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2018

A call for more science in forensic science

Bell, S., Sah, S., Albright, T. D., James Gates, S., Bonner Denton, M. & Casadevall, A., May 1 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 18, p. 4541-4544 4 p.

Research output: Contribution to journalReview article

Forensic Sciences
Social Justice
Financial Support
Law Enforcement
DNA

Acknowledgment of invited editors

Casadevall, A., Mar 1 2018, In : mBio. 9, 2, e00731-18.

Research output: Contribution to journalEditorial

Analysis and correction of inappropriate image duplication: The molecular and cellular biology experience

Bik, E. M., Fang, F. C., Kullas, A. L., Davis, R. J. & Casadevall, A., Oct 1 2018, In : Molecular and cellular biology. 38, 20, e00309.

Research output: Contribution to journalArticle

Cell Biology
Publications
Molecular Biology
Manuscripts
Biological Warfare Agents
Benchmarking
Weapons
Influenza in Birds
Physics

Antibody-based vaccine strategies against intracellular pathogens

Casadevall, A., Aug 1 2018, In : Current Opinion in Immunology. 53, p. 74-80 7 p.

Research output: Contribution to journalReview article

Vaccines
Antibodies
Allergy and Immunology
Humoral Immunity
Cellular Immunity

A Therapeutic Vaccine for Recurrent Vulvovaginal Candidiasis

Casadevall, A. & Pirofski, L. A., Jun 1 2018, In : Clinical Infectious Diseases. 66, 12, p. 1937-1939 3 p.

Research output: Contribution to journalReview article

Vulvovaginal Candidiasis
Vaccines
Therapeutics

A two-way road: novel roles for fungal extracellular vesicles

Rodrigues, M. L. & Casadevall, A., Jan 1 2018, (Accepted/In press) In : Molecular Microbiology.

Research output: Contribution to journalArticle

Virulence
Cryptococcus gattii
Exosomes
Extracellular Vesicles
Prions

Automated measurement of cryptococcal species polysaccharide capsule and cell body

Dragotakes, Q. & Casadevall, A., Jan 11 2018, In : Journal of Visualized Experiments. 2018, 131, e56957.

Research output: Contribution to journalArticle

Polysaccharides
Capsules
Cells
Cryptococcus
Spreadsheets

Cell-wall dyes interfere with cryptococcus neoformans melanin deposition

Perez-Dulzaides, R., Camacho, E., Cordero-Gonzalez, R. & Casadevall, A., Aug 1 2018, In : Microbiology (United Kingdom). 164, 8, p. 1012-1022 11 p., 000682.

Research output: Contribution to journalArticle

Cryptococcus neoformans
Melanins
Cell Wall
Coloring Agents
Chitin

Conservation of intracellular pathogenic strategy among distantly related cryptococcal species

Freij, J. B., Fu, M. S., De Leon Rodriguez, C. M., Dziedzic, A., Jedlicka, A. E., Dragotakes, Q., Rossi, D. C. P., Jung, E. H., Coelho, C. & Casadevall, A., Jul 1 2018, In : Infection and Immunity. 86, 7, e00946-17.

Research output: Contribution to journalArticle

Cryptococcus gattii
Cryptococcus neoformans
Macrophages
Exocytosis
Cryptococcus

Cryptococcal traits mediating adherence to biotic and abiotic surfaces

Camacho, E. & Casadevall, A., Sep 1 2018, In : Journal of Fungi. 4, 3, 88.

Research output: Contribution to journalReview article

pathogenesis
adhesion
adhesins
tool use
biofilm

Cryptococcus neoformans urease affects the outcome of intracellular pathogenesis by modulating phagolysosomal pH

Fu, M. S., Coelho, C., De Leon-Rodriguez, C. M., Rossi, D. C. P., Camacho, E., Jung, E. H., Kulkarni, M. & Casadevall, A., Jun 1 2018, In : PLoS Pathogens. 14, 6, e1007144.

