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2020
Desperate Times: Protecting the Public From Research Without Consent or Oversight During Public Health Emergencies
Beach, M. C., Lederman, H. M., Singleton, M., Brower, R. G., Carrese, J., Ford, D. E., Hansoti, B., Hendrix, C. W., Jorgensen, E. V., Moore, R. D., Rocca, P. & Zenilman, J. M., Dec 1 2020, In: Annals of internal medicine. 173, 11, p. 926-928 3 p.Research output: Contribution to journal › Editorial › peer-review
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Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients with COVID-19: A Randomized Clinical Trial
Self, W. H., Semler, M. W., Leither, L. M., Casey, J. D., Angus, D. C., Brower, R. G., Chang, S. Y., Collins, S. P., Eppensteiner, J. C., Filbin, M. R., Files, D. C., Gibbs, K. W., Ginde, A. A., Gong, M. N., Harrell, F. E., Hayden, D. L., Hough, C. L., Johnson, N. J., Khan, A., Lindsell, C. J. & 13 others, , Dec 1 2020, In: JAMA - Journal of the American Medical Association. 324, 21, p. 2165-2176 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Mean Airway Pressure As a Predictor of 90-Day Mortality in Mechanically Ventilated Patients∗
INTENSIVOS Cohort Study, 2020, (Accepted/In press) In: Critical care medicine. p. 688-695 8 p.Research output: Contribution to journal › Article › peer-review
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Peep titration to minimize driving pressure in subjects with ards: A prospective physiological study
Sahetya, S. K., Hager, D. N., Stephens, R. S., Needham, D. M. & Brower, R. G., May 1 2020, In: Respiratory care. 65, 5, p. 583-589 7 p.Research output: Contribution to journal › Article › peer-review
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Premature, Opportune, and Delayed Weaning in Mechanically Ventilated Patients: A Call for Implementation of Weaning Protocols in Low-and Middle-Income Countries
INTENSIVOS Cohort Study, 2020, (Accepted/In press) In: Critical care medicine. p. 673-679 7 p.Research output: Contribution to journal › Article › peer-review
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Rationale and design of ORCHID: A randomized placebo-controlled clinical trial of hydroxychloroquine for adults hospitalized with COVID-19
ORCHID Protocol Committee and the National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury (PETAL) Network Investigators, Sep 2020, In: Annals of the American Thoracic Society. 17, 9, p. 1144-1153 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Voice-Related Quality of Life Increases With a Talking Tracheostomy Tube: A Randomized Controlled Trial
Pandian, V., Cole, T., Kilonsky, D., Holden, K., Feller-Kopman, D. J., Brower, R. & Mirski, M., May 1 2020, In: Laryngoscope. 130, 5, p. 1249-1255 7 p.Research output: Contribution to journal › Article › peer-review
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2019
Association between hospital mortality and inspiratory airway pressures in mechanically ventilated patients without acute respiratory distress syndrome: A prospective cohort study
Sahetya, S. K., Mallow, C., Sevransky, J. E., Martin, G. S., Girard, T. D., Brower, R. G. & Checkley, W., Nov 21 2019, In: Critical Care. 23, 1, 367.Research output: Contribution to journal › Article › peer-review
Open Access -
Early high-dose Vitamin D3 for critically ill, Vitamin D–deficient patients
Ginde, A. A., Brower, R. G., Caterino, J. M., Finck, L., Banner‑Goodspeed, V. M., Grissom, C. K., Hayden, D., Hough, C. L., Hyzy, R. C., Khan, A., Levitt, J. E., Park, P. K., Ringwood, N., Rivers, E. P., Self, W. H., Shapiro, N. I., Thompson, B. T., Yealy, D. M. & Talmor, D., Dec 26 2019, In: New England Journal of Medicine. 381, 26, p. 2529-2540 12 p.Research output: Contribution to journal › Article › peer-review
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Early neuromuscular blockade in the acute respiratory distress syndrome
National Heart, Lung, and Blood Institute PETAL Clinical Trials Network, May 23 2019, In: New England Journal of Medicine. 380, 21, p. 1997-2008 12 p.Research output: Contribution to journal › Article › peer-review
