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2018

AAH2 gene is not required for dopamine-dependent neurochemical and behavioral abnormalities produced by Toxoplasma infection in mouse

McFarland, R., Wang, Z. T., Jouroukhin, Y., Li, Y., Mychko, O., Coppens, I., Xiao, J-C., Brando, L. V., Yolken, R. H., Sibley, L. D. & Pletnikov, M., Jul 16 2018, In : Behavioural Brain Research. 347, p. 193-200 8 p.

Research output: Contribution to journalArticle

Toxoplasma
Dopamine
Toxoplasmosis
Infection
Genes

Adjunctive probiotic microorganisms to prevent rehospitalization in patients with acute mania: A randomized controlled trial

Dickerson, F., Adamos, M., Katsafanas, E., Khushalani, S., Origoni, A., Savage, C., Schweinfurth, L., Stallings, C., Sweeney, K., Goga, J. & Yolken, R. H., Jan 1 2018, (Accepted/In press) In : Bipolar Disorders.

Research output: Contribution to journalArticle

Probiotics
Bipolar Disorder
Randomized Controlled Trials
Inflammation
Placebos

Aggression, impulsivity and inflammatory markers as risk factors for suicidal behavior

Coryell, W., Wilcox, H., Evans, S. J., Pandey, G. N., Brando, L. V., Dickerson, F. & Yolken, R. H., Nov 1 2018, In : Journal of Psychiatric Research. 106, p. 38-42 5 p.

Research output: Contribution to journalArticle

Impulsive Behavior
Aggression
Suicide
History
Research Personnel

A Nationwide Study in Denmark of the Association between Treated Infections and the Subsequent Risk of Treated Mental Disorders in Children and Adolescents

Köhler-Forsberg, O., Petersen, L., Gasse, C., Mortensen, P. B., Dalsgaard, S., Yolken, R. H., Mors, O. & Benros, M. E., Jan 1 2018, (Accepted/In press) In : JAMA psychiatry.

Research output: Contribution to journalArticle

Denmark
Mental Disorders
Infection
Prescriptions
Anti-Infective Agents

A New T. gondii Mouse Model of Gene-Environment Interaction Relevant to Psychiatric Disease

Kannan, G., Prandovszky, E., Severance, E. G., Yolken, R. H. & Pletnikov, M., Jan 1 2018, In : Scientifica. 2018, 7590958.

Research output: Contribution to journalArticle

Gene-Environment Interaction
genotype-environment interaction
Toxoplasma
Toxoplasma gondii
Psychiatry

Association of cytomegalovirus and Epstein-Barr virus with cognitive functioning and risk of dementia in the general population: 11-year follow-up study

Torniainen-Holm, M., Suvisaari, J., Lindgren, M., Härkänen, T., Dickerson, F. & Yolken, R. H., Jan 1 2018, (Accepted/In press) In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

Cytomegalovirus
Human Herpesvirus 4
Dementia
Population
Seroepidemiologic Studies

Autoimmune phenotypes in schizophrenia reveal novel treatment targets

Severance, E. G., Dickerson, F. B. & Yolken, R. H., Jan 1 2018, (Accepted/In press) In : Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Schizophrenia
Phenotype
Genetic Templates
Antipsychotic Agents
Dopamine
Toxoplasmosis
N-Methyl-D-Aspartate Receptors
Autoantibodies
Cysts
Toxoplasma

Cigarette smoking by patients with serious mental illness, 1999-2016: An increasing disparity

Dickerson, F., Schroeder, J., Katsafanas, E., Khushalani, S., Origoni, A. E., Savage, C., Schweinfurth, L., Stallings, C. R., Sweeney, K. & Yolken, R. H., Feb 1 2018, In : Psychiatric Services. 69, 2, p. 147-153 7 p.

Research output: Contribution to journalArticle

Smoking
Bipolar Disorder
Tobacco Products
Schizophrenia
Psychiatry

Clinical and serological predictors of suicide in schizophrenia and major mood disorders

Dickerson, F., Origoni, A., Schweinfurth, L. A. B., Stallings, C., Savage, C. L. G., Sweeney, K., Katsafanas, E., Wilcox, H., Khushalani, S. & Yolken, R. H., Jan 1 2018, In : Journal of Nervous and Mental Disease. 206, 3, p. 173-178 6 p.