Research output: Contribution to journalArticle

Cryptococcus neoformans
Urease
Macrophages
Exocytosis
Nitrogen

Divalent metal cations potentiate the predatory capacity of amoeba for Cryptococcus neoformans

Fu, M. S. & Casadevall, A., Feb 1 2018, In : Applied and Environmental Microbiology. 84, 3, e01717-17.

Research output: Contribution to journalArticle

Cryptococcus neoformans
Amoeba
Divalent Cations
Acanthamoeba castellanii
cations

Elegant science

Casadevall, A. & Fang, F. C., Jan 1 2018, In : mBio. 9, 1, e00043-18.

Research output: Contribution to journalEditorial

Beauty
Biological Science Disciplines

Extracellular vesicles and vesicle-free secretome of the protozoa Acanthamoeba castellanii under homeostasis and nutritional stress and their damaging potential to host cells

Gonçalves, D. D. S., Ferreira, M. D. S., Liedke, S. C., Gomes, K. X., de Oliveira, G. A., Leão, P. E. L., Cesar, G. V., Seabra, S. H., Cortines, J. R., Casadevall, A., Nimrichter, L., Domont, G. B., Junqueira, M. R., Peralta, J. M. & Guimaraes, A. J., Dec 31 2018, In : Virulence. 9, 1, p. 818-836 19 p.

Research output: Contribution to journalArticle

Acanthamoeba castellanii
Homeostasis
Proteins
Extracellular Vesicles
Glucose

Impact of Yeast Pigmentation on Heat Capture and Latitudinal Distribution

Cordero-Gonzalez, R., Robert, V., Cardinali, G., Arinze, E. S., Thon, S. M. & Casadevall, A., Aug 20 2018, In : Current Biology. 28, 16, p. 2657-2664.e3

Research output: Contribution to journalArticle

Pigmentation
pigmentation
Yeast
Hot Temperature
Yeasts

In Fungal Intracellular Pathogenesis, Form Determines Fate

May, R. C. & Casadevall, A., Oct 23 2018, In : mBio. 9, 5

Research output: Contribution to journalArticle

Cryptococcus
Phagosomes
Hyphae
Candida albicans
Candida

Making the scientific literature fail-safe

Casadevall, A. & Fang, F. C., Oct 1 2018, In : Journal of Clinical Investigation. 128, 10, p. 4243-4244 2 p.

Research output: Contribution to journalReview article

Literature

Mechanisms of Cryptococcus neoformans-mediated host damage

Casadevall, A., Coelho, C. & Alanio, A., Apr 30 2018, In : Frontiers in Immunology. 9, APR, 855.

Research output: Contribution to journalReview article

Cryptococcus neoformans
Cryptococcosis
Exocytosis
Organelles
Homeostasis

Melanin triggers antifungal defences

Casadevall, A., Mar 15 2018, In : Nature. 555, 7696, p. 319-320 2 p.

Research output: Contribution to journalShort survey

Melanins

Opsonin-free, real-time imaging of Cryptococcus neoformans capsule during budding

Paes, H. C., Frazão, S. D. O., Rosa, C. P., Albuquerque, P., Casadevall, A., Felipe, M. S. S. & Nicola, A. M., Jan 1 2018, In : Virulence. 9, 1, p. 1483-1488 6 p.

Research output: Contribution to journalArticle

Opsonin Proteins
Cryptococcus neoformans
Capsules

Serum-Mediated Cleavage of Bacillus anthracis Protective Antigen Is a Two-Step Process That Involves a Serum Carboxypeptidase

Goldman, D. L., Nieves, E., Nakouzi, A., Rivera, J., Phyu, E. E., Win, T. H., Achkar, J. M. & Casadevall, A., Jun 27 2018, In : mSphere. 3, 3

Research output: Contribution to journalArticle

Carboxypeptidases
Bacillus anthracis
Serum
Antigen Presentation
Furin

Structure-function analysis and therapeutic efficacy of antibodies to fungal melanin for melanoma radioimmunotherapy

Nosanchuk, J. D., Jeyakumar, A., Ray, A., Revskaya, E., Jiang, Z., Bryan, R. A., Allen, K. J. H., Jiao, R., Malo, M. E., Gómez, B. L., Morgenstern, A., Bruchertseifer, F., Rickles, D., Thornton, G. B., Bowen, A., Casadevall, A. & Dadachova, E., Dec 1 2018, In : Scientific Reports. 8, 1, 5466.

