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  • Kenneth Pienta
2012

Forging the Association for Clinical and Translational Science (ACTS)

Pienta, K. J., Gelato, M. C. & Lichtenstein, M. J., Apr 1 2012, In : Clinical and translational science. 5, 2, p. 117-118 2 p.

Research output: Contribution to journalArticle

Hypoxia stabilizes GAS6/Axl signaling in metastatic prostate cancer

Mishra, A., Wang, J., Shiozawa, Y., McGee, S., Kim, J., Jung, Y., Joseph, J., Berry, J. E., Havens, A., Pienta, K. J. & Taichman, R. S., Jun 1 2012, In : Molecular Cancer Research. 10, 6, p. 703-712 10 p.

Research output: Contribution to journalArticle

IL-4 induces proliferation in prostate cancer PC3 cells under nutrient-depletion stress through the activation of the JNK-pathway and survivin up-regulation

Roca, H., Craig, M. J., Ying, C., Varsos, Z. S., Czarnieski, P., Alva, A. S., Hernandez, J., Fuller, D., Daignault, S., Healy, P. N. & Pienta, K. J., May 2012, In : Journal of cellular biochemistry. 113, 5, p. 1569-1580 12 p.

Research output: Contribution to journalArticle

Inhibition of prostate cancer bone metastasis by synthetic TF antigen mimic/galectin-3 inhibitor lactulose-L-leucine

Glinskii, O. V., Sud, S., Mossine, V. V., Mawhinney, T. P., Anthony, D. C., Glinsky, G. V., Pienta, K. J. & Glinsky, V. V., Jan 2012, In : Neoplasia. 14, 1, p. 65-73 9 p.

Research output: Contribution to journalArticle

Micro-ring structures stabilize microdroplets to enable long term spheroid culture in 384 hanging drop array plates

Hsiao, A. Y., Tung, Y. C., Kuo, C. H., Mosadegh, B., Bedenis, R., Pienta, K. J. & Takayama, S., Apr 1 2012, In : Biomedical microdevices. 14, 2, p. 313-323 11 p.

Research output: Contribution to journalArticle

Phase II study of Cilengitide (EMD 121974, NSC 707544) in patients with non-metastatic castration resistant prostate cancer, NCI-6735. A study by the DOD/PCF prostate cancer clinical trials consortium

Alva, A., Slovin, S., Daignault, S., Carducci, M., DiPaola, R., Pienta, K., Agus, D., Cooney, K., Chen, A., Smith, D. C. & Hussain, M., Apr 1 2012, In : Investigational New Drugs. 30, 2, p. 749-757 9 p.

Research output: Contribution to journalArticle

Prevalence of prostate cancer metastases after intravenous inoculation provides clues into the molecular basis of dormancy in the bone marrow microenvironment

Jung, Y., Shiozawa, Y., Wang, J., Mcgregor, N., Dai, J., Park, S. I., Berry, J. E., Havens, A. M., Joseph, J., Kim, J. K., Patel, L., Carmeliet, P., Daignault, S., Keller, E. T., Mccauley, L. K., Pienta, K. J. & Taichman, R. S., May 2012, In : Neoplasia (United States). 14, 5, p. 429-439 11 p.

Research output: Contribution to journalArticle

Prostate cancer and parasitism of the bone hematopoietic stem cell niche

Yu, C., Shiozawa, Y., Taichman, R. S., McCauley, L. K., Pienta, K. J. & Keller, E. T., Sep 1 2012, In : Critical Reviews in Eukaryotic Gene Expression. 22, 2, p. 131-148 18 p.

Research output: Contribution to journalArticle

Role of dutasteride in pre-clinical ETS fusion-positive prostate cancer models

Ateeq, B., Vellaichamy, A., Tomlins, S. A., Wang, R., Cao, Q., Lonigro, R. J., Pienta, K. J. & Varambally, S., Oct 1 2012, In : Prostate. 72, 14, p. 1542-1549 8 p.

