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2018

Characterization of Urothelial Cancer Circulating Tumor Cells with a Novel Selection-Free Method

Chalfin, H. J., Kates, M., van der Toom, E. E., Glavaris, S., Verdone, J. E., Hahn, N. M., Pienta, K. J., Bivalacqua, T. J. & Gorin, M. A. Jan 1 2018 (Accepted/In press) In : Urology.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Urinary Bladder Neoplasms
Neoplasms
Carcinoma
Muscles

Characterization of voiding function and structural bladder changes in a rat model of neurogenic underactive bladder disease

Weyne, E., Dewulf, K., Deruyer, Y., Rietjens, R., Everaerts, W., Bivalacqua, T. J., De Ridder, D., Van der Aa, F. & Albersen, M. Jan 1 2018 (Accepted/In press) In : Neurourology and Urodynamics.

Research output: Contribution to journalArticle

Urinary Bladder Diseases
Neurogenic Urinary Bladder
Urinary Bladder
Osteopontin
Smooth Muscle Myocytes

Galanin Administration Partially Restores Erectile Function After Cavernous Nerve Injury and Mediates Endogenous Nitrergic Nerve Outgrowth In Vitro

Weyne, E., Hannan, J. L., Gevaert, T., Soebadi, Y., Matsui, H., Castiglione, F., van Renterghem, K., De Ridder, D., Van der Aa, F., Bivalacqua, T. J. & Albersen, M. Jan 1 2018 (Accepted/In press) In : Journal of Sexual Medicine.

Research output: Contribution to journalArticle

Nitrergic Neurons
Galanin
Erectile Dysfunction
Galanin Receptors
Wounds and Injuries

Immunotherapy with Checkpoint Blockade in the Treatment of Urothelial Carcinoma

Siefker-Radtke, A. O., Apolo, A. B., Bivalacqua, T. J., Spiess, P. E. & Black, P. C. May 1 2018 In : Journal of Urology. 199, 5, p. 1129-1142 14 p.

Research output: Contribution to journalReview article

Immunotherapy
Carcinoma
Therapeutics
Allergy and Immunology
PubMed

Molecular Profile of Priapism Associated with Low Nitric Oxide Bioavailability

La Favor, J. D., Fu, Z., Venkatraman, V., Bivalacqua, T. J., Van Eyk, J. E. & Burnett, A. L. Mar 2 2018 In : Journal of Proteome Research. 17, 3, p. 1031-1040 10 p.

Research output: Contribution to journalArticle

Priapism
Penis
Proteomics
Biological Availability
Mass Spectrometry
Positron-Emission Tomography
Prostatic Neoplasms
Tomography
Surgical Pathology
Lymph Nodes

Recommendations for follow-up of muscle-invasive bladder cancer patients: A consensus by the international bladder cancer network

Zuiverloon, T. C. M., van Kessel, K. E. M., Bivalacqua, T. J., Boormans, J. L., Ecke, T. H., Grivas, P. D., Kiltie, A. E., Liedberg, F., Necchi, A., van Rhijn, B. W., Roghmann, F., Sanchez-Carbayo, M., Schmitz-Dräger, B. J., Wezel, F. & Kamat, A. M. Jan 1 2018 (Accepted/In press) In : Urologic Oncology: Seminars and Original Investigations.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Muscles
Guidelines
Cell Biology
Physicians

Three-dimensional organoid culture reveals involvement of Wnt/β-catenin pathway in proliferation of bladder cancer cells

Yoshida, T., Sopko, N. A., Kates, M., Liu, X., Joice, G., McConkey, D. J. & Bivalacqua, T. J. Jan 1 2018 In : Oncotarget. 9, 13, p. 11060-11070 11 p.

Research output: Contribution to journalArticle

Organoids
beta Catenin
Urinary Bladder Neoplasms
Neoplasms
Cellular Spheroids
Paris
Cell Biology
Urology
Terminology
Urine
2017

Additive effects of the Rho kinase inhibitor Y-27632 and vardenafil on relaxation of the corpus cavernosum tissue of patients with erectile dysfunction and clinical phosphodiesterase type 5 inhibitor failure

Uvin, P., Albersen, M., Bollen, I., Falter, M., Weyne, E., Linsen, L., Tinel, H., Sandner, P., Bivalacqua, T. J., De Ridder, D. J. M. K., Van der Aa, F., Brône, B. & Van Renterghem, K. Feb 1 2017 In : BJU International. 119, 2, p. 325-332 8 p.

