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  • Roy G Brower
2020

Mean Airway Pressure As a Predictor of 90-Day Mortality in Mechanically Ventilated Patients∗

INTENSIVOS Cohort Study, Jan 1 2020, (Accepted/In press) In : Critical care medicine. p. 688-695 8 p.

Research output: Contribution to journalArticle

Premature, Opportune, and Delayed Weaning in Mechanically Ventilated Patients: A Call for Implementation of Weaning Protocols in Low-and Middle-Income Countries

INTENSIVOS Cohort Study, Jan 1 2020, (Accepted/In press) In : Critical care medicine. p. 673-679 7 p.

Research output: Contribution to journalArticle

Rationale and design of ORCHID: A randomized placebo-controlled clinical trial of hydroxychloroquine for adults hospitalized with COVID-19

ORCHID Protocol Committee and the National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury (PETAL) Network Investigators, Sep 2020, In : Annals of the American Thoracic Society. 17, 9, p. 1144-1153 10 p.

Research output: Contribution to journalArticle

Open Access

Voice-Related Quality of Life Increases With a Talking Tracheostomy Tube: A Randomized Controlled Trial

Pandian, V., Cole, T., Kilonsky, D., Holden, K., Feller-Kopman, D. J., Brower, R. & Mirski, M., May 1 2020, In : Laryngoscope. 130, 5, p. 1249-1255 7 p.

Research output: Contribution to journalArticle

2019
Open Access

Early high-dose Vitamin D3 for critically ill, Vitamin D–deficient patients

Ginde, A. A., Brower, R. G., Caterino, J. M., Finck, L., Banner‑Goodspeed, V. M., Grissom, C. K., Hayden, D., Hough, C. L., Hyzy, R. C., Khan, A., Levitt, J. E., Park, P. K., Ringwood, N., Rivers, E. P., Self, W. H., Shapiro, N. I., Thompson, B. T., Yealy, D. M. & Talmor, D., Dec 26 2019, In : New England Journal of Medicine. 381, 26, p. 2529-2540 12 p.

Research output: Contribution to journalArticle

Early neuromuscular blockade in the acute respiratory distress syndrome

National Heart, Lung, and Blood Institute PETAL Clinical Trials Network, May 23 2019, In : New England Journal of Medicine. 380, 21, p. 1997-2008 12 p.

Research output: Contribution to journalArticle

Effect of documenting prognosis on the information provided to ICU proxies: A randomized trial

Turnbull, A. E., Hayes, M. M., Brower, R. G., Colantuoni, E., Basyal, P. S., White, D. B., Curtis, J. R. & Needham, D. M., Jun 2019, In : Critical care medicine. 47, 6, p. 757-764 8 p.

Research output: Contribution to journalArticle

Prospective assessment of the feasibility of a trial of low–tidal volume ventilation for patients with acute respiratory failure

Lanspa, M. J., Gong, M. N., Schoenfeld, D. A., Lee, K. T., Grissom, C. K., Hou, P. C., Serpa-Neto, A., Brown, S. M., Iwashyna, T. J., Yealy, D. M., Hough, C. L., Brower, R. G., Calfee, C. S., Hyzy, R. C., Matthay, M. A., Miller, R. R., Steingrub, J. S., Thompson, B. T., Miller, C. D., Clemmer, T. P. & 5 others, Hendey, G. W., Huang, D. T., Mathews, K. S., Qadir, N. & Tidswell, M., Mar 2019, In : Annals of the American Thoracic Society. 16, 3, p. 356-362 7 p.

Research output: Contribution to journalArticle

Risk factors for the development of acute respiratory distress syndrome in mechanically ventilated adults in Peru: A multicenter observational study

Gupta, E., Hossen, S., Grigsby, M. R., Herrera, P., Roldan, R., Paz, E., Jaymez, A. A., Chirinos, E. E., Portugal, J., Quispe, R., Brower, R. G. & Checkley, W., Dec 6 2019, In : Critical Care. 23, 1, 398.