Research output: Contribution to journalArticle

Fungal Antibodies
Radioimmunotherapy
Melanins
Melanoma
Immunoglobulin G

Testing Hypotheses on Risk Factors for Scientific Misconduct via Matched-Control Analysis of Papers Containing Problematic Image Duplications

Fanelli, D., Costas, R., Fang, F. C., Casadevall, A. & Bik, E. M., Feb 19 2018, (Accepted/In press) In : Science and Engineering Ethics. p. 1-19 19 p.

Research output: Contribution to journalArticle

Scientific Misconduct
hypothesis testing
Pressure
Testing
Research

The Buoyancy of Cryptococcus neoformans Is Affected by Capsule Size

Vij, R., Cordero-Gonzalez, R. & Casadevall, A., Nov 7 2018, In : mSphere. 3, 6

Research output: Contribution to journalArticle

Cryptococcus neoformans
Capsules
Cell Count
Seawater
Infection

The capsule of Cryptococcus neoformans

Casadevall, A., Coelho, C., Cordero-Gonzalez, R., Dragotakes, Q., Jung, E., Vij, R. & Wear, M. P., Jan 1 2018, (Accepted/In press) In : Virulence.

Research output: Contribution to journalArticle

Cryptococcus neoformans
Capsules
Fungi
Physical Chemistry
Desiccation

The capsule of Cryptococcus neoformans modulates phagosomal pH through its acidbase properties

De Leon-Rodriguez, C. M., Fu, M. S., çorbali, M. O., Cordero, R. J. B. & Casadevall, A., Sep 1 2018, In : mSphere. 3, 5, e00437-18.

Research output: Contribution to journalArticle

Cryptococcus
Phagosomes
Cryptococcus neoformans
Capsules
Polysaccharides
Communicable Diseases
Physicians
Inflammation
Microbiology
Allergy and Immunology

The outcome of the cryptococcus neoformans–macrophage interaction depends on phagolysosomal membrane integrity

De Leon-Rodriguez, C. M., Rossi, D. C. P., Fu, M. S., Dragotakes, Q., Coelho, C., Ros, I. G., Caballero, B., Nolan, S. J. & Casadevall, A., Jul 15 2018, In : Journal of Immunology. 201, 2, p. 583-603 21 p.

Research output: Contribution to journalArticle

Cryptococcus neoformans
Macrophages
Membranes
Phospholipases
Exocytosis

The putative flippase Apt1 is required for intracellular membrane architecture and biosynthesis of polysaccharide and lipids in Cryptococcus neoformans

Rizzo, J., Colombo, A. C., Zamith-Miranda, D., Silva, V. K. A., Allegood, J. C., Casadevall, A., Del Poeta, M., Nosanchuk, J. D., Kronstad, J. W. & Rodrigues, M. L., Mar 1 2018, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1865, 3, p. 532-541 10 p.

Research output: Contribution to journalArticle

Intracellular Membranes
Cryptococcus neoformans
Polysaccharides
Lipids
Glucosylceramides

The Silver Lining in Gain-of-Function Experiments with Pathogens of Pandemic Potential

Imperiale, M. J., Howard, D. & Casadevall, A., Jan 1 2018, Methods in Molecular Biology. Humana Press Inc., p. 575-587 13 p. (Methods in Molecular Biology; vol. 1836).