Research output: Contribution to journalArticle

Phosphodiesterase 5 Inhibitors
rho-Associated Kinases
Erectile Dysfunction
Dimethyl Sulfoxide
Smooth Muscle

Analysis of Hospital Readmissions After Prosthetic Urologic Surgery in the United States: Nationally Representative Estimates of Causes, Costs, and Predictive Factors

Pederzoli, F., Chappidi, M. R., Collica, S., Kates, M., Joice, G. A., Sopko, N. A., Montorsi, F., Salonia, A. & Bivalacqua, T. J. Aug 1 2017 In : Journal of Sexual Medicine. 14, 8, p. 1059-1065 7 p.

Research output: Contribution to journalArticle

Artificial Urinary Sphincter
Patient Readmission
Penile Prosthesis
Costs and Cost Analysis
Hospital Costs

An Empirical vs Risk-Based Approach Algorithm to Intracavernosal Injection Therapy: A Prospective Study

Bernie, H. L., Segal, R., Le, B., Burnett, A. & Bivalacqua, T. J. Mar 1 2017 In : Sexual Medicine. 5, 1, p. e31-e36

Research output: Contribution to journalArticle

Erectile Dysfunction
Prospective Studies
Injections
Prostaglandins E
Papaverine

A phase II trial of dovitinib in BCG-unresponsive urothelial carcinoma with FGFR3 mutations or overexpression: Hoosier Cancer Research Network trial HCRN 12-157

Hahn, N. M. , Bivalacqua, T. J. , Ross, A. E. , Netto, G. J. , Baras, A. , Park, J. C. , Chapman, C. , Masterson, T. A. , Koch, M. O. , Bihrle, R. , Foster, R. S. , Gardner, T. A. , Cheng, L. , Jones, D. R. , McElyea, K. , Sandusky, G. E. , Breen, T. , Liu, Z. , Albany, C. , Moore, M. L. & 9 others Loman, R. L., Reed, A., Turner, S. A., De Abreu, F. B., Gallagher, T., Tsongalis, G. J., Plimack, E. R., Greenberg, R. E. & Geynisman, D. M. Jun 15 2017 In : Clinical Cancer Research. 23, 12, p. 3003-3011 9 p.

Research output: Contribution to journalArticle

Mycobacterium bovis
Carcinoma
Mutation
Research
Neoplasms

Biomanufacturing Seamless Tubular and Hollow Collagen Scaffolds with Unique Design Features and Biomechanical Properties

Singh, A., Lee, D., Sopko, N., Matsui, H., Sabnekar, P., Liu, X., Elisseeff, J., Schoenberg, M. P., Pienta, K. & Bivalacqua, T. J. 2017 (Accepted/In press) In : Advanced Healthcare Materials.

Research output: Contribution to journalArticle

Patient Readmission
Hospital Costs
Cystectomy
Logistic Models
High-Volume Hospitals

Cavernous Nerve Injury by Radiation Therapy May Potentiate Erectile Dysfunction in Rats

Mahmood, J., Connors, C. Q., Alexander, A. A., Pavlovic, R., Samanta, S., Soman, S., Matsui, H., Sopko, N. A., Bivalacqua, T. J., Weinreich, D., Ho, C. Y., Eley, J., Sawant, A., Jackson, I. L. & Vujaskovic, Z. Nov 1 2017 In : International Journal of Radiation Oncology Biology Physics. 99, 3, p. 680-688 9 p.