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Effect of documenting prognosis on the information provided to ICU proxies: A randomized trial
Turnbull, A. E., Hayes, M. M., Brower, R. G., Colantuoni, E., Basyal, P. S., White, D. B., Curtis, J. R. & Needham, D. M., Jun 2019, In: Critical care medicine. 47, 6, p. 757-764 8 p.Research output: Contribution to journal › Article › peer-review
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Prospective assessment of the feasibility of a trial of low–tidal volume ventilation for patients with acute respiratory failure
Lanspa, M. J., Gong, M. N., Schoenfeld, D. A., Lee, K. T., Grissom, C. K., Hou, P. C., Serpa-Neto, A., Brown, S. M., Iwashyna, T. J., Yealy, D. M., Hough, C. L., Brower, R. G., Calfee, C. S., Hyzy, R. C., Matthay, M. A., Miller, R. R., Steingrub, J. S., Thompson, B. T., Miller, C. D., Clemmer, T. P. & 5 others, , Mar 2019, In: Annals of the American Thoracic Society. 16, 3, p. 356-362 7 p.Research output: Contribution to journal › Article › peer-review
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Risk factors for the development of acute respiratory distress syndrome in mechanically ventilated adults in Peru: A multicenter observational study
Gupta, E., Hossen, S., Grigsby, M. R., Herrera, P., Roldan, R., Paz, E., Jaymez, A. A., Chirinos, E. E., Portugal, J., Quispe, R., Brower, R. G. & Checkley, W., Dec 6 2019, In: Critical Care. 23, 1, 398.Research output: Contribution to journal › Article › peer-review
Open Access -
Sedation practices and clinical outcomes in mechanically ventilated patients in a prospective multicenter cohort
Aragón, R. E., Proaño, A., Mongilardi, N., De Ferrari, A., Herrera, P., Roldan, R., Paz, E., Jaymez, A. A., Chirinos, E., Portugal, J., Quispe, R., Brower, R. G. & Checkley, W., Apr 17 2019, In: Critical Care. 23, 1, 130.Research output: Contribution to journal › Article › peer-review
Open Access -
Use and costs of inhaled nitric oxide and inhaled epoprostenol in adult critically ill patients: A quality improvement project
Davis, S. L., Crow, J. R., Fan, J. R., Mattare, K., Whitman, G., Brower, R. G., Rowden, A. & Pustavoitau, A., Sep 3 2019, In: American Journal of Health-System Pharmacy. 76, 18, p. 1413-1419 7 p.Research output: Contribution to journal › Article › peer-review
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2018
Can the plateau be higher than the peak pressure?
Sajjad, H., Schmidt, G. A., Brower, R. G. & Eberlein, M., Jun 2018, In: Annals of the American Thoracic Society. 15, 6, p. 754-759 6 p.Research output: Contribution to journal › Review article › peer-review
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Catheter-directed thrombolysis for intermediate-risk pulmonary embolism
Furfaro, D., Stephens, R., Streiff, M. B. & Brower, R. G., Feb 1 2018, In: Annals of the American Thoracic Society. 15, 2, p. 134-144 11 p.Research output: Contribution to journal › Article › peer-review
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Chest wall strapping increases expiratory airflow and detectable airway segments in computer tomographic scans of normal and obstructed lungs
Taher, H., Bauer, C., Abston, E., Kaczka, D. W., Bhatt, S. P., Zabner, J., Brower, R. G., Beichel, R. R. & Eberlein, M., May 2018, In: Journal of applied physiology. 124, 5, p. 1186-1193 8 p.Research output: Contribution to journal › Article › peer-review
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ECMO for severe acute respiratory distress syndrome
Shanholtz, C., Reed, R. M. & Brower, R. G., Sep 13 2018, In: New England Journal of Medicine. 379, 11, p. 1090 1 p.Research output: Contribution to journal › Letter › peer-review
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Mechanical ventilation in adults with acute respiratory distress syndrome: An official clinical guideline of American Thoracic Society/European Society of Intensive Care medicine/Society of Critical care medicine
Fan, E., Del Sorbo, L., Goligher, E. C., Hodgson, C. L., Munshi, L., Walkey, A. J., Adhikari, N. K. J., Amato, M. B. P., Branson, R., Brower, R. G., Ferguson, N. D., Gajic, O., Gattinoni, L., Hess, D., Mancebo, J., Meade, M. O., McAuley, D. F., Pesenti, A., Ranieri, V. M., Rubenfeld, G. D. & 9 others, , 2018, In: Pulmonologiya. 28, 4, p. 399-410 12 p.Research output: Contribution to journal › Article › peer-review
