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  • Roy G Brower
2020

Mean Airway Pressure As a Predictor of 90-Day Mortality in Mechanically Ventilated Patients∗

INTENSIVOS Cohort Study, Jan 1 2020, (Accepted/In press) In : Critical care medicine. p. 688-695 8 p.

Research output: Contribution to journalArticle

Premature, Opportune, and Delayed Weaning in Mechanically Ventilated Patients: A Call for Implementation of Weaning Protocols in Low-and Middle-Income Countries

INTENSIVOS Cohort Study, Jan 1 2020, (Accepted/In press) In : Critical care medicine. p. 673-679 7 p.

Research output: Contribution to journalArticle

Rationale and design of ORCHID: A randomized placebo-controlled clinical trial of hydroxychloroquine for adults hospitalized with COVID-19

ORCHID Protocol Committee and the National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury (PETAL) Network Investigators, Sep 2020, In : Annals of the American Thoracic Society. 17, 9, p. 1144-1153 10 p.

Research output: Contribution to journalArticle

Open Access

Voice-Related Quality of Life Increases With a Talking Tracheostomy Tube: A Randomized Controlled Trial

Pandian, V., Cole, T., Kilonsky, D., Holden, K., Feller-Kopman, D. J., Brower, R. & Mirski, M., May 1 2020, In : Laryngoscope. 130, 5, p. 1249-1255 7 p.

Research output: Contribution to journalArticle

2019
Open Access

Early high-dose Vitamin D3 for critically ill, Vitamin D–deficient patients

Ginde, A. A., Brower, R. G., Caterino, J. M., Finck, L., Banner‑Goodspeed, V. M., Grissom, C. K., Hayden, D., Hough, C. L., Hyzy, R. C., Khan, A., Levitt, J. E., Park, P. K., Ringwood, N., Rivers, E. P., Self, W. H., Shapiro, N. I., Thompson, B. T., Yealy, D. M. & Talmor, D., Dec 26 2019, In : New England Journal of Medicine. 381, 26, p. 2529-2540 12 p.

Research output: Contribution to journalArticle

Early neuromuscular blockade in the acute respiratory distress syndrome

National Heart, Lung, and Blood Institute PETAL Clinical Trials Network, May 23 2019, In : New England Journal of Medicine. 380, 21, p. 1997-2008 12 p.

Research output: Contribution to journalArticle

Effect of documenting prognosis on the information provided to ICU proxies: A randomized trial

Turnbull, A. E., Hayes, M. M., Brower, R. G., Colantuoni, E., Basyal, P. S., White, D. B., Curtis, J. R. & Needham, D. M., Jun 2019, In : Critical care medicine. 47, 6, p. 757-764 8 p.

Research output: Contribution to journalArticle

Prospective assessment of the feasibility of a trial of low–tidal volume ventilation for patients with acute respiratory failure

Lanspa, M. J., Gong, M. N., Schoenfeld, D. A., Lee, K. T., Grissom, C. K., Hou, P. C., Serpa-Neto, A., Brown, S. M., Iwashyna, T. J., Yealy, D. M., Hough, C. L., Brower, R. G., Calfee, C. S., Hyzy, R. C., Matthay, M. A., Miller, R. R., Steingrub, J. S., Thompson, B. T., Miller, C. D., Clemmer, T. P. & 5 others, Hendey, G. W., Huang, D. T., Mathews, K. S., Qadir, N. & Tidswell, M., Mar 2019, In : Annals of the American Thoracic Society. 16, 3, p. 356-362 7 p.

Research output: Contribution to journalArticle

Risk factors for the development of acute respiratory distress syndrome in mechanically ventilated adults in Peru: A multicenter observational study

Gupta, E., Hossen, S., Grigsby, M. R., Herrera, P., Roldan, R., Paz, E., Jaymez, A. A., Chirinos, E. E., Portugal, J., Quispe, R., Brower, R. G. & Checkley, W., Dec 6 2019, In : Critical Care. 23, 1, 398.

