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  • David A Kass
2020
Open Access

Multi-Beat Right Ventricular-Arterial Coupling Predicts Clinical Worsening in Pulmonary Arterial Hypertension

Hsu, S., Simpson, C. E., Houston, B. A., Wand, A., Sato, T., Kolb, T. M., Mathai, S. C., Kass, D. A., Hassoun, P. M., Damico, R. L. & Tedford, R. J., May 18 2020, In : Journal of the American Heart Association. 9, 10, p. e016031

Research output: Contribution to journalArticle

Open Access

Myocardial Phosphodiesterases and Their Role in cGMP Regulation

Dunkerly-Eyring, B. & Kass, D. A., Jun 1 2020, In : Journal of cardiovascular pharmacology. 75, 6, p. 483-493 11 p.

Research output: Contribution to journalArticle

Obesity could shift severe COVID-19 disease to younger ages

Kass, D. A., Duggal, P. & Cingolani, O., May 16 2020, In : The Lancet. 395, 10236, p. 1544-1545 2 p.

Research output: Contribution to journalLetter

Open Access

Research Priorities for Heart Failure with Preserved Ejection Fraction: National Heart, Lung, and Blood Institute Working Group Summary

Shah, S. J., Borlaug, B. A., Kitzman, D. W., McCulloch, A. D., Blaxall, B. C., Agarwal, R., Chirinos, J. A., Collins, S., Deo, R. C., Gladwin, M. T., Granzier, H., Hummel, S. L., Kass, D. A., Redfield, M. M., Sam, F., Wang, T. J., Desvigne-Nickens, P. & Adhikari, B. B., Mar 24 2020, In : Circulation. p. 1001-1026 26 p.

Research output: Contribution to journalReview article

2019

Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury

Barefield, D. Y., McNamara, J. W., Lynch, T. L., Kuster, D. W. D., Govindan, S., Haar, L., Wang, Y., Taylor, E. N., Lorenz, J. N., Nieman, M. L., Zhu, G., Luther, P. K., Varró, A., Dobrev, D., Ai, X., Janssen, P. M. L., Kass, D. A., Jones, W. K., Gilbert, R. J. & Sadayappan, S., Apr 2019, In : Journal of Molecular and Cellular Cardiology. 129, p. 236-246 11 p.

Research output: Contribution to journalArticle

Open Access

Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA

Ying, W., Zhao, D., Ouyang, P., Subramanya, V., Vaidya, D., Ndumele, C. E., Guallar, E., Sharma, K., Shah, S. J., Kass, D. A., Hoogeveen, R. C., Lima, J. A., Heckbert, S. R., deFilippi, C. R., Post, W. S. & Michos, E. D., Dec 17 2019, In : Journal of the American Heart Association. 8, 24, p. e013149

Research output: Contribution to journalArticle

Open Access

Chronic Atrial and Ventricular Pacing in the Mouse: Application to Model Cardiac Dyssynchrony and Resynchronization in Heart Failure

Ståhlberg, M., Nakagawa, R., Bedja, D., Zhu, G., Lin, B. L., Saberi, A., Lee, D. I. & Kass, D. A., Feb 1 2019, In : Circulation: Heart Failure. 12, 2, e005655.

Research output: Contribution to journalArticle

Fresh evidence overturns the identification of a factor involved in blood-vessel dilation

Kass, D. A., Feb 1 2019, In : Nature. 566, 7745, p. 462-464 3 p.

Research output: Contribution to journalComment/debate

Open Access

In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease

Lin, B. L., Matera, D., Doerner, J. F., Zheng, N., Del Camino, D., Mishra, S., Bian, H., Zeveleva, S., Zhen, X., Blair, N. T., Chong, J. A., Hessler, D. P., Bedja, D., Zhu, G., Muller, G. K., Ranek, M. J., Pantages, L., McFarland, M., Netherton, M. R., Berry, A. & 10 others, Wong, D., Rast, G., Qian, H. S., Weldon, S. M., Kuo, J. J., Sauer, A., Sarko, C., Moran, M. M., Kass, D. A. & Pullen, S. S., May 14 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 20, p. 10156-10161 6 p.

Research output: Contribution to journalArticle

Large particle fluorescence-activated cell sorting enables high-quality single-cell RNA sequencing and functional analysis of adult cardiomyocytes

Kannan, S., Miyamoto, M., Lin, B. L., Zhu, R., Murphy, S., Kass, D. A., Andersen, P. & Kwon, C., Aug 16 2019, In : Circulation research. 125, 5, p. 567-569 3 p.