Research output: Contribution to journalArticle

Role of transcriptional corepressor CtBP1 in prostate cancer progression

Wang, R., Asangani, I. A., Chakravarthi, B. V. S. K., Ateeq, B., Lonigro, R. J., Cao, Q., Mani, R. S., Camacho, D. F., McGregor, N., Schumann, T. E. W., Jing, X., Menawat, R., Tomlins, S. A., Zheng, H., Otte, A. P., Mehra, R., Siddiqui, J., Dhanasekaran, S. M., Nyati, M. K., Pienta, K. J. & 5 others, Palanisamy, N., Kunju, L. P., Rubin, M. A., Chinnaiyan, A. M. & Varambally, S., Oct 2012, In : Neoplasia (United States). 14, 10, p. 905-914 10 p.

Research output: Contribution to journalArticle

Systemic delivery of oncolytic adenoviruses targeting transforming growth factor-β inhibits established bone metastasis in a prostate cancer mouse model

Hu, Z., Gupta, J., Zhang, Z., Gerseny, H., Berg, A., Chen, Y. J., Zhang, Z., Du, H., Brendler, C. B., Xiao, X., Pienta, K. J., Guise, T., Lee, C., Stern, P. H., Stock, S. & Seth, P., Aug 1 2012, In : Human gene therapy. 23, 8, p. 871-882 12 p.

Research output: Contribution to journalArticle

The mutational landscape of lethal castration-resistant prostate cancer

Grasso, C. S., Wu, Y. M., Robinson, D. R., Cao, X., Dhanasekaran, S. M., Khan, A. P., Quist, M. J., Jing, X., Lonigro, R. J., Brenner, J. C., Asangani, I. A., Ateeq, B., Chun, S. Y., Siddiqui, J., Sam, L., Anstett, M., Mehra, R., Prensner, J. R., Palanisamy, N., Ryslik, G. A. & 7 others, Vandin, F., Raphael, B. J., Kunju, L. P., Rhodes, D. R., Pienta, K. J., Chinnaiyan, A. M. & Tomlins, S. A., Jul 12 2012, In : Nature. 487, 7406, p. 239-243 5 p.

Research output: Contribution to journalArticle

The prostate cancer bone marrow niche: More than just fertile soil

Pedersen, E. A., Shiozawa, Y., Pienta, K. J. & Taichman, R. S., May 1 2012, In : Asian Journal of Andrology. 14, 3, p. 423-427 5 p.

Research output: Contribution to journalReview article

2011

Activation of urokinase plasminogen activator and its receptor axis is essential for macrophage infiltration in a prostate cancer mouse model

Zhang, J., Sud, S., Mizutani, K., Gyetko, M. R. & Pienta, K. J., Jan 2011, In : Neoplasia. 13, 1, p. 23-30 8 p.

Research output: Contribution to journalArticle

Centralized research recruitment-evolving a local clinical research recruitment web application to better meet user needs.

Dwyer-White, M., Doshi, A., Hill, M. & Pienta, K. J., Oct 2011, In : Clinical and translational science. 4, 5, p. 363-368 6 p.

Research output: Contribution to journalArticle

Characterization of bone metastases from rapid autopsies of prostate cancer patients

Mehra, R., Kumar-Sinha, C., Shankar, S., Lonigro, R. J., Jing, X., Philips, N. E., Siddiqui, J., Han, B., Cao, X., Smith, D. C., Shah, R. B., Chinnaiyan, A. M. & Pienta, K. J., Jun 15 2011, In : Clinical Cancer Research. 17, 12, p. 3924-3932 9 p.