Research output: Contribution to journalArticle

Mood Disorders
Suicide
Schizophrenia
Cytomegalovirus
Antibodies

Cross-genetic determination of maternal and neonatal immune mediators during pregnancy

Traglia, M., Croen, L. A., Jones, K. L., Heuer, L. S., Yolken, R. H., Kharrazi, M., DeLorenze, G. N., Ashwood, P., Van de Water, J. & Weiss, L. A., Aug 22 2018, In : Genome Medicine. 10, 1, 67.

Research output: Contribution to journalArticle

Genetic Crosses
Mothers
Pregnancy
Immune System
Chemokines

Deciphering microbiome and neuroactive immune gene interactions in schizophrenia

Severance, E. G. & Yolken, R. H., Jan 1 2018, (Accepted/In press) In : Neurobiology of Disease.

Research output: Contribution to journalArticle

Complement C4
Enteric Nervous System
Microbiota
Synapses
Immune System

DISC1 regulates lactate metabolism in astrocytes: Implications for psychiatric disorders

Jouroukhin, Y., Kageyama, Y., Misheneva, V., Shevelkin, A., Andrabi, S., Prandovszky, E., Yolken, R. H., Dawson, V., Dawson, T. M., Aja, S. M., Sesaki, H. & Pletnikov, M., Dec 1 2018, In : Translational Psychiatry. 8, 1, 76.

Research output: Contribution to journalArticle

Astrocytes
Psychiatry
Lactic Acid
Schizophrenia
Glucose

Generation of three-dimensional human neuronal cultures: Application to modeling CNS viral infections

D'Aiuto, L., Naciri, J., Radio, N., Tekur, S., Clayton, D., Apodaca, G., Di Maio, R., Zhi, Y., Dimitrion, P., Piazza, P., Demers, M., Wood, J., Chu, C., Callio, J., McClain, L., Yolken, R. H., McNulty, J., Kinchington, P., Bloom, D. & Nimgaonkar, V., May 11 2018, In : Stem Cell Research and Therapy. 9, 1, 134.

Research output: Contribution to journalArticle

Central Nervous System Viral Diseases
Induced Pluripotent Stem Cells
Preclinical Drug Evaluations
Acyclovir
Neurology

Herpes simplex virus 1 infection and valacyclovir treatment in schizophrenia: Results from the VISTA study

Breier, A., Buchanan, R. W., D'Souza, D., Nuechterlein, K., Marder, S., Dunn, W., Preskorn, S., Macaluso, M., Wurfel, B., Maguire, G., Kakar, R., Highum, D., Hoffmeyer, D., Coskinas, E., Litman, R., Vohs, J. L., Radnovich, A., Francis, M. M., Metzler, E., Visco, A. & 5 othersMehdiyoun, N., Yang, Z., Zhang, Y., Yolken, R. H. & Dickerson, F. B., Jan 1 2018, (Accepted/In press) In : Schizophrenia Research.

Research output: Contribution to journalArticle

valacyclovir
Human Herpesvirus 1
Virus Diseases
Cognition
Schizophrenia

HLA typing using genome wide data reveals susceptibility types for infections in a psychiatric disease enriched sample

Parks, S., Avramopoulos, D., Mulle, J., McGrath, J., Wang, R., Goes, F. S., Conneely, K., Ruczinski, I., Yolken, R. H., Pulver, A. E. & Pearce, B. D., Jan 1 2018, (Accepted/In press) In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

Histocompatibility Testing
Psychiatry
Genome
HLA-C Antigens
Schizophrenia

Host–parasite interaction associated with major mental illness

Kano, S., Hodgkinson, C. A., Brando, L. V., Eastwood, S., Ishizuka, K., Niwa, M., Choi, E. Y., Chang, D. J., Chen, Y., Velivela, S. D., Leister, F., Wood, J., Chowdari, K., Ducci, F., Caycedo, D. A., Heinz, E., Newman, E. R., Cascella, N., Mortensen, P. B., Zandi, P. P. & 6 othersDickerson, F., Nimgaonkar, V., Goldman, D., Harrison, P. J., Yolken, R. H. & Sawa, A., Jan 1 2018, (Accepted/In press) In : Molecular psychiatry.

