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  • Dan Arking
2018

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Davies, G., Lam, M., Harris, S. E., Trampush, J. W., Luciano, M., Hill, W. D., Hagenaars, S. P., Ritchie, S. J., Marioni, R. E., Fawns-Ritchie, C., Liewald, D. C. M., Okely, J. A., Ahola-Olli, A. V., Barnes, C. L. K., Bertram, L., Bis, J. C., Burdick, K. E., Christoforou, A., Derosse, P., Djurovic, S. & 201 others, Espeseth, T., Giakoumaki, S., Giddaluru, S., Gustavson, D. E., Hayward, C., Hofer, E., Ikram, M. A., Karlsson, R., Knowles, E., Lahti, J., Leber, M., Li, S., Mather, K. A., Melle, I., Morris, D., Oldmeadow, C., Palviainen, T., Payton, A., Pazoki, R., Petrovic, K., Reynolds, C. A., Sargurupremraj, M., Scholz, M., Smith, J. A., Smith, A. V., Terzikhan, N., Thalamuthu, A., Trompet, S., Van Der Lee, S. J., Ware, E. B., Windham, B. G., Wright, M. J., Yang, J., Yu, J., Ames, D., Amin, N., Amouyel, P., Andreassen, O. A., Armstrong, N. J., Assareh, A. A., Attia, J. R., Attix, D., Avramopoulos, D., Bennett, D. A., Böhmer, A. C., Boyle, P. A., Brodaty, H., Campbell, H., Cannon, T. D., Cirulli, E. T., Congdon, E., Conley, E. D., Corley, J., Cox, S. R., Dale, A. M., Dehghan, A., Dick, D., Dickinson, D., Eriksson, J. G., Evangelou, E., Faul, J. D., Ford, I., Freimer, N. A., Gao, H., Giegling, I., Gillespie, N. A., Gordon, S. D., Gottesman, R. F., Griswold, M. E., Gudnason, V., Harris, T. B., Hartmann, A. M., Hatzimanolis, A., Heiss, G., Holliday, E. G., Joshi, P. K., Kähönen, M., Kardia, S. L. R., Karlsson, I., Kleineidam, L., Knopman, D. S., Kochan, N. A., Konte, B., Kwok, J. B., Le Hellard, S., Lee, T., Lehtimäki, T., Li, S. C., Liu, T., Koini, M., London, E., Longstreth, W. T., Lopez, O. L., Loukola, A., Luck, T., Lundervold, A. J., Lundquist, A., Lyytikäinen, L. P., Martin, N. G., Montgomery, G. W., Murray, A. D., Need, A. C., Noordam, R., Nyberg, L., Ollier, W., Papenberg, G., Pattie, A., Polasek, O., Poldrack, R. A., Psaty, B. M., Reppermund, S., Riedel-Heller, S. G., Rose, R. J., Rotter, J. I., Roussos, P., Rovio, S. P., Saba, Y., Sabb, F. W., Sachdev, P. S., Satizabal, C. L., Schmid, M., Scott, R. J., Scult, M. A., Simino, J., Slagboom, P. E., Smyrnis, N., Soumaré, A., Stefanis, N. C., Stott, D. J., Straub, R. E., Sundet, K., Taylor, A. M., Taylor, K. D., Tzoulaki, I., Tzourio, C., Uitterlinden, A., Vitart, V., Voineskos, A. N., Kaprio, J., Wagner, M., Wagner, H., Weinhold, L., Wen, K. H., Widen, E., Yang, Q., Zhao, W., Adams, H. H. H., Arking, D. E., Bilder, R. M., Bitsios, P., Boerwinkle, E., Chiba-Falek, O., Corvin, A., De Jager, P. L., Debette, S., Donohoe, G., Elliott, P., Fitzpatrick, A. L., Gill, M., Glahn, D. C., Hägg, S., Hansell, N. K., Hariri, A. R., Ikram, M. K., Jukema, J. W., Vuoksimaa, E., Keller, M. C., Kremen, W. S., Launer, L., Lindenberger, U., Palotie, A., Pedersen, N. L., Pendleton, N., Porteous, D. J., Räikkönen, K., Raitakari, O. T., Ramirez, A., Reinvang, I., Rudan, I., Rujescu, D., Schmidt, R., Schmidt, H., Schofield, P. W., Schofield, P. R., Starr, J. M., Steen, V. M., Trollor, J. N., Turner, S. T., Van Duijn, C. M., Villringer, A., Weinberger, D. R., Weir, D. R., Wilson, J. F., Malhotra, A., McIntosh, A. M., Gale, C. R., Seshadri, S., Mosley, T. H., Bressler, J., Lencz, T. & Deary, I. J., Dec 1 2018, In : Nature communications. 9, 1, 2098.

Research output: Contribution to journalArticle

Transethnic Evaluation Identifies Low-Frequency Loci Associated with 25-Hydroxyvitamin D Concentrations

Hong, J., Hatchell, K. E., Bradfield, J. P., Bjonnes, A., Chesi, A., Lai, C. Q., Langefeld, C. D., Lu, L., Lu, Y., Lutsey, P. L., Musani, S. K., Nalls, M. A., Robinson-Cohen, C., Roizen, J. D., Saxena, R., Tucker, K. L., Ziegler, J. T., Arking, D. E., Bis, J. C., Boerwinkle, E. & 40 others, Bottinger, E. P., Bowden, D. W., Gilsanz, V., Houston, D. K., Kalkwarf, H. J., Kelly, A., Lappe, J. M., Liu, Y., Michos, E. D., Oberfield, S. E., Palmer, N. D., Rotter, J. I., Sapkota, B., Shepherd, J. A., Wilson, J. G., Basu, S., De Boer, I. H., Divers, J., Freedman, B. I., Grant, S. F. A., Hakanarson, H., Harris, T. B., Kestenbaum, B. R., Kritchevsky, S. B., Loos, R. J. F., Norris, J. M., Norwood, A. F., Ordovas, J. M., Pankow, J. S., Psaty, B. M., Sanghera, D. K., Wagenknecht, L. E., Zemel, B. S., Meigs, J., Dupuis, J., Florez, J. C., Wang, T., Liu, C. T., Engelman, C. D. & Billings, L. K., Apr 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 4, p. 1380-1392 13 p.

Research output: Contribution to journalArticle

2017

Association between mitochondrial DNA copy number and sudden cardiac death: Findings from the Atherosclerosis Risk in Communities study (ARIC)

Zhang, Y., Guallar, E., Ashar, F. N., Longchamps, R. J., Castellani, C. A., Lane, J., Grove, M. L., Coresh, J., Sotoodehnia, N., Ilkhanoff, L., Boerwinkle, E., Pankratz, N. & Arking, D. E., 2017, In : European heart journal. 38, 46, p. 3443-3448 6 p.

Research output: Contribution to journalArticle

Association between telomere length and risk of cancer and non-neoplastic diseases a mendelian randomization study

Telomeres Mendelian Randomization Collaboration, 2017, In : JAMA Oncology. 3, 5, p. 636-651 16 p.

Research output: Contribution to journalArticle

Association of mitochondrial DNA copy number with cardiovascular disease

Ashar, F. N., Zhang, Y., Longchamps, R. J., Lane, J., Moes, A., Grove, M. L., Mychaleckyj, J. C., Taylor, K. D., Coresh, J., Rotter, J. I., Boerwinkle, E., Pankratz, N., Guallar, E. & Arking, D. E., Nov 1 2017, In : JAMA Cardiology. 2, 11, p. 1247-1255 9 p.

Research output: Contribution to journalArticle

Causal effect of plasminogen activator inhibitor type 1 on coronary heart disease

CHARGE Consortium Hemostatic Factor Working Group, ICBP Consortium & CHARGE Consortium Subclinical Working Group, Jun 1 2017, In : Journal of the American Heart Association. 6, 6, e004918.

