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  • Kenneth Pienta

384 hanging drop arrays give excellent Z-factors and allow versatile formation of co-culture spheroids

Hsiao, A. Y., Tung, Y. C., Qu, X., Patel, L. R., Pienta, K. J. & Takayama, S., May 1 2012, In : Biotechnology and bioengineering. 109, 5, p. 1293-1304 12 p.

Research output: Contribution to journalArticle

3D cell nuclear morphology: Microscopy imaging dataset and voxel-based morphometry classification results

Kalinin, A. A., Allyn-Feuer, A., Ade, A., Fon, G. V., Meixner, W., Dilworth, D., De Wet, J. R., Higgins, G. A., Zheng, G., Creekmore, A., Wiley, J. W., Verdone, J. E., Veltri, R. W., Pienta, K. J., Coffey, D. S., Athey, B. D. & Dinov, I. D., Dec 13 2018, Proceedings - 2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops, CVPRW 2018. IEEE Computer Society, Vol. 2018-June. p. 2353-2361 9 p. 8575476

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3D Shape Modeling for Cell Nuclear Morphological Analysis and Classification

Kalinin, A. A., Allyn-Feuer, A., Ade, A., Fon, G. V., Meixner, W., Dilworth, D., Husain, S. S., de Wett, J. R., Higgins, G. A., Zheng, G., Creekmore, A., Wiley, J. W., Verdone, J. E., Veltri, R., Pienta, K. J., Coffey, D. S., Athey, B. D. & Dinov, I. D., Dec 1 2018, In : Scientific reports. 8, 1, 13658.

Research output: Contribution to journalArticle

A Bayesian hierarchical model for prediction of latent health states from multiple data sources with application to active surveillance of prostate cancer

Coley, R. Y., Fisher, A. J., Mamawala, M., Carter, H. B., Pienta, K. & Zeger, S., Jun 1 2017, In : Biometrics. 73, 2, p. 625-634 10 p.

Research output: Contribution to journalArticle

A bioinformatics approach reveals novel interactions of the OVOL transcription factors in the regulation of epithelial - mesenchymal cell reprogramming and cancer progression

Roca, H., Pande, M., Huo, J. S., Hernandez, J., Cavalcoli, J. D., Pienta, K. J. & McEachin, R. C., Mar 10 2014, In : BMC Systems Biology. 8, 1, 29.

Research output: Contribution to journalArticle

Absence of myeloid Klf4 reduces prostate cancer growth with pro-atherosclerotic activation of tumor myeloid cells and infiltration of CD8 T cells

Barakat, D. J., Suresh, R., Barberi, T., Pienta, K. J., Simons, B. W. & Friedman, A. D., Jan 2018, In : PloS one. 13, 1, e0191188.

Research output: Contribution to journalArticle

Activating ESR1 mutations in hormone-resistant metastatic breast cancer

Robinson, D. R., Wu, Y. M., Vats, P., Su, F., Lonigro, R. J., Cao, X., Kalyana-Sundaram, S., Wang, R., Ning, Y., Hodges, L., Gursky, A., Siddiqui, J., Tomlins, S. A., Roychowdhury, S., Pienta, K. J., Kim, S. Y., Roberts, J. S., Rae, J. M., Van Poznak, C. H., Hayes, D. F. & 5 others, Chugh, R., Kunju, L. P., Talpaz, M., Schott, A. F. & Chinnaiyan, A. M., Dec 1 2013, In : Nature genetics. 45, 12, p. 1446-1451 6 p.

Research output: Contribution to journalArticle

Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer

Stoyanova, T., Riedinger, M., Lin, S., Faltermeier, C. M., Smith, B. A., Zhang, K. X., Going, C. C., Goldstein, A. S., Lee, J. K., Drake, J. M., Rice, M. A., Hsu, E. C., Nowroozizadeh, B., Castor, B., Orellana, S. Y., Blum, S. M., Cheng, D., Pienta, K. J., Reiter, R. E., Pitteri, S. J. & 2 others, Huang, J. & Witte, O. N., Oct 18 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 42, p. E6457-E6466

Research output: Contribution to journalArticle

Activation of urokinase plasminogen activator and its receptor axis is essential for macrophage infiltration in a prostate cancer mouse model

Zhang, J., Sud, S., Mizutani, K., Gyetko, M. R. & Pienta, K. J., Jan 2011, In : Neoplasia. 13, 1, p. 23-30 8 p.