Research output: Contribution to journalArticle

Host-Parasite Interactions
Toxoplasmosis
Toxoplasma
Schizophrenia
Activating Transcription Factor 4

Immunoglobulin sub-class distribution in bipolar disorder and schizophrenia: Potential relationship with latent Toxoplasma Gondii infection

Hamdani, N., Bengoufa, D., Godin, O., Doukhan, R., Le Guen, E., Daban-Huard, C., Bennabi, M., Delavest, M., Lépine, J. P., Boukouaci, W., Laouamri, H., Houenou, J., Jamain, S., Richard, J. R., Lecorvosier, P., Yolken, R. H., Rajagopal, K., Leboyer, M. & Tamouza, R., Jul 27 2018, In : BMC Psychiatry. 18, 1, 239.

Research output: Contribution to journalArticle

Immunoglobulin Isotypes
Toxoplasmosis
Bipolar Disorder
Schizophrenia
Immunoglobulin G

Inflammatory biomarkers in psychosis and clinical high risk populations

Delaney, S., Fallon, B., Alaedini, A., Yolken, R. H., Indart, A., Feng, T., Wang, Y. & Javitt, D., Jan 1 2018, (Accepted/In press) In : Schizophrenia Research.

Research output: Contribution to journalArticle

Psychotic Disorders
Interleukin-6
Biomarkers
Lipopolysaccharides
Population

Joint evaluation of serum C-Reactive Protein levels and polygenic risk scores as risk factors for schizophrenia

Nimgaonkar, V. L., Dickerson, F., Pouget, J. G., Chowdari, K., O'Dushlaine, C., Wood, J., Klei, L., Devlin, B. & Yolken, R. H., Mar 1 2018, In : Psychiatry Research. 261, p. 148-153 6 p.

Research output: Contribution to journalArticle

C-Reactive Protein
Blood Proteins
Schizophrenia
Odds Ratio
Confidence Intervals

Maternal immune activation: reporting guidelines to improve the rigor, reproducibility, and transparency of the model

Kentner, A. C., Bilbo, S. D., Brown, A. S., Hsiao, E. Y., McAllister, A. K., Meyer, U., Pearce, B. D., Pletnikov, M., Yolken, R. H. & Bauman, M. D., Jan 1 2018, (Accepted/In press) In : Neuropsychopharmacology.

Research output: Contribution to journalArticle

Practice Guidelines
Mothers
Guidelines
Checklist
Animal Models

Monocyte activation detected prior to a diagnosis of schizophrenia in the US Military New Onset Psychosis Project (MNOPP)

Weber, N. S., Gressitt, K. L., Cowan, D. N., Niebuhr, D. W., Yolken, R. H. & Severance, E. G., Jan 1 2018, (Accepted/In press) In : Schizophrenia Research.

Research output: Contribution to journalArticle

Psychotic Disorders
Monocytes
Schizophrenia
C-Reactive Protein
Inflammation

Natural cause mortality in persons with serious mental illness

Dickerson, F., Origoni, A., Schroeder, J., Adamos, M., Katsafanas, E., Khushalani, S., Savage, C. L. G., Schweinfurth, L. A. B., Stallings, C., Sweeney, K. & Yolken, R. H., Jan 1 2018, (Accepted/In press) In : Acta Psychiatrica Scandinavica.

Research output: Contribution to journalArticle

Mortality
Smoking
Human Herpesvirus 4
Widowhood
Divorce

Nitrated meat products are associated with mania in humans and altered behavior and brain gene expression in rats

Khambadkone, S. G., Cordner, Z. A., Dickerson, F., Severance, E. G., Prandovszky, E., Pletnikov, M., Xiao, J-C., Li, Y., Boersma, G. J., Talbot, C. C., Campbell, W. W., Wright, C. S., Siple, C. E., Moran, T. H., Tamashiro, K. & Yolken, R. H., Jan 1 2018, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Meat Products
Bipolar Disorder
Gene Expression
Brain
Meat

Obesity increases the risk of small intestinal bacterial overgrowth (SIBO)

Roland, B. C., Lee, D., Miller, L. S., Vegesna, A., Yolken, R. H., Severance, E. G., Prandovszky, E., Zheng, X. E. & Mullin, G., Mar 1 2018, In : Neurogastroenterology and Motility. 30, 3, e13199.

