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2017

Additive effects of the Rho kinase inhibitor Y-27632 and vardenafil on relaxation of the corpus cavernosum tissue of patients with erectile dysfunction and clinical phosphodiesterase type 5 inhibitor failure

Uvin, P., Albersen, M., Bollen, I., Falter, M., Weyne, E., Linsen, L., Tinel, H., Sandner, P., Bivalacqua, T. J., De Ridder, D. J. M. K., Van der Aa, F., Brône, B. & Van Renterghem, K. Feb 1 2017 In : BJU International. 119, 2, p. 325-332 8 p.

Research output: Research - peer-reviewArticle

Phosphodiesterase 5 Inhibitors
rho-Associated Kinases
Erectile Dysfunction
Vardenafil Dihydrochloride
Y 27632

Analysis of Hospital Readmissions After Prosthetic Urologic Surgery in the United States: Nationally Representative Estimates of Causes, Costs, and Predictive Factors

Pederzoli, F., Chappidi, M. R., Collica, S., Kates, M., Joice, G. A., Sopko, N. A., Montorsi, F., Salonia, A. & Bivalacqua, T. J. Aug 1 2017 In : Journal of Sexual Medicine. 14, 8, p. 1059-1065 7 p.

Research output: Research - peer-reviewArticle

Artificial Urinary Sphincter
Patient Readmission
Costs and Cost Analysis
Penile Prosthesis
Hospital Costs

An Empirical vs Risk-Based Approach Algorithm to Intracavernosal Injection Therapy: A Prospective Study

Bernie, H. L., Segal, R., Le, B., Burnett, A. & Bivalacqua, T. J. Mar 1 2017 In : Sexual Medicine. 5, 1, p. e31-e36

Research output: Research - peer-reviewArticle

Prospective Studies
Injections
Therapeutics
Erectile Dysfunction
Surveys and Questionnaires

A phase II trial of dovitinib in BCG-unresponsive urothelial carcinoma with FGFR3 mutations or overexpression: Hoosier Cancer Research Network trial HCRN 12-157

Hahn, N. M. , Bivalacqua, T. J. , Ross, A. E. , Netto, G. J. , Baras, A. , Park, J. C. , Chapman, C. , Masterson, T. A. , Koch, M. O. , Bihrle, R. , Foster, R. S. , Gardner, T. A. , Cheng, L. , Jones, D. R. , McElyea, K. , Sandusky, G. E. , Breen, T. , Liu, Z. , Albany, C. , Moore, M. L. & 9 others Loman, R. L., Reed, A., Turner, S. A., De Abreu, F. B., Gallagher, T., Tsongalis, G. J., Plimack, E. R., Greenberg, R. E. & Geynisman, D. M. Jun 15 2017 In : Clinical Cancer Research. 23, 12, p. 3003-3011 9 p.

Research output: Research - peer-reviewArticle

Mycobacterium bovis
Carcinoma
Mutation
Research
Neoplasms

Biomanufacturing Seamless Tubular and Hollow Collagen Scaffolds with Unique Design Features and Biomechanical Properties

Singh, A., Lee, D., Sopko, N., Matsui, H., Sabnekar, P., Liu, X., Elisseeff, J., Schoenberg, M. P., Pienta, K. & Bivalacqua, T. J. 2017 (Accepted/In press) In : Advanced Healthcare Materials.

Research output: Research - peer-reviewArticle

Patient Readmission
Hospital Costs
Cystectomy
Logistic Models
High-Volume Hospitals

Cavernous Nerve Injury by Radiation Therapy May Potentiate Erectile Dysfunction in Rats

Mahmood, J., Connors, C. Q., Alexander, A. A., Pavlovic, R., Samanta, S., Soman, S., Matsui, H., Sopko, N. A., Bivalacqua, T. J., Weinreich, D., Ho, C. Y., Eley, J., Sawant, A., Jackson, I. L. & Vujaskovic, Z. Nov 1 2017 In : International Journal of Radiation Oncology Biology Physics. 99, 3, p. 680-688 9 p.

