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2018

Attacking Heterogeneity in Schizophrenia by Deriving Clinical Subgroups from Widely Available Symptom Data

Dickinson, D., Pratt, D. N., Giangrande, E. J., Grunnagle, M., Orel, J., Weinberger, D. R., Callicott, J. H. & Berman, K. F. Jan 1 2018 In : Schizophrenia bulletin. 44, 1, p. 101-113 13 p.

Research output: Contribution to journalArticle

Cluster Analysis
Schizophrenia
Neurosciences
Psychiatry
Neurobehavioral Manifestations

Convergence of placenta biology and genetic risk for schizophrenia article

Ursini, G. , Punzi, G. , Chen, Q. , Marenco, S. , Robinson, J. F. , Porcelli, A. , Hamilton, E. G. , Mitjans, M. , Maddalena, G. , Begemann, M. , Seidel, J. , Yanamori, H. , Jaffe, A. E. , Berman, K. F. , Egan, M. F. , Straub, R. E. , Colantuoni, C. , Blasi, G. , Hashimoto, R. , Rujescu, D. & 3 others Ehrenreich, H., Bertolino, A. & Weinberger, D. R. Jun 1 2018 In : Nature medicine. 24, 6, p. 792-801 10 p.

Research output: Contribution to journalArticle

Placenta
Schizophrenia
Genes
Germany
Biological Phenomena

Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum Likelihood

Wellcome Trust Case Control Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium & Psychosis Endophenotypes International Consortium Jun 7 2018 In : American journal of human genetics. 102, 6, p. 1185-1194 10 p.

Research output: Contribution to journalArticle

Linkage Disequilibrium
Schizophrenia
Likelihood Functions
Genetic Heterogeneity
Nucleic Acid Regulatory Sequences

GAD1 alternative transcripts and DNA methylation in human prefrontal cortex and hippocampus in brain development, schizophrenia

Tao, R., Davis, K. N., Li, C., Shin, J. H., Gao, Y., Jaffe, A. E., Gondré-Lewis, M. C., Weinberger, D. R., Kleinman, J. E. & Hyde, T. M. Jun 1 2018 In : Molecular psychiatry. 23, 6, p. 1496-1505 10 p.

Research output: Contribution to journalArticle

DNA Methylation
Prefrontal Cortex
Hippocampus
Schizophrenia
gamma-Aminobutyric Acid

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium douglas.ruderfer@vanderbilt.edu, Psychosis Endophenotypes International Consortium & Wellcome Trust Case Control Consortium Jun 14 2018 In : Cell. 173, 7, p. 1705-1715.e16

Research output: Contribution to journalArticle

Bipolar Disorder
Dissection
Schizophrenia
Age of Onset
Potassium

Interaction of childhood urbanicity and variation in dopamine genes alters adult prefrontal function as measured by functional magnetic resonance imaging (fMRI)

Reed, J. L., D’Ambrosio, E., Marenco, S., Ursini, G., Zheutlin, A. B., Blasi, G., Spencer, B. E., Romano, R., Hochheiser, J., Reifman, A., Sturm, J., Berman, K. F., Bertolino, A., Weinberger, D. R. & Callicott, J. H. Apr 1 2018 In : PloS one. 13, 4, e0195189

Research output: Contribution to journalArticle

dopamine
magnetic resonance imaging
childhood
Dopamine
Magnetic Resonance Imaging

Investigating the neuroimmunogenic architecture of schizophrenia

Birnbaum, R., Jaffe, A. E., Chen, Q., Shin, J. H., Kleinman, J. E., Hyde, T. M. & Weinberger, D. R. May 1 2018 In : Molecular psychiatry. 23, 5, p. 1251-1260 10 p.

Research output: Contribution to journalArticle

Schizophrenia
Prefrontal Cortex
Genes
Immune System
Hippocampus

Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder

Rutten, B. P. F. , Vermetten, E. , Vinkers, C. H. , Ursini, G. , Daskalakis, N. P. , Pishva, E. , De Nijs, L. , Houtepen, L. C. , Eijssen, L. , Jaffe, A. E. , Kenis, G. , Viechtbauer, W. , Van Den Hove, D. , Schraut, K. G. , Lesch, K. P. , Kleinman, J. E. , Hyde, T. M. , Weinberger, D. R. , Schalkwyk, L. , Lunnon, K. & 8 others Mill, J., Cohen, H., Yehuda, R., Baker, D. G., Maihofer, A. X., Nievergelt, C. M., Geuze, E. & Boks, M. P. M. May 1 2018 In : Molecular psychiatry. 23, 5, p. 1145-1156 12 p.