Research output: Contribution to journalArticle

Open Access

Sedation practices and clinical outcomes in mechanically ventilated patients in a prospective multicenter cohort

Aragón, R. E., Proaño, A., Mongilardi, N., De Ferrari, A., Herrera, P., Roldan, R., Paz, E., Jaymez, A. A., Chirinos, E., Portugal, J., Quispe, R., Brower, R. G. & Checkley, W., Apr 17 2019, In : Critical Care. 23, 1, 130.

Research output: Contribution to journalArticle

Open Access

Use and costs of inhaled nitric oxide and inhaled epoprostenol in adult critically ill patients: A quality improvement project

Davis, S. L., Crow, J. R., Fan, J. R., Mattare, K., Whitman, G., Brower, R. G., Rowden, A. & Pustavoitau, A., Sep 3 2019, In : American Journal of Health-System Pharmacy. 76, 18, p. 1413-1419 7 p.

Research output: Contribution to journalArticle

2018

Can the plateau be higher than the peak pressure?

Sajjad, H., Schmidt, G. A., Brower, R. G. & Eberlein, M., Jun 2018, In : Annals of the American Thoracic Society. 15, 6, p. 754-759 6 p.

Research output: Contribution to journalReview article

Catheter-directed thrombolysis for intermediate-risk pulmonary embolism

Furfaro, D., Stephens, R., Streiff, M. B. & Brower, R. G., Feb 1 2018, In : Annals of the American Thoracic Society. 15, 2, p. 134-144 11 p.

Research output: Contribution to journalArticle

Chest wall strapping increases expiratory airflow and detectable airway segments in computer tomographic scans of normal and obstructed lungs

Taher, H., Bauer, C., Abston, E., Kaczka, D. W., Bhatt, S. P., Zabner, J., Brower, R. G., Beichel, R. R. & Eberlein, M., May 2018, In : Journal of applied physiology. 124, 5, p. 1186-1193 8 p.

Research output: Contribution to journalArticle

ECMO for severe acute respiratory distress syndrome

Shanholtz, C., Reed, R. M. & Brower, R. G., Sep 13 2018, In : New England Journal of Medicine. 379, 11, p. 1090 1 p.

Research output: Contribution to journalLetter

Mechanical ventilation in adults with acute respiratory distress syndrome: An official clinical guideline of American Thoracic Society/European Society of Intensive Care medicine/Society of Critical care medicine

Fan, E., Del Sorbo, L., Goligher, E. C., Hodgson, C. L., Munshi, L., Walkey, A. J., Adhikari, N. K. J., Amato, M. B. P., Branson, R., Brower, R. G., Ferguson, N. D., Gajic, O., Gattinoni, L., Hess, D., Mancebo, J., Meade, M. O., McAuley, D. F., Pesenti, A., Ranieri, V. M., Rubenfeld, G. D. & 9 others, Rubin, E., Seckel, M., Slutsky, A. S., Talmor, D., Thompson, B. T., Wunsch, H., Uleryk, E., Brozek, J. & Brochard, L. J., Jan 1 2018, In : Pulmonologiya. 28, 4, p. 399-410 12 p.

Research output: Contribution to journalArticle

Minimally invasive palliative interventions in advanced lung cancer

Mallow, C., Hayes, M., Semaan, R., Smith, T. J., Hales, R., Brower, R. G. & Yarmus, L., Jul 3 2018, In : Expert Review of Respiratory Medicine. 12, 7, p. 605-614 10 p.

Research output: Contribution to journalReview article

Oxygen Exposure Resulting in Arterial Oxygen Tensions Above the Protocol Goal Was Associated With Worse Clinical Outcomes in Acute Respiratory Distress Syndrome

National Institutes of Health Acute Respiratory Distress Syndrome Network Investigators, Apr 1 2018, In : Critical care medicine. 46, 4, p. 517-524 8 p.

Research output: Contribution to journalArticle

Progressive myocardial injury is associated with mortality in the acute respiratory distress syndrome

Metkus, T. S., Guallar, E., Sokoll, L., Morrow, D. A., Tomaselli, G., Brower, R., Kim, B. S., Schulman, S. & Korley, F. K., Dec 2018, In : Journal of Critical Care. 48, p. 26-31 6 p.