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Minimally invasive palliative interventions in advanced lung cancer
Mallow, C., Hayes, M., Semaan, R., Smith, T., Hales, R., Brower, R. & Yarmus, L., Jul 3 2018, In: Expert review of respiratory medicine. 12, 7, p. 605-614 10 p.Research output: Contribution to journal › Review article › peer-review
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Oxygen Exposure Resulting in Arterial Oxygen Tensions Above the Protocol Goal Was Associated With Worse Clinical Outcomes in Acute Respiratory Distress Syndrome
National Institutes of Health Acute Respiratory Distress Syndrome Network Investigators, Apr 1 2018, In: Critical care medicine. 46, 4, p. 517-524 8 p.Research output: Contribution to journal › Article › peer-review
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Progressive myocardial injury is associated with mortality in the acute respiratory distress syndrome
Metkus, T. S., Guallar, E., Sokoll, L., Morrow, D. A., Tomaselli, G., Brower, R., Kim, B. S., Schulman, S. & Korley, F. K., Dec 2018, In: Journal of Critical Care. 48, p. 26-31 6 p.Research output: Contribution to journal › Article › peer-review
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Risk factors for mortality and mortality rates in interstitial lung disease patients in the intensive care unit
Huapaya, J. A., Wilfong, E. M., Harden, C. T., Brower, R. G. & Danoff, S., Dec 31 2018, In: European respiratory review : an official journal of the European Respiratory Society. 27, 150Research output: Contribution to journal › Review article › peer-review
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Survival of patients with severe acute respiratory distress syndrome treated without extracorporeal membrane oxygenation
Sahetya, S. K., Brower, R. G. & Stephens, R. S., May 1 2018, In: American Journal of Critical Care. 27, 3, p. 220-227 8 p.Research output: Contribution to journal › Article › peer-review
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2017
An official American Thoracic Society/European Society of intensive care medicine/society of critical care medicine clinical practice guideline: Mechanical ventilation in adult patients with acute respiratory distress syndrome
Society of Critical Care Medicine, American Thoracic Society & European Society of Intensive Care Medicine, May 1 2017, In: American journal of respiratory and critical care medicine. 195, 9, p. 1253-1263 11 p.Research output: Contribution to journal › Article › peer-review
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Effects of neuromuscular electrical stimulation on cytokines in peripheral blood for healthy participants: a prospective, single-blinded Study
Truong, A. D., Kho, M. E., Brower, R. G., Feldman, D. R., Colantuoni, E. & Needham, D. M., May 1 2017, In: Clinical Physiology and Functional Imaging. 37, 3, p. 255-262 8 p.Research output: Contribution to journal › Article › peer-review
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Extracorporeal membrane oxygenation is not first-line therapy for the acute respiratory distress syndrome
Stephens, R. & Brower, R. G., Jan 1 2017, In: Critical Care Medicine. 45, 12, p. 2074-2077 4 p.Research output: Contribution to journal › Comment/debate › peer-review
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Fifty years of research in ARDS VT selection in acute respiratory distress syndrome
Sahetya, S. K., Mancebo, J. & Brower, R. G., Dec 15 2017, In: American journal of respiratory and critical care medicine. 196, 12, p. 1519-1525 7 p.Research output: Contribution to journal › Review article › peer-review
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Higher BMI is associated with higher expiratory airflow normalised for lung volume (FEF25–75/FVC) in COPD
Abston, E., Comellas, A., Reed, R. M., Kim, V., Wise, R. A., Brower, R., Fortis, S., Beichel, R., Bhatt, S., Zabner, J., Newell, J., Hoffman, E. A. & Eberlein, M., Oct 1 2017, In: BMJ Open Respiratory Research. 4, 1, e000231.Research output: Contribution to journal › Article › peer-review