Research output: Contribution to journalArticle

Post-Traumatic Stress Disorders
DNA Methylation
DNA
Military Personnel
Wounds and Injuries

Schizophrenia polygenic risk score predicts mnemonic hippocampal activity

Chen, Q., Ursini, G., Romer, A. L., Knodt, A. R., Mezeivtch, K., Xiao, E., Pergola, G., Blasi, G., Straub, R. E., Callicott, J. H., Berman, K. F., Hariri, A. R., Bertolino, A., Mattay, V. S. & Weinberger, D. R. Apr 1 2018 In : Brain. 141, 4, p. 1218-1228 11 p.

Research output: Contribution to journalArticle

Schizophrenia
Healthy Volunteers
Genome-Wide Association Study
Masks
Alleles

Small RNAs May Answer Big Questions in Mental Illness

Wight, C., Ross, D. A. & Weinberger, D. R. Jan 1 2018 In : Biological psychiatry. 83, 1, p. e1-e3

Research output: Contribution to journalComment/debate

RNA

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Davies, G. , Lam, M. , Harris, S. E. , Trampush, J. W. , Luciano, M. , Hill, W. D. , Hagenaars, S. P. , Ritchie, S. J. , Marioni, R. E. , Fawns-Ritchie, C. , Liewald, D. C. M. , Okely, J. A. , Ahola-Olli, A. V. , Barnes, C. L. K. , Bertram, L. , Bis, J. C. , Burdick, K. E. , Christoforou, A. , Derosse, P. , Djurovic, S. & 201 others Espeseth, T., Giakoumaki, S., Giddaluru, S., Gustavson, D. E., Hayward, C., Hofer, E., Ikram, M. A., Karlsson, R., Knowles, E., Lahti, J., Leber, M., Li, S., Mather, K. A., Melle, I., Morris, D., Oldmeadow, C., Palviainen, T., Payton, A., Pazoki, R., Petrovic, K., Reynolds, C. A., Sargurupremraj, M., Scholz, M., Smith, J. A., Smith, A. V., Terzikhan, N., Thalamuthu, A., Trompet, S., Van Der Lee, S. J., Ware, E. B., Windham, B. G., Wright, M. J., Yang, J., Yu, J., Ames, D., Amin, N., Amouyel, P., Andreassen, O. A., Armstrong, N. J., Assareh, A. A., Attia, J. R., Attix, D., Avramopoulos, D., Bennett, D. A., Böhmer, A. C., Boyle, P. A., Brodaty, H., Campbell, H., Cannon, T. D., Cirulli, E. T., Congdon, E., Conley, E. D., Corley, J., Cox, S. R., Dale, A. M., Dehghan, A., Dick, D., Dickinson, D., Eriksson, J. G., Evangelou, E., Faul, J. D., Ford, I., Freimer, N. A., Gao, H., Giegling, I., Gillespie, N. A., Gordon, S. D., Gottesman, R. F., Griswold, M. E., Gudnason, V., Harris, T. B., Hartmann, A. M., Hatzimanolis, A., Heiss, G., Holliday, E. G., Joshi, P. K., Kähönen, M., Kardia, S. L. R., Karlsson, I., Kleineidam, L., Knopman, D. S., Kochan, N. A., Konte, B., Kwok, J. B., Le Hellard, S., Lee, T., Lehtimäki, T., Li, S. C., Liu, T., Koini, M., London, E., Longstreth, W. T., Lopez, O. L., Loukola, A., Luck, T., Lundervold, A. J., Lundquist, A., Lyytikäinen, L. P., Martin, N. G., Montgomery, G. W., Murray, A. D., Need, A. C., Noordam, R., Nyberg, L., Ollier, W., Papenberg, G., Pattie, A., Polasek, O., Poldrack, R. A., Psaty, B. M., Reppermund, S., Riedel-Heller, S. G., Rose, R. J., Rotter, J. I., Roussos, P., Rovio, S. P., Saba, Y., Sabb, F. W., Sachdev, P. S., Satizabal, C. L., Schmid, M., Scott, R. J., Scult, M. A., Simino, J., Slagboom, P. E., Smyrnis, N., Soumaré, A., Stefanis, N. C., Stott, D. J., Straub, R. E., Sundet, K., Taylor, A. M., Taylor, K. D., Tzoulaki, I., Tzourio, C., Uitterlinden, A., Vitart, V., Voineskos, A. N., Kaprio, J., Wagner, M., Wagner, H., Weinhold, L., Wen, K. H., Widen, E., Yang, Q., Zhao, W., Adams, H. H. H., Arking, D. E., Bilder, R. M., Bitsios, P., Boerwinkle, E., Chiba-Falek, O., Corvin, A., De Jager, P. L., Debette, S., Donohoe, G., Elliott, P., Fitzpatrick, A. L., Gill, M., Glahn, D. C., Hägg, S., Hansell, N. K., Hariri, A. R., Ikram, M. K., Jukema, J. W., Vuoksimaa, E., Keller, M. C., Kremen, W. S., Launer, L., Lindenberger, U., Palotie, A., Pedersen, N. L., Pendleton, N., Porteous, D. J., Räikkönen, K., Raitakari, O. T., Ramirez, A., Reinvang, I., Rudan, I., Rujescu, D., Schmidt, R., Schmidt, H., Schofield, P. W., Schofield, P. R., Starr, J. M., Steen, V. M., Trollor, J. N., Turner, S. T., Van Duijn, C. M., Villringer, A., Weinberger, D. R., Weir, D. R., Wilson, J. F., Malhotra, A., McIntosh, A. M., Gale, C. R., Seshadri, S., Mosley, T. H., Bressler, J., Lencz, T. & Deary, I. J. Dec 1 2018 In : Nature Communications. 9, 1, 2098