Research output: Contribution to journalArticle

Open Access

Sedation practices and clinical outcomes in mechanically ventilated patients in a prospective multicenter cohort

Aragón, R. E., Proaño, A., Mongilardi, N., De Ferrari, A., Herrera, P., Roldan, R., Paz, E., Jaymez, A. A., Chirinos, E., Portugal, J., Quispe, R., Brower, R. G. & Checkley, W., Apr 17 2019, In : Critical Care. 23, 1, 130.

Research output: Contribution to journalArticle

Open Access

Use and costs of inhaled nitric oxide and inhaled epoprostenol in adult critically ill patients: A quality improvement project

Davis, S. L., Crow, J. R., Fan, J. R., Mattare, K., Whitman, G., Brower, R. G., Rowden, A. & Pustavoitau, A., Sep 3 2019, In : American Journal of Health-System Pharmacy. 76, 18, p. 1413-1419 7 p.

Research output: Contribution to journalArticle

2016

Mechanical ventilation in the acute respiratory distress syndrome

Brower, R. G. & Brochard, L., Apr 19 2016, Acute Respiratory Distress Syndrome, Second Edition. CRC Press, p. 335-358 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nonlinear Imputation of PaO2/FIO2 From SpO2/FIO2 Among Patients With Acute Respiratory Distress Syndrome

Brown, S. M., Grissom, C. K., Moss, M., Rice, T. W., Schoenfeld, D., Hou, P. C., Thompson, B. T. & Brower, R. G., Aug 1 2016, In : CHEST. 150, 2, p. 307-313 7 p.

Research output: Contribution to journalArticle

The creation of a biocontainment unit at a Tertiary Care Hospital the Johns Hopkins Medicine Experience

Garibaldi, B. T., Kelen, G. D., Brower, R. G., Bova, G., Ernst, N., Reimers, M., Langlotz, R., Gimburg, A., Iati, M., Smith, C., MacConnell, S., James, H., Lewin, J. J., Trexler, P., Black, M. A., Lynch, C., Clarke, W., Marzinke, M. A., Sokoll, L. J., Carroll, K. C. & 11 others, Parish, N. M., Dionne, K., Biddison, E. L. D., Gwon, H. S., Sauer, L., Hill, P., Newton, S., Garrett, M. R., Miller, R. G., Perl, T. M. & Maragakis, L. L., May 1 2016, In : Annals of the American Thoracic Society. 13, 5, p. 600-608 9 p.

Research output: Contribution to journalReview article

What’s new in ARDS: can we prevent it?

Brower, R. G. & Antonelli, M., May 1 2016, In : Intensive Care Medicine. 42, 5, p. 772-774 3 p.

Research output: Contribution to journalEditorial

2015

Body temperature and mortality in patients with acute respiratory distress syndrome

The National heart, Lung, and Blood Institute Acute Respiratory distress syndrome Network, 2015, In : American Journal of Critical Care. 24, 1, p. 15-23 9 p.