Research output: Contribution to journalLetter

Leveraging Signaling Pathways to Treat Heart Failure with Reduced Ejection Fraction: Past, Present, and Future

Pinilla-Vera, M., Hahn, V. S. & Kass, D. A., May 24 2019, In : Circulation research. 124, 11, p. 1618-1632 15 p.

Research output: Contribution to journalArticle

Open Access

Nitrosative stress drives heart failure with preserved ejection fraction

Schiattarella, G. G., Altamirano, F., Tong, D., French, K. M., Villalobos, E., Kim, S. Y., Luo, X., Jiang, N., May, H. I., Wang, Z. V., Hill, T. M., Mammen, P. P. A., Huang, J., Lee, D., Hahn, V. S., Sharma, K., Kass, D. A., Lavandero, S., Gillette, T. G. & Hill, J. A., Apr 18 2019, In : Nature. 568, 7752, p. 351-356 6 p.

Research output: Contribution to journalArticle

Osteopontin Promotes Left Ventricular Diastolic Dysfunction Through a Mitochondrial Pathway

Yousefi, K., Irion, C. I., Takeuchi, L. M., Ding, W., Lambert, G., Eisenberg, T., Sukkar, S., Granzier, H. L., Methawasin, M., Lee, D. I., Hahn, V. S., Kass, D. A., Hatzistergos, K. E., Hare, J. M., Webster, K. A. & Shehadeh, L. A., Jun 4 2019, In : Journal of the American College of Cardiology. 73, 21, p. 2705-2718 14 p.

Research output: Contribution to journalArticle

PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

Ranek, M. J., Kokkonen-Simon, K. M., Chen, A., Dunkerly-Eyring, B. L., Vera, M. P., Oeing, C. U., Patel, C. H., Nakamura, T., Zhu, G., Bedja, D., Sasaki, M., Holewinski, R. J., Van Eyk, J., Powell, J. D., Lee, D. I. & Kass, D. A., Feb 14 2019, In : Nature. 566, 7743, p. 264-269 6 p.

Research output: Contribution to journalLetter

2018

Acute Enhancement of Cardiac Function by Phosphodiesterase Type 1 Inhibition

Hashimoto, T., Kim, G. E., Tunin, R. S., Adesiyun, T., Hsu, S., Nakagawa, R., Zhu, G., O'Brien, J. J., Hendrick, J. P., Davis, R. E., Yao, W., Beard, D., Hoxie, H. R., Wennogle, L. P., Lee, D. & Kass, D. A., Oct 30 2018, In : Circulation. 138, 18, p. 1974-1987 14 p.

Research output: Contribution to journalArticle

Histone lysine dimethyl-demethylase KDM3A controls pathological cardiac hypertrophy and fibrosis

Zhang, Q. J., Tran, T. A. T., Wang, M., Ranek, M., Kokkonen-Simon, K. M., Gao, J., Luo, X., Tan, W., Kyrychenko, V., Liao, L., Xu, J., Hill, J. A., Olson, E. N., Kass, D. A., Martinez, E. D. & Liu, Z. P., Dec 1 2018, In : Nature Communications. 9, 1, 5230.

Research output: Contribution to journalArticle

Identification of new PDE9A isoforms and how their expression and subcellular compartmentalization in the brain change across the life span

Patel, N. S., Klett, J., Pilarzyk, K., Lee, D., Kass, D. A., Menniti, F. S. & Kelly, M. P., May 1 2018, In : Neurobiology of Aging. 65, p. 217-234 18 p.

Research output: Contribution to journalArticle

Marked disparity of microRNA modulation by cGMP-selective PDE5 versus PDE9 inhibitors in heart disease

Kokkonen-Simon, K. M., Saberi, A., Nakamura, T., Ranek, M. J., Zhu, G., Bedja, D., Kuhn, M., Halushka, M. K., Lee, D. I. & Kass, D. A., Aug 9 2018, In : JCI Insight. 3, 15, e121739.

Research output: Contribution to journalArticle

Prevention of PKG-1α Oxidation Suppresses Antihypertrophic/Antifibrotic Effects From PDE5 Inhibition but not sGC Stimulation

Nakamura, T., Zhu, G., Ranek, M. J., Kokkonen-Simon, K., Zhang, M., Kim, G. E., Tsujita, K. & Kass, D. A., Mar 1 2018, In : Circulation. Heart failure. 11, 3, p. e004740

Research output: Contribution to journalArticle

Open Access

Protein S-Nitrosylation Controls Glycogen Synthase Kinase 3β Function Independent of Its Phosphorylation State

Wang, S., Venkatraman, V., Crowgey, E. L., Liu, T., Fu, Z., Holewinski, R., Ranek, M., Kass, D. A., O'Rourke, B. & Van Eyk, J. E., May 25 2018, In : Circulation Research. 122, 11, p. 1517-1531 15 p.