Research output: Contribution to journalArticle

nerves
Erectile Dysfunction
rats
radiation therapy
Radiotherapy
Nerve Growth Factors
Ganglia
Type 2 Diabetes Mellitus
Down-Regulation
Gene Expression
Hematuria
Insurance
Databases
Carcinoma
Confidence Intervals

Ex vivo culture of tumor cells from N-methyl-N-nitrosourea-induced bladder cancer in rats: Development of organoids and an immortalized cell line

Yoshida, T., Kates, M., Sopko, N. A., Liu, X., Singh, A. K., Bishai, W. R., Joice, G., McConkey, D. J. & Bivalacqua, T. J. Jan 1 2017 (Accepted/In press) In : Urologic Oncology: Seminars and Original Investigations.

Research output: Contribution to journalArticle

Organoids
Methylnitrosourea
Urinary Bladder Neoplasms
Cell Culture Techniques
Cell Line

Hospital Charges and Length of Stay Following Radical Cystectomy in the Enhanced Recovery After Surgery Era

Semerjian, A., Milbar, N., Kates, M., Gorin, M. A., Patel, H. D., Chalfin, H. J., Frank, S. M., Wu, C. L., Yang, W. W., Hobson, D., Robertson, L., Wick, E., Schoenberg, M. P., Pierorazio, P. M., Johnson, M. H., Stimson, C. J. & Bivalacqua, T. J. Jan 1 2017 (Accepted/In press) In : Urology.

Research output: Contribution to journalArticle

Hospital Charges
Cystectomy
Length of Stay
Renal Veins
Ileus

Immune-checkpoint status in penile squamous cell carcinoma: a North American cohort

Cocks, M., Taheri, D., Ball, M. W., Bezerra, S. M., Del Carmen Rodriguez, M., Ricardo, B. F. P., Bivalacqua, T. J., Sharma, R. B., Meeker, A., Chaux, A., Burnett, A. L. & Netto, G. J. Jan 1 2017 In : Human Pathology. 59, p. 55-61 7 p.

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
Neoplasms
Stromal Cells
Penile Neoplasms
Surgical Pathology

Innumerable Condyloma Acuminatum Tumors of the Bladder

Murray, A. J., Bivalacqua, T. J. & Sopko, N. A. May 1 2017 In : Urology Case Reports. 12, p. 76-77 2 p.

Research output: Contribution to journalArticle

Condylomata Acuminata
Urinary Bladder Neoplasms
Genitalia
Urinary Bladder
Viruses

Intravesical BCG Induces CD4+ T-cell expansion in an immune competent model of bladder cancer

Kates, M., Nirschl, T., Sopko, N. A., Matsui, H., Kochel, C. M., Reis, L. O., Netto, G. J., Hoque, M., Hahn, N. M., McConkey, D. J., Baras, A. S., Drake, C. G. & Bivalacqua, T. J. Jul 1 2017 In : Cancer Immunology Research. 5, 7, p. 594-603 10 p.

Research output: Contribution to journalArticle

Mycobacterium bovis
Urinary Bladder Neoplasms
T-Lymphocytes
Adaptive Immunity
Urinary Bladder

Intravesical rAd–IFNa/Syn3 for patients with high-grade, bacillus calmette-guerin–refractory or relapsed non–muscle-invasive bladder cancer: A phase II randomized study

Shore, N. D. , Boorjian, S. A. , Canter, D. J. , Ogan, K. , Karsh, L. I. , Downs, T. M. , Gomella, L. G. , Kamat, A. M. , Lotan, Y. , Svatek, R. S. , Bivalacqua, T. J. , Grubb, R. L. , Krupski, T. L. , Lerner, S. P. , Woods, M. E. , Inman, B. A. , Milowsky, M. I. , Boyd, A. , Treasure, F. P. , Gregory, G. & 4 others Sawutz, D. G., Yla-Herttuala, S., Parker, N. R. & Dinney, C. P. N. Oct 20 2017 In : Journal of Clinical Oncology. 35, 30, p. 3410-3416 7 p.