Research output: Contribution to journalArticle

hypertension
gene
heritability
brain
genome
2017

Altered expression of histamine signaling genes in autism spectrum disorder

Wright, C., Shin, J. H., Rajpurohit, A., Deep-Soboslay, A., Collado-Torres, L., Brandon, N. J., Hyde, T. M., Kleinman, J. E., Jaffe, A. E., Cross, A. J. & Weinberger, D. R. Jan 1 2017 In : Translational Psychiatry. 7, 5, e1126

Research output: Contribution to journalArticle

Histamine
Genes
RNA Sequence Analysis
Prefrontal Cortex
Small Nucleolar RNA

A Study of TNF Pathway Activation in Schizophrenia and Bipolar Disorder in Plasma and Brain Tissue

Hoseth, E. Z., Ueland, T., Dieset, I., Birnbaum, R., Shin, J. H., Kleinman, J. E., Hyde, T. M., Mørch, R. H., Hope, S., Lekva, T., Abraityte, A. J., Michelsen, A. E., Melle, I., Westlye, L. T., Ueland, T., Djurovic, S., Aukrust, P., Weinberger, D. R. & Andreassen, O. A. Jul 1 2017 In : Schizophrenia Bulletin. 43, 4, p. 881-890 10 p.

Research output: Contribution to journalArticle

Bipolar Disorder
Schizophrenia
Tumor Necrosis Factor-alpha
Brain
Disintegrins

DRD2 co-expression network and a related polygenic index predict imaging, behavioral and clinical phenotypes linked to schizophrenia

Pergola, G., Di Carlo, P., D'Ambrosio, E., Gelao, B., Fazio, L., Papalino, M., Monda, A., Scozia, G., Pietrangelo, B., Attrotto, M., Apud, J. A., Chen, Q., Mattay, V. S., Rampino, A., Caforio, G., Weinberger, D. R., Blasi, G. & Bertolino, A. 2017 In : Translational Psychiatry. 7, 1, e1006

Research output: Contribution to journalArticle

Schizophrenia
Phenotype
Short-Term Memory
Genetic Loci
Genes

Future of Days Past: Neurodevelopment and Schizophrenia

Weinberger, D. R. Nov 1 2017 In : Schizophrenia bulletin. 43, 6, p. 1164-1168 5 p.

