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  • Thomas Hartung
2020

Antidepressant Paroxetine Exerts Developmental Neurotoxicity in an iPSC-Derived 3D Human Brain Model

Zhong, X., Harris, G., Smirnova, L., Zufferey, V., Sá, R. D. C. D. S. E., Baldino Russo, F., Baleeiro Beltrao Braga, P. C., Chesnut, M., Zurich, M. G., Hogberg, H. T., Hartung, T. & Pamies, D., Feb 21 2020, In : Frontiers in Cellular Neuroscience. 14, 25.

Research output: Contribution to journalArticle

Open Access
Open Access

EFSA - Johns Hopkins Food Safety Symposium 2019

Libowitz, L., Bloem, M. W., Hugas, M., Tsaioun, K., Url, B. & Hartung, T., Jan 1 2020, In : ALTEX. 37, 2, p. 312-314 3 p.

Research output: Contribution to journalEditorial

Open Access

Erratum to Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data

Krebs, A., Waldmann, T., Wilks, M. F., Van Vugt-Lussenburg, B. M. A., Van der Burg, B., Terron, A., Steger-Hartmann, T., Ruegg, J., Rovida, C., Pedersen, E., Pallocca, G., Luijten, M., Leite, S. B., Kustermann, S., Kamp, H., Hoeng, J., Hewitt, P., Herzler, M., Hengstler, J. G., Heinonen, T. & 16 others, Hartung, T., Hardy, B., Gantner, F., Fritsche, E., Fant, K., Ezendam, J., Exner, T., Dunkern, T., Dietrich, D. R., Coecke, S., Busquet, F., Braeuning, A., Bondarenko, O., Bennekou, S. H., Beilmann, M. & Leist, M., Jan 1 2020, In : ALTEX. 37, 1, 1 p.

Research output: Contribution to journalComment/debate

Open Access

Functionally Enigmatic Genes in Cancer: Using TCGA Data to Map the Limitations of Annotations

Maertens, A., Tran, V. H., Maertens, M., Kleensang, A., Luechtefeld, T. H., Hartung, T. & Paller, C. J., Dec 1 2020, In : Scientific reports. 10, 1, 4106.

Research output: Contribution to journalArticle

Open Access

Harnessing the power of novel animal-free test methods for the development of COVID-19 drugs and vaccines

Busquet, F., Hartung, T., Pallocca, G., Rovida, C. & Leist, M., Jun 1 2020, In : Archives of Toxicology. 94, 6, p. 2263-2272 10 p.

Research output: Contribution to journalEditorial

Open Access

iPS, organoids and 3D models as advanced tools for in vitro toxicology

Steimberg, N., Bertero, A., Chiono, V., Dell'Era, P., Di Angelantonio, S., Hartung, T., Perego, S., Raimondi, M., Xinaris, C., Caloni, F., De Angelis, I., Alloisio, S. & Baderna, D., Jan 1 2020, In : ALTEX. 37, 1, p. 136-140 5 p.

Research output: Contribution to journalEditorial

Open Access

Key read across framework components and biology based improvements

Ball, N., Madden, J., Paini, A., Mathea, M., Palmer, A. D., Sperber, S., Hartung, T. & van Ravenzwaay, B., May 2020, In : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 853, 503172.

Research output: Contribution to journalReview article

New European Union statistics on laboratory animal use - what really counts!

Busquet, F., Kleensang, A., Rovida, C., Herrmann, K., Leist, M. & Hartung, T., Jan 1 2020, In : ALTEX. 37, 2, p. 167-186 20 p.

Research output: Contribution to journalArticle

Open Access

The exposome - a new approach for risk assessment

Sillé, F. C. M., Karakitsios, S., Kleensang, A., Koehler, K., Maertens, A., Miller, G. W., Prasse, C., Quiros-Alcala, L., Ramachandran, G., Rappaport, S. M., Rule, A. M., Sarigiannis, D., Smirnova, L. & Hartung, T., Jan 1 2020, In : ALTEX. 37, 1, p. 3-23 21 p.

