diagnosis, correlate with cognition and predict progression in MCI and Alzheimer's disease

Alzheimer's Disease Neuroimaging Initiative (ADNI), 2019, In : Alzheimer's and Dementia: Translational Research and Clinical Interventions. 5, p. 871-882 12 p.

Research output: Contribution to journalArticle

Open Access

Vitamin D increases glucocorticoid efficacy via inhibition of mTORC1 in experimental models of multiple sclerosis

Hoepner, R., Bagnoud, M., Pistor, M., Salmen, A., Briner, M., Synn, H., Schrewe, L., Guse, K., Ahmadi, F., Demir, S., Laverick, L., Gresle, M., Worley, P. F., Reichardt, H. M., Butzkueven, H., Gold, R., Metz, I., Lühder, F. & Chan, A., Jan 1 2019, In : Acta neuropathologica.

Research output: Contribution to journalArticle

Open Access
2018

Clinical and Diagnostic Significance of Homer1 in hepatitis B virus-induced Hepatocellular Carcinoma

Luo, P., Feng, X., Jing, W., Zhu, M., Li, N., Zhou, H., Worley, P. F., Chai, H. & Tu, J., Jan 1 2018, In : Journal of Cancer. 9, 4, p. 683-689 7 p.

Research output: Contribution to journalArticle

Delayed degradation and impaired dendritic delivery of intron-lacking EGFP-Arc/Arg3.1 mRNA in EGFP-Arc transgenic mice

Steward, O., Matsudaira Yee, K., Farris, S., Pirbhoy, P. S., Worley, P., Okamura, K., Okuno, H. & Bito, H., Jan 31 2018, In : Frontiers in Molecular Neuroscience. 10, 435.

Research output: Contribution to journalArticle

Distinct roles of Rheb and Raptor in activating mTOR complex 1 for the self-renewal of hematopoietic stem cells

Peng, H., Kasada, A., Ueno, M., Hoshii, T., Tadokoro, Y., Nomura, N., Ito, C., Takase, Y., Vu, H. T., Kobayashi, M., Xiao, B., Worley, P. F. & Hirao, A., Jan 1 2018, In : Biochemical and Biophysical Research Communications. 495, 1, p. 1129-1135 7 p.

Research output: Contribution to journalArticle

FRMPD4 mutations cause X-linked intellectual disability and disrupt dendritic spine morphogenesis

Piard, J., Hu, J. H., Campeau, P. M., Rzońca, S., Esch, H. V., Vincent, E., Han, M., Rossignol, E., Castaneda, J., Chelly, J., Skinner, C., Kalscheuer, V. M., Wang, R., Lemyre, E., Kosińska, J., Stawinski, P., Bal, J., Hoffman, D. A., Schwartz, C. E., Maldergem, L. V. & 2 others, Wang, T. & Worley, P. F., Feb 15 2018, In : Human molecular genetics. 27, 4, p. 589-600 12 p., ddx426.

Research output: Contribution to journalArticle

Narp Mediates Antidepressant-Like Effects of Electroconvulsive Seizures

Chang, A. D., Vaidya, P. V., Retzbach, E. P., Chung, S. J., Kim, U., Baselice, K., Maynard, K., Stepanian, A., Staley, M., Xiao, L., Blouin, A., Han, S., Lee, J., Worley, P. F., Tamashiro, K., Hempstead, B. L., Martinowich, K., Wilson, M. A. A., Baraban, J. M. & Reti, I. M., Apr 1 2018, In : Neuropsychopharmacology. 43, 5, p. 1088-1098 11 p.

Research output: Contribution to journalArticle

Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy

Thannickal, T. C., John, J., Shan, L., Swaab, D. F., Wu, M. F., Ramanathan, L., McGregor, R., Chew, K. T., Cornford, M., Yamanaka, A., Inutsuka, A., Fronczek, R., Lammers, G. J., Worley, P. F. & Siegel, J. M., Jun 27 2018, In : Science translational medicine. 10, 447, eaao4953.

Research output: Contribution to journalArticle

2017

Behavioral and neurochemical phenotyping of mice incapable of homer1a induction

Datko, M. C., Hu, J. H., Williams, M., Reyes, C. M., Lominac, K. D., von Jonquieres, G., Klugmann, M., Worley, P. F. & Szumlinski, K. K., Nov 1 2017, In : Frontiers in Behavioral Neuroscience. 11, 208.

Research output: Contribution to journalArticle

Dynamic regulation of homer binding to group i metabotropic glutamate receptors by preso1 and converging kinase cascades

Hu, J. H., Worley, P. F. & Kammermeier, P. J., Apr 1 2017, In : Journal of Pharmacology and Experimental Therapeutics. 361, 1, p. 122-129 8 p.

Research output: Contribution to journalArticle

Exposure to complex environments results in more sparse representations of space in the hippocampus

Bilkey, D. K., Cheyne, K. R., Eckert, M. J., Lu, X., Chowdhury, S., Worley, P. F., Crandall, J. E. & Abraham, W. C., Nov 1 2017, In : Hippocampus. 27, 11, p. 1178-1191 14 p.

Research output: Contribution to journalArticle

Homer1a drives homeostatic scaling-down of excitatory synapses during sleep

Diering, G. H., Nirujogi, R. S., Roth, R. H., Worley, P. F., Pandey, A. & Huganir, R. L., Feb 3 2017, In : Science. 355, 6324, p. 511-515 5 p.