Research output: Contribution to journalArticle

Circulating ceruloplasmin, ceruloplasmin-associated genes, and the incidence of atrial fibrillation in the atherosclerosis risk in communities study

Arenas de Larriva, A. P., Norby, F. L., Chen, L. Y., Soliman, E. Z., Hoogeveen, R. C., Arking, D. E., Loehr, L. R. & Alonso, A., Aug 15 2017, In : International Journal of Cardiology. 241, p. 223-228 6 p.

Research output: Contribution to journalArticle

Cross-tissue integration of genetic and epigenetic data offers insight into autism spectrum disorder

Andrews, S. V., Ellis, S. E., Bakulski, K. M., Sheppard, B., Croen, L. A., Hertz-Picciotto, I., Newschaffer, C. J., Feinberg, A. P., Arking, D. E., Ladd-Acosta, C. & Fallin, M. D., Dec 1 2017, In : Nature communications. 8, 1, 1011.

Research output: Contribution to journalArticle

Discovery of novel heart rate-associated loci using the Exome Chip

van den Berg, M. E., Warren, H. R., Cabrera, C. P., Verweij, N., Mifsud, B., Haessler, J., Bihlmeyer, N. A., Fu, Y. P., Weiss, S., Lin, H. J., Grarup, N., Li-Gao, R., Pistis, G., Shah, N., Brody, J. A., Müller-Nurasyid, M., Lin, H., Mei, H., Smith, A. V., Lyytikäinen, L. P. & 101 others, Hall, L. M., van Setten, J., Trompet, S., Prins, B. P., Isaacs, A., Radmanesh, F., Marten, J., Entwistle, A., Kors, J. A., Silva, C. T., Alonso, A., Bis, J. C., de Boer, R., de Haan, H. G., de Mutsert, R., Dedoussis, G., Dominiczak, A. F., Doney, A. S. F., Ellinor, P. T., Eppinga, R. N., Felix, S. B., Guo, X., Hagemeijer, Y., Hansen, T., Harris, T. B., Heckbert, S. R., Huang, P. L., Hwang, S. J., Kähönen, M., Kanters, J. K., Kolcic, I., Launer, L. J., Li, M., Yao, J., Linneberg, A., Liu, S., Macfarlane, P. W., Mangino, M., Morris, A. D., Mulas, A., Murray, A. D., Nelson, C. P., Orrú, M., Padmanabhan, S., Peters, A., Porteous, D. J., Poulter, N., Psaty, B. M., Qi, L., Raitakari, O. T., Rivadeneira, F., Roselli, C., Rudan, I., Sattar, N., Sever, P., Sinner, M. F., Soliman, E. Z., Spector, T. D., Stanton, A. V., Stirrups, K. E., Taylor, K. D., Tobin, M. D., Uitterlinden, A., Vaartjes, I., Hoes, A. W., van der Meer, P., Völker, U., Waldenberger, M., Xie, Z., Zoledziewska, M., Tinker, A., Polasek, O., Rosand, J., Jamshidi, Y., van Duijn, C. M., Zeggini, E., Jukema, J. W., Asselbergs, F. W., Samani, N. J., Lehtimäki, T., Gudnason, V., Wilson, J., Lubitz, S. A., Kääb, S., Sotoodehnia, N., Caulfield, M. J., Palmer, C. N. A., Sanna, S., Mook-Kanamori, D. O., Deloukas, P., Pedersen, O., Rotter, J. I., Dörr, M., O'Donnell, C. J., Hayward, C., Arking, D. E., Kooperberg, C., van der Harst, P., Eijgelsheim, M., Stricker, B. H. & Munroe, P. B., Jun 15 2017, In : Human molecular genetics. 26, 12, p. 2346-2363 18 p.

Research output: Contribution to journalArticle

Exaggerated CpH methylation in the autism-affected brain

Ellis, S. E., Gupta, S., Moes, A., West, A. B. & Arking, D. E., Feb 17 2017, In : Molecular Autism. 8, 1, 6.

Research output: Contribution to journalArticle

Fifteen Genetic Loci Associated with the Electrocardiographic P Wave

Christophersen, I. E., Magnani, J. W., Yin, X., Barnard, J., Weng, L. C., Arking, D. E., Niemeijer, M. N., Lubitz, S. A., Avery, C. L., Duan, Q., Felix, S. B., Bis, J. C., Kerr, K. F., Isaacs, A., Müller-Nurasyid, M., Müller, C., North, K. E., Reiner, A. P., Tinker, L. F., Kors, J. A. & 32 others, Teumer, A., Petersmann, A., Sinner, M. F., Buzkova, P., Smith, J. D., Van Wagoner, D. R., Völker, U., Waldenberger, M., Peters, A., Meitinger, T., Limacher, M. C., Wilhelmsen, K. C., Psaty, B. M., Hofman, A., Uitterlinden, A., Krijthe, B. P., Zhang, Z. M., Schnabel, R. B., Kääb, S., Van Duijn, C., Rotter, J. I., Sotoodehnia, N., Dörr, M., Li, Y., Chung, M. K., Soliman, E. Z., Alonso, A., Whitsel, E. A., Stricker, B. H., Benjamin, E. J., Heckbert, S. R. & Ellinor, P. T., Aug 1 2017, In : Circulation: Cardiovascular Genetics. 10, 4, e001667.

Research output: Contribution to journalArticle

Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium

Weng, L. C., Lunetta, K. L., Müller-Nurasyid, M., Smith, A. V., Thériault, S., Weeke, P. E., Barnard, J., Bis, J. C., Lyytikäinen, L. P., Kleber, M. E., Martinsson, A., Lin, H. J., Rienstra, M., Trompet, S., Krijthe, B. P., Dörr, M., Klarin, D., Chasman, D. I., Sinner, M. F., Waldenberger, M. & 50 others, Launer, L. J., Harris, T. B., Soliman, E. Z., Alonso, A., Paré, G., Teixeira, P. L., Denny, J. C., Shoemaker, M. B., Van Wagoner, D. R., Smith, J. D., Psaty, B. M., Sotoodehnia, N., Taylor, K. D., Kähönen, M., Nikus, K., Delgado, G. E., Melander, O., Engström, G., Yao, J., Guo, X., Christophersen, I. E., Ellinor, P. T., Geelhoed, B., Verweij, N., Macfarlane, P., Ford, I., Heeringa, J., Franco, O. H., Uitterlinden, A. G., Völker, U., Teumer, A., Rose, L. M., Kääb, S., Gudnason, V., Arking, D. E., Conen, D., Roden, D. M., Chung, M. K., Heckbert, S. R., Benjamin, E. J., Lehtimäki, T., März, W., Smith, J. G., Rotter, J. I., Van Der Harst, P., Jukema, J. W., Stricker, B. H., Felix, S. B., Albert, C. M. & Lubitz, S. A., Dec 1 2017, In : Scientific reports. 7, 1, 11303.

Research output: Contribution to journalArticle

Genetic Obesity and the Risk of Atrial Fibrillation: Causal Estimates from Mendelian Randomization

Chatterjee, N. A., Giulianini, F., Geelhoed, B., Lunetta, K. L., Misialek, J. R., Niemeijer, M. N., Rienstra, M., Rose, L. M., Smith, A. V., Arking, D. E., Ellinor, P. T., Heeringa, J., Lin, H., Lubitz, S. A., Soliman, E. Z., Verweij, N., Alonso, A., Benjamin, E. J., Gudnason, V., Stricker, B. H. C. & 3 others, Van Der Harst, P., Chasman, D. I. & Albert, C. M., Feb 21 2017, In : Circulation. 135, 8, p. 741-754 14 p.

Research output: Contribution to journalArticle

Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk

The GoT2DGenes Consortium, The Cohorts for Heart and Ageing Research in Genome Epidemiology (CHARGE) BP Exome Consortium, The International Genomics of Blood Pressure (iGEN-BP) Consortium, for The UK Biobank CardioMetabolic Consortium BP working group Louise, BIOS Consortium, Lifelines Cohort Study, Understanding Society Scientific group, The International Consortium of Blood Pressure (ICBP) 1000G Analyses, The CHD Exome+ Consortium, The ExomeBP Consortium & The T2D-GENES Consortium, Mar 1 2017, In : Nature genetics. 49, 3, p. 403-415 13 p.