Research output: Research - peer-reviewArticle

Erectile Dysfunction
Radiotherapy
Wounds and Injuries
nerves
rats
Nerve Growth Factors
Ganglia
Type 2 Diabetes Mellitus
Down-Regulation
Gene Expression
Hematuria
Insurance
Databases
Carcinoma
Confidence Intervals

Immune-checkpoint status in penile squamous cell carcinoma: a North American cohort

Cocks, M., Taheri, D., Ball, M. W., Bezerra, S. M., Del Carmen Rodriguez, M., Ricardo, B. F. P., Bivalacqua, T. J., Sharma, R. B., Meeker, A., Chaux, A., Burnett, A. L. & Netto, G. J. Jan 1 2017 In : Human Pathology. 59, p. 55-61 7 p.

Research output: Research - peer-reviewArticle

Squamous Cell Carcinoma
Neoplasms
Stromal Cells
Penile Neoplasms
Surgical Pathology

Innumerable Condyloma Acuminatum Tumors of the Bladder

Murray, A. J., Bivalacqua, T. J. & Sopko, N. A. May 1 2017 In : Urology Case Reports. 12, p. 76-77 2 p.

Research output: Research - peer-reviewArticle

Condylomata Acuminata
Urinary Bladder Neoplasms
Genitalia
Urinary Bladder
Viruses

Intravesical BCG Induces CD4+ T-cell expansion in an immune competent model of bladder cancer

Kates, M., Nirschl, T., Sopko, N. A., Matsui, H., Kochel, C. M., Reis, L. O., Netto, G. J., Hoque, M., Hahn, N. M., McConkey, D. J., Baras, A. S., Drake, C. G. & Bivalacqua, T. J. Jul 1 2017 In : Cancer Immunology Research. 5, 7, p. 594-603 10 p.

Research output: Research - peer-reviewArticle

Mycobacterium bovis
Urinary Bladder Neoplasms
T-Lymphocytes
Adaptive Immunity
Urinary Bladder

Intravesical rAd–IFNa/Syn3 for patients with high-grade, bacillus calmette-guerin–refractory or relapsed non–muscle-invasive bladder cancer: A phase II randomized study

Shore, N. D. , Boorjian, S. A. , Canter, D. J. , Ogan, K. , Karsh, L. I. , Downs, T. M. , Gomella, L. G. , Kamat, A. M. , Lotan, Y. , Svatek, R. S. , Bivalacqua, T. J. , Grubb, R. L. , Krupski, T. L. , Lerner, S. P. , Woods, M. E. , Inman, B. A. , Milowsky, M. I. , Boyd, A. , Treasure, F. P. , Gregory, G. & 4 others Sawutz, D. G., Yla-Herttuala, S., Parker, N. R. & Dinney, C. P. N. Oct 20 2017 In : Journal of Clinical Oncology. 35, 30, p. 3410-3416 7 p.

Research output: Research - peer-reviewArticle

Mycobacterium bovis
Urinary Bladder Neoplasms
Interferon-alpha
Adenoviridae
Muscles

Longer average blood storage duration is associated with increased risk of infection and overall morbidity following radical cystectomy

Chappidi, M. R., Chalfin, H. J., Johnson, D. J., Kates, M., Sopko, N. A., Johnson, M. H., Liu, J. J., Frank, S. M. & Bivalacqua, T. J. Feb 1 2017 In : Urologic Oncology: Seminars and Original Investigations. 35, 2, p. 38.e17-38.e24

Research output: Research - peer-reviewArticle

Cystectomy
Morbidity
Infection
Odds Ratio
Blood Transfusion

Low levels of PSMA expression limit the utility of 18F-DCFPyL PET/CT for imaging urothelial carcinoma

Campbell, S. P., Baras, A. S., Ball, M. W., Kates, M., Hahn, N. M., Bivalacqua, T. J., Johnson, M. H., Pomper, M. G., Allaf, M. E., Rowe, S. P. & Gorin, M. A. Oct 24 2017 (Accepted/In press) In : Annals of Nuclear Medicine. p. 1-6 6 p.