Research output: Contribution to journalArticle

Obesity
Lactulose
Breath Tests
Microbiota
rRNA Genes

One-pot, multicomponent synthesis of 2,3-disubstituted quinazolin-ones with potent and selective activity against Toxoplasma gondii

Brown, C. E., Kong, T., Bordón, C., Yolken, R. H., Brando, L. V. & McNulty, J., Jan 1 2018, (Accepted/In press) In : Bioorganic and Medicinal Chemistry Letters.

Research output: Contribution to journalArticle

Quinazolinones
Derivatives

Otitis media, antibiotics, and risk of autism spectrum disorder

Wimberley, T., Agerbo, E., Pedersen, C. B., Dalsgaard, S., Horsdal, H. T., Mortensen, P. B., Thompson, W. K., Köhler-Forsberg, O. & Yolken, R. H., Jan 1 2018, (Accepted/In press) In : Autism Research.

Research output: Contribution to journalArticle

Otitis Media
Anti-Bacterial Agents
Autistic Disorder
Confidence Intervals
Infection

Parental Infections Before, During, and After Pregnancy as Risk Factors for Mental Disorders in Childhood and Adolescence: A Nationwide Danish Study

Lydholm, C. N., Köhler-Forsberg, O., Nordentoft, M., Yolken, R. H., Mortensen, P. B., Petersen, L. & Benros, M. E., Jan 1 2018, (Accepted/In press) In : Biological psychiatry.

Research output: Contribution to journalArticle

Mental Disorders
Pregnancy
Mothers
Infection
Anti-Infective Agents
Toxoplasma
Toxoplasmosis
Cysts
Leukocytes
Brain

R430: A potent inhibitor of DNA and RNA viruses

D’Aiuto, L., McNulty, J., Hartline, C., Demers, M., Kalkeri, R., Wood, J., McClain, L., Chattopadhyay, A., Zhi, Y., Naciri, J., Smith, A., Yolken, R. H., Chowdari, K., Zepeda-Velazquez, C., Dokuburra, C. B., Marques, E., Ptak, R., Kinchington, P., Watkins, S., Prichard, M. & 2 othersBloom, D. & Nimgaonkar, V., Dec 1 2018, In : Scientific Reports. 8, 1, 16662.

Research output: Contribution to journalArticle

DNA Viruses
RNA Viruses
Human Herpesvirus 1
Acyclovir
Antiviral Agents

Reduced immunity to measles in adults with major depressive disorder

Ford, B. N., Yolken, R. H., Dickerson, F. B., Teague, T. K., Irwin, M. R., Paulus, M. P. & Savitz, J., Mar 19 2018, (Accepted/In press) In : Psychological Medicine. p. 1-7 7 p.

Research output: Contribution to journalArticle

Major Depressive Disorder
Measles
Immunity
Age of Onset
Vaccination

The effect of minocycline on symptoms in schizophrenia: Results from a randomized controlled trial

Weiser, M., Levi, L., Burshtein, S., Chiriță, R., Cirjaliu, D., Gonen, I., Yolken, R. H., Davidson, M., Zamora, D. & Davis, J. M., Jan 1 2018, (Accepted/In press) In : Schizophrenia Research.

Research output: Contribution to journalArticle

Minocycline
Schizophrenia
Randomized Controlled Trials
Placebos
Psychotic Disorders

Toxoplasma gondii: Biological Parameters of the Connection to Schizophrenia

Xiao, J-C., Prandovszky, E., Kannan, G., Pletnikov, M., Dickerson, F., Severance, E. G. & Yolken, R. H., Jan 1 2018, In : Schizophrenia bulletin. 44, 5, p. 983-992 10 p.

Research output: Contribution to journalArticle

Toxoplasma
Schizophrenia
Infection
Brain
Parasites
2017

A Prospective Evaluation of Ileocecal Valve Dysfunction and Intestinal Motility Derangements in Small Intestinal Bacterial Overgrowth

Chander Roland, B., Mullin, G., Passi, M., Zheng, X., Salem, A., Yolken, R. H. & Pasricha, P. J., Sep 4 2017, (Accepted/In press) In : Digestive Diseases and Sciences. p. 1-11 11 p.