Research output: Contribution to journalArticle

Mycobacterium bovis
Urinary Bladder Neoplasms
Interferon-alpha
Adenoviridae
Muscles

Longer average blood storage duration is associated with increased risk of infection and overall morbidity following radical cystectomy

Chappidi, M. R., Chalfin, H. J., Johnson, D. J., Kates, M., Sopko, N. A., Johnson, M. H., Liu, J. J., Frank, S. M. & Bivalacqua, T. J. Feb 1 2017 In : Urologic Oncology: Seminars and Original Investigations. 35, 2, p. 38.e17-38.e24

Research output: Contribution to journalArticle

Cystectomy
Morbidity
Infection
Odds Ratio
Blood Transfusion

Low levels of PSMA expression limit the utility of 18F-DCFPyL PET/CT for imaging urothelial carcinoma

Campbell, S. P., Baras, A. S., Ball, M. W., Kates, M., Hahn, N. M., Bivalacqua, T. J., Johnson, M. H., Pomper, M. G., Allaf, M. E., Rowe, S. P. & Gorin, M. A. Oct 24 2017 (Accepted/In press) In : Annals of Nuclear Medicine. p. 1-6 6 p.

Research output: Contribution to journalArticle

Carcinoma
RNA Sequence Analysis
Prostatic Neoplasms
Renal Cell Carcinoma
Urinary Bladder Neoplasms

Lymph node density predicts recurrence and death after inguinal lymph node dissection for penile cancer

Ball, M. W., Schwen, Z. R., Ko, J. S., Meyer, A., Netto, G. J., Burnett, A. L. & Bivalacqua, T. J. Jan 1 2017 In : Investigative and Clinical Urology. 58, 1, p. 20-25 6 p.

Research output: Contribution to journalArticle

Penile Neoplasms
Groin
Lymph Node Excision
Lymph Nodes
Recurrence

M1 Macrophages Are Predominantly Recruited to the Major Pelvic Ganglion of the Rat Following Cavernous Nerve Injury

Matsui, H., Sopko, N. A., Hannan, J. L., Reinhardt, A. A., Kates, M., Yoshida, T., Liu, X., Castiglione, F., Hedlund, P., Weyne, E., Albersen, M. & Bivalacqua, T. J. Feb 1 2017 In : Journal of Sexual Medicine. 14, 2, p. 187-195 9 p.

Research output: Contribution to journalArticle

Ganglia
Macrophages
Wounds and Injuries
Erectile Dysfunction
Electric Stimulation

Penile Allotransplantation for Complex Genitourinary Reconstruction

Sopko, N. A., Tuffaha, S. H., Lough, D., Brandacher, G., Lee, W. P. A., Bivalacqua, T. J., Redett, R. J. & Burnett, A. L. 2017 (Accepted/In press) In : Journal of Urology.

Research output: Contribution to journalArticle

Vascularized Composite Allotransplantation
Transplantation
Transplants
Penis
Immunosuppression

Penile transplantation: An emerging option for genitourinary reconstruction

Tuffaha, S. H., Cooney, D. S., Sopko, N. A., Bivalacqua, T. J., Lough, D. M., Cooney, C. M., Brandacher, G., Lee, W. P. A., Burnett, A. L. & Redett, R. J. 2017 (Accepted/In press) In : Transplant International.

Research output: Contribution to journalArticle

Transplantation
Wounds and Injuries
Research

Pharmacodynamic and pharmacokinetic neoadjuvant study of hedgehog pathway inhibitor Sonidegib (LDE-225) in men with high-risk localized prostate cancer undergoing prostatectomy

Ross, A. E., Hughes, R. M., Glavaris, S., Ghabili, K., He, P., Anders, N. M., Harb, R., Tosoian, J. J., Marchionni, L., Schaeffer, E. M., Partin, A. W., Allaf, M. E., Bivalacqua, T. J., Chapman, C., O'Neal, T., DeMarzo, A. M., Hurley, P. J., Rudek, M. A. & Antonarakis, E. S. Jan 1 2017 In : Oncotarget. 8, 61, p. 104182-104192 11 p.