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Higher PEEP versus lower PEEP strategies for patients with acute respiratory distress syndrome: A systematic review and meta-analysis
Walkey, A. J., Del Sorbo, L., Hodgson, C. L., Adhikari, N. K. J., Wunsch, H., Meade, M. O., Uleryk, E., Hess, D., Talmor, D. S., Thompson, B. T., Brower, R. G. & Fan, E., Oct 1 2017, In: Annals of the American Thoracic Society. 14, p. S297-S303Research output: Contribution to journal › Review article › peer-review
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Intermediate care to intensive care triage: A quality improvement project to reduce mortality
Hager, D. N., Chandrashekar, P., Bradsher, R. W., Abdel-Halim, A. M., Chatterjee, S., Sawyer, M., Brower, R. G. & Needham, D. M., Dec 2017, In: Journal of Critical Care. 42, p. 282-288 7 p.Research output: Contribution to journal › Article › peer-review
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Low tidal volume versus non–volume-limited strategies for patients with acute respiratory distress syndrome: A systematic review and meta-analysis
Walkey, A. J., Goligher, E. C., Del Sorbo, L., Hodgson, C. L., Adhikari, N. K. J., Wunsch, H., Meade, M. O., Uleryk, E., Hess, D., Talmor, D. S., Thompson, B. T., Brower, R. G. & Fan, E., Oct 2017, In: Annals of the American Thoracic Society. 14, p. S271-S279Research output: Contribution to journal › Review article › peer-review
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Lung recruitment and titrated PEEP in moderate to severe ARDS: Is the door closing on the open lung?
Sahetya, S. K. & Brower, R. G., Oct 10 2017, In: JAMA - Journal of the American Medical Association. 318, 14, p. 1327-1329 3 p.Research output: Contribution to journal › Editorial › peer-review
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Nonlinear imputation of pa o 2/F io 2 from Sp o 2/F io 2 among mechanically ventilated patients in the ICU: A prospective, observational study
Brown, S. M., Duggal, A., Hou, P. C., Tidswell, M., Khan, A., Exline, M., Park, P. K., Schoenfeld, D. A., Liu, M., Grissom, C. K., Moss, M., Rice, T. W., Hough, C. L., Rivers, E., Thompson, B. T. & Brower, R. G., Aug 1 2017, In: Critical care medicine. 45, 8, p. 1317-1324 8 p.Research output: Contribution to journal › Article › peer-review
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Prevalence and prognostic association of circulating troponin in the acute respiratory distress syndrome
Metkus, T. S., Guallar, E., Sokoll, L., Morrow, D., Tomaselli, G., Brower, R., Schulman, S. & Korley, F. K., Oct 1 2017, In: Critical care medicine. 45, 10, p. 1709-1717 9 p.Research output: Contribution to journal › Article › peer-review
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Pulmonary Arterial Compliance in Acute Respiratory Distress Syndrome: Clinical Determinants and Association with Outcome from the Fluid and Catheter Treatment Trial Cohort∗
Metkus, T. S., Tampakakis, E., Mullin, C. J., Houston, B. A., Kolb, T. M., Mathai, S. C., Damico, R., Maron, B. A., Hassoun, P. M., Brower, R. G. & Tedford, R. J., Mar 1 2017, In: Critical care medicine. 45, 3, p. 422-429 8 p.Research output: Contribution to journal › Article › peer-review
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Setting positive end-expiratory pressure in acute respiratory distress syndrome
Sahetya, S. K., Goligher, E. C. & Brower, R. G., Jun 1 2017, In: American journal of respiratory and critical care medicine. 195, 11, p. 1429-1438 10 p.Research output: Contribution to journal › Review article › peer-review
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Severity of hypoxemia and effect of high-frequency oscillatory ventilation in acute respiratory distress syndrome
Meade, M. O., Young, D., Hanna, S., Zhou, Q., Bachman, T. E., Bollen, C., Slutsky, A. S., Lamb, S. E., Adhikari, N. K. J., Mentzelopoulos, S. D., Cook, D. J., Sud, S., Brower, R. G., Thompson, B. T., Shah, S., Stenzler, A., Guyatt, G. & Ferguson, N. D., Sep 15 2017, In: American journal of respiratory and critical care medicine. 196, 6, p. 727-733 7 p.Research output: Contribution to journal › Article › peer-review
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2016