Research output: Contribution to journalEditorial

Open Access

Toxicity testing in the 21st century: progress in the past decade and future perspectives

Krewski, D., Andersen, M. E., Tyshenko, M. G., Krishnan, K., Hartung, T., Boekelheide, K., Wambaugh, J. F., Jones, D., Whelan, M., Thomas, R., Yauk, C., Barton-Maclaren, T. & Cote, I., Jan 1 2020, In : Archives of Toxicology. 94, 1

Research output: Contribution to journalReview article

Open Access
2019

Adaptation of the Systematic Review Framework to the Assessment of Toxicological Test Methods: Challenges and Lessons Learned with the Zebrafish Embryotoxicity Test

Stephens, M. L., Akgün-Ölmez, S. G., Hoffmann, S., De Vries, R., Flick, B., Hartung, T., Lalu, M., Maertens, A., Witters, H., Wright, R. & Tsaioun, K., Sep 1 2019, In : Toxicological Sciences. 171, 1, p. 56-68 13 p.

Research output: Contribution to journalReview article

Open Access

A Human iPSC-derived 3D platform using primary brain cancer cells to study drug development and personalized medicine

Plummer, S., Wallace, S., Ball, G., Lloyd, R., Schiapparelli, P., Quiñones-Hinojosa, A., Hartung, T. & Pamies, D., Dec 1 2019, In : Scientific reports. 9, 1, 1407.

Research output: Contribution to journalArticle

Corrigendum to Stage-specific metabolic features of differentiating neurons: Implications for toxicant sensitivity(Toxicology and Applied Pharmacology (2018)354 (64–80), (S0041008X17304945), (10.1016/j.taap.2017.12.013))

Delp, J., Gutbier, S., Cerff, M., Zasada, C., Niedenführ, S., Zhao, L., Smirnova, L., Hartung, T., Borlinghaus, H., Schreiber, F., Bergemann, J., Gätgens, J., Beyss, M., Azzouzi, S., Waldmann, T., Kempa, S., Nöh, K. & Leist, M., Jun 1 2019, In : Toxicology and Applied Pharmacology. 372, 1 p.

Research output: Contribution to journalComment/debate

Long-term effects of chromium on morphological and immunological parameters of Wistar rats

Karaulov, A. V., Renieri, E. A., Smolyagin, A. I., Mikhaylova, I. V., Stadnikov, A. A., Begun, D. N., Tsarouhas, K., Buha Djordjevic, A., Hartung, T. & Tsatsakis, A., Nov 2019, In : Food and Chemical Toxicology. 133, 110748.

Research output: Contribution to journalArticle

Nonanimal Models for Acute Toxicity Evaluations: Applying Data-Driven Profiling and Read-Across

Russo, D. P., Strickland, J., Karmaus, A. L., Wang, W., Shende, S., Hartung, T., Aleksunes, L. M. & Zhu, H., Apr 1 2019, In : Environmental health perspectives. 127, 4, 1 p.

Research output: Contribution to journalArticle

Open Access

Optimizing drug discovery by investigative toxicology: Current and future trends

Beilmann, M., Boonen, H., Czich, A., Dear, G., Hewitt, P., Mow, T., Newham, P., Oinonen, T., Pognan, F., Roth, A., Valentin, J. P., Van Goethem, F., Weaver, R. J., Birk, B., Boyer, S., Caloni, F., Chen, A. E., Corvi, R., Cronin, M. T. D., Daneshian, M. & 14 others, Ewart, L. C., FitzGerald, R. E., Hamilton, G. A., Hartung, T., Kangas, J. D., Kramer, N. I., Leist, M., Marx, U., Polak, S., Rovida, C., Testai, E., Van de Water, B., Vulto, P. & Steger-Hartmann, T., Jan 1 2019, In : ALTEX. 36, 2, p. 289-313 25 p.

Research output: Contribution to journalArticle

Open Access

Predicting toxicity of chemicals: software beats animal testing

Hartung, T., Jul 2019, In : EFSA Journal. 17, S1, e170710.

Research output: Contribution to journalArticle

Open Access

Suitability of 3D human brain spheroid models to distinguish toxic effects of gold and poly-lactic acid nanoparticles to assess biocompatibility for brain drug delivery

Leite, P. E. C., Pereira, M. R., Harris, G., Pamies, D., Dos Santos, L. M. G., Granjeiro, J. M., Hogberg, H. T., Hartung, T. & Smirnova, L., Jun 3 2019, In : Particle and Fibre Toxicology. 16, 1, 22.