Research output: Contribution to journalArticle

Genome-wide association study to identify variants associated with acute severe vaso-occlusive pain in sickle cell anemia

Chaturvedi, S., Bhatnagar, P., Bean, C. J., Steinberg, M. H., Milton, J. N., Casella, J. F., Barron-Casella, E., Arking, D. E. & DeBaun, M. R., Aug 3 2017, In : Blood. 130, 5, p. 686-688 3 p.

Research output: Contribution to journalLetter

GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: A report from the COGENT consortium

Trampush, J. W., Yang, M. L. Z., Yu, J., Knowles, E., Davies, G., Liewald, D. C., Starr, J. M., Djurovic, S., Melle, I., Sundet, K., Christoforou, A., Reinvang, I., Derosse, P., Lundervold, A. J., Steen, V. M., Espeseth, T., Räikkönen, K., Widen, E., Palotie, A., Eriksson, J. G. & 46 others, Giegling, I., Konte, B., Roussos, P., Giakoumaki, S., Burdick, K. E., Payton, A., Ollier, W., Horan, M., Chiba-Falek, O., Attix, D. K., Need, A. C., Cirulli, E. T., Voineskos, A. N., Stefanis, N. C., Avramopoulos, D., Hatzimanolis, A., Arking, D. E., Smyrnis, N., Bilder, R. M., Freimer, N. A., Cannon, T. D., London, E., Poldrack, R. A., Sabb, F. W., Congdon, E., Conley, E. D., Scult, M. A., Dickinson, D., Straub, R. E., Donohoe, G., Morris, D., Corvin, A., Gill, M., Hariri, A. R., Weinberger, D. R., Pendleton, N., Bitsios, P., Rujescu, D., Lahti, J., Le Hellard, S., Keller, M. C., Andreassen, O. A., Deary, I. J., Glahn, D. C., Malhotra, A. K. & Lencz, T., Mar 1 2017, In : Molecular psychiatry. 22, 3, p. 336-345 10 p.

Research output: Contribution to journalArticle

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

Christophersen, I. E., Rienstra, M., Roselli, C., Yin, X., Geelhoed, B., Barnard, J., Lin, H., Arking, D. E., Smith, A. V., Albert, C. M., Chaffin, M., Tucker, N. R., Li, M., Klarin, D., Bihlmeyer, N. A., Low, S. K., Weeke, P. E., Müller-Nurasyid, M., Smith, J. G., Brody, J. A. & 142 others, Niemeijer, M. N., Dörr, M., Trompet, S., Huffman, J., Gustafsson, S., Schurmann, C., Kleber, M. E., Lyytikäinen, L. P., Seppälä, I., Malik, R., Horimoto, A. R. V. R., Perez, M., Sinisalo, J., Aeschbacher, S., Thériault, S., Yao, J., Radmanesh, F., Weiss, S., Teumer, A., Choi, S. H., Weng, L. C., Clauss, S., Deo, R., Rader, D. J., Shah, S. H., Sun, A., Hopewell, J. C., Debette, S., Chauhan, G., Yang, Q., Worrall, B. B., Paré, G., Kamatani, Y., Hagemeijer, Y. P., Verweij, N., Siland, J. E., Kubo, M., Smith, J. D., Van Wagoner, D. R., Bis, J. C., Perz, S., Psaty, B. M., Ridker, P. M., Magnani, J. W., Harris, T. B., Launer, L. J., Shoemaker, M. B., Padmanabhan, S., Haessler, J., Bartz, T. M., Waldenberger, M., Lichtner, P., Arendt, M., Krieger, J. E., Kähönen, M., Risch, L., Mansur, A. J., Peters, A., Smith, B. H., Lind, L., Scott, S. A., Lu, Y., Bottinger, E. B., Hernesniemi, J., Lindgren, C. M., Wong, J. A., Huang, J., Eskola, M., Morris, A. P., Ford, I., Reiner, A. P., Delgado, G., Chen, L. Y., Chen, Y. D. I., Sandhu, R. K., Li, M., Boerwinkle, E., Eisele, L., Lannfelt, L., Rost, N., Anderson, C. D., Taylor, K. D., Campbell, A., Magnusson, P. K., Porteous, D., Hocking, L. J., Vlachopoulou, E., Pedersen, N. L., Nikus, K., Orho-Melander, M., Hamsten, A., Heeringa, J., Denny, J. C., Kriebel, J., Darbar, D., Newton-Cheh, C., Shaffer, C., Macfarlane, P. W., Heilmann-Heimbach, S., Almgren, P., Huang, P. L., Sotoodehnia, N., Soliman, E. Z., Uitterlinden, A. G., Hofman, A., Franco, O. H., Völker, U., Jöckel, K. H., Sinner, M. F., Lin, H. J., Guo, X., Dichgans, M., Ingelsson, E., Kooperberg, C., Melander, O., Loos, R. J. F., Laurikka, J., Conen, D., Rosand, J., Van Der Harst, P., Lokki, M. L., Kathiresan, S., Pereira, A., Jukema, J. W., Hayward, C., Rotter, J. I., März, W., Lehtimäki, T., Stricker, B. H., Chung, M. K., Felix, S. B., Gudnason, V., Alonso, A., Roden, D. M., Kääb, S., Chasman, D. I., Heckbert, S. R., Benjamin, E. J., Tanaka, T., Lunetta, K. L., Lubitz, S. A. & Ellinor, P. T., Jun 1 2017, In : Nature genetics. 49, 6, p. 946-952 7 p.

Research output: Contribution to journalArticle

Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets

Lam, M., Trampush, J. W., Yu, J., Knowles, E., Davies, G., Liewald, D. C., Starr, J. M., Djurovic, S., Melle, I., Sundet, K., Christoforou, A., Reinvang, I., DeRosse, P., Lundervold, A. J., Steen, V. M., Espeseth, T., Räikkönen, K., Widen, E., Palotie, A., Eriksson, J. G. & 45 others, Giegling, I., Konte, B., Roussos, P., Giakoumaki, S., Burdick, K. E., Payton, A., Ollier, W., Chiba-Falek, O., Attix, D. K., Need, A. C., Cirulli, E. T., Voineskos, A. N., Stefanis, N. C., Avramopoulos, D., Hatzimanolis, A., Arking, D. E., Smyrnis, N., Bilder, R. M., Freimer, N. A., Cannon, T. D., London, E., Poldrack, R. A., Sabb, F. W., Congdon, E., Conley, E. D., Scult, M. A., Dickinson, D., Straub, R. E., Donohoe, G., Morris, D., Corvin, A., Gill, M., Hariri, A. R., Weinberger, D. R., Pendleton, N., Bitsios, P., Rujescu, D., Lahti, J., Le Hellard, S., Keller, M. C., Andreassen, O. A., Deary, I. J., Glahn, D. C., Malhotra, A. K. & Lencz, T., Nov 28 2017, In : Cell Reports. 21, 9, p. 2597-2613 17 p.