Research output: Contribution to journalReview article

Epigenomics
Placenta
Schizophrenia
Gene Expression
Psychiatry

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

McLaughlin, R. L. , Schijven, D. , Van Rheenen, W. , Van Eijk, K. R. , O'Brien, M. , Kahn, R. S. , Ophoff, R. A. , Goris, A. , Bradley, D. G. , Al-Chalabi, A. , Van Den Berg, L. H. , Luykx, J. J. , Hardiman, O. , Veldink, J. H. , Shatunov, A. , Dekker, A. M. , Diekstra, F. P. , Pulit, S. L. , Van Der Spek, R. A. A. , Van Doormaal, P. T. C. & 416 others Sproviero, W., Jones, A. R., Nicholson, G. A., Rowe, D. B., Pamphlett, R., Kiernan, M. C., Bauer, D., Kahlke, T., Williams, K., Eftimov, F., Fogh, I., Ticozzi, N., Lin, K., Millecamps, S., Salachas, F., Meininger, V., Carvalho, M. D., Pinto, S., Mora, J. S., Rojas-Garcyá, R., Polak, M., Chandran, S., Colville, S., Swingler, R., Morrison, K. E., Shaw, P. J., Hardy, J., Orrell, R. W., Pittman, A., Sidle, K., Fratta, P., Malaspina, A., Petri, S., Abdulla, S., Drepper, C., Sendtner, M., Meyer, T., Wiedau-Pazos, M., Lomen-Hoerth, C., Deerlin, V. M. V., Trojanowski, J. Q., Elman, L., McCluskey, L., Basak, N., Meitinger, T., Lichtner, P., Blagojevic-Radivojkov, M., Andres, C. R., Maurel, C., Bensimon, G., Landwehrmeyer, B., Brice, A., Payan, C. A. M., Saker-Delye, S., Durr, A., Wood, N., Tittmann, L., Lieb, W., Franke, A., Rietschel, M., Cichon, S., Nothen, M. M., Amouyel, P., Tzourio, C., Dartigues, J. F., Uitterlinden, A. G., Rivadeneira, F., Estrada, K., Hofman, A., Curtis, C., Derkooi, A. J. V., De Visser, M., Weber, M., Shaw, C. E., Smith, B. N., Pansarasa, O., Cereda, C., Bo, R. D., Comi, G. P., D'Alfonso, S., Bertolin, C., Soraru, G., Mazzini, L., Pensato, V., Gellera, C., Tiloca, C., Ratti, A., Calvo, A., Moglia, C., Brunetti, M., Arcuti, S., Capozzo, R., Zecca, C., Lunetta, C., Penco, S., Riva, N., Padovani, A., Filosto, M., Blair, I., Nigel Leigh, P., Casale, F., Chio, A., Beghi, E., Pupillo, E., Tortelli, R., Logroscino, G., Powell, J., Ludolph, A. C., Weishaupt, J. H., Robberecht, W., Damme, P. V., Brown, R. H., Glass, J., Landers, J. E., Andersen, P. M., Corcia, P., Vourc'H, P., Silani, V., Es, M. A. V., Pasterkamp, R. J., Lewis, C. M., Breen, G., Ripke, S., Neale, B. M., Corvin, A., Walters, J. T. R., Farh, K. H., Holmans, P. A., Lee, P., Bulik-Sullivan, B., Collier, D. A., Huang, H., Pers, T. H., Agartz, I., Agerbo, E., Albus, M., Alexander, M., Amin, F., Bacanu, S. A., Begemann, M., Belliveau, R. A., Bene, J., Bergen, S. E., Bevilacqua, E., Bigdeli, T. B., Black, D. W., Bruggeman, R., Buccola, N. G., Buckner, R. L., Byerley, W., Cahn, W., Cai, G., Campion, D., Cantor, R. M., Carr, V. J., Carrera, N., Catts, S. V., Chambert, K. D., Chan, R. C. K., Chan, R. Y. L., Chen, E. Y. H., Cheng, W., Cheung, E. F. C., Chong, S. A., Cloninger, C. R., Cohen, D., Cohen, N., Cormican, P., Craddock, N., Crowley, J. J., Curtis, D., Davidson, M., Davis, K. L., Degenhardt, F., Favero, J. D., Demontis, D., Dikeos, D., Dinan, T., Djurovic, S., Donohoe, G., Drapeau, E., Duan, J., Dudbridge, F., Durmishi, N., Eichhammer, P., Eriksson, J., Escott-Price, V., Essioux, L., Fanous, A. H., Farrell, M. S., Frank, J., Franke, L., Freedman, R., Freimer, N. B., Friedl, M., Friedman, J. I., Fromer, M., Genovese, G., Georgieva, L., Giegling, I., Giusti-Rodrýguez, P., Godard, S., Goldstein, J. I., Golimbet, V., Gopal, S., Gratten, J., De Haan, L., Hammer, C., Hamshere, M. L., Hansen, M., Hansen, T., Haroutunian, V., Hartmann, A. M., Henskens, F. A., Herms, S., Hirschhorn, J. N., Hoffmann, P., Hofman, A., Hollegaard, M. V., Hougaard, D. M., Ikeda, M., Joa, I., Julia, A., Kalaydjieva, L., Karachanak-Yankova, S., Karjalainen, J., Kavanagh, D., Keller, M. C., Kennedy, J. L., Khrunin, A., Kim, Y., Klovins, J., Knowles, J. A., Konte, B., Kucinskas, V., Kucinskiene, Z. A., Kuzelova-Ptackova, H., Kahler, A. K., Laurent, C., Lee, J., Hong Lee, S., Legge, S. E., Lerer, B., Li, M., Li, T., Liang, K. Y., Lieberman, J., Limborska, S., Loughland, C. M., Lubinski, J., Lonnqvist, J., MacEk, M., Magnusson, P. K. E., Maher, B. S., Maier, W., Mallet, J., Marsal, S., Mattheisen, M., Mattingsdal, M., McCarley, R. W., McDonald, C., McIntosh, A. M., Meier, S., Meijer, C. J., Melegh, B., Melle, I., Mesholam-Gately, R. I., Metspalu, A., Michie, P. T., Milani, L., Milanova, V., Mokrab, Y., Morris, D. W., Mors, O., Murphy, K. C., Murray, R. M., Myin-Germeys, I., Muller-Myhsok, B., Nelis, M., Nenadic, I., Nertney, D. A., Nestadt, G., Nicodemus, K. K., Nikitina-Zake, L., Nisenbaum, L., Nordin, A., O'Callaghan, E., O'Dushlaine, C., Anthony O'Neill, F., Oh, S. Y., Olincy, A., Olsen, L., Vanos, J., Pantelis, C., Papadimitriou, G. N., Papiol, S., Parkhomenko, E., Pato, M. T., Paunio, T., Pejovic-Milovancevic, M., Perkins, D. O., Pietilainen, O., Pimm, J., Pocklington, A. J., Price, A., Pulver, A. E., Purcell, S. M., Quested, D., Rasmussen, H. B., Reichenberg, A., Reimers, M. A., Richards, A. L., Roffman, J. L., Roussos, P., Ruderfer, D. M., Salomaa, V., Sanders, A. R., Schall, U., Schubert, C. R., Schulze, T. G., Schwab, S. G., Scolnick, E. M., Scott, R. J., Seidman, L. J., Shi, J., Sigurdsson, E., Silagadze, T., Silverman, J. M., Sim, K., Slominsky, P., Smoller, J. W., So, H. C., Spencer, C. C. A., Stah, E. A., Stefansson, H., Steinberg, S., Stogmann, E., Straub, R. E., Strengman, E., Strohmaier, J., Scott Stroup, T., Subramaniam, M., Suvisaari, J., Svrakic, D. M., Szatkiewicz, J. P., Söderman, E., Thirumalai, S., Toncheva, D., Tosato, S., Veijola, J., Waddington, J., Walsh, D., Wang, D., Wang, Q., Webb, B. T., Weiser, M., Wildenauer, D. B., Williams, N. M., Williams, S., Witt, S. H., Wolen, A. R., Wong, E. H. M., Wormley, B. K., Xi, H. S., Zai, C. C., Zheng, X., Zimprich, F., Wray, N. R., Stefansson, K., Visscher, P. M., Adolfsson, R., Andreassen, O. A., Blackwood, D. H. R., Bramon, E., Buxbaum, J. D., Børglum, A. D., Darvasi, A., Domenici, E., Ehrenreich, H., Esko, T., Gejman, P. V., Gil, M., Gurling, H., Hultman, C. M., Iwata, N., Jablensky, A. V., Jonsson, E. G., Kendler, K. S., Kirov, G., Knight, J., Lencz, T., Levinson, D. F., Li, Q. S., Liu, J., Malhotra, A. K., McCarrol, S. A., McQuillin, A., Moran, J. L., Mortensen, P. B., Mowry, B. J., Owen, M. J., Palotie, A., Pato, C. N., Petryshen, T. L., Posthuma, D., Riley, B. P., Rujescu, D., Sham, P. C., Sklar, P., Clair, D. S., Weinberger, D. R., Wendland, J. R., Werge, T., Daly, M. J., Sullivan, P. F. & O'Donovan, M. C. Mar 21 2017 In : Nature Communications. 8, 14774