Research output: Contribution to journalArticle

Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome

Grissom, C. K., Hirshberg, E. L., Dickerson, J. B., Brown, S. M., Lanspa, M. J., Liu, K. D., Schoenfeld, D., Tidswell, M., Hite, R. D., Rock, P., Miller, R. R., Morris, A. H., Hudson, L., Gundel, S., Hough, C., Neff, M., Sims, K., Ungar, A., Watkins, T., Steingrub, J. & 190 others, Tidswell, M., Braden, E., DeSouza, L., Germain, J., Kardos, C., Kelley, D., Kozikowski, L., Ouellette, S., Guntupalli, K., Bandi, V., Pope, C., Ross, C., Brower, R., Fessler, H., Hager, D., Mendez-Tellez, P., Needham, D., Oakjones, K., Sevransky, J., Workneh, A., Shanholtz, C., Herr, D., Howes, H., Netzer, G., Rock, P., Sampaio, A., Titus, J., Sloane, P., Beck, T., Highfield, H., King, S., Lee, B., Bolouri, N., Wiedemann, H. P., Ashton, R. W., Culver, D. A., Frederick, T., Guzman, J. A., Komara, J. J., Reddy, A. J., Hejal, R., Andrews, M., Haney, D., Connors, A. F., Lasalvia, S., Thornton, J. D., Warren, E. L., Moss, M., Burnham, E. L., Gray, L., Maloney, J., Mealer, M., Douglas, I., Overdier, K., Thompson, K., Wolken, R., Frankel, S., McKeehan, J., Warner, M. L., Bost, T., Higgins, C., Hodgin, K., MacIntyre, N., Brown, L., Cox, C., Gentile, M., Govert, J., Knudsen, N., Carson, S., Chang, L., Choudhury, S., Hall, W., Lanier, J., Wheeler, A. P., Bernard, G. R., Hays, M., Mogan, S., Rice, T., Hite, R. D., Bender, K., Harvey, A., Morris, P. E., Ragusky, M., Wright, P., Groce, S., McLean, J., Overton, A., Truwit, J., Enfield, K., Marshall, M., Morris, A., Austin, A., Barney, S., Brown, S., Ferguson, J., Gallo, H., Graydon, T., Grissom, C., Hirshberg, E., Jephson, A., Kumar, N., Miller, R., Murphy, D., Orme, J., Stowe, A., Struck, L., Thomas, F., Ward, D., Weaver, L., Bailey, P., Beninati, W., Bezdijan, L., Clemmer, T., Rimkus, S., Tanaka, R., Lawton, C., Hanselman, D., Sundar, K., Alward, W., Bishop, C., Eckley, D., Hill, T., Jensen, B., Ludwig, K., Nielsen, D., Pearce, M., Matthay, M. A., Calfee, C., Daniel, B., Eisner, M., Garcia, O., Kordesch, K., Liu, K., Shum, N., Zhou, H., Peterson, M. W., Blaauw, J., Van Gundy, K., Albertson, T., Morrissey, B., Vlastelin, E., Hubmayr, R., Brown, D., Dubin, M., Festic, E., Gajic, O., Hinds, R., Holets, S., Kor, D., Lee, A., Passe, M., Simpson, G., Wright, J., DeBoisblanc, B., Antoine, A., Charbonnet, D., Hunt, J., Lauto, P., Marr, A., Meyaski, G., Romaine, C., Tejedor, R., Brierre, S., Byrne, J., Jagneaux, T., LeBlanc, C., Moreau, K., Thomas, C., Jain, S., Taylor, D., Seoane, L., Hebert, C., Thompson, J., Simeone, F., Fearon, J., Schoenfeld, D., Guha, M., Hammond, E., Lavery, N., Lazar, P., Morse, R., Oldmixon, C., Ringwood, N., Smoot, E., Thompson, B. T., Wilson, R., Harabin, A., Bredow, S., Waclawiw, M. & Weinmann, G., Feb 1 2015, In : Critical care medicine. 43, 2, p. 288-295 8 p.

Research output: Contribution to journalArticle

Lung size mismatch and primary graft dysfunction after bilateral lung transplantation

Eberlein, M., Reed, R. M., Bolukbas, S., Diamond, J. M., Wille, K. M., Orens, J. B., Brower, R. G. & Christie, J. D., Feb 1 2015, In : Journal of Heart and Lung Transplantation. 34, 2, p. 233-240 8 p.

Research output: Contribution to journalArticle

Neuromuscular electrical stimulation in mechanically ventilated patients: A randomized, sham-controlled pilot trial with blinded outcome assessment

Kho, M. E., Truong, A. D., Zanni, J. M., Ciesla, N. D., Brower, R. G., Palmer, J. B. & Needham, D. M., Feb 1 2015, In : Journal of Critical Care. 30, 1, p. 32-39 8 p.

Research output: Contribution to journalArticle

Standardizing predicted body weight equations for mechanical ventilation tidal volume settings

Linares-Perdomo, O., East, T. D., Brower, R. & Morris, A. H., Jul 1 2015, In : CHEST. 148, 1, p. 73-78 6 p.

Research output: Contribution to journalArticle

The ten diseases that look like ARDS

Guérin, C., Thompson, T. & Brower, R., Dec 20 2015, In : Intensive Care Medicine. 41, 6, p. 1099-1102 4 p.

Research output: Contribution to journalArticle

2014

Chest wall strapping: An old physiology experiment with new relevance to small airways diseases

Eberlein, M., Schmidt, G. A. & Brower, R. G., Oct 1 2014, In : Annals of the American Thoracic Society. 11, 8, p. 1258-1266 9 p.

