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  • Kenneth Pienta
2020

Cancer Cells and M2 Macrophages: Cooperative Invasive Ecosystem Engineers

Myers, K. V., Pienta, K. J. & Amend, S. R., Jan 1 2020, In : Cancer Control. 27, 1

Research output: Contribution to journalArticle

Open Access

Convergent Evolution, Evolving Evolvability, and the Origins of Lethal Cancer

Pienta, K. J., Hammarlund, E. U., Axelrod, R., Amend, S. R. & Brown, J. S., Jun 1 2020, In : Molecular cancer research : MCR. 18, 6, p. 801-810 10 p.

Research output: Contribution to journalReview article

Extracellular vesicle isolation from human renal cancer tissue

Zieren, R. C., Dong, L., Pierorazio, P. M., Pienta, K. J., de Reijke, T. M. & Amend, S. R., Apr 1 2020, In : Medical Oncology. 37, 4, 28.

Research output: Contribution to journalArticle

Open Access
Open Access

Online Prostate-Specific Membrane Antigen and Positron Emission Tomography–Guided Radiation Therapy for Oligometastatic Prostate Cancer

Hrinivich, W. T., Phillips, R., Da Silva, A. J., Radwan, N., Gorin, M. A., Rowe, S. P., Pienta, K. J., Pomper, M. G., Wong, J., Tran, P. T. & Kang-Hsin Wang, K., Mar 1 2020, In : Advances in Radiation Oncology. 5, 2, p. 260-268 9 p.

Research output: Contribution to journalArticle

Open Access

Outcomes of Observation vs Stereotactic Ablative Radiation for Oligometastatic Prostate Cancer: The ORIOLE Phase 2 Randomized Clinical Trial

Phillips, R., Shi, W. Y., Deek, M., Radwan, N., Lim, S. J., Antonarakis, E., Rowe, S., Ross, A. E., Gorin, M., Deville, C., Greco, S. C., Wang, H., Denmeade, S. R., Paller, C., Dipasquale, S., DeWeese, T., Song, D. Y., Wang, H., Carducci, M. A., Pienta, K. J. & 6 others, Pomper, M. G., Dicker, A. P., Eisenberger, M., Alizadeh, A. A., Diehn, M. & Tran, P. T., May 2020, In : JAMA Oncology. 6, 5, p. 650-659 10 p.

Research output: Contribution to journalArticle

Open Access

Perspectives in Oncology: a new article type for Medical Oncology

Pienta, K. J., Mar 1 2020, In : Medical Oncology. 37, 3, 21.

Research output: Contribution to journalEditorial

Open Access

Prospective comparison of PET imaging with PSMA-targeted 18F-DCFPyL versus NA18F for bone lesion detection in patients with metastatic prostate cancer

Rowe, S. P., Li, X., Trock, B. J., Werner, R. A., Frey, S., DiGianvittorio, M., Keith Bleiler, J., Reyes, D. K., Abdallah, R., Pienta, K. J., Gorin, M. A. & Pomper, M. G., Feb 1 2020, In : Journal of Nuclear Medicine. 61, 2, p. 183-188 6 p.

Research output: Contribution to journalArticle

Prostate cancer research: The next generation; report from the 2019 Coffey-Holden Prostate Cancer Academy Meeting

Miyahira, A. K., Sharp, A., Ellis, L., Jones, J., Kaochar, S., Larman, H. B., Quigley, D. A., Ye, H., Simons, J. W., Pienta, K. J. & Soule, H. R., Feb 1 2020, In : Prostate. 80, 2, p. 113-132 20 p.

Research output: Contribution to journalReview article

Semiquantitative Parameters in PSMA-Targeted PET Imaging with [18F]DCFPyL: Impact of Tumor Burden on Normal Organ Uptake

Werner, R. A., Bundschuh, R. A., Bundschuh, L., Lapa, C., Yin, Y., Javadi, M. S., Buck, A. K., Higuchi, T., Pienta, K. J., Pomper, M. G., Lodge, M. A., Gorin, M. A. & Rowe, S. P., Feb 1 2020, In : Molecular Imaging and Biology. 22, 1, p. 190-197 8 p.

