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  • Kenneth Pienta
2015

Oligometastatic Prostate Cancer to the Navicular Bone: Case Report

Reyes, D. K., Miller, J. A., Cerrato, R. A. & Pienta, K. J., May 1 2015, In : Urology Case Reports. 3, 3, p. 59-62 4 p.

Research output: Contribution to journalArticle

OVOL guides the epithelial-hybrid-mesenchymal transition

Jia, D., Jolly, M. K., Boareto, M., Parsana, P., Mooney, S. M., Pienta, K. J., Levine, H. & Ben-Jacob, E., Jan 1 2015, In : Oncotarget. 6, 17, p. 15436-15448 13 p.

Research output: Contribution to journalArticle

Open Access

The biology and treatment of oligometastatic cancer

Reyes, D. K. & Pienta, K. J., 2015, In : Oncotarget. 6, 11, p. 8491-8524 34 p.

Research output: Contribution to journalArticle

Open Access

The presence of androgen receptor elements regulates ZEB1 expression in the absence of androgen receptor

Mooney, S. M., Parsana, P., Hernandez, J. R., Liu, X., Verdone, J. E., Torga, G., Harberg, C. A. & Pienta, K. J., Jan 1 2015, In : Journal of cellular biochemistry. 116, 1, p. 115-123 9 p.

Research output: Contribution to journalArticle

Therapy decisions for the symptomatic patient with metastatic castration-resistant prostate cancer

Markowski, M. C. & Pienta, K. J., Nov 1 2015, In : Asian Journal of Andrology. 17, 6, p. 936-938 3 p.

Research output: Contribution to journalReview article

Tumor repression of VCaP xenografts by a pyrrole-imidazole polyamide

Hargrove, A. E., Martinez, T. F., Hare, A. A., Kurmis, A. A., Phillips, J. W., Sud, S., Pienta, K. J. & Dervan, P. B., Nov 1 2015, In : PloS one. 10, 11, e0143161.

Research output: Contribution to journalArticle

2014

A bioinformatics approach reveals novel interactions of the OVOL transcription factors in the regulation of epithelial - mesenchymal cell reprogramming and cancer progression

Roca, H., Pande, M., Huo, J. S., Hernandez, J., Cavalcoli, J. D., Pienta, K. J. & McEachin, R. C., Mar 10 2014, In : BMC Systems Biology. 8, 1, 29.

Research output: Contribution to journalArticle

A multi-targeted approach to treating bone metastases

Camacho, D. F. & Pienta, K. J., Sep 2014, In : Cancer and Metastasis Reviews. 33, 2-3, p. 545-553 9 p.

Research output: Contribution to journalArticle

Axl as a mediator of cellular growth and survival

Axelrod, H. & Pienta, K. J., Jan 1 2014, In : Oncotarget. 5, 19, p. 8818-8852 35 p.

Research output: Contribution to journalArticle

Open Access

Beyond the androgen receptor: New approaches to treating metastatic prostate cancer. Report of the 2013 Prouts Neck Prostate Cancer Meeting

Pienta, K. J., Walia, G., Simons, J. W. & Soule, H. R., Feb 1 2014, In : Prostate. 74, 3, p. 314-320 7 p.

Research output: Contribution to journalArticle

Classification of current anticancer immunotherapies

Galluzzi, L., Vacchelli, E., Bravo-San Pedro, J. M., Buqué, A., Senovilla, L., Baracco, E. E., Bloy, N., Castoldi, F., Abastado, J. P., Agostinis, P., Apte, R. N., Aranda, F., Ayyoub, M., Beckhove, P., Blay, J. Y., Bracci, L., Caignard, A., Castelli, C., Cavallo, F., Celis, E. & 68 others, Cerundolo, V., Clayton, A., Colombo, M. P., Coussens, L., Dhodapkar, M. V., Eggermont, A. M., Fearon, D. T., Fridman, W. H., Fucíková, J., Gabrilovich, D. I., Galon, J., Garg, A., Ghiringhelli, F., Giaccone, G., Gilboa, E., Gnjatic, S., Hoos, A., Hosmalin, A., Jäger, D., Kalinski, P., Kärre, K., Kepp, O., Kiessling, R., Kirkwood, J. M., Klein, E., Knuth, A., Lewis, C. E., Liblau, R., Lotze, M. T., Lugli, E., Mach, J. P., Mattei, F., Mavilio, D., Melero, I., Melief, C. J., Mittendorf, E. A., Moretta, L., Odunsi, A., Okada, H., Palucka, A. K., Peter, M. E., Pienta, K. J., Porgador, A., Prendergast, G. C., Rabinovich, G. A., Restifo, N. P., Rizvi, N., Sautès-Fridman, C., Schreiber, H., Seliger, B., Shiku, H., Silva-Santos, B., Smyth, M. J., Speiser, D. E., Spisek, R., Srivastava, P. K., Talmadge, J. E., Tartour, E., Van Der Burg, S. H., Van Den Eynde, B. J., Vile, R., Wagner, H., Weber, J. S., Whiteside, T. L., Wolchok, J. D., Zitvogel, L., Zou, W. & Kroemer, G., 2014, In : Oncotarget. 5, 24, p. 12472-12508 37 p.