Research output: Contribution to journalArticle

Open Access

Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data

Krebs, A., Waldmann, T., Wilks, M. F., Van Vugt-Lussenburg, B. M. A., Van der Burg, B., Terron, A., Steger-Hartmann, T., Ruegg, J., Rovida, C., Pedersen, E., Pallocca, G., Luijten, M., Leite, S. B., Kustermann, S., Kamp, H., Hoeng, J., Hewitt, P., Herzler, M., Hengstler, J. G., Heinonen, T. & 16 others, Hartung, T., Hardy, B., Gantner, F., Fritsche, E., Fant, K., Ezendam, J., Exner, T., Dunkern, T., Dietrich, D. R., Coecke, S., Busquet, F., Braeuning, A., Bondarenko, O., Bennekou, S. H., Beilmann, M. & Leist, M., Jan 1 2019, In : ALTEX. 36, 4, p. 682-699 18 p.

Research output: Contribution to journalArticle

Open Access

The effect of chronic vitamin deficiency and long term very low dose exposure to 6 pesticides mixture on neurological outcomes – A real-life risk simulation approach

Tsatsakis, A., Tyshko, N. V., Docea, A. O., Shestakova, S. I., Sidorova, Y. S., Petrov, N. A., Zlatian, O., Mach, M., Hartung, T. & Tutelyan, V. A., Oct 15 2019, In : Toxicology Letters. 315, p. 96-106 11 p.

Research output: Contribution to journalArticle

Toward good in vitro reporting standards

Hartung, T., de Vries, R., Hoffmann, S., Hogberg, H. T., Smirnova, L., Tsaioun, K., Whaley, P. & Leist, M., Jan 1 2019, In : ALTEX. 36, 1, p. 3-17 15 p.

Research output: Contribution to journalArticle

Towards quality assurance and quality control in untargeted metabolomics studies

Beger, R. D., Dunn, W. B., Bandukwala, A., Bethan, B., Broadhurst, D., Clish, C. B., Dasari, S., Derr, L., Evans, A., Fischer, S., Flynn, T., Hartung, T., Herrington, D., Higashi, R., Hsu, P. C., Jones, C., Kachman, M., Karuso, H., Kruppa, G., Lippa, K. & 18 others, Maruvada, P., Mosley, J., Ntai, I., O’Donovan, C., Playdon, M., Raftery, D., Shaughnessy, D., Souza, A., Spaeder, T., Spalholz, B., Tayyari, F., Ubhi, B., Verma, M., Walk, T., Wilson, I., Witkin, K., Bearden, D. W. & Zanetti, K. A., Jan 1 2019, In : Metabolomics. 15, 1, 4.

Research output: Contribution to journalArticle

Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer

Nguyen, T., Kirsch, B. J., Asaka, R., Nabi, K., Quinones, A., Tan, J., Antonio, M. J., Camelo, F., Li, T., Nguyen, S., Hoang, G., Nguyen, K., Udupa, S., Sazeides, C., Shen, Y. A., Elgogary, A., Reyes, J., Zhao, L., Kleensang, A., Chaichana, K. L. & 7 others, Hartung, T., Betenbaugh, M. J., Marie, S. K., Jung, J. G., Wang, T. L., Gabrielson, E. & Le, A., Apr 9 2019, In : Cell Reports. 27, 2, p. 491-501.e6

Research output: Contribution to journalArticle

Open Access
2018

3S - Systematic, systemic, and systems biology and toxicology

Smirnova, L., Kleinstreuer, N., Corvi, R., Levchenko, A., Fitzpatrick, S. C. & Hartung, T., Jan 1 2018, In : Altex. 35, 2, p. 139-162 24 p.

Research output: Contribution to journalArticle

Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems

Pamies, D., Bal-Price, A., Chesné, C., Coecke, S., Dinnyes, A., Eskes, C., Grillari, R., Gstraunthaler, G., Hartung, T., Jennings, P., Leist, M., Martin, U., Passier, R., Schwamborn, J. C., Stacey, G. N., Ellinger-Ziegelbauer, H. & Daneshian, M., Jan 1 2018, In : ALTEX. 35, 3, p. 353-378 26 p.