Research output: Contribution to journalArticle

Semiquantitative Parameters in PSMA-Targeted PET Imaging with [18F]DCFPyL: Intrapatient and Interpatient Variability of Normal Organ Uptake

Sahakyan, K., Li, X., Lodge, M. A., Werner, R. A., Bundschuh, R. A., Bundschuh, L., Kulkarni, H. R., Schuchardt, C., Baum, R. P., Pienta, K. J., Pomper, M. G., Ross, A. E., Gorin, M. A. & Rowe, S. P., Feb 1 2020, In : Molecular Imaging and Biology. 22, 1, p. 181-189 9 p.

Research output: Contribution to journalArticle

The combination of size-based separation and selection-free technology provides higher circulating tumour cells detection sensitivity than either method alone in patients with metastatic prostate cancer

Dong, L., Zhang, Z., Smith, K., Kuczler, M. D., Reyes, D., Amend, S. R., Cho, Y. K., Xue, W. & Pienta, K. J., Jan 1 2020, (Accepted/In press) In : BJU International.

Research output: Contribution to journalArticle

The issues with tissues: the wide range of cell fate separation enables the evolution of multicellularity and cancer

Hammarlund, E. U., Amend, S. & Pienta, K. J., Jul 1 2020, In : Medical Oncology. 37, 7, 62.

Research output: Contribution to journalArticle

Open Access

Wnt Signaling Drives Prostate Cancer Bone Metastatic Tropism and Invasion

Wang, Y., Singhal, U., Qiao, Y., Kasputis, T., Chung, J. S., Zhao, H., Chammaa, F., Belardo, J. A., Roth, T. M., Zhang, H., Zaslavsky, A. B., Palapattu, G. S., Pienta, K. J., Chinnaiyan, A. M., Taichman, R. S., Cackowski, F. C. & Morgan, T. M., Apr 2020, In : Translational Oncology. 13, 4, 100747.

Research output: Contribution to journalArticle

Open Access
2019

AXL is a putative tumor suppressor and dormancy regulator in prostate cancer

Axelrod, H. D., Valkenburg, K. C., Amend, S., Hicks, J. L., Parsana, P., Torga, G., Demarzo, A. M. & Pienta, K., Feb 1 2019, In : Molecular Cancer Research. 17, 2, p. 356-369 14 p.

Research output: Contribution to journalArticle

Computational modeling of the crosstalk between macrophage polarization and tumor cell plasticity in the tumor microenvironment

Li, X., Jolly, M. K., George, J. T., Pienta, K. J. & Levine, H., Jan 1 2019, In : Frontiers in Oncology. 9, JAN, 10.

Research output: Contribution to journalArticle

Open Access

Cooperation among cancer cells: applying game theory to cancer

Archetti, M. & Pienta, K. J., Feb 1 2019, In : Nature Reviews Cancer. 19, 2, p. 110-117 8 p.

Research output: Contribution to journalArticle

Detection and isolation of disseminated tumor cells in bone marrow of patients with clinically localized prostate cancer

Cackowski, F. C., Wang, Y., Decker, J. T., Sifuentes, C., Weindorf, S., Jung, Y., Wang, Y., Decker, A. M., Yumoto, K., Szerlip, N., Buttitta, L., Pienta, K. J., Morgan, T. M. & Taichman, R. S., Jan 1 2019, In : Prostate. 79, 14, p. 1715-1727 13 p.

Research output: Contribution to journalArticle

Evaluation of intense androgen deprivation before prostatectomy: A randomized Phase II trial of enzalutamide and leuprolide with or without abiraterone

McKay, R. R., Ye, H., Xie, W., Lis, R., Calagua, C., Zhang, Z., Trinh, Q. D., Chang, S. L., Harshman, L. C., Ross, A. E., Pienta, K. J., Lin, D. W., Ellis, W. J., Montgomery, B., Chang, P., Wagner, A. A., Bubley, G. J., Kibel, A. S. & Taplin, M. E., Jan 1 2019, In : Journal of Clinical Oncology. 37, 11, p. 923-931 9 p.

Research output: Contribution to journalArticle

Open Access

Generation of heterogeneous drug gradients across cancer populations on a microfluidic evolution accelerator for real-time observation

Lin, K. C., Torga, G., Sun, Y., Pienta, K. J., Sturm, J. C. & Austin, R. H., Jan 1 2019, In : Journal of Visualized Experiments. 2019, 151, e60185.