Research output: Contribution to journalArticle

Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia

Anney, R. J. L., Ripke, S., Anttila, V., Grove, J., Holmans, P., Huang, H., Klei, L., Lee, P. H., Medland, S. E., Neale, B., Robinson, E., Weiss, L. A., Zwaigenbaum, L., Yu, T. W., Wittemeyer, K., Willsey, A. J., Wijsman, E. M., Werge, T., Wassink, T. H., Waltes, R. & 143 others, Walsh, C. A., Wallace, S., Vorstman, J. A. S., Vieland, V. J., Vicente, A. M., Vanengeland, H., Tsang, K., Thompson, A. P., Szatmari, P., Svantesson, O., Steinberg, S., Stefansson, K., Stefansson, H., State, M. W., Soorya, L., Silagadze, T., Scherer, S. W., Schellenberg, G. D., Sandin, S., Sanders, S. J., Saemundsen, E., Rouleau, G. A., Rogé, B., Roeder, K., Roberts, W., Reichert, J., Reichenberg, A., Rehnström, K., Regan, R., Poustka, F., Poultney, C. S., Piven, J., Pinto, D., Pericak-Vance, M. A., Pejovic-Milovancevic, M., Pedersen, M. G., Pedersen, C. B., Paterson, A. D., Parr, J. R., Pagnamenta, A. T., Oliveira, G., Nurnberger, J. I., Nordentoft, M., Murtha, M. T., Mouga, S., Mortensen, P. B., Mors, O., Morrow, E. M., Moreno-De-Luca, D., Monaco, A. P., Minshew, N., Merikangas, A., McMahon, W. M., McGrew, S. G., Mattheisen, M., Martsenkovsky, I., Martin, D. M., Mane, S. M., Magnusson, P., Magalhaes, T., Maestrini, E., Lowe, J. K., Lord, C., Levitt, P., Martin, C. L., Ledbetter, D. H., Leboyer, M., Lecouteur, A. S., Ladd-Acosta, C., Kolevzon, A., Klauck, S. M., Jacob, S., Iliadou, B., Hultman, C. M., Hougaard, D. M., Hertz-Picciotto, I., Hendren, R., Hansen, C. S., Haines, J. L., Guter, S. J., Grice, D. E., Green, J. M., Green, A., Goldberg, A. P., Gillberg, C., Gilbert, J., Gallagher, L., Freitag, C. M., Fombonne, E., Folstein, S. E., Fernandez, B., Fallin, M. D., Ercan-Sencicek, A. G., Ennis, S., Duque, F., Duketis, E., Delorme, R., Derubeis, S., Dejonge, M. V., Dawson, G., Cuccaro, M. L., Correia, C. T., Conroy, J., Conceição, I. C., Chiocchetti, A. G., Celestino-Soper, P. B. S., Casey, J., Cantor, R. M., Café, C., Bybjerg-Grauholm, J., Brennan, S., Bourgeron, T., Bolton, P. F., Bölte, S., Bolshakova, N., Betancur, C., Bernier, R., Beaudet, A. L., Battaglia, A., Bal, V. H., Baird, G., Bailey, A. J., Bækvad-Hansen, M., Bader, J. S., Bacchelli, E., Anagnostou, E., Amaral, D., Almeida, J., Børglum, A. D., Buxbaum, J. D., Chakravarti, A., Cook, E. H., Coon, H., Geschwind, D. H., Gill, M., Hallmayer, J., Palotie, A., Santangelo, S., Sutcliffe, J. S., Arking, D. E., Devlin, B., Daly, M. J. & Hakonarson, H., May 22 2017, In : Molecular Autism. 8, 1, 21.

Research output: Contribution to journalArticle

Moderate coffee intake can be part of a healthy diet

Guallar, E., Blasco-Colmenares, E., Arking, D. & Zhao, D., Aug 15 2017, In : Annals of Internal Medicine. 167, 4, p. 283-284 2 p.

Research output: Contribution to journalEditorial

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets from Blood and the Kidney

Wain, L. V., Vaez, A., Jansen, R., Joehanes, R., Van Der Most, P. J., Erzurumluoglu, A. M., O'Reilly, P. F., Cabrera, C. P., Warren, H. R., Rose, L. M., Verwoert, G. C., Hottenga, J. J., Strawbridge, R. J., Esko, T., Arking, D. E., Hwang, S. J., Guo, X., Kutalik, Z., Trompet, S., Shrine, N. & 223 others, Teumer, A., Ried, J. S., Bis, J. C., Smith, A. V., Amin, N., Nolte, I. M., Lyytikäinen, L. P., Mahajan, A., Wareham, N. J., Hofer, E., Joshi, P. K., Kristiansson, K., Traglia, M., Havulinna, A. S., Goel, A., Nalls, M. A., Sõber, S., Vuckovic, D., Luan, JA., Del Greco, F. M., Ayers, K. L., Marrugat, J., Ruggiero, D., Lopez, L. M., Niiranen, T., Enroth, S., Jackson, A. U., Nelson, C. P., Huffman, J. E., Zhang, W., Marten, J., Gandin, I., Harris, S. E., Zemunik, T., Lu, Y., Evangelou, E., Shah, N., De Borst, M. H., Mangino, M., Prins, B. P., Campbell, A., Li-Gao, R., Chauhan, G., Oldmeadow, C., Abecasis, G., Abedi, M., Barbieri, C. M., Barnes, M. R., Batini, C., Beilby, J., Blake, T., Boehnke, M., Bottinger, E. P., Braund, P. S., Brown, M., Brumat, M., Campbell, H., Chambers, J. C., Cocca, M., Collins, F., Connell, J., Cordell, H. J., Damman, J. J., Davies, G., De Geus, E. J., De Mutsert, R., Deelen, J., Demirkale, Y., Doney, A. S. F., Dörr, M., Farrall, M., Ferreira, T., Frånberg, M., Gao, H., Giedraitis, V., Gieger, C., Giulianini, F., Gow, A. J., Hamsten, A., Harris, T. B., Hofman, A., Holliday, E. G., Hui, J., Jarvelin, M. R., Johansson, Å., Johnson, A. D., Jousilahti, P., Jula, A., Kähönen, M., Kathiresan, S., Khaw, K. T., Kolcic, I., Koskinen, S., Langenberg, C., Larson, M., Launer, L. J., Lehne, B., Liewald, D. C. M., Lin, L., Lind, L., Mach, F., Mamasoula, C., Menni, C., Mifsud, B., Milaneschi, Y., Morgan, A., Morris, A. D., Morrison, A. C., Munson, P. J., Nandakumar, P., Nguyen, Q. T., Nutile, T., Oldehinkel, A. J., Oostra, B. A., Org, E., Padmanabhan, S., Palotie, A., Paré, G., Pattie, A., Penninx, B. W. J. H., Poulter, N., Pramstaller, P. P., Raitakari, O. T., Ren, M., Rice, K., Ridker, P. M., Riese, H., Ripatti, S., Robino, A., Rotter, J. I., Rudan, I., Saba, Y., Saint Pierre, A., Sala, C. F., Sarin, A. P., Schmidt, R., Scott, R., Seelen, M. A., Shields, D. C., Siscovick, D., Sorice, R., Stanton, A., Stott, D. J., Sundström, J., Swertz, M., Taylor, K. D., Thom, S., Tzoulaki, I., Tzourio, C., Uitterlinden, A. G., Völker, U., Vollenweider, P., Wild, S., Willemsen, G., Wright, A. F., Yao, J., Thériault, S., Conen, D., Attia, J., Sever, P., Debette, S., Mook-Kanamori, D. O., Zeggini, E., Spector, T. D., Van Der Harst, P., Palmer, C. N. A., Vergnaud, A. C., Loos, R. J. F., Polasek, O., Starr, J. M., Girotto, G., Hayward, C., Kooner, J. S., Lindgren, C. M., Vitart, V., Samani, N. J., Tuomilehto, J., Gyllensten, U., Knekt, P., Deary, I. J., Ciullo, M., Elosua, R., Keavney, B. D., Hicks, A. A., Scott, R. A., Gasparini, P., Laan, M., Liu, Y., Watkins, H., Hartman, C. A., Salomaa, V., Toniolo, D., Perola, M., Wilson, J. F., Schmidt, H., Zhao, J. H., Lehtimäki, T., Van Duijn, C. M., Gudnason, V., Psaty, B. M., Peters, A., Rettig, R., James, A., Jukema, J. W., Strachan, D. P., Palmas, W., Metspalu, A., Ingelsson, E., Boomsma, D. I., Franco, O. H., Bochud, M., Newton-Cheh, C., Munroe, P. B., Elliott, P., Chasman, D. I., Chakravarti, A., Knight, J., Morris, A. P., Levy, D., Tobin, M. D., Snieder, H., Caulfield, M. J. & Ehret, G. B., Sep 1 2017, In : Hypertension. 70, 3, p. e4-e19

Research output: Contribution to journalArticle

Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders

Psychiatric Genomics Consortium Autism Group & iPSYCH-Broad Autism Group, Jul 1 2017, In : Nature genetics. 49, 7, p. 978-985 8 p.