Research output: Contribution to journalArticle

Ileocecal Valve
Gastrointestinal Motility
Lactulose
Hydrogen
Capsules

Association of cognitive function and liability to addiction with childhood herpesvirus infections: A prospective cohort study

Vanyukov, M. M., Nimgaonkar, V. L., Kirisci, L., Kirillova, G. P., Reynolds, M. D., Prasad, K., Tarter, R. E. & Yolken, R. H., Apr 19 2017, (Accepted/In press) In : Development and Psychopathology. p. 1-10 10 p.

Research output: Contribution to journalArticle

Herpesviridae Infections
Cognition
Substance-Related Disorders
Cohort Studies
Prospective Studies

Comparison of three cell-based drug screening platforms for HSV-1 infection

D'Aiuto, L., Williamson, K., Dimitrion, P., McNulty, J., Brown, C. E., Dokuburra, C. B., Nielsen, A. J., Lin, W. J., Piazza, P., Schurdak, M. E., Wood, J., Yolken, R. H., Kinchington, P. R., Bloom, D. C. & Nimgaonkar, V. L., Jun 1 2017, In : Antiviral Research. 142, p. 136-140 5 p.

Research output: Contribution to journalArticle

Preclinical Drug Evaluations
Human Herpesvirus 1
Virus Diseases
Induced Pluripotent Stem Cells
Acyclovir

Dynamic disorganization of synaptic NMDA receptors triggered by autoantibodies from psychotic patients

Jézéquel, J., Johansson, E. M., Dupuis, J. P., Rogemond, V., Gréa, H., Kellermayer, B., Hamdani, N., Le Guen, E., Rabu, C., Lepleux, M., Spatola, M., Mathias, E., Bouchet, D., Ramsey, A. J., Yolken, R. H., Tamouza, R., Dalmau, J., Honnorat, J., Leboyer, M. & Groc, L., Dec 1 2017, In : Nature Communications. 8, 1, 1791.

Research output: Contribution to journalArticle

Neurotransmitter Receptor
N-Methyl-D-Aspartate Receptors
Autoantibodies
Healthy Volunteers
Neurons

Effects of cumulative Herpesviridae and Toxoplasma gondii infections on cognitive function in healthy, bipolar, and schizophrenia subjects

Hamdani, N., Daban-Huard, C., Godin, O., Laouamri, H., Jamain, S., Attiba, D., Delavest, M., Lépine, J. P., Le Corvoisier, P., Houenou, J., Richard, J. R., Yolken, R. H., Krishnamoorthy, R., Tamouza, R., Leboyer, M. & Dickerson, F. B., Jan 1 2017, In : Journal of Clinical Psychiatry. 78, 1, p. e18-e27

Research output: Contribution to journalArticle

Herpesviridae
Toxoplasmosis
Toxoplasma
Cognition
Schizophrenia

Emotion discrimination in humans: Its association with HSV-1 infection and its improvement with antiviral treatment

Bhatia, T., Wood, J., Iyengar, S., Narayanan, S. S., Beniwal, R. P., Prasad, K. M., Chen, K., Yolken, R. H., Dickerson, F., Gur, R. C., Gur, R. E., Deshpande, S. N. & Nimgaonkar, V. L., 2017, (Accepted/In press) In : Schizophrenia Research.

Research output: Contribution to journalArticle

Human Herpesvirus 1
Virus Diseases
Antiviral Agents
Emotions
Therapeutics

Evidence of increased exposure to Toxoplasma gondii in individuals with recent onset psychosis but not with established schizophrenia

Yolken, R. H., Torrey, E. F. & Dickerson, F., Nov 6 2017, In : PLoS Neglected Tropical Diseases. 11, 11, e0006040.

Research output: Contribution to journalArticle

Toxoplasma
Psychotic Disorders
Schizophrenia
Psychiatry
Case-Control Studies

Infections and exposure to anti-infective agents and the risk of severe mental disorders: a nationwide study

Köhler, O., Petersen, L., Mors, O., Mortensen, P. B., Yolken, R. H., Gasse, C. & Benros, M. E., Feb 1 2017, In : Acta Psychiatrica Scandinavica. 135, 2, p. 97-105 9 p.