Research output: Contribution to journalArticle

2017

An official American Thoracic Society/European Society of intensive care medicine/society of critical care medicine clinical practice guideline: Mechanical ventilation in adult patients with acute respiratory distress syndrome

American Thoracic Society, European Society of Intensive Care Medicine & Society of Critical Care Medicine, May 1 2017, In : American Journal of Respiratory and Critical Care Medicine. 195, 9, p. 1253-1263 11 p.

Research output: Contribution to journalArticle

Extracorporeal membrane oxygenation is not first-line therapy for the acute respiratory distress syndrome

Stephens, R. & Brower, R. G., Jan 1 2017, In : Critical Care Medicine. 45, 12, p. 2074-2077 4 p.

Research output: Contribution to journalComment/debate

Fifty years of research in ARDS VT selection in acute respiratory distress syndrome

Sahetya, S., Mancebo, J. & Brower, R. G., Dec 15 2017, In : American Journal of Respiratory and Critical Care Medicine. 196, 12, p. 1519-1525 7 p.

Research output: Contribution to journalReview article

Higher BMI is associated with higher expiratory airflow normalised for lung volume (FEF25–75/FVC) in COPD

Abston, E., Comellas, A., Reed, R. M., Kim, V., Wise, R. A., Brower, R., Fortis, S., Beichel, R., Bhatt, S., Zabner, J., Newell, J., Hoffman, E. A. & Eberlein, M., Oct 1 2017, In : BMJ Open Respiratory Research. 4, 1, e000231.

Research output: Contribution to journalArticle

Higher PEEP versus lower PEEP strategies for patients with acute respiratory distress syndrome: A systematic review and meta-analysis

Walkey, A. J., Del Sorbo, L., Hodgson, C. L., Adhikari, N. K. J., Wunsch, H., Meade, M. O., Uleryk, E., Hess, D., Talmor, D. S., Thompson, B. T., Brower, R. G. & Fan, E., Oct 1 2017, In : Annals of the American Thoracic Society. 14, p. S297-S303

Research output: Contribution to journalReview article

Intermediate care to intensive care triage: A quality improvement project to reduce mortality

Hager, D. N., Chandrashekar, P., Bradsher, R. W., Abdel-Halim, A. M., Chatterjee, S., Sawyer, M., Brower, R. G. & Needham, D., Dec 1 2017, In : Journal of Critical Care. 42, p. 282-288 7 p.

Research output: Contribution to journalArticle

Low tidal volume versus non–volume-limited strategies for patients with acute respiratory distress syndrome: A systematic review and meta-analysis

Walkey, A. J., Goligher, E. C., Del Sorbo, L., Hodgson, C. L., Adhikari, N. K. J., Wunsch, H., Meade, M. O., Uleryk, E., Hess, D., Talmor, D. S., Thompson, B. T., Brower, R. G. & Fan, E., Oct 2017, In : Annals of the American Thoracic Society. 14, p. S271-S279

Research output: Contribution to journalReview article

Nonlinear imputation of pa o 2/F io 2 from Sp o 2/F io 2 among mechanically ventilated patients in the ICU: A prospective, observational study

Brown, S. M., Duggal, A., Hou, P. C., Tidswell, M., Khan, A., Exline, M., Park, P. K., Schoenfeld, D. A., Liu, M., Grissom, C. K., Moss, M., Rice, T. W., Hough, C. L., Rivers, E., Thompson, B. T. & Brower, R. G., Aug 1 2017, In : Critical care medicine. 45, 8, p. 1317-1324 8 p.

Research output: Contribution to journalArticle

Prevalence and Prognostic Association of Circulating Troponin in the Acute Respiratory Distress Syndrome

Metkus, T. S., Guallar, E., Sokoll, L., Morrow, D., Tomaselli, G., Brower, R., Schulman, S. & Korley, F. K., Oct 1 2017, In : Critical Care Medicine. 45, 10, p. 1709-1717 9 p.

Research output: Contribution to journalArticle

Setting positive end-expiratory pressure in acute respiratory distress syndrome

Sahetya, S., Goligher, E. C. & Brower, R. G., Jun 1 2017, In : American Journal of Respiratory and Critical Care Medicine. 195, 11, p. 1429-1438 10 p.