Research output: Contribution to journalArticle

Pulmonary Effective Arterial Elastance as a Measure of Right Ventricular Afterload and Its Prognostic Value in Pulmonary Hypertension Due to Left Heart Disease

Tampakakis, E., Shah, S. J., Borlaug, B. A., Leary, P. J., Patel, H. H., Miller, W. L., Kelemen, B. W., Houston, B. A., Kolb, T. M., Damico, R., Mathai, S. C., Kasper, E. K., Hassoun, P. M., Kass, D. A. & Tedford, R., Apr 1 2018, In : Circulation: Heart Failure. 11, 4, e004436.

Research output: Contribution to journalArticle

Randomized Evaluation of Heart Failure With Preserved Ejection Fraction Patients With Acute Heart Failure and Dopamine: The ROPA-DOP Trial

Osler Medical Housestaff, Oct 1 2018, In : JACC: Heart Failure. 6, 10, p. 859-870 12 p.

Research output: Contribution to journalArticle

2017

Cardiac phosphodiesterases and their modulation for treating heart disease

Kim, G. E. & Kass, D. A., 2017, Handbook of Experimental Pharmacology. Springer New York LLC, Vol. 243. p. 249-269 21 p. (Handbook of Experimental Pharmacology; vol. 243).

Research output: Chapter in Book/Report/Conference proceedingChapter

Cellular and Molecular Aspects of Dyssynchrony and Resynchronization

Kirk, J. A. & Kass, D. A., Jan 1 2017, In : Heart Failure Clinics. 13, 1, p. 29-41 13 p.

Research output: Contribution to journalReview article

From Heaven to Heart: Nitroxyl (HNO) in the Cardiovascular System and Beyond

Paolocci, N., Keceli, G., Wink, D. A. & Kass, D. A., Jan 1 2017, The Chemistry and Biology of Nitroxyl (HNO). Elsevier Inc., p. 353-387 35 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Heart Failure-Related Hyperphosphorylation in the Cardiac Troponin I C Terminus Has Divergent Effects on Cardiac Function In Vivo

Li, Y., Zhu, G., Paolocci, N., Zhang, P., Takahashi, C., Okumus, N., Heravi, A., Keceli, G., Ramirez-Correa, G., Kass, D. A. & Murphy, A. M., Sep 1 2017, In : Circulation. Heart failure. 10, 9

Research output: Contribution to journalArticle

Inorganic nitrates: Qi for heart failure with preserved ejection fraction?

Sharma, K. & Kass, D. A., Mar 31 2017, In : Circulation research. 120, 7, p. 1057-1059 3 p.

Research output: Contribution to journalReview article

Nanodomain Regulation of Cardiac Cyclic Nucleotide Signaling by Phosphodiesterases

Kokkonen, K. & Kass, D. A., Jan 6 2017, In : Annual Review of Pharmacology and Toxicology. 57, p. 455-479 25 p.

Research output: Contribution to journalReview article

Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy

Cho, G. S., Lee, D., Tampakakis, E., Murphy, S., Andersen, P., Uosaki, H., Chelko, S., Chakir, K., Hong, I., Seo, K., Chen, H. S. V., Chen, X., Basso, C., Houser, S. R., Tomaselli, G. F., O'Rourke, B., Judge, D. P., Kass, D. A. & Kwon, C., Jan 10 2017, In : Cell Reports. 18, 2, p. 571-582 12 p.

Research output: Contribution to journalArticle

Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice

Rouf, R., MacFarlane, E., Takimoto, E., Chaudhary, R., Nagpal, V., Rainer, P. P., Bindman, J. G., Gerber, E. E., Bedja, D., Schiefer, C., Miller, K. L., Zhu, G., Myers, L., Amat-Alarcon, N., Lee, D., Koitabashi, N., Judge, D. P., Kass, D. A. & Dietz, H. C., Aug 3 2017, In : JCI insight. 2, 15

Research output: Contribution to journalArticle

Open Access

Transient receptor potential channel 6 regulates abnormal cardiac S-nitrosylation in Duchenne muscular dystrophy

Chung, H. S., Kim, G. E., Holewinski, R. J., Venkatraman, V., Zhu, G., Bedja, D., Kass, D. A. & Van Eyk, J., Dec 12 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 50, p. E10763-E10771

Research output: Contribution to journalArticle

Ventricular Systolic Function

Kass, D. A., Jan 1 2017, Cardioskeletal Myopathies in Children and Young Adults. Elsevier Inc., p. 3-19 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Why publish in the American Journal of Physiology-heart and circulatory physiology?