Mechanical ventilation in the acute respiratory distress syndrome
Brower, R. G. & Brochard, L., Apr 19 2016, Acute Respiratory Distress Syndrome, Second Edition. CRC Press, p. 335-358 24 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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Nonlinear Imputation of PaO2/FIO2 From SpO2/FIO2 Among Patients With Acute Respiratory Distress Syndrome
Brown, S. M., Grissom, C. K., Moss, M., Rice, T. W., Schoenfeld, D., Hou, P. C., Thompson, B. T. & Brower, R. G., Aug 1 2016, In: CHEST. 150, 2, p. 307-313 7 p.Research output: Contribution to journal › Article › peer-review
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The creation of a biocontainment unit at a Tertiary Care Hospital the Johns Hopkins Medicine Experience
Garibaldi, B. T., Kelen, G. D., Brower, R. G., Bova, G., Ernst, N., Reimers, M., Langlotz, R., Gimburg, A., Iati, M., Smith, C., MacConnell, S., James, H., Lewin, J. J., Trexler, P., Black, M. A., Lynch, C., Clarke, W., Marzinke, M. A., Sokoll, L. J., Carroll, K. C. & 11 others, , May 1 2016, In: Annals of the American Thoracic Society. 13, 5, p. 600-608 9 p.Research output: Contribution to journal › Review article › peer-review
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The promises and problems of transpulmonary pressure measurements in acute respiratory distress syndrome
Sahetya, S. K. & Brower, R. G., 2016, In: Current opinion in critical care. 22, 1, p. 7-13 7 p.Research output: Contribution to journal › Review article › peer-review
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What’s new in ARDS: can we prevent it?
Brower, R. G. & Antonelli, M., May 1 2016, In: Intensive Care Medicine. 42, 5, p. 772-774 3 p.Research output: Contribution to journal › Editorial › peer-review
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2015
Body temperature and mortality in patients with acute respiratory distress syndrome
The National heart, Lung, and Blood Institute Acute Respiratory distress syndrome Network, 2015, In: American Journal of Critical Care. 24, 1, p. 15-23 9 p.Research output: Contribution to journal › Article › peer-review
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Establishment of a prospective cohort of mechanically ventilated patients in five intensive care units in Lima, Peru: Protocol and organisational characteristics of participating centres
INTENSIVOS Cohort Study, 2015, In: BMJ open. 5, 1, e005803.Research output: Contribution to journal › Article › peer-review
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Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome
Grissom, C. K., Hirshberg, E. L., Dickerson, J. B., Brown, S. M., Lanspa, M. J., Liu, K. D., Schoenfeld, D., Tidswell, M., Hite, R. D., Rock, P., Miller, R. R., Morris, A. H., Hudson, L., Gundel, S., Hough, C., Neff, M., Sims, K., Ungar, A., Watkins, T., Steingrub, J. & 190 others, , Feb 1 2015, In: Critical care medicine. 43, 2, p. 288-295 8 p.Research output: Contribution to journal › Article › peer-review
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Lung size mismatch and primary graft dysfunction after bilateral lung transplantation
Eberlein, M., Reed, R. M., Bolukbas, S., Diamond, J. M., Wille, K. M., Orens, J. B., Brower, R. G. & Christie, J. D., Feb 1 2015, In: Journal of Heart and Lung Transplantation. 34, 2, p. 233-240 8 p.Research output: Contribution to journal › Article › peer-review
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Neuromuscular electrical stimulation in mechanically ventilated patients: A randomized, sham-controlled pilot trial with blinded outcome assessment
Kho, M. E., Truong, A. D., Zanni, J. M., Ciesla, N. D., Brower, R. G., Palmer, J. B. & Needham, D. M., Feb 1 2015, In: Journal of Critical Care. 30, 1, p. 32-39 8 p.Research output: Contribution to journal › Article › peer-review
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Standardizing predicted body weight equations for mechanical ventilation tidal volume settings
Linares-Perdomo, O., East, T. D., Brower, R. & Morris, A. H., Jul 1 2015, In: CHEST. 148, 1, p. 73-78 6 p.Research output: Contribution to journal › Article › peer-review