Research output: Contribution to journalArticle

schizophrenia
Amyotrophic Lateral Sclerosis
Schizophrenia
Genes
genome

Genetic insights into the neurodevelopmental origins of schizophrenia

Birnbaum, R. & Weinberger, D. R. Dec 1 2017 In : Nature Reviews Neuroscience. 18, 12, p. 727-740 14 p.

Research output: Contribution to journalReview article

Animal Disease Models
Genetic Predisposition to Disease
Neurotransmitter Agents
Schizophrenia
Brain

GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium

Trampush, J. W. , Yang, M. L. Z. , Yu, J. , Knowles, E. , Davies, G. , Liewald, D. C. , Starr, J. M. , Djurovic, S. , Melle, I. , Sundet, K. , Christoforou, A. , Reinvang, I. , DeRosse, P. , Lundervold, A. J. , Steen, V. M. , Espeseth, T. , Räikkönen, K. , Widen, E. , Palotie, A. , Eriksson, J. G. & 46 others Giegling, I., Konte, B., Roussos, P., Giakoumaki, S., Burdick, K. E., Payton, A., Ollier, W., Horan, M., Chiba-Falek, O., Attix, D. K., Need, A. C., Cirulli, E. T., Voineskos, A. N., Stefanis, N. C., Avramopoulos, D., Hatzimanolis, A., Arking, D. E., Smyrnis, N., Bilder, R. M., Freimer, N. A., Cannon, T. D., London, E., Poldrack, R. A., Sabb, F. W., Congdon, E., Conley, E. D., Scult, M. A., Dickinson, D., Straub, R. E., Donohoe, G., Morris, D., Corvin, A., Gill, M., Hariri, A. R., Weinberger, D. R., Pendleton, N., Bitsios, P., Rujescu, D., Lahti, J., Le Hellard, S., Keller, M. C., Andreassen, O. A., Deary, I. J., Glahn, D. C., Malhotra, A. K. & Lencz, T. Jan 17 2017 (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Genetic Loci
Genome-Wide Association Study
Genomics
Cognition
Single Nucleotide Polymorphism