Zucker, I. H., Lindsey, M. L., Delmar, M., De Windt, L. J., Des Rosiers, C., Diz, D. I., Hester, R. L., Jones, S. P., Kanagy, N. L., Kitakaze, M., Liao, R., Lopaschuk, G. D., Patel, K. P., Recchia, F. A., Sadoshima, J., Shah, A. M., Ungvari, Z., Benjamin, I. J., Blaustein, M. P., Charkoudian, N. & 7 others, Efimov, I. R., Gutterman, D., Kass, D. A., Liao, Y., O’Leary, D. S., Ripplinger, C. M. & Wolin, M. S., 2017, In : American Journal of Physiology - Heart and Circulatory Physiology. 313, 2, p. H221-H223

Research output: Contribution to journalEditorial

2016

A Simple Adaptive Transfer Function for Deriving the Central Blood Pressure Waveform from a Radial Blood Pressure Waveform

Gao, M., Rose, W. C., Fetics, B., Kass, D. A., Chen, C. H. & Mukkamala, R., Sep 14 2016, In : Scientific Reports. 6, 33230.

Research output: Contribution to journalArticle

Can Nitrite AMPk Up Sirt-ainty to Treat Heart Failure with Preserved Ejection Fraction?

Hsu, S. & Kass, D. A., Feb 23 2016, In : Circulation. 133, 8, p. 692-694 3 p.

Research output: Contribution to journalEditorial

Heart rate dependence of the pulmonary resistance x compliance (rc) time and impact on right ventricular load

Metkus, T., Mullin, C. J., Grandin, E. W., Rame, J. E., Tampakakis, E., Hsu, S., Kolb, T. M., Damico, R. L., Hassoun, P. M., Kass, D. A., Mathai, S. & Tedford, R. J., Nov 1 2016, In : PLoS One. 11, 11, e0166463.

Research output: Contribution to journalArticle

Mast cells regulate myofilament calcium sensitization and heart function after myocardial infarction

Ngkelo, A., Richart, A., Kirk, J. A., Bonnin, P., Vilar, J., Lemitre, M., Marck, P., Branchereau, M., Le Gall, S., Renault, N., Guerin, C., Ranek, M. J., Kervadec, A., Danelli, L., Gautier, G., Blank, U., Launay, P., Camerer, E., Bruneval, P., Menasche, P. & 7 others, Heymes, C., Luche, E., Casteilla, L., Cousin, B., Rodewald, H. R., Kass, D. A. & Silvestre, J. S., Jun 27 2016, In : Journal of Experimental Medicine. 213, 7, p. 1353-1374 22 p.

Research output: Contribution to journalArticle

Novel, single-beat approach for determining both end-systolic pressure-dimension relationship and preload recruitable stroke work

Inuzuka, R., Kass, D. A. & Senzaki, H., Jun 1 2016, In : Open Heart. 3, 1, e000451.

Research output: Contribution to journalArticle

Old dog, new tricks: Novel cardiac targets and stress regulation by protein kinase G

Rainer, P. P. & Kass, D. A., 2016, In : Cardiovascular Research. 111, 2, p. 154-162 9 p.

Research output: Contribution to journalReview article

Phenotype-specific treatment of heart failure with preserved ejection fraction

Shah, S. J., Kitzman, D. W., Borlaug, B. A., Van Heerebeek, L., Zile, M. R., Kass, D. A. & Paulus, W. J., Jul 5 2016, In : Circulation. 134, 1, p. 73-90 18 p.

Research output: Contribution to journalArticle

Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Iα Oxidation

Prysyazhna, O., Burgoyne, J. R., Scotcher, J., Grover, S., Kass, D. & Eaton, P., Aug 12 2016, In : Journal of Biological Chemistry. 291, 33, p. 17427-17436 10 p.

Research output: Contribution to journalArticle

Profilin modulates sarcomeric organization and mediates cardiomyocyte hypertrophy

Kooij, V., Viswanathan, M. C., Lee, D., Rainer, P. P., Schmidt, W., Kronert, W. A., Harding, S. E., Kass, D. A., Bernstein, S. I., Van Eyk, J. E. & Cammarato, A. R., May 15 2016, In : Cardiovascular Research. 110, 2, p. 238-248 11 p.

Research output: Contribution to journalArticle