Research output: Chapter in Book/Report/Conference proceedingChapter

Influenza in Birds
Pandemics
Orthomyxoviridae
Uncertainty
Accidents

The viscoelastic properties of the fungal cell wall allow traffic of ambisome as intact liposome vesicles

Walker, L., Sood, P., Lenardon, M. D., Milne, G., Olson, J., Jensen, G., Wolf, J., Casadevall, A., Adler-Moore, J. & Gow, N. A. R., Jan 1 2018, In : mBio. 9, 1, e02383-17.

Research output: Contribution to journalArticle

Liposomes
Cell Wall
Amphotericin B
Candida albicans
Ergosterol

Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators

Hommel, B., Mukaremera, L., Cordero-Gonzalez, R., Coelho, C., Desjardins, C. A., Sturny-Leclère, A., Janbon, G., Perfect, J. R., Fraser, J. A., Casadevall, A., Cuomo, C. A., Dromer, F., Nielsen, K. & Alanio, A., May 1 2018, In : PLoS Pathogens. 14, 5, e1006982.

Research output: Contribution to journalArticle

Saturn
Cryptococcus neoformans
Quorum Sensing
Cell Size
Cell Enlargement

Using preprints for journal clubs

Casadevall, A. & Gow, N., Mar 1 2018, In : mBio. 9, 2, e00516-18.

Research output: Contribution to journalEditorial

Publications
Teaching
Literature
Art
Students

What is a host? Attributes of individual susceptibility

Casadevall, A. & Pirofski, L. A., Feb 1 2018, In : Infection and Immunity. 86, 2, e00636-17.

Research output: Contribution to journalShort survey

Causality
Germ Theory of Disease
History
Microbiota
Signs and Symptoms
2017

32-Phosphorus selectively delivered by listeria to pancreatic cancer demonstrates a strong therapeutic effect

Chandra, D., Selvanesan, B. C., Yuan, Z., Libutti, S. K., Koba, W., Beck, A., Zhu, K., Casadevall, A., Dadachova, E. & Gravekamp, C., 2017, In : Oncotarget. 8, 13, p. 20729-20740 12 p.

Research output: Contribution to journalArticle

Listeria
Therapeutic Uses
Pancreatic Neoplasms
Phosphorus
Neoplasms

A Monoclonal Antibody to Cryptococcus neoformans Glucuronoxylomannan Manifests Hydrolytic Activity for Both Peptides and Polysaccharides

Bowen, A., Wear, M. P., Cordero-Gonzalez, R., Oscarson, S. & Casadevall, A., Jan 13 2017, In : Journal of Biological Chemistry. 292, 2, p. 417-434 18 p.

Research output: Contribution to journalArticle

Catalytic Antibodies
Cryptococcus neoformans
Monoclonal Antibodies
Antibodies
Polysaccharides

Antibodies to mycobacterium tuberculosis

Casadevall, A., Jan 19 2017, In : New England Journal of Medicine. 376, 3, p. 283-285 3 p.

Research output: Contribution to journalShort survey

Bacterial Antibodies
Fc Receptors
Humoral Immunity
Mycobacterium tuberculosis
B-Lymphocytes

Antibody-mediated catalysis in infection and immunity

Bowen, A., Wear, M. & Casadevall, A., Sep 1 2017, In : Infection and Immunity. 85, 9, e00202-17.

Research output: Contribution to journalShort survey

Catalytic Antibodies
Catalysis
Immunity
Antibodies
Infection

Continental drift and speciation of the Cryptococcus neoformans and Cryptococcus gattii species complexes

Casadevall, A., Freij, J. B., Hann-Soden, C. & Taylor, J., Mar 1 2017, In : mSphere. 2, 2, e00103-17.

Research output: Contribution to journalComment/debate

Cryptococcus gattii
Cryptococcus neoformans
South America
South Africa
Virulence Factors

Crisis in infectious diseases: 2 decades later

Casadevall, A., Apr 1 2017, In : Clinical Infectious Diseases. 64, 7, p. 823-828 6 p.