Research output: Contribution to journalArticle

SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function

Li, M., Li, Y., Weeks, O., Mijatovic, V., Teumer, A., Huffman, J. E., Tromp, G., Fuchsberger, C., Gorski, M., Lyytikäinen, L. P., Nutile, T., Sedaghat, S., Sorice, R., Tin, A., Yang, Q., Ahluwalia, T. S., Arking, D. E., Bihlmeyer, N. A., Böger, C. A., Carroll, R. J. & 136 others, Chasman, D. I., Cornelis, M. C., Dehghan, A., Faul, J. D., Feitosa, M. F., Gambaro, G., Gasparini, P., Giulianini, F., Heid, I., Huang, J., Imboden, M., Jackson, A. U., Jeff, J., Jhun, M. A., Katz, R., Kifley, A., Kilpeläinen, T. O., Kumar, A., Laakso, M., Li-Gao, R., Lohman, K., Lu, Y., Mägi, R., Malerba, G., Mihailov, E., Mohlke, K. L., Mook-Kanamori, D. O., Robino, A., Ruderfer, D., Salvi, E., Schick, U. M., Schulz, C. A., Smith, A. V., Smith, J. A., Traglia, M., Yerges-Armstrong, L. M., Zhao, W., Goodarzi, M. O., Kraja, A. T., Liu, C., Wessel, J., Boerwinkle, E., Borecki, I. B., Bork-Jensen, J., Bottinger, E. P., Braga, D., Brandslund, I., Brody, J. A., Campbell, A., Carey, D. J., Christensen, C., Coresh, J., Crook, E., Curhan, G. C., Cusi, D., De Boer, I. H., De Vries, A. P. J., Denny, J. C., Devuyst, O., Dreisbach, A. W., Endlich, K., Esko, T., Franco, O. H., Fulop, T., Gerhard, G. S., Glümer, C., Gottesman, O., Grarup, N., Gudnason, V., Hansen, T., Harris, T. B., Hayward, C., Hocking, L., Hofman, A., Hu, F. B., Husemoen, L. L. N., Jackson, R. D., Jørgensen, T., Jørgensen, M. E., Kähönen, M., Kardia, S. L. R., König, W., Kooperberg, C., Kriebel, J., Launer, L. J., Lauritzen, T., Lehtimäki, T., Levy, D., Linksted, P., Linneberg, A., Liu, Y., Loos, R. J. F., Lupo, A., Meisinger, C., Melander, O., Metspalu, A., Mitchell, P., Nauck, M., Nürnberg, P., Orho-Melander, M., Parsa, A., Pedersen, O., Peters, A., Peters, U., Polasek, O., Porteous, D., Probst-Hensch, N. M., Psaty, B. M., Qi, L., Raitakari, O. T., Reiner, A. P., Rettig, R., Ridker, P. M., Rivadeneira, F., Rossouw, J. E., Schmidt, F., Siscovick, D., Soranzo, N., Strauch, K., Toniolo, D., Turner, S. T., Uitterlinden, A. G., Ulivi, S., Velayutham, D., Völker, U., Völzke, H., Waldenberger, M., Wang, J. J., Weir, D. R., Witte, D., Kuivaniemi, H., Fox, C. S., Franceschini, N., Goessling, W., Köttgen, A. & Chu, A. Y., Mar 2017, In : Journal of the American Society of Nephrology. 28, 3, p. 981-994 14 p.

Research output: Contribution to journalArticle

The loss of GSTM1 associates with kidney failure and heart failure

Tin, A., Scharpf, R., Estrella, M., Yu, B., Grove, M. L., Chang, P. P., Matsushita, K., Köttgen, A., Arking, D. E., Boerwinkle, E., Le, T. H., Coresh, J. & Grams, M. E., Nov 1 2017, In : Journal of the American Society of Nephrology. 28, 11, p. 3345-3352 8 p.

Research output: Contribution to journalArticle

Toward the human cellular microRNAome

McCall, M. N., Kim, M. S., Adil, M., Patil, A. H., Lu, Y., Mitchell, C. J., Leal-Rojas, P., Xu, J., Kumar, M., Dawson, V. L., Dawson, T. M., Baras, A. S., Rosenberg, A. Z., Arking, D. E., Burns, K. H., Pandey, A. & Halushka, M. K., Oct 2017, In : Genome research. 27, 10, p. 1769-1781 13 p.

Research output: Contribution to journalArticle

Usefulness of Maintaining a Normal Electrocardiogram Over Time for Predicting Cardiovascular Health

Soliman, E. Z., Zhang, Z. M., Chen, L. Y., Tereshchenko, L. G., Arking, D. & Alonso, A., Jan 15 2017, In : American Journal of Cardiology. 119, 2, p. 249-255 7 p.

Research output: Contribution to journalArticle

2016

52 Genetic Loci Influencing Myocardial Mass

van der Harst, P., van Setten, J., Verweij, N., Vogler, G., Franke, L., Maurano, M. T., Wang, X., Mateo Leach, I., Eijgelsheim, M., Sotoodehnia, N., Hayward, C., Sorice, R., Meirelles, O., Lyytikäinen, L. P., Polašek, O., Tanaka, T., Arking, D. E., Ulivi, S., Trompet, S., Müller-Nurasyid, M. & 140 others, Smith, A. V., Dörr, M., Kerr, K. F., Magnani, J. W., Del Greco M., F., Zhang, W., Nolte, I. M., Silva, C. T., Padmanabhan, S., Tragante, V., Esko, T., Abecasis, G. R., Adriaens, M. E., Andersen, K., Barnett, P., Bis, J. C., Bodmer, R., Buckley, B. M., Campbell, H., Cannon, M. V., Chakravarti, A., Chen, L. Y., Delitala, A., Devereux, R. B., Doevendans, P. A., Dominiczak, A. F., Ferrucci, L., Ford, I., Gieger, C., Harris, T. B., Haugen, E., Heinig, M., Hernandez, D. G., Hillege, H. L., Hirschhorn, J. N., Hofman, A., Hubner, N., Hwang, S. J., Iorio, A., Kähönen, M., Kellis, M., Kolcic, I., Kooner, I. K., Kooner, J. S., Kors, J. A., Lakatta, E. G., Lage, K., Launer, L. J., Levy, D., Lundby, A., Macfarlane, P. W., May, D., Meitinger, T., Metspalu, A., Nappo, S., Naitza, S., Neph, S., Nord, A. S., Nutile, T., Okin, P. M., Olsen, J. V., Oostra, B. A., Penninger, J. M., Pennacchio, L. A., Pers, T. H., Perz, S., Peters, A., Pinto, Y. M., Pfeufer, A., Pilia, M. G., Pramstaller, P. P., Prins, B. P., Raitakari, O. T., Raychaudhuri, S., Rice, K. M., Rossin, E. J., Rotter, J. I., Schafer, S., Schlessinger, D., Schmidt, C. O., Sehmi, J., Silljé, H. H. W., Sinagra, G., Sinner, M. F., Slowikowski, K., Soliman, E. Z., Spector, T. D., Spiering, W., Stamatoyannopoulos, J. A., Stolk, R. P., Strauch, K., Tan, S. T., Tarasov, K. V., Trinh, B., Uitterlinden, A. G., van den Boogaard, M., van Duijn, C. M., van Gilst, W. H., Viikari, J. S., Visscher, P. M., Vitart, V., Völker, U., Waldenberger, M., Weichenberger, C. X., Westra, H. J., Wijmenga, C., Wolffenbuttel, B. H., Yang, J., Bezzina, C. R., Munroe, P. B., Snieder, H., Wright, A. F., Rudan, I., Boyer, L. A., Asselbergs, F. W., van Veldhuisen, D. J., Stricker, B. H., Psaty, B. M., Ciullo, M., Sanna, S., Lehtimäki, T., Wilson, J. F., Bandinelli, S., Alonso, A., Gasparini, P., Jukema, J. W., Kääb, S., Gudnason, V., Felix, S. B., Heckbert, S. R., de Boer, R. A., Newton-Cheh, C., Hicks, A. A., Chambers, J. C., Jamshidi, Y., Visel, A., Christoffels, V. M., Isaacs, A., Samani, N. J. & de Bakker, P. I. W., Sep 27 2016, In : Journal of the American College of Cardiology. 68, 13, p. 1435-1448 14 p.