Illuminating the dark road from schizophrenia genetic associations to disease mechanisms

Li, M. & Weinberger, D. R. Mar 1 2017 In : National Science Review. 4, 2, p. 240-251 12 p., nww065

Research output: Contribution to journalReview article

Genome-Wide Association Study
Schizophrenia
Epidemiologic Methods
Drug Discovery
Neurosciences

Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network

Brain Somatic Mosaicism Network Apr 28 2017 In : Science. 356, 6336, 395

Research output: Contribution to journalArticle

Mosaicism
Brain Diseases
Genome
Brain
Neurons

Late-Onset Alzheimer's Disease Polygenic Risk Profile Score Predicts Hippocampal Function

Xiao, E., Chen, Q., Goldman, A. L., Tan, H. Y., Healy, K., Zoltick, B., Das, S., Kolachana, B., Callicott, J. H., Dickinson, D., Berman, K. F., Weinberger, D. R. & Mattay, V. S. 2017 (Accepted/In press) In : Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.

Research output: Contribution to journalArticle

Alzheimer Disease
Haplotypes
Single Nucleotide Polymorphism
Healthy Volunteers
Episodic Memory

Molecular and cellular reorganization of neural circuits in the human lineage

Sousa, A. M. M. , Zhu, Y. , Raghanti, M. A. , Kitchen, R. R. , Onorati, M. , Tebbenkamp, A. T. N. , Stutz, B. , Meyer, K. A. , Li, M. , Kawasawa, Y. I. , Liu, F. , Perez, R. G. , Mele, M. , Carvalho, T. , Skarica, M. , Gulden, F. O. , Pletikos, M. , Shibata, A. , Stephenson, A. R. , Edler, M. K. & 18 others Ely, J. J., Elsworth, J. D., Horvath, T. L., Hof, P. R., Hyde, T. M., Kleinman, J. E., Weinberger, D. R., Reimers, M., Lifton, R. P., Mane, S. M., Noonan, J. P., State, M. W., Lein, E. S., Knowles, J. A., Marques-Bonet, T., Sherwood, C. C., Gerstein, M. B. & Sestan, N. Nov 24 2017 In : Science. 358, 6366, p. 1027-1032 6 p.

Research output: Contribution to journalArticle

brain
gene
primate
phylogenetics

Neanderthal-Derived Genetic Variation Shapes Modern Human Cranium and Brain

Gregory, M. D., Kippenhan, J. S., Eisenberg, D. P., Kohn, P. D., Dickinson, D., Mattay, V. S., Chen, Q., Weinberger, D. R., Saad, Z. S. & Berman, K. F. Dec 1 2017 In : Scientific Reports. 7, 1, 6308

Research output: Contribution to journalArticle

Neanderthals
Skull
Brain
Occipital Bone
Parietal Bone

New repeat polymorphism in the AKT1 gene predicts striatal dopamine D2/D3 receptor availability and stimulant-induced dopamine release in the healthy human brain

Shumay, E., Wiers, C. E., Shokri-Kojori, E., Kim, S. W., Hodgkinson, C. A., Sun, H., Tomasi, D., Wong, C. T., Weinberger, D. R., Wang, G. J., Fowler, J. S. & Volkow, N. D. May 10 2017 In : Journal of Neuroscience. 37, 19, p. 4982-4991 10 p.