Research output: Research - peer-reviewArticle

Carcinoma
Prostatic Neoplasms
RNA Sequence Analysis
Renal Cell Carcinoma
Urinary Bladder Neoplasms

Lymph node density predicts recurrence and death after inguinal lymph node dissection for penile cancer

Ball, M. W., Schwen, Z. R., Ko, J. S., Meyer, A., Netto, G. J., Burnett, A. L. & Bivalacqua, T. J. Jan 1 2017 In : Investigative and Clinical Urology. 58, 1, p. 20-25 6 p.

Research output: Research - peer-reviewArticle

Penile Neoplasms
Groin
Lymph Node Excision
Lymph Nodes
Recurrence

M1 Macrophages Are Predominantly Recruited to the Major Pelvic Ganglion of the Rat Following Cavernous Nerve Injury

Matsui, H., Sopko, N. A., Hannan, J. L., Reinhardt, A. A., Kates, M., Yoshida, T., Liu, X., Castiglione, F., Hedlund, P., Weyne, E., Albersen, M. & Bivalacqua, T. J. Feb 1 2017 In : Journal of Sexual Medicine. 14, 2, p. 187-195 9 p.

Research output: Research - peer-reviewArticle

Ganglia
Macrophages
Wounds and Injuries
Proteins
Erectile Dysfunction

Penile Allotransplantation for Complex Genitourinary Reconstruction

Sopko, N. A., Tuffaha, S. H., Lough, D., Brandacher, G., Lee, W. P. A., Bivalacqua, T. J., Redett, R. J. & Burnett, A. L. 2017 (Accepted/In press) In : Journal of Urology.

Research output: Research - peer-reviewArticle

Transplantation
Transplants
Vascularized Composite Allotransplantation
Penis
Immunosuppression

Penile transplantation: An emerging option for genitourinary reconstruction

Tuffaha, S. H., Cooney, D. S., Sopko, N. A., Bivalacqua, T. J., Lough, D. M., Cooney, C. M., Brandacher, G., Lee, W. P. A., Burnett, A. L. & Redett, R. J. 2017 (Accepted/In press) In : Transplant International.

Research output: Research - peer-reviewArticle

Transplantation
Wounds and Injuries
Research
Robotics
Carcinoma
Recurrence
Neoplasms
Urinary Tract

Postoperative complications following intraoperative radiotherapy in abdominopelvic malignancy: A single institution analysis of 113 consecutive patients

Abdelfatah, E., Page, A., Sacks, J., Pierorazio, P., Bivalacqua, T., Efron, J., Terezakis, S., Gearhart, S., Fang, S., Safar, B., Pawlik, T. M., Armour, E., Hacker-Prietz, A., Herman, J. & Ahuja, N. Jun 1 2017 In : Journal of Surgical Oncology. 115, 7, p. 883-890 8 p.

Research output: Research - peer-reviewArticle

Radiotherapy
Neoplasms
Research Ethics Committees
Brachytherapy
Sarcoma

Preclinical evaluation of intravesical cisplatin nanoparticles for non–muscle-invasive bladder cancer

Kates, M., Date, A., Yoshida, T., Afzal, U., Kanvinde, P., Babu, T., Sopko, N. A., Matsui, H., Hahn, N. M., McConkey, D. J., Baras, A., Hanes, J., Ensign, L. & Bivalacqua, T. J. Nov 1 2017 In : Clinical Cancer Research. 23, 21, p. 6592-6601 10 p.

Research output: Research - peer-reviewArticle

Intravesical Administration
Urinary Bladder Neoplasms
Nanoparticles
Cisplatin
Muscles
Patient Readmission
Databases
Nephrectomy
Logistic Models
Neoplasms

Reply

Chappidi, M. R., Kates, M. & Bivalacqua, T. J. 2017 (Accepted/In press) In : Urology.