Research output: Contribution to journalArticle

Gleason pattern 5 is associated with an increased risk for metastasis following androgen deprivation therapy and radiation: An analysis of RTOG 9202 and 9902

Hamstra, D. A., Pugh, S. L., Lepor, H., Rosenthal, S. A., Pienta, K. J., Gomella, L., Peters, C., D'Souza, D. P., Zeitzer, K. L., Jones, C. U., Hall, W. A., Horwitz, E., Pisansky, T. M., Souhami, L., Hartford, A. C., Dominello, M., Feng, F. & Sandler, H. M., Dec 2019, In : Radiotherapy and Oncology. 141, p. 137-143 7 p.

Research output: Contribution to journalArticle

Imaging and Characterization of Macrophage Distribution in Mouse Models of Human Prostate Cancer

Copeland, B. T., Shallal, H., Shen, C., Pienta, K. J., Foss, C. A. & Pomper, M. G., Dec 1 2019, In : Molecular Imaging and Biology. 21, 6, p. 1054-1063 10 p.

Research output: Contribution to journalArticle

Open Access

Metastatic prostate cancer remains incurable, why?

Dong, L., Zieren, R. C., Xue, W., de Reijke, T. M. & Pienta, K. J., Jan 2019, In : Asian Journal of Urology. 6, 1, p. 26-41 16 p.

Research output: Contribution to journalReview article

Open Access

Novel structured reporting systems for theranostic radiotracers

Werner, R. A., Bundschuh, R. A., Bundschuh, L., Fanti, S., Javadi, M. S., Higuchi, T., Weich, A., Pienta, K. J., Buck, A. K., Pomper, M. G., Gorin, M. A., Herrmann, K., Lapa, C. & Rowe, S. P., May 1 2019, In : Journal of Nuclear Medicine. 60, 5, p. 577-584 8 p.

Research output: Contribution to journalArticle

Open Access

Optimization of prostate cancer cell detection using multiplex tyramide signal amplification

Roy, S., Axelrod, H. D., Valkenburg, K. C., Amend, S. & Pienta, K. J., Apr 2019, In : Journal of cellular biochemistry. 120, 4, p. 4804-4812 9 p.

Research output: Contribution to journalArticle

Polyploid giant cancer cells: Unrecognized actuators of tumorigenesis, metastasis, and resistance

Amend, S., Torga, G., Lin, K. C., Kostecka, L. G., Demarzo, A. M., Austin, R. H. & Pienta, K., Jan 1 2019, In : Prostate.

Research output: Contribution to journalReview article

Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis

Dai, J., Escara-Wilke, J., Keller, J. M., Jung, Y., Taichman, R. S., Pienta, K. J. & Keller, E. T., Dec 1 2019, In : Journal of Experimental Medicine. 216, 12, p. 2883-2899 17 p.

Research output: Contribution to journalArticle

Open Access

Prostate-Specific Membrane Antigen (PSMA)-Targeted PET Imaging of Prostate Cancer: An Update on Important Pitfalls

Sheikhbahaei, S., Werner, R. A., Solnes, L. B., Pienta, K. J., Pomper, M. G., Gorin, M. A. & Rowe, S. P., Jul 2019, In : Seminars in Nuclear Medicine. 49, 4, p. 255-270 16 p.

Research output: Contribution to journalReview article

Open Access

Recent advances in extracellular vesicle research for urological cancers: From technology to application

Dong, L., Zieren, R. C., Wang, Y., de Reijke, T. M., Xue, W. & Pienta, K. J., Apr 2019, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1871, 2, p. 342-360 19 p.

Research output: Contribution to journalReview article

Stereotactic ablative radiation therapy for oligometastatic prostate cancer delays time-to-next systemic treatment

Moyer, C. L., Phillips, R., Deek, M. P., Radwan, N., Ross, A. E., Antonarakis, E. S., Reyes, D., Wright, J., Terezakis, S. A., Song, D. Y., DeVille, C., Walsh, P. C., DeWeese, T. L., Carducci, M., Schaeffer, E. M., Pienta, K. J., Eisenberger, M. & Tran, P. T., Dec 1 2019, In : World journal of urology. 37, 12, p. 2623-2629 7 p.

Research output: Contribution to journalArticle

Targeting Tyro3, Axl and MerTK (TAM receptors): Implications for macrophages in the tumor microenvironment

Myers, K. V., Amend, S. R. & Pienta, K. J., May 14 2019, In : Molecular Cancer. 18, 1, 94.

Research output: Contribution to journalReview article

Open Access

The role of heterogeneous environment and docetaxel gradient in the emergence of polyploid, mesenchymal and resistant prostate cancer cells

Lin, K. C., Torga, G., Sun, Y., Axelrod, R., Pienta, K., Sturm, J. C. & Austin, R. H., Jan 1 2019, In : Clinical and Experimental Metastasis.