Research output: Contribution to journalArticle

Developing, Implementing, and Evaluating a Multifaceted Quality Improvement Intervention to Promote Sleep in an ICU

Kamdar, B. B., Yang, J., King, L. M., Neufeld, K. J., Bienvenu, O. J., Rowden, A. M., Brower, R. G., Collop, N. A. & Needham, D. M., Nov 8 2014, In : American Journal of Medical Quality. 29, 6, p. 546-554 9 p.

Research output: Contribution to journalArticle

Driving pressure and survival in the acute respiratory distress syndrome

Amato, M. B. P., Meade, M. O., Slutsky, A. S., Brochard, L., Costa, E. L. V., Schoenfeld, D. A., Stewart, T. E., Briel, M., Talmor, D., Mercat, A., Richard, J. C. M., Carvalho, C. R. R. & Brower, R. G., Feb 19 2014, In : New England Journal of Medicine. 372, 8, p. 747-755 9 p.

Research output: Contribution to journalArticle

Mechanical ventilation after lung transplantation: An international survey of practices and preferences

Beer, A., Reed, R. M., Bölükbas, S., Budev, M., Chaux, G., Zamora, M. R., Snell, G., Orens, J. B., Klesney-Tait, J. A., Schmidt, G. A., Brower, R. G. & Eberlein, M., May 2014, In : Annals of the American Thoracic Society. 11, 4, p. 546-553 8 p.

Research output: Contribution to journalArticle

Position paper for the organization of extracorporeal membrane oxygenation programs for acute respiratory failure in adult patients

International ECMO Network (ECMONet), Sep 1 2014, In : American journal of respiratory and critical care medicine. 190, 5, p. 488-496 9 p.

Research output: Contribution to journalArticle

Rosuvastatin for sepsis-associated acute respiratory distress syndrome

Truwit, J. D., Bernard, G. R., Steingrub, J., Matthay, M. A., Liu, K. D., Albertson, T. E., Brower, R. G., Shanholtz, C., Rock, P., Douglas, I. S., DeBoisblanc, B. P., Hough, C. L., Duncan Hite, R. & Taylor Thompson, B., 2014, In : New England Journal of Medicine. 370, 23, p. 2191-2200 10 p.

Research output: Contribution to journalArticle

Targeting normoxemia in acute respiratory distress syndrome may cause worse short-term outcomes because of oxygen toxicity

Aggarwal, N. R. & Brower, R. G., Nov 1 2014, In : Annals of the American Thoracic Society. 11, 9, p. 1449-1453 5 p.

Research output: Contribution to journalReview article

2013

Corticosteroid therapy in acute respiratory distress syndrome

Lamontagne, F., Brower, R. & Meade, M., Feb 19 2013, In : CMAJ. 185, 3, p. 216-221 6 p.

Research output: Contribution to journalReview article

Donor-recipient size matching and survival after lung transplantation

Eberlein, M., Reed, R. M., Maidaa, M., Bolukbas, S., Arnaoutakis, G. J., Orens, J. B., Brower, R. G., Merlo, C. A. & Hunsicker, L. G., Oct 2013, In : Annals of the American Thoracic Society. 10, 5, p. 418-425 8 p.

Research output: Contribution to journalArticle

Erratum: Randomized, placebo-controlled clinical trial of an aerosolized β2-agonist for treatment of acute lung injury (American Journal of Respiratory and Critical Care Medicine (2011) 184 (561-568))

Matthay, M. A., Brower, R. G., Carson, S., Douglas, I. S., Eisner, M., Hite, D., Holets, S., Kallet, R. H., Liu, K. D. & MacIntyre, N., Dec 1 2013, In : American journal of respiratory and critical care medicine. 188, 11, 1 p.

Research output: Contribution to journalComment/debate

Factors associated with elevated plateau pressure in patients with acute lung injury receiving lower tidal volume ventilation

Prescott, H. C., Brower, R. G., Cooke, C. R., Phillips, G. & O'Brien, J. M., Mar 1 2013, In : Critical care medicine. 41, 3, p. 756-764 9 p.