Research output: Contribution to journalArticle

Copy number and targeted mutational analysis reveals novel somatic events in metastatic prostate tumors

Robbins, C. M., Tembe, W. A., Baker, A., Sinari, S., Moses, T. Y., Beckstrom-Sternberg, S., Beckstrom-Sternberg, J., Barrett, M., Long, J., Chinnaiyan, A., Lowey, J., Suh, E., Pearson, J. V., Craig, D. W., Agus, D. B., Pienta, K. J. & Carpten, J. D., Jan 2011, In : Genome research. 21, 1, p. 47-55 9 p.

Research output: Contribution to journalArticle

Detection of somatic copy number alterations in cancerusing targeted exome capture sequencing

Lonigro, R. J., Grasso, C. S., Robinson, D. R., Jing, X., Wu, Y. M., Cao, X., Quist, M. J., Tomlins, S. A., Pienta, K. J. & Chinnaiyan, A. M., Nov 2011, In : Neoplasia. 13, 11, p. 1019-1025 7 p.

Research output: Contribution to journalArticle

Drugs which inhibit osteoclast function suppress tumor growth through calcium reduction in bone

Li, X., Liao, J., Park, S. I., Koh, A. J., Sadler, W. D., Pienta, K. J., Rosol, T. J. & McCauley, L. K., Jun 1 2011, In : Bone. 48, 6, p. 1354-1361 8 p.

Research output: Contribution to journalArticle

Erratum: CXCL12 / CXCR4 / CXCR7 chemokine axis and cancer progression (Cancer and Metastasis Reviews (2010) 29 (709-722) DOI: 10.1007/s10555-010-9256- x)

Sun, X., Cheng, G., Hao, M., Zheng, J., Zhou, X., Zhang, J., Taichman, R. S., Pienta, K. J. & Wang, J., Jun 1 2011, In : Cancer and Metastasis Reviews. 30, 2, p. 269-270 2 p.

Research output: Contribution to journalComment/debate

Erratum: Cilengitide (EMD 121974, NSC 707544) in asymptomatic metastatic castration resistant prostate cancer patients: A randomized phase II trial by the prostate cancer clinical trials consortium (Investigational New Drugs DOI: 10.1007/s10637-010-9420-8)

Bradley, D. A., Daignault, S., Ryan, C. J., DiPaola, R. S., Cooney, K. A., Smith, D. C., Small, E., Mathew, P., Gross, M. E., Stein, M. N., Chen, A., Pienta, K. J., Escara-Wilke, J., Doyle, G., Al-Hawary, M., Keller, E. T. & Hussain, M., Dec 1 2011, In : Investigational New Drugs. 29, 6, p. 1517-1518 2 p.

Research output: Contribution to journalComment/debate

Hematopoietic stem cell niche is a potential therapeutic target for bone metastatic tumors

Shiozawa, Y., Pienta, K. J. & Taichman, R. S., Sep 1 2011, In : Clinical Cancer Research. 17, 17, p. 5553-5558 6 p.

Research output: Contribution to journalReview article

Homing of cancer cells to the bone

Mishra, A., Shiozawa, Y., Pienta, K. J. & Taichman, R. S., Dec 1 2011, In : Cancer Microenvironment. 4, 3, p. 221-235 15 p.

Research output: Contribution to journalReview article

Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow

Shiozawa, Y., Pedersen, E. A., Havens, A. M., Jung, Y., Mishra, A., Joseph, J., Kim, J. K., Patel, L. R., Ying, C., Ziegler, A. M., Pienta, M. J., Song, J., Wang, J., Loberg, R. D., Krebsbach, P. H., Pienta, K. J. & Taichman, R. S., Apr 1 2011, In : Journal of Clinical Investigation. 121, 4, p. 1298-1312 15 p.

Research output: Contribution to journalArticle

Inherited variants in the chemokine CCL2 gene and prostate cancer aggressiveness in a caucasian cohort

Sun, T., Lee, G. S. M., Oh, W. K., Freedman, M. L., Pomerantz, M., Pienta, K. J. & Kantoff, P. W., Mar 15 2011, In : Clinical Cancer Research. 17, 6, p. 1546-1552 7 p.