Research output: Contribution to journalArticle

Open Access

Critical transitions in a game theoretic model of tumour metabolism

Ardeshir, K., Veltri, R. & Pienta, K. J., Aug 6 2014, In : Interface Focus. 4, 4, 20140014.

Research output: Contribution to journalArticle

Cross-Species Regulatory Network Analysis Identifies a Synergistic Interaction between FOXM1 and CENPF that Drives Prostate Cancer Malignancy

Aytes, A., Mitrofanova, A., Lefebvre, C., Alvarez, M. J., Castillo-Martin, M., Zheng, T., Eastham, J. A., Gopalan, A., Pienta, K. J., Shen, M. M., Califano, A. & Abate-Shen, C., May 12 2014, In : Cancer cell. 25, 5, p. 638-651 14 p.

Research output: Contribution to journalArticle

Dynamic regulation of Rad51 by E2F1 and p53 in prostate cancer cells upon drug-induced DNA damage under hypoxia

Wu, M., Wang, X., McGregor, N., Pienta, K. J. & Zhang, J., Jun 2014, In : Molecular Pharmacology. 85, 6, p. 866-876 11 p.

Research output: Contribution to journalArticle

Endothelial integrin α3β1 stabilizes carbohydrate-mediated tumor/endothelial cell adhesion and induces macromolecular signaling complex formation at the endothelial cell membrane

Glinskii, O. V., Li, F., Wilson, L. S., Barnes, S., Rittenhouse-Olson, K., Barchi, J. J., Pienta, K. J. & Glinsky, V. V., 2014, In : Oncotarget. 5, 5, p. 1382-1389 8 p.

Research output: Contribution to journalArticle

Open Access

Frequent discordance between ERG gene rearrangement and ERG protein expression in a rapid autopsy cohort of patients with lethal, metastatic, castration-resistant prostate cancer

Udager, A. M., Shi, Y., Tomlins, S. A., Alva, A., Siddiqui, J., Cao, X., Pienta, K. J., Jiang, H., Chinnaiyan, A. M. & Mehra, R., Sep 2014, In : Prostate. 74, 12, p. 1199-1208 10 p.

Research output: Contribution to journalArticle

Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis

Wan, L., Hu, G., Wei, Y., Yuan, M., Bronson, R. T., Yang, Q., Siddiqui, J., Pienta, K. J. & Kang, Y., Jul 29 2014, In : Cancer Research. 74, 18, p. 5336-5347 12 p.

Research output: Contribution to journalArticle

Niche inheritance: A cooperative pathway to enhance cancer cell fitness though ecosystem engineering

Yang, K. R., Mooney, S. M., Zarif, J. C., Coffey, D. S., Taichman, R. S. & Pienta, K. J., Sep 2014, In : Journal of cellular biochemistry. 115, 9, p. 1478-1485 8 p.

Research output: Contribution to journalArticle

Polarization of prostate cancer-associated macrophages is induced by milk fat globule-EGF factor 8 (MFG-E8)-mediated efferocytosis

Soki, F. N., Koh, A. J., Jones, J. D., Kim, Y. W., Dai, J., Keller, E. T., Pienta, K. J., Atabai, K., Roca, H. & McCauley, L. K., Jan 1 2014, In : Journal of Biological Chemistry. 289, 35, p. 24560-24572 13 p.

Research output: Contribution to journalArticle

Response to " Comment on ' A method to measure cellular adhesion utilizing a polymer micro-cantilever'" [Appl. Phys. Lett. 104, 236103 (2014)]

Gaitas, A., Malhotra, R., Pienta, K. & Kim, G., Jun 9 2014, In : Applied Physics Letters. 104, 23, 236104.