Research output: Contribution to journalArticle

Prostatectomy
Prostatic Neoplasms
Pharmacokinetics
Observation
Neoplasms
Robotics
Carcinoma
Recurrence
Urinary Tract
Neoplasms

Postoperative complications following intraoperative radiotherapy in abdominopelvic malignancy: A single institution analysis of 113 consecutive patients

Abdelfatah, E., Page, A., Sacks, J., Pierorazio, P., Bivalacqua, T., Efron, J., Terezakis, S., Gearhart, S., Fang, S., Safar, B., Pawlik, T. M., Armour, E., Hacker-Prietz, A., Herman, J. & Ahuja, N. Jun 1 2017 In : Journal of Surgical Oncology. 115, 7, p. 883-890 8 p.

Research output: Contribution to journalArticle

Radiotherapy
Neoplasms
Research Ethics Committees
Brachytherapy
Sarcoma

Preclinical evaluation of intravesical cisplatin nanoparticles for non–muscle-invasive bladder cancer

Kates, M., Date, A., Yoshida, T., Afzal, U., Kanvinde, P., Babu, T., Sopko, N. A., Matsui, H., Hahn, N. M., McConkey, D. J., Baras, A., Hanes, J., Ensign, L. & Bivalacqua, T. J. Nov 1 2017 In : Clinical Cancer Research. 23, 21, p. 6592-6601 10 p.

Research output: Contribution to journalArticle

Intravesical Administration
Urinary Bladder Neoplasms
Nanoparticles
Cisplatin
Muscles

Quantifying Nonindex Hospital Readmissions and Care Fragmentation after Major Urological Oncology Surgeries in a Nationally Representative Sample

Chappidi, M. R., Kates, M., Stimson, C. J., Bivalacqua, T. J. & Pierorazio, P. M. Jan 1 2017 In : Journal of Urology. 197, 1, p. 235-240 6 p.

Research output: Contribution to journalArticle

Patient Readmission
Databases
Nephrectomy
Logistic Models
Patient Acceptance of Health Care

Reply

Chappidi, M. R., Kates, M. & Bivalacqua, T. J. 2017 (Accepted/In press) In : Urology.

Research output: Contribution to journalArticle

Rhoa/rock activation in major pelvic ganglion mediates caspase-3 dependent nitrergic neuronal apoptosis following cavernous nerve injury

Bell, M., Sopko, N. A., Matsui, H., Hannan, J. L. & Bivalacqua, T. J. Apr 1 2017 In : Neural Regeneration Research. 12, 4, p. 572-573 2 p.

Research output: Contribution to journalComment/debate

Ganglia
Caspase 3
Apoptosis
Wounds and Injuries

Spectrum of genetic mutations in de novo PUNLMP of the urinary bladder

Rodriguez Pena, M. D. C., Tregnago, A. C., Eich, M. L., Springer, S., Wang, Y., Taheri, D., Ertoy, D., Fujita, K., Bezerra, S. M., Cunha, I. W., Raspollini, M. R., Yu, L., Bivalacqua, T. J., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Netto, G. J. Jun 8 2017 (Accepted/In press) In : Virchows Archiv. p. 1-7 7 p.

Research output: Contribution to journalArticle

Urinary Bladder
Mutation
Neoplasms
Urinary Bladder Neoplasms
Genes

The Epidemiology and Pathophysiology of Erectile Dysfunction and the Role of Environment-Current Updates

Collica, S., Pederzoli, F. & Bivalacqua, T. Nov 14 2017 Bioenvironmental Issues Affecting Men's Reproductive and Sexual Health. Elsevier Inc., p. 439-455 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Erectile Dysfunction
Epidemiology
amsonic acid
Aphrodisiacs
Penile Erection

Urinary Tissue Engineering: Challenges and Opportunities

Singh, A., Bivalacqua, T. J. & Sopko, N. 2017 (Accepted/In press) In : Sexual Medicine Reviews.