Research output: Contribution to journalReview article

Severity of hypoxemia and effect of high-frequency oscillatory ventilation in acute respiratory distress syndrome

Meade, M. O., Young, D., Hanna, S., Zhou, Q., Bachman, T. E., Bollen, C., Slutsky, A. S., Lamb, S. E., Adhikari, N. K. J., Mentzelopoulos, S. D., Cook, D. J., Sud, S., Brower, R. G., Thompson, B. T., Shah, S., Stenzler, A., Guyatt, G. & Ferguson, N. D., Sep 15 2017, In : American journal of respiratory and critical care medicine. 196, 6, p. 727-733 7 p.

Research output: Contribution to journalArticle

2016

Mechanical ventilation in the acute respiratory distress syndrome

Brower, R. G. & Brochard, L., Apr 19 2016, Acute Respiratory Distress Syndrome, Second Edition. CRC Press, p. 335-358 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nonlinear Imputation of PaO2/FIO2 From SpO2/FIO2 Among Patients With Acute Respiratory Distress Syndrome

Brown, S. M., Grissom, C. K., Moss, M., Rice, T. W., Schoenfeld, D., Hou, P. C., Thompson, B. T. & Brower, R. G., Aug 1 2016, In : CHEST. 150, 2, p. 307-313 7 p.

Research output: Contribution to journalArticle

The creation of a biocontainment unit at a Tertiary Care Hospital the Johns Hopkins Medicine Experience

Garibaldi, B. T., Kelen, G. D., Brower, R. G., Bova, G., Ernst, N., Reimers, M., Langlotz, R., Gimburg, A., Iati, M., Smith, C., MacConnell, S., James, H., Lewin, J. J., Trexler, P., Black, M. A., Lynch, C., Clarke, W., Marzinke, M. A., Sokoll, L. J., Carroll, K. C. & 11 others, Parish, N. M., Dionne, K., Biddison, E. L. D., Gwon, H. S., Sauer, L., Hill, P., Newton, S., Garrett, M. R., Miller, R. G., Perl, T. M. & Maragakis, L. L., May 1 2016, In : Annals of the American Thoracic Society. 13, 5, p. 600-608 9 p.

Research output: Contribution to journalReview article

What’s new in ARDS: can we prevent it?

Brower, R. G. & Antonelli, M., May 1 2016, In : Intensive Care Medicine. 42, 5, p. 772-774 3 p.

Research output: Contribution to journalEditorial

2015

Body temperature and mortality in patients with acute respiratory distress syndrome

The National heart, Lung, and Blood Institute Acute Respiratory distress syndrome Network, 2015, In : American Journal of Critical Care. 24, 1, p. 15-23 9 p.