Research output: Contribution to journalArticle

Alternative Approaches for Carcinogenicity and Reproductive Toxicity

Corvi, R., Spielmann, H. & Hartung, T., Oct 22 2018, The History of Alternative Test Methods in Toxicology. Elsevier, p. 209-217 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Animal testing and its alternatives - the most important omics is economics

Meigs, L., Smirnova, L., Rovida, C., Leist, M. & Hartung, T., Jan 1 2018, In : ALTEX. 35, 3, p. 275-305 31 p.

Research output: Contribution to journalArticle

A Perspective and a New Integrated Computational Strategy for Skin Sensitization Assessment

Alves, V. M., Capuzzi, S. J., Braga, R. C., Borba, J. V. B., Silva, A. C., Luechtefeld, T., Hartung, T., Andrade, C. H., Muratov, E. N. & Tropsha, A., Mar 5 2018, In : ACS Sustainable Chemistry and Engineering. 6, 3, p. 2845-2859 15 p.

Research output: Contribution to journalReview article

Big-data and machine learning to revamp computational toxicology and its use in risk assessment

Luechtefeld, T., Rowlands, C. & Hartung, T., Jan 1 2018, In : Toxicology Research. 7, 5, p. 732-744 13 p.

Research output: Contribution to journalArticle

Green Toxicology-know early about and avoid toxic product liabilities

Maertens, A. & Hartung, T., Feb 1 2018, In : Toxicological Sciences. 161, 2, p. 285-289 5 p., kfx243.

Research output: Contribution to journalEditorial

Human 3D in vitro models for developmental neurotoxicity

Smirnova, L. & Hartung, T., Jan 1 2018, Handbook of Developmental Neurotoxicology. Elsevier, p. 163-172 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Induction of IL-10-balanced immune profiles following exposure to LTA from Staphylococcus epidermidis

Volz, T., Kaesler, S., Draing, C., Hartung, T., Röcken, M., Skabytska, Y. & Biedermann, T., Apr 1 2018, In : Experimental Dermatology. 27, 4, p. 318-326 9 p.

Research output: Contribution to journalArticle

Machine learning of toxicological big data enables read-across structure activity relationships (RASAR) outperforming animal test reproducibility

Luechtefeld, T., Marsh, D., Rowlands, C. & Hartung, T., Jan 1 2018, In : Toxicological Sciences. 165, 1, p. 198-212 15 p.

Research output: Contribution to journalArticle

Perspectives on in vitro to in vivo extrapolations

Hartung, T., Dec 1 2018, In : Applied In Vitro Toxicology. 4, 4, p. 305-316 12 p.

Research output: Contribution to journalReview article

Rebooting the generally recognized as safe (GRAS) approach for food additive safety in the US

Hartung, T., Jan 1 2018, In : Altex. 35, 1, p. 3-25 23 p.

Research output: Contribution to journalArticle

Regulatory acceptance of read-across

Chesnut, M., Yamada, T., Adams, T., Knight, D., Kleinstreuer, N., Kass, G., Luechtefeld, T. & Hartung, T., Jan 1 2018, In : ALTEX. 35, 3, p. 413-419 7 p.

Research output: Contribution to journalArticle

Rotenone exerts developmental neurotoxicity in a human brain spheroid model

Pamies, D., Block, K., Lau, P., Gribaldo, L., Pardo, C. A., Barreras, P., Smirnova, L., Wiersma, D., Zhao, L., Harris, G., Hartung, T. & Hogberg, H. T., Sep 1 2018, In : Toxicology and Applied Pharmacology. 354, p. 101-114 14 p.

Research output: Contribution to journalArticle

Stage-specific metabolic features of differentiating neurons: Implications for toxicant sensitivity

Delp, J., Gutbier, S., Cerff, M., Zasada, C., Niedenführ, S., Zhao, L., Smirnova, L., Hartung, T., Borlinghaus, H., Schreiber, F., Bergemann, J., Gätgens, J., Beyss, M., Azzouzi, S., Waldmann, T., Kempa, S., Nöh, K. & Leist, M., Jan 1 2018, (Accepted/In press) In : Toxicology and Applied Pharmacology.