Research output: Contribution to journalArticle

Tissue Engineering
Urothelium
Urine
Regeneration
Collagen

Use of regenerative tissue for urinary diversion

Sopko, N. A., Kates, M., Singh, A., Steinberg, G. D., Smith, N. D., Schoenberg, M. P. & Bivalacqua, T. J. Apr 20 2017 Urinary Diversion. Springer International Publishing, p. 81-99 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Urinary Diversion
2016

Accuracy of urethral frozen section during radical cystectomy for bladder cancer

Kates, M., Ball, M. W., Chappidi, M. R., Baras, A. S., Gordetsky, J., Sopko, N. A., Brant, A., Pierorazio, P. M., Epstein, J. I., Schoenberg, M. P. & Bivalacqua, T. J. Dec 1 2016 In : Urologic Oncology: Seminars and Original Investigations. 34, 12, p. 532.e1-532.e6

Research output: Contribution to journalArticle

Cystectomy
Frozen Sections
Urinary Bladder Neoplasms
Aptitude

Adipose-derived Stem Cells Counteract Urethral Stricture Formation in Rats

Castiglione, F., Dewulf, K., Hakim, L., Weyne, E., Montorsi, F., Russo, A., Boeri, L., Bivalacqua, T. J., De Ridder, D., Joniau, S., Albersen, M. & Hedlund, P. 2016 (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

Urethral Stricture
Stem Cells
Adipose Tissue
Urination
Urinary Bladder

A Retrospective Analysis of the Effect on Survival of Time from Diagnosis to Neoadjuvant Chemotherapy to Cystectomy for Muscle Invasive Bladder Cancer

Park, J. C., Gandhi, N. M., Carducci, M. A., Eisenberger, M. A., Baras, A. S., Netto, G. J., Liu, J. J., Drake, C. G., Schoenberg, M. P., Bivalacqua, T. J. & Hahn, N. M. 2016 (Accepted/In press) In : Journal of Urology.

Research output: Contribution to journalArticle

Cystectomy
Urinary Bladder Neoplasms
Drug Therapy
Muscles
Survival
Arginase
Vascular Stiffness
Pulmonary Hypertension
Nitric Oxide
Sickle Cell Anemia

Assessing Cancer Progression and Stable Disease After Neoadjuvant Chemotherapy for Organ-confined Muscle-invasive Bladder Cancer

Chappidi, M. R., Kates, M., Brant, A., Baras, A. S., Netto, G. J., Pierorazio, P. M., Hahn, N. M. & Bivalacqua, T. J. Jul 26 2016 (Accepted/In press) In : Urology.

Research output: Contribution to journalArticle

Urinary Bladder Neoplasms
Disease Progression
Drug Therapy
Muscles
Survival
Type 5 Cyclic Nucleotide Phosphodiesterases
Priapism
Nitric Oxide Donors
NADPH Oxidase
Penis

Blood Transfusion is Associated with Increased Perioperative Morbidity and Adverse Oncologic Outcomes in Bladder Cancer Patients Receiving Neoadjuvant Chemotherapy and Radical Cystectomy

Chalfin, H. J., Liu, J. J., Gandhi, N., Feng, Z., Johnson, D., Netto, G. J., Drake, C. G., Hahn, N. M., Schoenberg, M. P., Trock, B. J., Scott, A. V., Frank, S. M. & Bivalacqua, T. J. Mar 24 2016 (Accepted/In press) In : Annals of Surgical Oncology. p. 1-8 8 p.

Research output: Contribution to journalArticle

Cystectomy
Urinary Bladder Neoplasms
Blood Transfusion
Morbidity
Drug Therapy

Caspase-3 dependent nitrergic neuronal apoptosis following cavernous nerve injury is mediated via RhoA and ROCK activation in major pelvic ganglion

Hannan, J. L., Matsui, H., Sopko, N. A., Liu, X., Weyne, E., Albersen, M., Watson, J. W., Hoke, A., Burnett, A. L. & Bivalacqua, T. J. Jul 8 2016 In : Scientific Reports. 6, 29416

Research output: Contribution to journalArticle

Ganglia
Caspase 3
Apoptosis
Wounds and Injuries
Penis

Circulating tumour cells as biomarkers of prostate, bladder, and kidney cancer

Gorin, M. A., Verdone, J. E., van der Toom, E., Bivalacqua, T. J., Allaf, M. E. & Pienta, K. J. Nov 22 2016 (Accepted/In press) In : Nature Reviews Urology.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Kidney Neoplasms
Urinary Bladder Neoplasms
Prostatic Neoplasms
Biomarkers