Research output: Research - peer-reviewArticle

Rhoa/rock activation in major pelvic ganglion mediates caspase-3 dependent nitrergic neuronal apoptosis following cavernous nerve injury

Bell, M., Sopko, N. A., Matsui, H., Hannan, J. L. & Bivalacqua, T. J. Apr 1 2017 In : Neural Regeneration Research. 12, 4, p. 572-573 2 p.

Research output: Research - peer-reviewComment/debate

Spectrum of genetic mutations in de novo PUNLMP of the urinary bladder

Rodriguez Pena, M. D. C., Tregnago, A. C., Eich, M. L., Springer, S., Wang, Y., Taheri, D., Ertoy, D., Fujita, K., Bezerra, S. M., Cunha, I. W., Raspollini, M. R., Yu, L., Bivalacqua, T. J., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Netto, G. J. Jun 8 2017 (Accepted/In press) In : Virchows Archiv. p. 1-7 7 p.

Research output: Research - peer-reviewArticle

Urinary Bladder
Mutation
Neoplasms
Urinary Bladder Neoplasms
Genes

Urinary Tissue Engineering: Challenges and Opportunities

Singh, A., Bivalacqua, T. J. & Sopko, N. 2017 (Accepted/In press) In : Sexual Medicine Reviews.

Research output: Research - peer-reviewArticle

Tissue Engineering
Urothelium
Urine
Regeneration
Collagen

Use of regenerative tissue for urinary diversion

Sopko, N. A., Kates, M., Singh, A., Steinberg, G. D., Smith, N. D., Schoenberg, M. P. & Bivalacqua, T. J. Apr 20 2017 Urinary Diversion. Springer International Publishing, p. 81-99 19 p.

Research output: ResearchChapter

2016

Accuracy of urethral frozen section during radical cystectomy for bladder cancer

Kates, M., Ball, M. W., Chappidi, M. R., Baras, A. S., Gordetsky, J., Sopko, N. A., Brant, A., Pierorazio, P. M., Epstein, J. I., Schoenberg, M. P. & Bivalacqua, T. J. Dec 1 2016 In : Urologic Oncology: Seminars and Original Investigations. 34, 12, p. 532.e1-532.e6

Research output: Research - peer-reviewArticle

Cystectomy
Frozen Sections
Urinary Bladder Neoplasms
Aptitude
Decision Making

Adipose-derived Stem Cells Counteract Urethral Stricture Formation in Rats

Castiglione, F., Dewulf, K., Hakim, L., Weyne, E., Montorsi, F., Russo, A., Boeri, L., Bivalacqua, T. J., De Ridder, D., Joniau, S., Albersen, M. & Hedlund, P. 2016 (Accepted/In press) In : European Urology.

Research output: Research - peer-reviewArticle

Urethral Stricture
Stem Cells
Adipose Tissue
Urination
Urinary Bladder

A Retrospective Analysis of the Effect on Survival of Time from Diagnosis to Neoadjuvant Chemotherapy to Cystectomy for Muscle Invasive Bladder Cancer

Park, J. C., Gandhi, N. M., Carducci, M. A., Eisenberger, M. A., Baras, A. S., Netto, G. J., Liu, J. J., Drake, C. G., Schoenberg, M. P., Bivalacqua, T. J. & Hahn, N. M. 2016 (Accepted/In press) In : Journal of Urology.

Research output: Research - peer-reviewArticle

Cystectomy
Urinary Bladder Neoplasms
Drug Therapy
Muscles
Survival
Arginase
Vascular Stiffness
Pulmonary Hypertension
Nitric Oxide
Sickle Cell Anemia

Assessing Cancer Progression and Stable Disease After Neoadjuvant Chemotherapy for Organ-confined Muscle-invasive Bladder Cancer

Chappidi, M. R., Kates, M., Brant, A., Baras, A. S., Netto, G. J., Pierorazio, P. M., Hahn, N. M. & Bivalacqua, T. J. Jul 26 2016 (Accepted/In press) In : Urology.