Research output: Contribution to journalArticle

Anti-Infective Agents
Mental Disorders
Infection
Mood Disorders
Schizophrenia

Neurodevelopment: The impact of nutrition and inflammation during adolescence in low-resource settings

Galler, J. R., Koethe, J. R. & Yolken, R. H., Apr 1 2017, In : Pediatrics. 139, p. S72-S84

Research output: Contribution to journalReview article

Inflammation
Malnutrition
Brain Diseases
Age Groups
Infection

Pathogen-mediated NMDA receptor autoimmunity and cellular barrier dysfunction in schizophrenia

Kannan, G., Gressitt, K. L., Yang, S., Stallings, C. R., Katsafanas, E., Schweinfurth, L. A., Savage, C. L. G., Adamos, M. B., Sweeney, K. M., Origoni, A. E., Khushalani, S., Bahn, S., Leweke, F. M., Dickerson, F. B., Yolken, R. H., Pletnikov, M. & Severance, E. G., Aug 1 2017, In : Translational Psychiatry. 7, 8, e1186.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Autoimmunity
Schizophrenia
Toxoplasma
Autoantibodies

Persistent herpesvirus infections and telomere attrition over 3 years in the whitehall II cohort

Dowd, J. B., Bosch, J. A., Steptoe, A., Jayabalasingham, B., Lin, J., Yolken, R. H. & Aiello, A. E., Sep 1 2017, In : Journal of Infectious Diseases. 216, 5, p. 565-572 8 p.

Research output: Contribution to journalArticle

Herpesviridae Infections
Telomere
Cytomegalovirus
Leukocytes
Human Herpesvirus 4

Schizophrenia and Infections: The Eyes Have It

Torrey, E. F. & Yolken, R. H., Mar 1 2017, In : Schizophrenia Bulletin. 43, 2, p. 247-252 6 p.

Research output: Contribution to journalReview article

Eye Infections
Schizophrenia
Perceptual Distortion
Eye Abnormalities
Human Herpesvirus 3

Stability of Toxoplasma gondii: Antibody levels in schizophrenia

Yuksel, P., Kocazeybek, B., Ozdemir, A., Yolken, R. H. & Torrey, E. F., 2017, (Accepted/In press) In : Schizophrenia Research.

Research output: Contribution to journalArticle

Suicide attempts and markers of immune response in individuals with serious mental illness

Dickerson, F., Wilcox, H., Adamos, M., Katsafanas, E., Khushalani, S., Origoni, A., Savage, C., Schweinfurth, L., Stallings, C., Sweeney, K. & Yolken, R. H., Apr 1 2017, In : Journal of Psychiatric Research. 87, p. 37-43 7 p.

Research output: Contribution to journalArticle

Suicide
Biomarkers
Toxoplasma
Antibodies
Cytomegalovirus

The association between immune markers and recent suicide attempts in patients with serious mental illness: A pilot study

Dickerson, F., Adamos, M., Katsafanas, E., Khushalani, S., Origoni, A., Savage, C., Schweinfurth, L., Stallings, C., Sweeney, K., Alaedini, A., Uhde, M., Severance, E. G., Wilcox, H. & Yolken, R. H., Sep 1 2017, In : Psychiatry Research. 255, p. 8-12 5 p.

Research output: Contribution to journalArticle

Suicide
Biomarkers
Psychiatry
Inflammation
Schizophrenia

The association between toxoplasma and the psychosis continuum in a general population setting

Lindgren, M., Torniainen-Holm, M., Härkänen, T., Dickerson, F., Yolken, R. H. & Suvisaari, J., 2017, (Accepted/In press) In : Schizophrenia Research.

Research output: Contribution to journalArticle

Toxoplasma
Psychotic Disorders
Population
C-Reactive Protein
Interviews

The complement system: A gateway to gene-environment interactions in schizophrenia pathogenesis

Nimgaonkar, V. L., Prasad, K. M., Chowdari, K. V., Severance, E. G. & Yolken, R. H., Nov 1 2017, In : Molecular Psychiatry. 22, 11, p. 1554-1561 8 p.

Research output: Contribution to journalReview article

Gene-Environment Interaction
Schizophrenia
Complement C4a
Complement C4b
Inflammation