Research output: Contribution to journalArticle

Association between mitochondrial DNA copy number in peripheral blood and incident CKD in the atherosclerosis risk in communities study

Tin, A., Grams, M. E., Ashar, F. N., Lane, J. A., Rosenberg, A. Z., Grove, M. L., Boerwinkle, E., Selvin, E., Coresh, J., Pankratz, N. & Arking, D. E., 2016, In : Journal of the American Society of Nephrology. 27, 8, p. 2467-2473 7 p.

Research output: Contribution to journalArticle

Association of lipid-related genetic variants with the incidence of atrial fibrillation: The AFGen consortium

Norby, F. L., Eryd, S. A., Niemeijer, M. N., Rose, L. M., Smith, A. V., Yin, X., Agarwal, S. K., Arking, D. E., Chasman, D. L., Chen, L. Y., Eijgelsheim, M., Engström, G., Franco, O. H., Heeringa, J., Hindy, G., Hofman, A., Lutsey, P. L., Magnani, J. W., McManus, D. D., Orho-Melander, M. & 10 others, Pankow, J. S., Rukh, G., Schulz, C. A., Uitterlinden, A. G., Albert, C. M., Benjamin, E. J., Gudnason, V., Smith, J. G., Stricker, B. H. C. & Alonso, A., Mar 2016, In : PloS one. 11, 3, e0151932.

Research output: Contribution to journalArticle

Fine-mapping, novel loci identification, and SNP association transferability in a genome-wide association study of QRS duration in African Americans

CHARGE QRS Consortium, Oct 1 2016, In : Human molecular genetics. 25, 19, p. 4350-4368 19 p.

Research output: Contribution to journalArticle

Gene-gene Interaction Analyses for Atrial Fibrillation

Lin, H., Mueller-Nurasyid, M., Smith, A. V., Arking, D. E., Barnard, J., Bartz, T. M., Lunetta, K. L., Lohman, K., Kleber, M. E., Lubitz, S. A., Geelhoed, B., Trompet, S., Niemeijer, M. N., Kacprowski, T., Chasman, D. I., Klarin, D., Sinner, M. F., Waldenberger, M., Meitinger, T., Harris, T. B. & 39 others, Launer, L. J., Soliman, E. Z., Chen, L. Y., Smith, J. D., Van Wagoner, D. R., Rotter, J. I., Psaty, B. M., Xie, Z., Hendricks, A. E., Ding, J., Delgado, G. E., Verweij, N., Van Der Harst, P., Macfarlane, P. W., Ford, I., Hofman, A., Uitterlinden, A., Heeringa, J., Franco, O. H., Kors, J. A., Weiss, S., Völzke, H., Rose, L. M., Natarajan, P., Kathiresan, S., Kääb, S., Gudnason, V., Alonso, A., Chung, M. K., Heckbert, S. R., Benjamin, E. J., Liu, Y., März, W., Rienstra, M., Jukema, J. W., Stricker, B. H., Dörr, M., Albert, C. M. & Ellinor, P. T., Nov 8 2016, In : Scientific reports. 6, 35371.

Research output: Contribution to journalArticle

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Pattaro, C., Teumer, A., Gorski, M., Chu, A. Y., Li, M., Mijatovic, V., Garnaas, M., Tin, A., Sorice, R., Li, Y., Taliun, D., Olden, M., Foster, M., Yang, Q., Chen, M. H., Pers, T. H., Johnson, A. D., Ko, Y. A., Fuchsberger, C., Tayo, B. & 678 others, Nalls, M., Feitosa, M. F., Isaacs, A., Dehghan, A., D'Adamo, P., Adeyemo, A., Dieffenbach, A. K., Zonderman, A. B., Nolte, I. M., Van Der Most, P. J., Wright, A. F., Shuldiner, A. R., Morrison, A. C., Hofman, A., Smith, A. V., Dreisbach, A. W., Franke, A., Uitterlinden, A. G., Metspalu, A., Tonjes, A., Lupo, A., Robino, A., Johansson, Å., Demirkan, A., Kollerits, B., Freedman, B. I., Ponte, B., Oostra, B. A., Paulweber, B., Krämer, B. K., Mitchell, B. D., Buckley, B. M., Peralta, C. A., Hayward, C., Helmer, C., Rotimi, C. N., Shaffer, C. M., Müller, C., Sala, C., Van Duijn, C. M., Saint-Pierre, A., Ackermann, D., Shriner, D., Ruggiero, D., Toniolo, D., Lu, Y., Cusi, D., Czamara, D., Ellinghaus, D., Siscovick, D. S., Ruderfer, D., Gieger, C., Grallert, H., Rochtchina, E., Atkinson, E. J., Holliday, E. G., Boerwinkle, E., Salvi, E., Bottinger, E. P., Murgia, F., Rivadeneira, F., Ernst, F., Kronenberg, F., Hu, F. B., Navis, G. J., Curhan, G. C., Ehret, G. B., Homuth, G., Coassin, S., Thun, G. A., Pistis, G., Gambaro, G., Malerba, G., Montgomery, G. W., Eiriksdottir, G., Jacobs, G., Li, G., Wichmann, H. E., Campbell, H., Schmidt, H., Wallaschofski, H., Völzke, H., Brenner, H., Kroemer, H. K., Kramer, H., Lin, H., Leach, I. M., Ford, I., Guessous, I., Rudan, I., Prokopenko, I., Borecki, I., Heid, I. M., Kolcic, I., Persico, I., Jukema, J. W., Wilson, J. F., Felix, J. F., Divers, J., Lambert, J. C., Stafford, J. M., Gaspoz, J. M., Smith, J. A., Faul, J. D., Wang, J. J., Ding, J., Hirschhorn, J. N., Attia, J., Whitfield, J. B., Chalmers, J., Viikari, J., Coresh, J., Denny, J. C., Karjalainen, J., Fernandes, J. K., Endlich, K., Butterbach, K., Keene, K. L., Lohman, K., Portas, L., Launer, L. J., Lyytikäinen, L. P., Yengo, L., Franke, L., Ferrucci, L., Rose, L. M., Kedenko, L., Rao, M., Struchalin, M., Kleber, M. E., Cavalieri, M., Haun, M., Cornelis, M. C., Ciullo, M., Pirastu, M., De Andrade, M., McEvoy, M. A., Woodward, M., Adam, M., Cocca, M., Nauck, M., Imboden, M., Waldenberger, M., Pruijm, M., Metzger, M., Stumvoll, M., Evans, M. K., Sale, M. M., Kähönen, M., Boban, M., Bochud, M., Rheinberger, M., Verweij, N., Bouatia-Naji, N., Martin, N. G., Hastie, N., Probst-Hensch, N., Soranzo, N., Devuyst, O., Raitakari, O., Gottesman, O., Franco, O. H., Polasek, O., Gasparini, P., Munroe, P. B., Ridker, P. M., Mitchell, P., Muntner, P., Meisinger, C., Smit, J. H., Abecasis, G. R., Adair, L. S., Alexander, M., Altshuler, D., Amin, N., Arking, D. E., Arora, P., Aulchenko, Y., Bakker, S. J. L., Bandinelli, S., Barroso, I., Beckmann, J. S., Beilby, J. P., Bergman, R. N., Bergmann, S., Bis, J. C., Boehnke, M., Bonnycastle, L. L., Bornstein, S. R., Bots, M. L., Bragg-Gresham, J. L., Brand, S. M., Brand, E., Braund, P. S., Brown, M. J., Burton, P. R., Casas, J. P., Caulfield, M. J., Chakravarti, A., Chambers, J. C., Chandak, G. R., Chang, Y. P. C., Charchar, F. J., Chaturvedi, N., Cho, Y. S., Clarke, R., Collins, F. S., Collins, R., Connell, J. M., Cooper, J. A., Cooper, M. N., Cooper, R. S., Corsi, A. M., Dörr, M., Dahgam, S., Danesh, J., Smith, G. D., Day, I. N. M., Deloukas, P., Denniff, M., Dominiczak, A. F., Dong, Y., Doumatey, A., Elliott, P., Elosua, R., Erdmann, J., Eyheramendy, S., Farrall, M., Fava, C., Forrester, T., Fowkes, F. G. R., Fox, E. R., Frayling, T. M., Galan, P., Ganesh, S. K., Garcia, M., Gaunt, T. R., Glazer, N. L., Go, M. J., Goel, A., Grässler, J., Grobbee, D. E., Groop, L., Guarrera, S., Guo, X., Hadley, D., Hamsten, A., Han, B. G., Hardy, R., Hartikainen, A. L., Heath, S., Heckbert, S. R., Hedblad, B., Hercberg, S., Hernandez, D., Hicks, A. A., Hilton, G., Hingorani, A. D., Hoffman Bolton, J. A., Hopewell, J. 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R., Susztak, K., Hamet, P., Tremblay, J., De Boer, I. H., Böger, C. A., Goessling, W., Chasman, D. I., Köttgen, A., Kao, W. H. L. & Fox, C. S., Jan 21 2016, In : Nature communications. 7, 10023.