Research output: Contribution to journalArticle

Communicable Diseases

Don't Forget the Fungi When Considering Global Catastrophic Biorisks

Casadevall, A., Jul 1 2017, In : Health security. 15, 4, p. 341-342 2 p.

Research output: Contribution to journalShort survey

Fungi
fungus

Enhanced control of Mycobacterium tuberculosis extrapulmonary dissemination in mice by an arabinomannan-protein conjugate vaccine

Prados-Rosales, R., Carreño, L., Cheng, T., Blanc, C., Weinrick, B., Malek, A., Lowary, T. L., Baena, A., Joe, M., Bai, Y., Kalscheuer, R., Batista-Gonzalez, A., Saavedra, N. A., Sampedro, L., Tomás, J., Anguita, J., Hung, S. C., Tripathi, A., Xu, J., Glatman-Freedman, A. & 5 othersJacobs, W. R., Chan, J., Porcelli, S. A., Achkar, J. M. & Casadevall, A., Mar 1 2017, In : PLoS Pathogens. 13, 3, e1006250.

Research output: Contribution to journalArticle

Conjugate Vaccines
Mycobacterium tuberculosis
Antibody Formation
Polysaccharides
Tuberculosis

First draft genome sequence of the pathogenic fungus Lomentospora prolificans (formerly Scedosporium prolificans)

Luo, R., Zimin, A., Workman, R., Fan, Y., Pertea, G., Grossman, N., Wear, M. P., Jia, B., Miller, H., Casadevall, A., Timp, W., Zhang, S. X. & Salzberg, S. L., Nov 1 2017, In : G3: Genes, Genomes, Genetics. 7, 11, p. 3831-3836 6 p.

Research output: Contribution to journalArticle

Scedosporium
Nanopores
Chromosomes, Human, Pair 11
Fungi
Gels

Forensic science must be scientific

Sah, S., Casadevall, A., Bell, S., Gates, S. J., Albright, T. D. & Denton, M. B., Oct 1 2017, In : Scientific American. 317, 4, 1 p.

Research output: Contribution to journalComment/debate

Fungi that infect humans

Köhler, J. R., Hube, B., Puccia, R., Casadevall, A. & Perfect, J. R., Jun 1 2017, In : Microbiology spectrum. 5, 3, FUNK-0014-2016.

Research output: Contribution to journalArticle

Fungi
fungus
pathogen
body temperature
commensalism

Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects

Almeida, F., Wolf, J. M., Da Silva, T. A., Deleon-Rodriguez, C. M., Rezende, C. P., Pessoni, A. M., Fernandes, F. F., Silva-Rocha, R., Martinez, R., Rodrigues, M. L., Roque-Barreira, M. C. & Casadevall, A., Dec 1 2017, In : Nature Communications. 8, 1, 1968.

Research output: Contribution to journalArticle

Galectin 3
Cryptococcus neoformans
infectious diseases
Cryptococcosis
Infection

Graduate biomedical science education needs a new philosophy

Bosch, G. & Casadevall, A., Nov 1 2017, In : mBio. 8, 6, e01539-17.

Research output: Contribution to journalArticle

Graduate Education
Education
Research
Publications
Teaching

Immune-mediated damage completes the parabola: Cryptococcus neoformans pathogenesis can reflect the outcome of a weak or strong immune response

Pirofski, L. A. & Casadevall, A., Nov 1 2017, In : mBio. 8, 6, e02063-17.

Research output: Contribution to journalComment/debate

Cryptococcosis
Cryptococcus neoformans
Immunotherapy
Fungi
HIV

Lipids affect the Cryptococcus neoformans-macrophage interaction and promote nonlytic exocytosis

Nolan, S. J., Fu, M. S., Coppens, I. & Casadevall, A., Jan 1 2017, In : Infection and Immunity. 85, 12, e00564-17.

Research output: Contribution to journalArticle

Cryptococcus neoformans
Exocytosis
Macrophages
Lipids
Oleic Acid