Research output: Contribution to journalArticle

TAM macrophages promote growth and metastasis within the cancer ecosystem

Zarif, J. C., Taichman, R. S. & Pienta, K. J., Jan 1 2014, In : OncoImmunology. 3, 7, e941734.

Research output: Contribution to journalArticle

2013

Activating ESR1 mutations in hormone-resistant metastatic breast cancer

Robinson, D. R., Wu, Y. M., Vats, P., Su, F., Lonigro, R. J., Cao, X., Kalyana-Sundaram, S., Wang, R., Ning, Y., Hodges, L., Gursky, A., Siddiqui, J., Tomlins, S. A., Roychowdhury, S., Pienta, K. J., Kim, S. Y., Roberts, J. S., Rae, J. M., Van Poznak, C. H., Hayes, D. F. & 5 others, Chugh, R., Kunju, L. P., Talpaz, M., Schott, A. F. & Chinnaiyan, A. M., Dec 1 2013, In : Nature genetics. 45, 12, p. 1446-1451 6 p.

Research output: Contribution to journalArticle

A method to measure cellular adhesion utilizing a polymer micro-cantilever

Gaitas, A., Malhotra, R. & Pienta, K., Sep 16 2013, In : Applied Physics Letters. 103, 12, 123702.

Research output: Contribution to journalArticle

Cancer stem cells and their role in metastasis

Shiozawa, Y., Nie, B., Pienta, K. J., Morgan, T. M. & Taichman, R. S., May 1 2013, In : Pharmacology and Therapeutics. 138, 2, p. 285-293 9 p.

Research output: Contribution to journalReview article

Circulating fibroblast-like cells in men with metastatic prostate cancer

Jones, M. L., Siddiqui, J., Pienta, K. J. & Getzenberg, R. H., Jan 1 2013, In : Prostate. 73, 2, p. 176-181 6 p.

Research output: Contribution to journalArticle

Circulating microRNA Profiling Identifies a Subset of Metastatic Prostate Cancer Patients with Evidence of Cancer-Associated Hypoxia

Cheng, H. H., Mitchell, P. S., Kroh, E. M., Dowell, A. E., Chéry, L., Siddiqui, J., Nelson, P. S., Vessella, R. L., Knudsen, B. S., Chinnaiyan, A. M., Pienta, K. J., Morrissey, C. & Tewari, M., Jul 30 2013, In : PloS one. 8, 7, e69239.

Research output: Contribution to journalArticle

Definition of molecular determinants of prostate cancer cell bone extravasation

Barthel, S. R., Hays, D. L., Yazawa, E. M., Opperman, M., Walley, K. C., Nimrichter, L., Burdick, M. M., Gillard, B. M., Moser, M. T., Pantel, K., Foster, B. A., Pienta, K. J. & Dimitroff, C. J., Jan 15 2013, In : Cancer Research. 73, 2, p. 942-952 11 p.

Research output: Contribution to journalArticle

Erratum to Mechanistic rationale for inhibition of poly(ADP-Ribose) polymerase in ETS gene fusion-positive prostate cancer [Cancer Cell, 19 (2011) 664-678]

Brenner, J. C., Ateeq, B., Li, Y., Yocum, A. K., Cao, Q., Asangani, I. A., Patel, S., Wang, X., Liang, H., Yu, J., Palanisamy, N., Siddiqui, J., Yan, W., Cao, X., Mehra, R., Sabolch, A., Basrur, V., Lonigro, R. J., Yang, J., Tomlins, S. A. & 8 others, Maher, C. A., Elenitoba-Johnson, K. S. J., Hussain, M., Navone, N. M., Pienta, K. J., Varambally, S., Feng, F. Y. & Chinnaiyan, A. M., Apr 15 2013, In : Cancer cell. 23, 4, 1 p.

Research output: Contribution to journalComment/debate

Erythropoietin supports the survival of prostate cancer, but not growth and bone metastasis

Shiozawa, Y., McGee, S., Pienta, M. J., McGregor, N., Jung, Y., Yumoto, K., Wang, J., Berry, J. E., Pienta, K. J. & Taichman, R. S., Nov 1 2013, In : Journal of cellular biochemistry. 114, 11, p. 2471-2478 8 p.