Research output: Contribution to journalArticle

Lung size mismatch and survival after single and bilateral lung transplantation

Eberlein, M., Reed, R. M., Bolukbas, S., Parekh, K. R., Arnaoutakis, G. J., Orens, J. B., Brower, R. G., Shah, A. S., Hunsicker, L. & Merlo, C. A., Aug 2013, In : Annals of Thoracic Surgery. 96, 2, p. 457-463 7 p.

Research output: Contribution to journalArticle

Reducing deep sedation and delirium in acute lung injury patients: A quality improvement project

Hager, D. N., Dinglas, V. D., Subhas, S., Rowden, A. M., Neufeld, K. J., Bienvenu, O. J., Touradji, P., Colantuoni, E., Reddy, D. R. S., Brower, R. G. & Needham, D. M., Jun 1 2013, In : Critical care medicine. 41, 6, p. 1435-1442 8 p.

Research output: Contribution to journalArticle

The effect of a quality improvement intervention on perceived sleep quality and cognition in a medical ICU

Kamdar, B. B., King, L. M., Collop, N. A., Sakamuri, S., Colantuoni, E., Neufeld, K. J., Bienvenu, O. J., Rowden, A. M., Touradji, P., Brower, R. G. & Needham, D. M., Mar 2013, In : Critical care medicine. 41, 3, p. 800-809 10 p.

Research output: Contribution to journalArticle

The effect of lung-size mismatch on mechanical ventilation tidal volumes after bilateral lung transplantation

Dezube, R., Arnaoutakis, G. J., Reed, R. M., Bolukbas, S., Shah, A. S., Orens, J. B., Brower, R. G. & Eberlein, M., Mar 2013, In : Interactive cardiovascular and thoracic surgery. 16, 3, p. 275-281 7 p.

Research output: Contribution to journalArticle

Time to reach a new equilibrium after changes in PEEP in acute respiratory distress syndrome patients

Brower, R. G., Aug 20 2013, In : Intensive Care Medicine. 39, 11, p. 2053-2055 3 p.

Research output: Contribution to journalEditorial

2012

Erratum: The Berlin definition of ARDS: An expanded rationale, justification, and supplementary material (Intensive Care Medicine DOI 10.1007/s00134-012-2682-1)

Ferguson, N. D., Fan, E., Camporota, L., Antonelli, M., Anzueto, A., Beale, R., Brochard, L., Brower, R., Esteban, A., Gattinoni, L., Rhodes, A., Slutsky, A. S., Vincent, J. L., Rubenfeld, G. D., Taylor Thompson, B. & Marco Ranieri, V., Oct 2012, In : Intensive Care Medicine. 38, 10, p. 1731-1732 2 p.

Research output: Contribution to journalComment/debate

Lung size mismatch in bilateral lung transplantation is associated with allograft function and bronchiolitis obliterans syndrome

Eberlein, M., Permutt, S., Chahla, M. F., Bolukbas, S., Nathan, S. D., Shlobin, O. A., Shelhamer, J. H., Reed, R. M., Pearse, D. B., Orens, J. B. & Brower, R. G., Feb 2012, In : CHEST. 141, 2, p. 451-460 10 p.

Research output: Contribution to journalArticle

Neuromuscular electrical stimulation for intensive care unit-acquired weakness: Protocol and methodological implications for a randomized, sham-controlled, phase II trial

Kho, M. E., Truong, A. D., Brower, R. G., Palmer, J. B., Fan, E., Zanni, J. M., Ciesla, N. D., Feldman, D. R., Korupolu, R. & Needham, D. M., Dec 2012, In : Physical therapy. 92, 12, p. 1564-1579 16 p.

Research output: Contribution to journalArticle

Parameters of donor-recipient size mismatch and survival after bilateral lung transplantation

Eberlein, M., Reed, R. M., Permutt, S., Chahla, M. F., Bolukbas, S., Nathan, S. D., Iacono, A., Pearse, D. B., Fessler, H. E., Shah, A. S., Orens, J. B. & Brower, R. G., Nov 2012, In : Journal of Heart and Lung Transplantation. 31, 11, p. 1207-1213.e7

Research output: Contribution to journalArticle