Research output: Contribution to journalArticle

Aerobic glycolysis, motility, and cytoskeletal remodeling

Verdone, J. E., Zarif, J. C. & Pienta, K. J., Jan 15 2015, In : Cell Cycle. 14, 2, p. 169-170 2 p.

Research output: Contribution to journalEditorial

Alternative CD44 splicing identifies epithelial prostate cancer cells from the mesenchymal counterparts

Hernandez, J. R., Kim, J. J., Verdone, J. E., Liu, X., Torga, G., Pienta, K. J. & Mooney, S. M., May 1 2015, In : Medical Oncology. 32, 5, p. 1-9 9 p.

Research output: Contribution to journalArticle

A method to measure cellular adhesion utilizing a polymer micro-cantilever

Gaitas, A., Malhotra, R. & Pienta, K., Sep 16 2013, In : Applied Physics Letters. 103, 12, 123702.

Research output: Contribution to journalArticle

A multi-targeted approach to treating bone metastases

Camacho, D. F. & Pienta, K. J., Jan 1 2015, Bone Cancer: Primary Bone Cancers and Bone Metastases: Second Edition. Elsevier Inc., p. 647-655 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

A multi-targeted approach to treating bone metastases

Camacho, D. F. & Pienta, K. J., Sep 2014, In : Cancer and Metastasis Reviews. 33, 2-3, p. 545-553 9 p.

Research output: Contribution to journalArticle

Analogous detection of circulating tumor cells using the AccuCyte®-CyteFinder® system and ISET system in patients with locally advanced and metastatic prostate cancer

van der Toom, E. E., Groot, V. P., Glavaris, S. A., Gemenetzis, G., Chalfin, H. J., Wood, L. D., Wolfgang, C., de la Rosette, J. J. M. C. H., de Reijke, T. M. & Pienta, K., Jan 1 2018, (Accepted/In press) In : Prostate.

Research output: Contribution to journalArticle

Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling

Bluemn, E. G., Coleman, I. M., Lucas, J. M., Coleman, R. T., Hernandez-Lopez, S., Tharakan, R., Bianchi-Frias, D., Dumpit, R. F., Kaipainen, A., Corella, A. N., Yang, Y. C., Nyquist, M. D., Mostaghel, E., Hsieh, A. C., Zhang, X., Corey, E., Brown, L. G., Nguyen, H. M., Pienta, K., Ittmann, M. & 7 others, Schweizer, M., True, L. D., Wise, D., Rennie, P. S., Vessella, R. L., Morrissey, C. & Nelson, P. S., Oct 9 2017, In : Cancer cell. 32, 4, p. 474-489.e6

Research output: Contribution to journalArticle

A Novel Approach for Performing Bone Marrow Aspiration at the Time of Radical Prostatectomy

Tosoian, J. J., Reyes, D. K., Gorin, M. A., Hortopan, S., Partin, A. W., Pienta, K. J., Ross, A. E. & Schaeffer, E. M., May 1 2016, In : Urology Case Reports. 6, p. 45-46 2 p.

Research output: Contribution to journalArticle

A phase 2 trial of salvage radiation and concurrent weekly docetaxel after a rising prostate-specific antigen level after radical prostatectomy

Jackson, W. C., Feng, F. Y., Daignault, S., Hussain, M., Smith, D., Cooney, K., Pienta, K., Jolly, S., Hollenbeck, B., Olson, K. B., Sandler, H. M., Ray, M. E. & Hamstra, D. A., Jan 1 2016, In : Advances in Radiation Oncology. 1, 1, p. 59-66 8 p.

Research output: Contribution to journalArticle

A phase 3 trial of 2 years of androgen suppression and radiation therapy with or without adjuvant chemotherapy for high-risk prostate cancer: Final results of radiation therapy oncology group phase 3 randomized trial NRG oncology RTOG 9902

Rosenthal, S. A., Hunt, D., Sartor, A. O., Pienta, K. J., Gomella, L., Grignon, D., Rajan, R., Kerlin, K. J., Jones, C. U., Dobelbower, M., Shipley, W. U., Zeitzer, K., Hamstra, D. A., Donavanik, V., Rotman, M., Hartford, A. C., Michalski, J., Seider, M., Kim, H., Kuban, D. A. & 2 others, Moughan, J. & Sandler, H., Oct 1 2015, In : International Journal of Radiation Oncology Biology Physics. 93, 2, p. 294-302 9 p.