Research output: Contribution to journalArticle

GAS6 Receptor Status Is Associated with Dormancy and Bone Metastatic Tumor Formation

Taichman, R. S., Patel, L. R., Bedenis, R., Wang, J., Weidner, S., Schumann, T., Yumoto, K., Berry, J. E., Shiozawa, Y. & Pienta, K. J., Apr 24 2013, In : PloS one. 8, 4, e61873.

Research output: Contribution to journalArticle

Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing

Robinson, D. R., Wu, Y. M., Kalyana-Sundaram, S., Cao, X., Lonigro, R. J., Sung, Y. S., Chen, C. L., Zhang, L., Wang, R., Su, F., Iyer, M. K., Roychowdhury, S., Siddiqui, J., Pienta, K. J., Kunju, L. P., Talpaz, M., Mosquera, J. M., Singer, S., Schuetze, S. M., Antonescu, C. R. & 1 others, Chinnaiyan, A. M., Feb 1 2013, In : Nature genetics. 45, 2, p. 180-185 6 p.

Research output: Contribution to journalArticle

Identification of targetable FGFR gene fusions in diverse cancers

Wu, Y. M., Su, F., Kalyana-Sundaram, S., Khazanov, N., Ateeq, B., Cao, X., Lonigro, R. J., Vats, P., Wang, R., Lin, S. F., Cheng, A. J., Kunju, L. P., Siddiqui, J., Tomlins, S. A., Wyngaard, P., Sadis, S., Roychowdhury, S., Hussain, M. H., Feng, F. Y., Zalupski, M. M. & 5 others, Talpaz, M., Pienta, K. J., Rhodes, D. R., Robinson, D. R. & Chinnaiyan, A. M., 2013, In : Cancer discovery. 3, 6, p. 636-647 12 p.

Research output: Contribution to journalArticle

Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets

Drake, J. M., Graham, N. A., Lee, J. K., Stoyanova, T., Faltermeier, C. M., Sud, S., Titz, B., Huang, J., Pienta, K. J., Graeber, T. G. & Witte, O. N., Dec 3 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 49, p. E4762-E4769

Research output: Contribution to journalArticle

New and emerging therapies for bone metastases in genitourinary cancers

Saylor, P. J., Armstrong, A. J., Fizazi, K., Freedland, S., Saad, F., Smith, M. R., Tombal, B. & Pienta, K., Feb 1 2013, In : European Urology. 63, 2, p. 309-320 12 p.

Research output: Contribution to journalReview article

Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer

Pienta, K. J., Machiels, J. P., Schrijvers, D., Alekseev, B., Shkolnik, M., Crabb, S. J., Li, S., Seetharam, S., Puchalski, T. A., Takimoto, C., Elsayed, Y., Dawkins, F. & De Bono, J. S., Jun 2013, In : Investigational New Drugs. 31, 3, p. 760-768 9 p.

Research output: Contribution to journalArticle

Phospho-proteomics reveals oncogenic phospho-tyrosine signaling networks in cancers lacking mutated or amplified tyrosine kinases

Graham, N. A., Drake, J. M., Tahmasian, M., Pienta, K. J., Witte, O. N. & Graeber, T. G., Jan 1 2013, Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future. AIChE, p. 297-298 2 p. (Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Prostate cancer originating in basal cells progresses to adenocarcinoma propagated by luminal-like cells

Stoyanova, T., Cooper, A. R., Drake, J. M., Liu, X., Armstrong, A. J., Pienta, K. J., Zhang, H., Kohn, D. B., Huang, J., Witte, O. N. & Goldstein, A. S., Dec 10 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 50, p. 20111-20116 6 p.

Research output: Contribution to journalArticle

Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis

Jung, Y., Kim, J. K., Shiozawa, Y., Wang, J., Mishra, A., Joseph, J., Berry, J. E., McGee, S., Lee, E., Sun, H., Wang, J., Jin, T., Zhang, H., Dai, J., Krebsbach, P. H., Keller, E. T., Pienta, K. J. & Taichman, R. S., 2013, In : Nature communications. 4, 1795.

Research output: Contribution to journalArticle

TBK1 regulates prostate cancer dormancy through mTOR inhibition

Kim, J. K. O., Jung, Y., Wang, J., Joseph, J., Mishra, A., Hill, E. E., Krebsbach, P. H., Pienta, K. J., Shiozawa, Y. & Taichman, R. S., Sep 1 2013, In : Neoplasia (New York, N.Y.). 15, 9, p. 1064-1074 11 p.