Research output: Contribution to journalArticle

Genetic investigation into the differential risk of atrial fibrillation among black and white individuals

Roberts, J. D., Hu, D., Heckbert, S. R., Alonso, A., Dewland, T. A., Vittinghoff, E., Liu, Y., Psaty, B. M., Olgin, J. E., Magnani, J. W., Huntsman, S., Burchard, E. G., Arking, D. E., Bibbins-Domingo, K., Harris, T. B., Perez, M. V., Ziv, E. & Marcus, G. M., Jul 2016, In : JAMA cardiology. 1, 4, p. 442-450 9 p.

Research output: Contribution to journalArticle

GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium

Matteini, A. M., Tanaka, T., Karasik, D., Atzmon, G., Chou, W. C., Eicher, J. D., Johnson, A. D., Arnold, A. M., Callisaya, M. L., Davies, G., Evans, D. S., Holtfreter, B., Lohman, K., Lunetta, K. L., Mangino, M., Smith, A. V., Smith, J. A., Teumer, A., Yu, L., Arking, D. E. & 47 others, Buchman, A. S., Chibinik, L. B., DeJager, P. L., Evans, D. A., Faul, J. D., Garcia, M. E., Gillham-Nasenya, I., Gudnason, V., Hofman, A., Hsu, Y. H., Ittermann, T., Lahousse, L., Liewald, D. C., Liu, Y., Lopez, L., Rivadeneira, F., Rotter, J. I., Siggeirsdottir, K., Starr, J. M., Thomson, R., Tranah, G. J., Uitterlinden, A. G., Völker, U., Völzke, H., Weir, D. R., Yaffe, K., Zhao, W., Zhuang, W. V., Zmuda, J. M., Bennett, D. A., Cummings, S. R., Deary, I. J., Ferrucci, L., Harris, T. B., Kardia, S. L. R., Kocher, T., Kritchevsky, S. B., Psaty, B. M., Seshadri, S., Spector, T. D., Srikanth, V. K., Windham, B. G., Zillikens, M. C., Newman, A. B., Walston, J. D., Kiel, D. P. & Murabito, J. M., Oct 1 2016, In : Aging Cell. 15, 5, p. 792-800 9 p.

Research output: Contribution to journalArticle

Impact of genetic variants on the upstream efficacy of renin-angiotensin system inhibitors for the prevention of atrial fibrillation

Roberts, J. D., Dewland, T. A., Glidden, D. V., Hoffmann, T. J., Arking, D. E., Chen, L. Y., Psaty, B. M., Olgin, J. E., Alonso, A., Heckbert, S. R. & Marcus, G. M., May 1 2016, In : American heart journal. 175, p. 9-17 9 p.

Research output: Contribution to journalArticle

Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study

PAGE Consortium, International Stroke Genetics Consortium, Systemic Sclerosis consortium, Treat OA consortium, DIAGRAM Consortium, CARDIoGRAMplusC4D Consortium, ALS consortium, International Parkinson’s Disease Genomics Consortium, Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, CKDGen consortium, GERAD1 Consortium, International Consortium for Blood Pressure, Schizophrenia Working Group of the Psychiatric Genomics Consortium & Inflammation Working Group of the CHARGE Consortium, Jun 2016, In : PLoS medicine. 13, 6, e1001976.

Research output: Contribution to journalArticle

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

The LifeLines Cohort Study & CHARGE Lipids Working Group, Jul 1 2016, In : Journal of medical genetics. 53, 7, p. 441-449 9 p.

Research output: Contribution to journalArticle

Rare coding TTN variants are associated with electrocardiographic QT interval in the general population

Kapoor, A., Bakshy, K., Xu, L., Nandakumar, P., Lee, D., Boerwinkle, E., Grove, M. L., Arking, D. E. & Chakravarti, A., Jun 20 2016, In : Scientific reports. 6, 28356.