Research output: Contribution to journalArticle

Dopamine D3 Receptors
Corpus Striatum
Dopamine D2 Receptors
Dopamine
Brain

Novel genetic loci associated with hippocampal volume

Hibar, D. P. , Adams, H. H. H. , Jahanshad, N. , Chauhan, G. , Stein, J. L. , Hofer, E. , Renteria, M. E. , Bis, J. C. , Arias-Vasquez, A. , Ikram, M. K. , Desrivières, S. , Vernooij, M. W. , Abramovic, L. , Alhusaini, S. , Amin, N. , Andersson, M. , Arfanakis, K. , Aribisala, B. S. , Armstrong, N. J. , Athanasiu, L. & 312 others Axelsson, T., Beecham, A. H., Beiser, A., Bernard, M., Blanton, S. H., Bohlken, M. M., Boks, M. P., Bralten, J., Brickman, A. M., Carmichael, O., Chakravarty, M. M., Chen, Q., Ching, C. R. K., Chouraki, V., Cuellar-Partida, G., Crivello, F., Den Braber, A., Doan, N. T., Ehrlich, S., Giddaluru, S., Goldman, A. L., Gottesman, R. F., Grimm, O., Griswold, M. E., Guadalupe, T., Becker, D. M., Hass, J., Haukvik, U. K., Hoehn, D., Holmes, A. J., Hoogman, M., Janowitz, D., Jia, T., Jørgensen, K. N., Karbalai, N., Kasperaviciute, D., Kim, S., Klein, M., Kraemer, B., Lee, P. H., Liewald, D. C. M., Lopez, L. M., Luciano, M., MacAre, C., Marquand, A. F., Matarin, M., Mather, K. A., Mattheisen, M., McKay, D. R., Milaneschi, Y., Muñoz Maniega, S., Nho, K., Nugent, A. C., Nyquist, P., Loohuis, L. M. O., Oosterlaan, J., Papmeyer, M., Pirpamer, L., Pütz, B., Ramasamy, A., Richards, J. S., Risacher, S. L., Roiz-Santiañez, R., Rommelse, N., Ropele, S., Rose, E. J., Royle, N. A., Rundek, T., Sämann, P. G., Saremi, A., Satizabal, C. L., Schmaal, L., Schork, A. J., Shen, L., Shin, J., Shumskaya, E., Smith, A. V., Sprooten, E., Strike, L. T., Teumer, A., Tordesillas-Gutierrez, D., Toro, R., Trabzuni, D., Trompet, S., Vaidya, D., Van Der Grond, J., Van Der Lee, S. J., Van Der Meer, D., Van Donkelaar, M. M. J., Van Eijk, K. R., Van Erp, T. G. M., Van Rooij, D., Walton, E., Westlye, L. T., Whelan, C. D., Windham, B. G., Winkler, A. M., Wittfeld, K., Woldehawariat, G., Wolf, C., Wolfers, T., Yanek, L. R., Yang, J., Zijdenbos, A., Zwiers, M. P., Agartz, I., Almasy, L., Ames, D., Amouyel, P., Andreassen, O. A., Arepalli, S., Assareh, A. A., Barral, S., Bastin, M. E., Becker, D. M., Becker, J. T., Bennett, D. A., Blangero, J., Van Bokhoven, H., Boomsma, D. I., Brodaty, H., Brouwer, R. M., Brunner, H. G., Buckner, R. L., Buitelaar, J. K., Bulayeva, K. B., Cahn, W., Calhoun, V. D., Cannon, D. M., Cavalleri, G. L., Cheng, C. Y., Cichon, S., Cookson, M. R., Corvin, A., Crespo-Facorro, B., Curran, J. E., Czisch, M., Dale, A. M., Davies, G. E., De Craen, A. J. M., De Geus, E. J. C., De Jager, P. L., De Zubicaray, G. I., Deary, I. J., Debette, S., Decarli, C., Delanty, N., Depondt, C., Destefano, A., Dillman, A., Djurovic, S., Donohoe, G., Drevets, W. C., Duggirala, R., Dyer, T. D., Enzinger, C., Erk, S., Espeseth, T., Fedko, I. O., Fernández, G., Ferrucci, L., Fisher, S. E., Fleischman, D. A., Ford, I., Fornage, M., Foroud, T. M., Fox, P. T., Francks, C., Fukunaga, M., Gibbs, J. R., Glahn, D. C., Gollub, R. L., Göring, H. H. H., Green, R. C., Gruber, O., Gudnason, V., Guelfi, S., Håberg, A. K., Hansell, N. K., Hardy, J., Hartman, C. A., Hashimoto, R., Hegenscheid, K., Heinz, A., Le Hellard, S., Hernandez, D. G., Heslenfeld, D. J., Ho, B. C., Hoekstra, P. J., Hoffmann, W., Hofman, A., Holsboer, F., Homuth, G., Hosten, N., Hottenga, J. J., Huentelman, M., Pol, H. E. H., Ikeda, M., Jack, C. R., Jenkinson, M., Johnson, R., Jönsson, E. G., Jukema, J. W., Kahn, R. S., Kanai, R., Kloszewska, I., Knopman, D. S., Kochunov, P., Kwok, J. B., Lawrie, S. M., Lemaître, H., Liu, X., Longo, D. L., Lopez, O. L., Lovestone, S., Martinez, O., Martinot, J. L., Mattay, V. S., McDonald, C., McIntosh, A. M., McMahon, F. J., McMahon, K. L., Mecocci, P., Melle, I., Meyer-Lindenberg, A., Mohnke, S., Montgomery, G. W., Morris, D. W., Mosley, T. H., Mühleisen, T. W., Müller-Myhsok, B., Nalls, M. A., Nauck, M., Nichols, T. E., Niessen, W. J., Nöthen, M. M., Nyberg, L., Ohi, K., Olvera, R. L., Ophoff, R. A., Pandolfo, M., Paus, T., Pausova, Z., Penninx, B. W. J. H., Pike, G. B., Potkin, S. G., Psaty, B. M., Reppermund, S., Rietschel, M., Roffman, J. L., Romanczuk-Seiferth, N., Rotter, J. I., Ryten, M., Sacco, R. L., Sachdev, P. S., Saykin, A. J., Schmidt, R., Schmidt, H., Schofield, P. R., Sigursson, S., Simmons, A., Singleton, A., Sisodiya, S. M., Smith, C., Smoller, J. W., Soininen, H., Steen, V. M., Stott, D. J., Sussmann, J. E., Thalamuthu, A., Toga, A. W., Traynor, B. J., Troncoso, J., Tsolaki, M., Tzourio, C., Uitterlinden, A. G., Hernández, M. C. V., Van Der Brug, M., Van Der Lugt, A., Van Der Wee, N. J. A., Van Haren, N. E. M., Van 'T Ent, D., Van Tol, M. J., Vardarajan, B. N., Vellas, B., Veltman, D. J., Völzke, H., Walter, H., Wardlaw, J. M., Wassink, T. H., Weale, M. E., Weinberger, D. R., Weiner, M. W., Wen, W., Westman, E., White, T., Wong, T. Y., Wright, C. B., Zielke, R. H., Zonderman, A. B., Martin, N. G., Van Duijn, C. M., Wright, M. J., Longstreth, W. T., Schumann, G., Grabe, H. J., Franke, B., Launer, L. J., Medland, S. E., Seshadri, S., Thompson, P. M. & Ikram, M. A. Jan 18 2017 In : Nature Communications. 8, 13624