Research output: Contribution to journalArticle

The Center for Alternatives to Animal Testing in the USA and Europe

Goldberg, A., Leist, M. & Hartung, T., Oct 22 2018, The History of Alternative Test Methods in Toxicology. Elsevier, p. 109-117 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Toxicity, recovery, and resilience in a 3D dopaminergic neuronal in vitro model exposed to rotenone

Harris, G., Eschment, M., Orozco, S. P., McCaffery, J. M., Maclennan, R., Severin, D., Leist, M., Kleensang, A., Pamies, D., Maertens, A., Hogberg, H. T., Freeman, D., Kirkwood, A., Hartung, T. & Smirnova, L., Aug 1 2018, In : Archives of Toxicology. 92, 8, p. 2587-2606 20 p.

Research output: Contribution to journalArticle

2017

21st Century Cell Culture for 21st Century Toxicology

Pamies, D. & Hartung, T., Jan 17 2017, In : Chemical Research in Toxicology. 30, 1, p. 43-52 10 p.

Research output: Contribution to journalArticle

A Comprehensive Overview of the Current Status and Application of Predictive ADMET: Introduction and Overview

Hartung, T., Jun 3 2017, Experimental Adme and Toxicology. Elsevier Inc., Vol. 4-8. p. 150-155 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Advanced cell techniques to study developmental neurobiology and toxicology

Hartung, T., Hogberg, H., Leist, M., Pamies, D. & Smirnova, L., Jan 1 2017, Neural Cell Biology. CRC Press, p. 187-217 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Adverse outcome pathways: opportunities, limitations and open questions

Leist, M., Ghallab, A., Graepel, R., Marchan, R., Hassan, R., Bennekou, S. H., Limonciel, A., Vinken, M., Schildknecht, S., Waldmann, T., Danen, E., van Ravenzwaay, B., Kamp, H., Gardner, I., Godoy, P., Bois, F. Y., Braeuning, A., Reif, R., Oesch, F., Drasdo, D. & 33 others, Höhme, S., Schwarz, M., Hartung, T., Braunbeck, T., Beltman, J., Vrieling, H., Sanz, F., Forsby, A., Gadaleta, D., Fisher, C., Kelm, J., Fluri, D., Ecker, G., Zdrazil, B., Terron, A., Jennings, P., van der Burg, B., Dooley, S., Meijer, A. H., Willighagen, E., Martens, M., Evelo, C., Mombelli, E., Taboureau, O., Mantovani, A., Hardy, B., Koch, B., Escher, S., van Thriel, C., Cadenas, C., Kroese, D., van de Water, B. & Hengstler, J. G., Nov 1 2017, In : Archives of Toxicology. 91, 11, p. 3477-3505 29 p.

Research output: Contribution to journalArticle

A human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity

Pamies, D., Barreras, P., Block, K., Makri, G., Kumar, A., Wiersma, D., Smirnova, L., Zhang, C., Bressler, J., Christian, K. M., Harris, G., Ming, G. L., Berlinicke, C. J., Kyro, K., Song, H., Pardo, C. A., Hartung, T. & Hogberg, H. T., Jan 1 2017, In : ALTEX. 34, 3, p. 362-376 15 p.

Research output: Contribution to journalArticle

A primer on systematic reviews in toxicology

Hoffmann, S., de Vries, R. B. M., Stephens, M. L., Beck, N. B., Dirven, H. A. A. M., Fowle, J. R., Goodman, J. E., Hartung, T., Kimber, I., Lalu, M. M., Thayer, K., Whaley, P., Wikoff, D. & Tsaioun, K., May 13 2017, (Accepted/In press) In : Archives of Toxicology. p. 1-25 25 p.

Research output: Contribution to journalArticle

CIIPro: a new read-across portal to fill data gaps using public large-scale chemical and biological data

Russo, D. P., Kim, M. T., Wang, W., Pinolini, D., Shende, S., Strickland, J., Hartung, T. & Zhu, H., Feb 1 2017, In : Bioinformatics (Oxford, England). 33, 3, p. 464-466 3 p.

Research output: Contribution to journalArticle