Research output: Contribution to journalArticle

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Ehret, G. B., Ferreira, T., Chasman, D. I., Jackson, A. U., Schmidt, E. M., Johnson, T., Thorleifsson, G., Luan, JA., Donnelly, L. A., Kanoni, S., Petersen, A. K., Pihur, V., Strawbridge, R. J., Shungin, D., Hughes, M. F., Meirelles, O., Kaakinen, M., Bouatia-Naji, N., Kristiansson, K., Shah, S. & 293 others, Kleber, M. E., Guo, X., Lyytikäinen, L. P., Fava, C., Eriksson, N., Nolte, I. M., Magnusson, P. K., Salfati, E. L., Rallidis, L. S., Theusch, E., Smith, A. J. P., Folkersen, L., Witkowska, K., Pers, T. H., Joehanes, R., Kim, S. K., Lataniotis, L., Jansen, R., Johnson, A. D., Warren, H., Kim, Y. J., Zhao, W., Wu, Y., Tayo, B. O., Bochud, M., Absher, D., Adair, L. S., Amin, N., Arking, D. E., Axelsson, T., Baldassarre, D., Balkau, B., Bandinelli, S., Barnes, M. R., Barroso, I., Bevan, S., Bis, J. C., Bjornsdottir, G., Boehnke, M., Boerwinkle, E., Bonnycastle, L. L., Boomsma, D. I., Bornstein, S. R., Brown, M. J., Burnier, M., Cabrera, C. P., Chambers, J. C., Chang, I. S., Cheng, C. Y., Chines, P. S., Chung, R. H., Collins, F. S., Connell, J. M., Döring, A., Dallongeville, J., Danesh, J., De Faire, U., Delgado, G., Dominiczak, A. F., Doney, A. S. F., Drenos, F., Edkins, S., Eicher, J. D., Elosua, R., Enroth, S., Erdmann, J., Eriksson, P., Esko, T., Evangelou, E., Evans, A., Fall, T., Farrall, M., Felix, J. F., Ferrières, J., Ferrucci, L., Fornage, M., Forrester, T., Franceschini, N., Franco, O. H., Franco-Cereceda, A., Fraser, R. M., Ganesh, S. K., Gao, H., Gertow, K., Gianfagna, F., Gigante, B., Giulianini, F., Goel, A., Goodall, A. H., Goodarzi, M. O., Gorski, M., Gräßler, J., Groves, C. J., Gudnason, V., Gyllensten, U., Hallmans, G., Hartikainen, A. L., Hassinen, M., Havulinna, A. S., Hayward, C., Hercberg, S., Herzig, K. H., Hicks, A. A., Hingorani, A. D., Hirschhorn, J. N., Hofman, A., Holmen, J., Holmen, O. L., Hottenga, J. J., Howard, P., Hsiung, C. A., Hunt, S. C., Ikram, M. A., Illig, T., Iribarren, C., Jensen, R. A., Kähönen, M., Kang, H. M., Kathiresan, S., Keating, B. J., Khaw, K. T., Kim, Y. K., Kim, E., Kivimaki, M., Klopp, N., Kolovou, G., Komulainen, P., Kooner, J. S., Kosova, G., Krauss, R. M., Kuh, D., Kutalik, Z., Kuusisto, J., Kvaløy, K., Lakka, T. A., Lee, N. R., Lee, I. T., Lee, W. J., Levy, D., Li, X., Liang, K. W., Lin, H., Lin, L., Lindström, J., Lobbens, S., Männistö, S., Müller, G., Müller-Nurasyid, M., Mach, F., Markus, H. S., Marouli, E., McCarthy, M. I., McKenzie, C. A., Meneton, P., Menni, C., Metspalu, A., Mijatovic, V., Moilanen, L., Montasser, M. E., Morris, A. D., Morrison, A. C., Mulas, A., Nagaraja, R., Narisu, N., Nikus, K., O'Donnell, C. J., O'Reilly, P. F., Ong, K. K., Paccaud, F., Palmer, C. D., Parsa, A., Pedersen, N. L., Penninx, B. W., Perola, M., Peters, A., Poulter, N., Pramstaller, P. P., Psaty, B. M., Quertermous, T., Rao, D. C., Rasheed, A., Rayner, N. W., Renström, F., Rettig, R., Rice, K. M., Roberts, R., Rose, L. M., Rossouw, J., Samani, N. J., Sanna, S., Saramies, J., Schunkert, H., Sebert, S., Sheu, W. H. H., Shin, Y. A., Sim, X., Smit, J. H., Smith, A. V., Sosa, M. X., Spector, T. D., Stančáková, A., Stanton, A. V., Stirrups, K. E., Stringham, H. M., Sundstrom, J., Swift, A. J., Syvänen, A. C., Tai, E. S., Tanaka, T., Tarasov, K. V., Teumer, A., Thorsteinsdottir, U., Tobin, M. D., Tremoli, E., Uitterlinden, A. G., Uusitupa, M., Vaez, A., Vaidya, D., Van Duijn, C. M., Van Iperen, E. P. A., Vasan, R. S., Verwoert, G. C., Virtamo, J., Vitart, V., Voight, B. F., Vollenweider, P., Wagner, A., Wain, L. V., Wareham, N. J., Watkins, H., Weder, A. B., Westra, H. J., Wilks, R., Wilsgaard, T., Wilson, J. F., Wong, T. Y., Yang, T. P., Yao, J., Yengo, L., Zhang, W., Zhao, J. H., Zhu, X., Bovet, P., Cooper, R. S., Mohlke, K. L., Saleheen, D., Lee, J. Y., Elliott, P., Gierman, H. J., Willer, C. J., Franke, L., Hovingh, G. K., Taylor, K. D., Dedoussis, G., Sever, P., Wong, A., Lind, L., Assimes, T. L., Njølstad, I., Schwarz, P. E. H., Langenberg, C., Snieder, H., Caulfield, M. J., Melander, O., Laakso, M., Saltevo, J., Rauramaa, R., Tuomilehto, J., Ingelsson, E., Lehtimäki, T., Hveem, K., Palmas, W., März, W., Kumari, M., Salomaa, V., Chen, Y. D. I., Rotter, J. I., Froguel, P., Jarvelin, M. R., Lakatta, E. G., Kuulasmaa, K., Franks, P. W., Hamsten, A., Wichmann, H. E., Palmer, C. N. A., Stefansson, K., Ridker, P. M., Loos, R. J. F., Chakravarti, A., Deloukas, P., Morris, A. P., Newton-Cheh, C. & Munroe, P. B., Oct 1 2016, In : Nature genetics. 48, 10, p. 1171-1184 14 p.

Research output: Contribution to journalArticle

Transcriptome analysis of cortical tissue reveals shared sets of downregulated genes in autism and schizophrenia

Ellis, S. E., Panitch, R., West, A. B. & Arking, D., May 24 2016, In : Translational Psychiatry. 6, p. e817

Research output: Contribution to journalArticle

Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram

Lifelines Cohort Study & LifeLines GWAS Working Group, May 15 2016, In : Human molecular genetics. 25, 10, p. 2093-2103 11 p.

Research output: Contribution to journalArticle

Whole Exome Sequencing in Atrial Fibrillation

NHLBI GO Exome Sequencing Project, Sep 2016, In : PLoS genetics. 12, 9, e1006284.

Research output: Contribution to journalArticle

2015

A Meta-analysis of Gene Expression Signatures of Blood Pressure and Hypertension

International Consortium for Blood Pressure GWAS (ICBP), CARDIoGRAM consortium, CKDGen consortium, KidneyGen consortium, EchoGen consortium & CHARGE-HF consortium, Mar 18 2015, In : PLoS genetics. 11, 3, e1005035.

Research output: Contribution to journalArticle

Association of mitochondrial DNA levels with frailty and all-cause mortality

Ashar, F. N., Moes, A., Moore, A. Z., Grove, M. L., Chaves, P. H. M., Coresh, J., Newman, A. B., Matteini, A. M., Bandeen-Roche, K., Boerwinkle, E., Walston, J. D. & Arking, D. E., 2015, In : Journal of Molecular Medicine. 93, 2, p. 177-186 10 p.

Research output: Contribution to journalArticle

Beat-to-beat spatiotemporal variability in the T vector is associated with sudden cardiac death in participants without left ventricular hypertrophy: The Atherosclerosis Risk in Communities (ARIC) study

Waks, J. W., Soliman, E. Z., Henrikson, C. A., Sotoodehnia, N., Han, L., Agarwal, S. K., Arking, D. E., Siscovick, D. S., Solomon, S. D., Post, W. S., Josephson, M. E., Coresh, J. & Tereshchenko, L. G., 2015, In : Journal of the American Heart Association. 4, 1, e001357.

Research output: Contribution to journalArticle

Common genetic variation and schizophrenia polygenic risk influence neurocognitive performance in young adulthood

Hatzimanolis, A., Bhatnagar, P., Moes, A., Wang, R., Roussos, P., Bitsios, P., Stefanis, C. N., Pulver, A. E., Arking, D. E., Smyrnis, N., Stefanis, N. C. & Avramopoulos, D., Jul 1 2015, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 168, 5, p. 392-401 10 p.

Research output: Contribution to journalArticle

Editorial overview: Molecular and genetic bases of disease: Enter the post-GWAS era

Arking, D. & Rommens, J., Aug 1 2015, In : Current Opinion in Genetics and Development. 33, p. 77-79 3 p.

Research output: Contribution to journalEditorial

Fine mapping the CETP region reveals a common intronic insertion associated to HDL-C

Generation Scotland, Lifelines Cohort Study & CHARGE Lipids Working Group, Nov 12 2015, In : npj Aging and Mechanisms of Disease. 1, 1, 15011.

Research output: Contribution to journalArticle

Genetic studies of body mass index yield new insights for obesity biology

Lifelines Cohort Study & ADIPOGen Consortium; AGEN-BMI Working Group; CARDIOGRAMplusC4D Consortium; CKDGen Consortium; GLGC; ICBP; MAGIC Investigators; MuTHER Consortium; MIGen Consortium; PAGE Consortium; ReproGen Consortium; GENIE Consortium; International Endogene Consortium, Feb 12 2015, In : Nature. 518, 7538, p. 197-206 10 p.

Research output: Contribution to journalArticle

Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder

Cross-Disorder Working Group of the Psychiatric Genomics Consortium, Feb 5 2015, In : American journal of human genetics. 96, 2, p. 283-294 12 p.

Research output: Contribution to journalArticle