Research output: Contribution to journalArticle

The 19th annual prostate cancer foundation scientific retreat

Walia, G., Pienta, K. J., Simons, J. W. & Soule, H. R., Aug 15 2013, In : Cancer Research. 73, 16, p. 4988-4991 4 p.

Research output: Contribution to journalArticle

The cancer diaspora: Metastasis beyond the seed and soil hypothesis

Pienta, K. J., Robertson, B. A., Coffey, D. S. & Taichman, R. S., Nov 1 2013, In : Clinical Cancer Research. 19, 21, p. 5849-5855 7 p.

Research output: Contribution to journalReview article

The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex

Prensner, J. R., Iyer, M. K., Sahu, A., Asangani, I. A., Cao, Q., Patel, L., Vergara, I. A., Davicioni, E., Erho, N., Ghadessi, M., Jenkins, R. B., Triche, T. J., Malik, R., Bedenis, R., McGregor, N., Ma, T., Chen, W., Han, S., Jing, X., Cao, X. & 9 others, Wang, X., Chandler, B., Yan, W., Siddiqui, J., Kunju, L. P., Dhanasekaran, S. M., Pienta, K. J., Feng, F. Y. & Chinnaiyan, A. M., Nov 2013, In : Nature genetics. 45, 11, p. 1392-1403 12 p.

Research output: Contribution to journalLetter

Transcription Factors OVOL1 and OVOL2 Induce the Mesenchymal to Epithelial Transition in Human Cancer

Roca, H., Hernandez, J., Weidner, S., McEachin, R. C., Fuller, D., Sud, S., Schumann, T., Wilkinson, J. E., Zaslavsky, A., Li, H., Maher, C. A., Daignault-Newton, S., Healy, P. N. & Pienta, K. J., Oct 4 2013, In : PloS one. 8, 10, e76773.

Research output: Contribution to journalArticle

2012

384 hanging drop arrays give excellent Z-factors and allow versatile formation of co-culture spheroids

Hsiao, A. Y., Tung, Y. C., Qu, X., Patel, L. R., Pienta, K. J. & Takayama, S., May 1 2012, In : Biotechnology and bioengineering. 109, 5, p. 1293-1304 12 p.

Research output: Contribution to journalArticle

Chemical transfection of dye-conjugated microRNA precursors for microRNA functional analysis of M2 macrophages

Ng, Y. S., Roca, H., Fuller, D., Sud, S. & Pienta, K. J., May 1 2012, In : Journal of cellular biochemistry. 113, 5, p. 1714-1723 10 p.

Research output: Contribution to journalArticle

Common structural and epigenetic changes in the genome of castration-resistant prostate cancer

Friedlander, T. W., Roy, R., Tomlins, S. A., Ngo, V. T., Kobayashi, Y., Azameera, A., Rubin, M. A., Pienta, K. J., Chinnaiyan, A., Ittmann, M. M., Ryan, C. J. & Paris, P. L., Feb 1 2012, In : Cancer Research. 72, 3, p. 616-625 10 p.

Research output: Contribution to journalArticle

Cyclophosphamide creates a receptive microenvironment for prostate cancer skeletal metastasis

Park, S. I., Liao, J., Berry, J. E., Li, X., Koh, A. J., Michalski, M. E., Eber, M. R., Soki, F. N., Sadler, D., Sud, H., Tisdelle, S., Daignault, S. D., Nemeth, J. A., Snyder, L. A., Wronski, T. J., Pienta, K. J. & McCauley, L. K., May 15 2012, In : Cancer Research. 72, 10, p. 2522-2532 11 p.

Research output: Contribution to journalArticle

Disrupting the networks of cancer

Camacho, D. F. & Pienta, K. J., May 15 2012, In : Clinical Cancer Research. 18, 10, p. 2801-2808 8 p.

Research output: Contribution to journalReview article

Disseminated prostate cancer cells can instruct hematopoietic stem and progenitor cells to regulate bone phenotype

Joseph, J., Shiozawa, Y., Jung, Y., Kim, J. K., Pedersen, E., Mishra, A., Zalucha, J. L., Wang, J., Keller, E. T., Pienta, K. J. & Taichman, R. S., Mar 1 2012, In : Molecular Cancer Research. 10, 3, p. 282-292 11 p.

Research output: Contribution to journalArticle