Research output: Research - peer-reviewArticle

Urinary Bladder Neoplasms
Disease Progression
Drug Therapy
Muscles
Survival
Type 5 Cyclic Nucleotide Phosphodiesterases
Priapism
Nitric Oxide Donors
NADPH Oxidase
Penis

Blood Transfusion is Associated with Increased Perioperative Morbidity and Adverse Oncologic Outcomes in Bladder Cancer Patients Receiving Neoadjuvant Chemotherapy and Radical Cystectomy

Chalfin, H. J., Liu, J. J., Gandhi, N., Feng, Z., Johnson, D., Netto, G. J., Drake, C. G., Hahn, N. M., Schoenberg, M. P., Trock, B. J., Scott, A. V., Frank, S. M. & Bivalacqua, T. J. Mar 24 2016 (Accepted/In press) In : Annals of Surgical Oncology. p. 1-8 8 p.

Research output: Research - peer-reviewArticle

Cystectomy
Urinary Bladder Neoplasms
Blood Transfusion
Morbidity
Drug Therapy

Caspase-3 dependent nitrergic neuronal apoptosis following cavernous nerve injury is mediated via RhoA and ROCK activation in major pelvic ganglion

Hannan, J. L., Matsui, H., Sopko, N. A., Liu, X., Weyne, E., Albersen, M., Watson, J. W., Hoke, A., Burnett, A. L. & Bivalacqua, T. J. Jul 8 2016 In : Scientific Reports. 6, 29416

Research output: Research - peer-reviewArticle

Ganglia
Caspase 3
Apoptosis
Wounds and Injuries
Penis

Circulating tumour cells as biomarkers of prostate, bladder, and kidney cancer

Gorin, M. A., Verdone, J. E., van der Toom, E., Bivalacqua, T. J., Allaf, M. E. & Pienta, K. J. Nov 22 2016 (Accepted/In press) In : Nature Reviews Urology.

Research output: Research - peer-reviewArticle

Circulating Neoplastic Cells
Kidney Neoplasms
Urinary Bladder Neoplasms
Prostatic Neoplasms
Biomarkers

Detection of TERT promoter mutations in primary adenocarcinoma of the urinary bladder

Cowan, M. L., Springer, S., Nguyen, D., Taheri, D., Guner, G., Mendoza Rodriguez, M. A., Wang, Y., Kinde, I., Del Carmen Rodriguez Pena, M., Vandenbussche, C. J., Olson, M. T., Cunha, I., Fujita, K., Ertoy, D., Kinzler, K., Bivalacqua, T., Papadopoulos, N., Vogelstein, B. & Netto, G. J. Jul 1 2016 In : Human Pathology. 53, p. 8-13 6 p.

Research output: Research - peer-reviewArticle

Urinary Bladder
Adenocarcinoma
Mutation
Carcinoma
Urine
Prostate-Specific Antigen
Prostatectomy
Recurrence
Survival
Prostatic Neoplasms

Erectile Dysfunction Treatment Following Radical Cystoprostatectomy: Analysis of a Nationwide Insurance Claims Database

Chappidi, M. R., Kates, M., Sopko, N. A., Joice, G. A., Tosoian, J. J., Pierorazio, P. M. & Bivalacqua, T. J. Dec 26 2016 (Accepted/In press) In : Journal of Sexual Medicine.

Research output: Research - peer-reviewArticle

Erectile Dysfunction
Insurance
Databases
Therapeutics
Odds Ratio

Evidence-based management guidelines on peyronie's disease

Chung, E., Ralph, D., Kagioglu, A., Garaffa, G., Shamsodini, A., Bivalacqua, T., Glina, S., Hakim, L., Sadeghi-Nejad, H. & Broderick, G. Jun 1 2016 In : Journal of Sexual Medicine. 13, 6, p. 905-923 19 p.

Research output: Research - peer-reviewArticle

Penile Induration
Guidelines
Referral and Consultation
Medicine
Therapeutics

Ex Vivo Model of Human Penile Transplantation and Rejection: Implications for Erectile Tissue Physiology

Sopko, N. A., Matsui, H., Lough, D. M., Miller, D., Harris, K., Kates, M., Liu, X., Billups, K., Redett, R., Burnett, A. L., Brandacher, G. & Bivalacqua, T. J. 2016 (Accepted/In press) In : European Urology.