Research output: Contribution to journalArticle

Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome

Grissom, C. K., Hirshberg, E. L., Dickerson, J. B., Brown, S. M., Lanspa, M. J., Liu, K. D., Schoenfeld, D., Tidswell, M., Hite, R. D., Rock, P., Miller, R. R., Morris, A. H., Hudson, L., Gundel, S., Hough, C., Neff, M., Sims, K., Ungar, A., Watkins, T., Steingrub, J. & 190 others, Tidswell, M., Braden, E., DeSouza, L., Germain, J., Kardos, C., Kelley, D., Kozikowski, L., Ouellette, S., Guntupalli, K., Bandi, V., Pope, C., Ross, C., Brower, R., Fessler, H., Hager, D., Mendez-Tellez, P., Needham, D., Oakjones, K., Sevransky, J., Workneh, A., Shanholtz, C., Herr, D., Howes, H., Netzer, G., Rock, P., Sampaio, A., Titus, J., Sloane, P., Beck, T., Highfield, H., King, S., Lee, B., Bolouri, N., Wiedemann, H. P., Ashton, R. W., Culver, D. A., Frederick, T., Guzman, J. A., Komara, J. J., Reddy, A. J., Hejal, R., Andrews, M., Haney, D., Connors, A. F., Lasalvia, S., Thornton, J. D., Warren, E. L., Moss, M., Burnham, E. L., Gray, L., Maloney, J., Mealer, M., Douglas, I., Overdier, K., Thompson, K., Wolken, R., Frankel, S., McKeehan, J., Warner, M. L., Bost, T., Higgins, C., Hodgin, K., MacIntyre, N., Brown, L., Cox, C., Gentile, M., Govert, J., Knudsen, N., Carson, S., Chang, L., Choudhury, S., Hall, W., Lanier, J., Wheeler, A. P., Bernard, G. R., Hays, M., Mogan, S., Rice, T., Hite, R. D., Bender, K., Harvey, A., Morris, P. E., Ragusky, M., Wright, P., Groce, S., McLean, J., Overton, A., Truwit, J., Enfield, K., Marshall, M., Morris, A., Austin, A., Barney, S., Brown, S., Ferguson, J., Gallo, H., Graydon, T., Grissom, C., Hirshberg, E., Jephson, A., Kumar, N., Miller, R., Murphy, D., Orme, J., Stowe, A., Struck, L., Thomas, F., Ward, D., Weaver, L., Bailey, P., Beninati, W., Bezdijan, L., Clemmer, T., Rimkus, S., Tanaka, R., Lawton, C., Hanselman, D., Sundar, K., Alward, W., Bishop, C., Eckley, D., Hill, T., Jensen, B., Ludwig, K., Nielsen, D., Pearce, M., Matthay, M. A., Calfee, C., Daniel, B., Eisner, M., Garcia, O., Kordesch, K., Liu, K., Shum, N., Zhou, H., Peterson, M. W., Blaauw, J., Van Gundy, K., Albertson, T., Morrissey, B., Vlastelin, E., Hubmayr, R., Brown, D., Dubin, M., Festic, E., Gajic, O., Hinds, R., Holets, S., Kor, D., Lee, A., Passe, M., Simpson, G., Wright, J., DeBoisblanc, B., Antoine, A., Charbonnet, D., Hunt, J., Lauto, P., Marr, A., Meyaski, G., Romaine, C., Tejedor, R., Brierre, S., Byrne, J., Jagneaux, T., LeBlanc, C., Moreau, K., Thomas, C., Jain, S., Taylor, D., Seoane, L., Hebert, C., Thompson, J., Simeone, F., Fearon, J., Schoenfeld, D., Guha, M., Hammond, E., Lavery, N., Lazar, P., Morse, R., Oldmixon, C., Ringwood, N., Smoot, E., Thompson, B. T., Wilson, R., Harabin, A., Bredow, S., Waclawiw, M. & Weinmann, G., Feb 1 2015, In : Critical care medicine. 43, 2, p. 288-295 8 p.

Research output: Contribution to journalArticle

Lung size mismatch and primary graft dysfunction after bilateral lung transplantation

Eberlein, M., Reed, R. M., Bolukbas, S., Diamond, J. M., Wille, K. M., Orens, J. B., Brower, R. G. & Christie, J. D., Feb 1 2015, In : Journal of Heart and Lung Transplantation. 34, 2, p. 233-240 8 p.

Research output: Contribution to journalArticle

Neuromuscular electrical stimulation in mechanically ventilated patients: A randomized, sham-controlled pilot trial with blinded outcome assessment

Kho, M. E., Truong, A. D., Zanni, J. M., Ciesla, N. D., Brower, R. G., Palmer, J. B. & Needham, D. M., Feb 1 2015, In : Journal of Critical Care. 30, 1, p. 32-39 8 p.

Research output: Contribution to journalArticle

Standardizing predicted body weight equations for mechanical ventilation tidal volume settings

Linares-Perdomo, O., East, T. D., Brower, R. & Morris, A. H., Jul 1 2015, In : CHEST. 148, 1, p. 73-78 6 p.

Research output: Contribution to journalArticle

The ten diseases that look like ARDS

Guérin, C., Thompson, T. & Brower, R., Dec 20 2015, In : Intensive Care Medicine. 41, 6, p. 1099-1102 4 p.

Research output: Contribution to journalArticle