Research output: Contribution to journalArticle

A phased strategy to differentiate human CD14+ monocytes into classically and alternatively activated macrophages and dendritic cells

Zarif, J., Hernandez, J. R., Verdone, J. E., Campbell, S. P., Drake, C. G. & Pienta, K., Jul 1 2016, In : BioTechniques. 61, 1, p. 33-41 9 p.

Research output: Contribution to journalArticle

A phase II randomized trial of RAdium-223 dichloride and SABR Versus SABR for oligomEtastatic prostate caNcerS (RAVENS)

Hasan, H., Deek, M. P., Phillips, R., Hobbs, R. F., Malek, R., Radwan, N., Kiess, A. P., Dipasquale, S., Huang, J., Caldwell, T., Leitzel, J., Wendler, D., Wang, H., Thompson, E., Powell, J., Dudley, S., Deville, C., Greco, S. C., Song, D. Y., Deweese, T. L. & 11 others, Gorin, M. A., Rowe, S. P., Denmeade, S., Markowski, M., Antonarakis, E. S., Carducci, M. A., Eisenberger, M. A., Pomper, M. G., Pienta, K. J., Paller, C. J. & Tran, P. T., Jun 1 2020, In : BMC cancer. 20, 1, 492.

Research output: Contribution to journalArticle

Open Access

Apoptosis-induced CXCL5 accelerates inflammation and growth of prostate tumor metastases in bone

Roca, H., Jones, J. D., Purica, M. C., Weidner, S., Koh, A. J., Kuo, R., Wilkinson, J. E., Wang, Y., Daignault-Newton, S., Pienta, K. J., Morgan, T. M., Keller, E. T., Nör, J. E., Shea, L. D. & McCauley, L. K., Jan 2 2018, In : Journal of Clinical Investigation. 128, 1, p. 248-266 19 p.

Research output: Contribution to journalArticle

A simple selection-free method for detecting disseminated tumor cells (DTCs) in murine bone marrow

Valkenburg, K. C., Amend, S. R., Verdone, J. E., van der Toom, E. E., Hernandez, J. R., Gorin, M. A. & Pienta, K. J., 2016, In : Oncotarget. 7, 43, p. 69794-69803 10 p.

Research output: Contribution to journalArticle

A surface tension magnetophoretic device for rare cell isolation and characterization

van der Toom, E. E., Verdone, J. E., Jun, C., Petrisor, D., Lim, S., de la Rosette, J. J. M. C. H., de Reijke, T. M., Gorin, M., Pienta, K. & Stoianovici, D., Feb 1 2017, In : Medical Oncology. 34, 2, 22.

Research output: Contribution to journalArticle

A Voice From the Past: Rediscovering the Virchow Node With Prostate-specific Membrane Antigen-targeted 18F-DCFPyL Positron Emission Tomography Imaging

Werner, R. A., Andree, C., Javadi, M. S., Lapa, C., Buck, A. K., Higuchi, T., Pomper, M. G., Gorin, M. A., Rowe, S. P. & Pienta, K. J., Jul 2018, In : Urology. 117, p. 18-21 4 p.

Research output: Contribution to journalArticle

Axl as a mediator of cellular growth and survival

Axelrod, H. & Pienta, K. J., Jan 1 2014, In : Oncotarget. 5, 19, p. 8818-8852 35 p.

Research output: Contribution to journalArticle

Open Access

AXL is a putative tumor suppressor and dormancy regulator in prostate cancer

Axelrod, H. D., Valkenburg, K. C., Amend, S., Hicks, J. L., Parsana, P., Torga, G., Demarzo, A. M. & Pienta, K., Feb 1 2019, In : Molecular Cancer Research. 17, 2, p. 356-369 14 p.

Research output: Contribution to journalArticle

Beyond immune checkpoint blockade:New approaches to targeting host-tumor interactions in prostate cancer: Report from the 2014 Coffey-Holden Prostate Cancer Academy Meeting

Miyahira, A. K., Kissick, H. T., Bishop, J. L., Takeda, D. Y., Barbieri, C. E., Simons, J. W., Pienta, K. J. & Soule, H. R., Mar 1 2015, In : Prostate. 75, 4, p. 337-347 11 p.

Research output: Contribution to journalArticle

Beyond Seed and Soil: Understanding and Targeting Metastatic Prostate Cancer; Report From the 2016 Coffey-Holden Prostate Cancer Academy Meeting

Miyahira, A. K., Roychowdhury, S., Goswami, S., Ippolito, J. E., Priceman, S. J., Pritchard, C. C., Sfanos, K., Subudhi, S. K., Simons, J. W., Pienta, K. & Soule, H. R., 2016, (Accepted/In press) In : Prostate.