Research output: Contribution to journalArticle

Tumor cell heterogeneity and resistance; report from the 2018 Coffey-Holden Prostate Cancer Academy Meeting

Miyahira, A. K., Den, R. B., Carlo, M. I., de Leeuw, R., Hope, T. A., Karzai, F., McKay, R. R., Salami, S. S., Simons, J. W., Pienta, K. J. & Soule, H. R., Feb 15 2019, In : Prostate. 79, 3, p. 244-258 15 p.

Research output: Contribution to journalReview article

2018

3D cell nuclear morphology: Microscopy imaging dataset and voxel-based morphometry classification results

Kalinin, A. A., Allyn-Feuer, A., Ade, A., Fon, G. V., Meixner, W., Dilworth, D., De Wet, J. R., Higgins, G. A., Zheng, G., Creekmore, A., Wiley, J. W., Verdone, J. E., Veltri, R. W., Pienta, K., Coffey, D. S., Athey, B. D. & Dinov, I. D., Dec 13 2018, Proceedings - 2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops, CVPRW 2018. IEEE Computer Society, Vol. 2018-June. p. 2353-2361 9 p. 8575476

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3D Shape Modeling for Cell Nuclear Morphological Analysis and Classification

Kalinin, A. A., Allyn-Feuer, A., Ade, A., Fon, G. V., Meixner, W., Dilworth, D., Husain, S. S., de Wett, J. R., Higgins, G. A., Zheng, G., Creekmore, A., Wiley, J. W., Verdone, J. E., Veltri, R. W., Pienta, K. J., Coffey, D. S., Athey, B. D. & Dinov, I. D., Dec 1 2018, In : Scientific reports. 8, 1, 13658.

Research output: Contribution to journalArticle

Absence of myeloid Klf4 reduces prostate cancer growth with pro-atherosclerotic activation of tumor myeloid cells and infiltration of CD8 T cells

Barakat, D. J., Suresh, R., Barberi, T., Pienta, K., Simons, B. W. & Friedman, A. D., Jan 1 2018, In : PLoS One. 13, 1, e0191188.

Research output: Contribution to journalArticle

Analogous detection of circulating tumor cells using the AccuCyte®-CyteFinder® system and ISET system in patients with locally advanced and metastatic prostate cancer

van der Toom, E. E., Groot, V. P., Glavaris, S. A., Gemenetzis, G., Chalfin, H. J., Wood, L. D., Wolfgang, C., de la Rosette, J. J. M. C. H., de Reijke, T. M. & Pienta, K., Jan 1 2018, (Accepted/In press) In : Prostate.

Research output: Contribution to journalArticle

Apoptosis-induced CXCL5 accelerates inflammation and growth of prostate tumor metastases in bone

Roca, H., Jones, J. D., Purica, M. C., Weidner, S., Koh, A. J., Kuo, R., Wilkinson, J. E., Wang, Y., Daignault-Newton, S., Pienta, K. J., Morgan, T. M., Keller, E. T., Nör, J. E., Shea, L. D. & McCauley, L. K., Jan 2 2018, In : Journal of Clinical Investigation. 128, 1, p. 248-266 19 p.

Research output: Contribution to journalArticle

A Voice From the Past: Rediscovering the Virchow Node With Prostate-specific Membrane Antigen-targeted 18F-DCFPyL Positron Emission Tomography Imaging

Werner, R. A., Andree, C., Javadi, M. S., Lapa, C., Buck, A. K., Higuchi, T., Pomper, M. G., Gorin, M. A., Rowe, S. P. & Pienta, K. J., Jul 2018, In : Urology. 117, p. 18-21 4 p.

Research output: Contribution to journalArticle

Cancer as a social dysfunction—why cancer research needs new thinking

Axelrod, R. & Pienta, K., Sep 1 2018, In : Molecular Cancer Research. 16, 9, p. 1346-1347 2 p.

Research output: Contribution to journalReview article

Cancer Foraging Ecology: Diet Choice, Patch Use, and Habitat Selection of Cancer Cells

Amend, S., Gatenby, R. A., Pienta, K. & Brown, J. S., Dec 1 2018, In : Current Pathobiology Reports. 6, 4, p. 209-218 10 p.

Research output: Contribution to journalReview article