Research output: Research - peer-reviewArticle

Graft Rejection
Rejection (Psychology)
Blood Cells
Immunosuppression
Cyclosporine

High prevalence of TERT promoter mutations in micropapillary urothelial carcinoma

Nguyen, D., Taheri, D., Springer, S., Cowan, M., Guner, G., Rodriguez, M. A. M., Wang, Y., Kinde, I., VandenBussche, C. J., Olson, M. T., Ricardo, B. F. P., Cunha, I., Fujita, K., Ertoy, D., Kinzler, K. W., Bivalacqua, T. J., Papadopoulos, N., Vogelstein, B. & Netto, G. J. Aug 12 2016 (Accepted/In press) In : Virchows Archiv. p. 1-8 8 p.

Research output: Research - peer-reviewArticle

Telomerase
Carcinoma
Mutation
Histology
Urinary Tract

High prevalence of TERT promoter mutations in primary squamous cell carcinoma of the urinary bladder

Cowan, M., Springer, S., Nguyen, D., Taheri, D., Guner, G., Rodriguez, M. A. M., Wang, Y., Kinde, I., Bussche, C. J. V., Olson, M. T., Cunha, I., Fujita, K., Ertoy, D., Bivalacqua, T. J., Kinzler, K., Vogelstein, B., Netto, G. J. & Papadopoulos, N. Mar 11 2016 (Accepted/In press) In : Modern Pathology.

Research output: Research - peer-reviewArticle

Squamous Cell Carcinoma
Urinary Bladder
Mutation
Urine
Carcinoma

Immune checkpoint inhibitors: a new frontier in bladder cancer

Kates, M., Sopko, N. A., Matsui, H., Drake, C. G., Hahn, N. M. & Bivalacqua, T. J. Jan 1 2016 In : World Journal of Urology. 34, 1, p. 49-55 7 p.

Research output: Research - peer-reviewArticle

Urinary Bladder Neoplasms
Neoplasms
Immunotherapy
Immune System
Pharmaceutical Preparations

Impaired contraction and decreased detrusor innervation in a female rat model of pelvic neuropraxia

Hannan, J. L., Powers, S. A., Wang, V. M., Castiglione, F., Hedlund, P. & Bivalacqua, T. J. Dec 16 2016 (Accepted/In press) In : International Urogynecology Journal and Pelvic Floor Dysfunction. p. 1-8 8 p.

Research output: Research - peer-reviewArticle

Wounds and Injuries
Smooth Muscle
Urinary Bladder
Gene Expression
Vesicular Acetylcholine Transport Proteins

Infectious complications in transfused patients after radical cystectomy

Liu, J. J., Mullane, P., Kates, M., Gandhi, N., Schoenberg, M. P., Drake, C., Hahn, N. M., Frank, S. & Bivalacqua, T. J. 2016 In : Canadian Journal of Urology. 23, 4, p. 8342-8347 6 p.

Research output: Research - peer-reviewArticle

Cystectomy
Blood Transfusion
Infection
Bloodless Medical and Surgical Procedures
Urinary Diversion

Mechanistic link between erectile dysfunction and systemic endothelial dysfunction in type 2 diabetic rats

Musicki, B., Hannan, J. L., Lagoda, G., Bivalacqua, T. J. & Burnett, A. L. Sep 1 2016 In : Andrology. 4, 5, p. 977-983 7 p.

Research output: Research - peer-reviewArticle

Erectile Dysfunction
Type 2 Diabetes Mellitus
Carotid Arteries
Penis
Oxidoreductases

New strategies in bladder cancer: A second coming for immunotherapy

Ghasemzadeh, A., Bivalacqua, T. J., Hahn, N. M. & Drake, C. G. Feb 15 2016 In : Clinical Cancer Research. 22, 4, p. 793-801 9 p.

Research output: Research - peer-reviewArticle

Urinary Bladder Neoplasms
Immunotherapy
Neoplasms
Therapeutics
Cancer Vaccines