Research output: Contribution to journalArticle

Beyond the androgen receptor: New approaches to treating metastatic prostate cancer. Report of the 2013 Prouts Neck Prostate Cancer Meeting

Pienta, K. J., Walia, G., Simons, J. W. & Soule, H. R., Feb 1 2014, In : Prostate. 74, 3, p. 314-320 7 p.

Research output: Contribution to journalArticle

Beyond the androgen receptor II: New approaches to understanding and treating metastatic prostate cancer; Report from the 2017 Coffey-Holden Prostate Cancer Academy Meeting

Miyahira, A. K., Cheng, H. H., Abida, W., Ellis, L., Harshman, L. C., Spratt, D. E., Simons, J. W., Pienta, K. J. & Soule, H. R., Nov 1 2017, In : Prostate. 77, 15, p. 1478-1488 11 p.

Research output: Contribution to journalReview article

Biomanufacturing Seamless Tubular and Hollow Collagen Scaffolds with Unique Design Features and Biomechanical Properties

Singh, A., Lee, D., Sopko, N., Matsui, H., Sabnekar, P., Liu, X., Elisseeff, J. H., Schoenberg, M. P., Pienta, K. & Bivalacqua, T., 2017, (Accepted/In press) In : Advanced healthcare materials.

Research output: Contribution to journalArticle

Bone marrow macrophages support prostate cancer growth in bone

Soki, F. N., Cho, S. W., Kim, Y. W., Jones, J. D., Park, S. I., Koh, A. J., Entezami, P., Daignault-Newton, S., Pienta, K. J., Roca, H. & McCauley, L. K., Jan 1 2015, In : Oncotarget. 6, 34, p. 35782-35796 15 p.

Research output: Contribution to journalArticle

Cancer as a social dysfunction—why cancer research needs new thinking

Axelrod, R. & Pienta, K., Sep 1 2018, In : Molecular Cancer Research. 16, 9, p. 1346-1347 2 p.

Research output: Contribution to journalReview article

Cancer Cells and M2 Macrophages: Cooperative Invasive Ecosystem Engineers

Myers, K. V., Pienta, K. J. & Amend, S. R., Jan 1 2020, In : Cancer Control. 27, 1

Research output: Contribution to journalArticle

Open Access

Cancer Foraging Ecology: Diet Choice, Patch Use, and Habitat Selection of Cancer Cells

Amend, S., Gatenby, R. A., Pienta, K. & Brown, J. S., Dec 1 2018, In : Current Pathobiology Reports. 6, 4, p. 209-218 10 p.

Research output: Contribution to journalReview article

Cancer stem cells and their role in metastasis

Shiozawa, Y., Nie, B., Pienta, K. J., Morgan, T. M. & Taichman, R. S., May 1 2013, In : Pharmacology and Therapeutics. 138, 2, p. 285-293 9 p.

Research output: Contribution to journalReview article

Cell surface Thomsen-Friedenreich proteome profiling of metastatic prostate cancer cells reveals potential link with cancer stem cell-like phenotype

Li, F., Glinskii, O. V., Mooney, B. P., Rittenhouse-Olson, K., Pienta, K. J. & Glinsky, V. V., 2017, In : Oncotarget. 8, 58, p. 98598-98608 11 p.

Research output: Contribution to journalArticle

Centralized research recruitment-evolving a local clinical research recruitment web application to better meet user needs.

Dwyer-White, M., Doshi, A., Hill, M. & Pienta, K. J., Oct 2011, In : Clinical and translational science. 4, 5, p. 363-368 6 p.

Research output: Contribution to journalArticle

Characterization of bone metastases from rapid autopsies of prostate cancer patients

Mehra, R., Kumar-Sinha, C., Shankar, S., Lonigro, R. J., Jing, X., Philips, N. E., Siddiqui, J., Han, B., Cao, X., Smith, D. C., Shah, R. B., Chinnaiyan, A. M. & Pienta, K. J., Jun 15 2011, In : Clinical Cancer Research. 17, 12, p. 3924-3932 9 p.

Research output: Contribution to journalArticle

Characterization of Urothelial Cancer Circulating Tumor Cells with a Novel Selection-Free Method

Chalfin, H. J., Kates, M., van der Toom, E. E., Glavaris, S., Verdone, J. E., Hahn, N., Pienta, K., Bivalacqua, T. & Gorin, M., Jan 1 2018, (Accepted/In press) In : Urology.