Research output: Contribution to journalArticle

Inhibitory effects of megakaryocytic cells in prostate cancer skeletal metastasis

Li, X., Koh, A. J., Wang, Z., Soki, F. N., Park, S. I., Pienta, K. J. & McCauley, L. K., Jan 1 2011, In : Journal of Bone and Mineral Research. 26, 1, p. 125-134 10 p.

Research output: Contribution to journalArticle

Mechanisms of cancer cell metastasis to the bone: A multistep process

Patel, L. R., Camacho, D. F., Shiozawa, Y., Pienta, K. J. & Taichman, R. S., Nov 1 2011, In : Future Oncology. 7, 11, p. 1285-1297 13 p.

Research output: Contribution to journalReview article

Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer

Brenner, J. C., Ateeq, B., Li, Y., Yocum, A. K., Cao, Q., Asangani, I. A., Patel, S., Wang, X., Liang, H., Yu, J., Palanisamy, N., Siddiqui, J., Yan, W., Cao, X., Mehra, R., Sabolch, A., Basrur, V., Lonigro, R. J., Yang, J., Tomlins, S. A. & 8 others, Maher, C. A., Elenitoba-Johnson, K. S. J., Hussain, M., Navone, N. M., Pienta, K. J., Varambally, S., Feng, F. Y. & Chinnaiyan, A. M., May 17 2011, In : Cancer cell. 19, 5, p. 664-678 15 p.

Research output: Contribution to journalArticle

Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets

Beltran, H., Rickman, D. S., Park, K., Chae, S. S., Sboner, A., MacDonald, T. Y., Wang, Y., Sheikh, K. L., Terry, S., Tagawa, S. T., Dhir, R., Nelson, J. B., de la Taille, A., Allory, Y., Gerstein, M. B., Perner, S., Pienta, K. J., Chinnaiyan, A. M., Wang, Y., Collins, C. C. & 4 others, Gleave, M. E., Demichelis, F., Nanus, D. M. & Rubin, M. A., Nov 2011, In : Cancer discovery. 1, 6, p. 487-495 9 p.

Research output: Contribution to journalArticle

Nanoparticle induced cell magneto-rotation: Monitoring morphology, stress and drug sensitivity of a suspended single cancer cell

Elbez, R., McNaughton, B. H., Patel, L., Pienta, K. J. & Kopelman, R., Dec 13 2011, In : PloS one. 6, 12, e28475.

Research output: Contribution to journalArticle

Personalized oncology through integrative high-throughput sequencing: A pilot study

Roychowdhury, S., Iyer, M. K., Robinson, D. R., Lonigro, R. J., Wu, Y. M., Cao, X., Kalyana-Sundaram, S., Sam, L., Balbin, O. A., Quist, M. J., Barrette, T., Everett, J., Siddiqui, J., Kunju, L. P., Navone, N., Araujo, J. C., Troncoso, P., Logothetis, C. J., Innis, J. W., Smith, D. C. & 7 others, Lao, C. D., Kim, S. Y., Roberts, J. S., Gruber, S. B., Pienta, K. J., Talpaz, M. & Chinnaiyan, A. M., Nov 30 2011, In : Science translational medicine. 3, 111, 111ra121.

Research output: Contribution to journalArticle

The importance of proposed changes in the "Common Rule" for -clinical and translational researchers.

Selker, H. P. & Pienta, K. J., Oct 2011, In : Clinical and translational science. 4, 5, p. 312-313 2 p.

Research output: Contribution to journalEditorial

Therapeutic targeting of SPINK1-positive prostate cancer

Ateeq, B., Tomlins, S. A., Laxman, B., Asangani, I. A., Cao, Q., Cao, X., Li, Y., Wang, X., Feng, F. Y., Pienta, K. J., Varambally, S. & Chinnaiyan, A. M., Mar 2 2011, In : Science translational medicine. 3, 72, 72ra17.

Research output: Contribution to journalArticle