Research output: Contribution to journalArticle

MTORC1 loss impairs epidermal adhesion via TGF-β/Rho kinase activation

Asrani, K., Sood, A., Torres, A., Georgess, D., Phatak, P., Kaur, H., Dubin, A., Talbot, C. C., Elhelu, L., Ewald, A., Xiao, B., Worley, P. F. & Lotan, T., Nov 1 2017, In : Journal of Clinical Investigation. 127, 11, p. 4001-4017 17 p.

Research output: Contribution to journalArticle

NPTX2 and cognitive dysfunction in Alzheimer’s Disease

Xiao, M., Xu, D., Craig, M. T., Pelkey, K. A., Chien, C. C., Shi, Y., Zhang, J., Resnick, S., Pletnikova, O., Salmon, D., Brewer, J., Edland, S., Wegiel, J., Tycko, B., Savonenko, A., Reeves, R. H., Troncoso, J. C., McBain, C. J., Galasko, D. & Worley, P. F., Apr 25 2017, In : eLife. 6, p. 1-27 27 p., e23798.

Research output: Contribution to journalComment/debate

Orai1-Mediated Antimicrobial Secretion from Pancreatic Acini Shapes the Gut Microbiome and Regulates Gut Innate Immunity

Ahuja, M., Schwartz, D. M., Tandon, M., Son, A., Zeng, M., Swaim, W., Eckhaus, M., Hoffman, V., Cui, Y., Xiao, B., Worley, P. F. & Muallem, S., Mar 7 2017, In : Cell Metabolism. 25, 3, p. 635-646 12 p.

Research output: Contribution to journalArticle

STIM1 regulates somatic Ca2+ signals and intrinsic firing properties of cerebellar purkinje neurons

Ryu, C., Jang, D. C., Jung, D., Kim, Y. G., Shim, H. G., Ryu, H. H., Lee, Y. S., Linden, D. J., Worley, P. F. & Kim, S. J., 2017, In : Journal of Neuroscience. 37, 37, p. 8876-8894 19 p.

Research output: Contribution to journalArticle

2016

Altered NMDA receptor function in primary cultures of hippocampal neurons from mice lacking the Homer2 gene

Smothers, C. T., Szumlinski, K. K., Worley, P. F. & Woodward, J. J., Jan 2016, In : Synapse. 70, 1, p. 33-39 7 p.

Research output: Contribution to journalArticle

Corrections to "Pentraxins Coordinate Excitatory Synapse Maturation and Circuit Integration of Parvalbumin Interneurons" [Neuron 85, 1257-1272; March 18, 2015]

Pelkey, K. A., Barksdale, E., Craig, M. T., Yuan, X., Sukumaran, M., Vargish, G. A., Mitchell, R. M., Wyeth, M. S., Petralia, R. S., Chittajallu, R., Karlsson, R. M., Cameron, H. A., Murata, Y., Colonnese, M. T., Worley, P. F. & McBain, C. J., May 4 2016, In : Neuron. 90, 3, 1 p.

Research output: Contribution to journalComment/debate

Metabotropic glutamate receptors induce a form of LTP controlled by translation and arc signaling in the hippocampus

Wang, H., Ardiles, A. O., Yang, S., Tran, T., Posada-Duque, R., Valdivia, G., Baek, M., Chuang, Y. A., Palacios, A. G., Gallagher, M., Worley, P. & Kirkwood, A., Feb 3 2016, In : Journal of Neuroscience. 36, 5, p. 1723-1729 7 p.

Research output: Contribution to journalArticle

Protein kinase C epsilon activity in the nucleus accumbens and central nucleus of the amygdala mediates binge alcohol consumption

Cozzoli, D. K., Courson, J., Rostock, C., Campbell, R. R., Wroten, M. G., McGregor, H., Caruana, A. L., Miller, B. W., Hu, J. H., Zhang, P. W., Xiao, B., Worley, P. F., Crabbe, J. C., Finn, D. A. & Szumlinski, K. K., Mar 15 2016, In : Biological psychiatry. 79, 6, p. 443-451 9 p.

Research output: Contribution to journalArticle

Real-Time Imaging Reveals Properties of Glutamate-Induced Arc/Arg 3.1 Translation in Neuronal Dendrites

Na, Y., Park, S., Lee, C., Kim, D. K., Park, J. M., Sockanathan, S., Huganir, R. L. & Worley, P. F., Aug 3 2016, In : Neuron. 91, 3, p. 561-573 13 p.

Research output: Contribution to journalArticle

Selective disruption of metabotropic glutamate receptor 5-homer interactions mimics phenotypes of fragile X syndrome in mice

Guo, W., Molinaro, G., Collins, K. A., Hays, S. A., Paylor, R., Worley, P. F., Szumlinski, K. K. & Huber, K. M., Feb 17 2016, In : Journal of Neuroscience. 36, 7, p. 2131-2147 17 p.

Research output: Contribution to journalArticle

Sensitivity to isoflurane anesthesia increases in autism spectrum disorder Shank3+/c mutant mouse model

Li, C., Schaefer, M., Gray, C., Yang, Y., Furmanski, O., Liu, S., Worley, P. F., Mintz, C. D., Tao, F. & Johns, R. A., Jul 3 2016, (Accepted/In press) In : Neurotoxicology and Teratology.

Research output: Contribution to journalArticle

TRIAD3/RNF216 mutations associated with Gordon Holmes syndrome lead to synaptic and cognitive impairments via Arc misregulation

Husain, N., Yuan, Q., Yen, Y. C., Pletnikova, O., Sally, D. Q., Worley, P. F., Bichler, Z. & Shawn Je, H., 2016, (Accepted/In press) In : Aging Cell.

Research output: Contribution to journalArticle