Research output: Contribution to journalArticle

Chemical transfection of dye-conjugated microRNA precursors for microRNA functional analysis of M2 macrophages

Ng, Y. S., Roca, H., Fuller, D., Sud, S. & Pienta, K. J., May 1 2012, In : Journal of cellular biochemistry. 113, 5, p. 1714-1723 10 p.

Research output: Contribution to journalArticle

Circulating fibroblast-like cells in men with metastatic prostate cancer

Jones, M. L., Siddiqui, J., Pienta, K. J. & Getzenberg, R. H., Jan 1 2013, In : Prostate. 73, 2, p. 176-181 6 p.

Research output: Contribution to journalArticle

Circulating microRNA Profiling Identifies a Subset of Metastatic Prostate Cancer Patients with Evidence of Cancer-Associated Hypoxia

Cheng, H. H., Mitchell, P. S., Kroh, E. M., Dowell, A. E., Chéry, L., Siddiqui, J., Nelson, P. S., Vessella, R. L., Knudsen, B. S., Chinnaiyan, A. M., Pienta, K. J., Morrissey, C. & Tewari, M., Jul 30 2013, In : PloS one. 8, 7, e69239.

Research output: Contribution to journalArticle

Circulating tumour cells as biomarkers of prostate, bladder, and kidney cancer

Gorin, M. A., Verdone, J. E., Van Der Toom, E., Bivalacqua, T. J., Allaf, M. E. & Pienta, K. J., Feb 1 2017, In : Nature Reviews Urology. 14, 2, p. 90-97 8 p.

Research output: Contribution to journalReview article

Classification of current anticancer immunotherapies

Galluzzi, L., Vacchelli, E., Bravo-San Pedro, J. M., Buqué, A., Senovilla, L., Baracco, E. E., Bloy, N., Castoldi, F., Abastado, J. P., Agostinis, P., Apte, R. N., Aranda, F., Ayyoub, M., Beckhove, P., Blay, J. Y., Bracci, L., Caignard, A., Castelli, C., Cavallo, F., Celis, E. & 68 others, Cerundolo, V., Clayton, A., Colombo, M. P., Coussens, L., Dhodapkar, M. V., Eggermont, A. M., Fearon, D. T., Fridman, W. H., Fucíková, J., Gabrilovich, D. I., Galon, J., Garg, A., Ghiringhelli, F., Giaccone, G., Gilboa, E., Gnjatic, S., Hoos, A., Hosmalin, A., Jäger, D., Kalinski, P., Kärre, K., Kepp, O., Kiessling, R., Kirkwood, J. M., Klein, E., Knuth, A., Lewis, C. E., Liblau, R., Lotze, M. T., Lugli, E., Mach, J. P., Mattei, F., Mavilio, D., Melero, I., Melief, C. J., Mittendorf, E. A., Moretta, L., Odunsi, A., Okada, H., Palucka, A. K., Peter, M. E., Pienta, K. J., Porgador, A., Prendergast, G. C., Rabinovich, G. A., Restifo, N. P., Rizvi, N., Sautès-Fridman, C., Schreiber, H., Seliger, B., Shiku, H., Silva-Santos, B., Smyth, M. J., Speiser, D. E., Spisek, R., Srivastava, P. K., Talmadge, J. E., Tartour, E., Van Der Burg, S. H., Van Den Eynde, B. J., Vile, R., Wagner, H., Weber, J. S., Whiteside, T. L., Wolchok, J. D., Zitvogel, L., Zou, W. & Kroemer, G., 2014, In : Oncotarget. 5, 24, p. 12472-12508 37 p.

Research output: Contribution to journalArticle

Open Access

Classifying the evolutionary and ecological features of neoplasms

Maley, C. C., Aktipis, A., Graham, T. A., Sottoriva, A., Boddy, A. M., Janiszewska, M., Silva, A. S., Gerlinger, M., Yuan, Y., Pienta, K. J., Anderson, K. S., Gatenby, R., Swanton, C., Posada, D., Wu, C. I., Schiffman, J. D., Hwang, E. S., Polyak, K., Anderson, A. R. A., Brown, J. S. & 2 others, Greaves, M. & Shibata, D., Oct 1 2017, In : Nature Reviews Cancer. 17, 10, p. 605-619 15 p.

Research output: Contribution to journalReview article