Research output: Contribution to journalArticle

Genetic Loci
loci
Hippocampus
Genes
Episodic Memory

QSVA framework for RNA quality correction in differential expression analysis

Jaffe, A. E., Tao, R., Norris, A. L., Kealhofer, M., Nellore, A., Shin, J. H., Kim, D., Jia, Y., Hyde, T. M., Kleinman, J. E., Straub, R. E., Leek, J. T. & Weinberger, D. R. Jul 3 2017 In : Proceedings of the National Academy of Sciences of the United States of America. 114, 27, p. 7130-7135 6 p.

Research output: Contribution to journalArticle

RNA
RNA Sequence Analysis
Social Adjustment
RNA Stability
Brain
Neuregulins
Brain Diseases
Human Development
Mood Disorders
Protein Isoforms

The dopamine D5 receptor is involved in working memory

Carr, G. V., Maltese, F., Sibley, D. R., Weinberger, D. R. & Papaleo, F. Oct 6 2017 In : Frontiers in Pharmacology. 8, OCT, 666

Research output: Contribution to journalArticle

Dopamine D5 Receptors
Short-Term Memory
Pharmacology
Prefrontal Cortex
Knockout Mice

The neurodevelopmental origins of schizophrenia in the penumbra of genomic medicine

Weinberger, D. R. Oct 1 2017 In : World Psychiatry. 16, 3, p. 225-226 2 p.

Research output: Contribution to journalEditorial

Schizophrenia
Medicine

World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia–a short version for primary care

WFSBP Task Force on Treatment Guidelines for Schizophrenia Apr 3 2017 In : International Journal of Psychiatry in Clinical Practice. 21, 2, p. 82-90 9 p.

Research output: Contribution to journalReview article

Biological Psychiatry
Primary Health Care
Schizophrenia
Guidelines
Pharmacology
2016

A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus

Li, M., Jaffe, A. E., Straub, R. E., Tao, R., Shin, J. H., Wang, Y., Chen, Q., Li, C., Jia, Y., Ohi, K., Maher, B. J., Brandon, N. J., Cross, A., Chenoweth, J. G., Hoeppner, D. J., Wei, H., Hyde, T. M., McKay, R., Kleinman, J. E. & Weinberger, D. R. Jun 1 2016 In : Nature Medicine. 22, 6, p. 649-656 8 p.

Research output: Contribution to journalArticle

Schizophrenia
Protein Isoforms
Genes
Polymorphism
Minisatellite Repeats

Altering the course of schizophrenia: progress and perspectives

Millan, M. J. , Andrieux, A. , Bartzokis, G. , Cadenhead, K. , Dazzan, P. , Fusar-Poli, P. , Gallinat, J. , Giedd, J. , Grayson, D. R. , Heinrichs, M. , Kahn, R. , Krebs, M. O. , Leboyer, M. , Lewis, D. , Marin, O. , Marin, P. , Meyer-Lindenberg, A. , McGorry, P. , McGuire, P. , Owen, M. J. & 7 others Patterson, P., Sawa, A., Spedding, M., Uhlhaas, P., Vaccarino, F., Wahlestedt, C. & Weinberger, D. Mar 4 2016 (Accepted/In press) In : Nature Reviews Drug Discovery.

Research output: Contribution to journalArticle

Schizophrenia
Psychotic Disorders
Psychiatry
Rodentia
Drug Therapy

Association of DNA methylation differences with schizophrenia in an epigenome-wide association study

Montano, C. , Taub, M. A. , Jaffe, A. , Briem, E. , Feinberg, J. I. , Trygvadottir, R. , Idrizi, A. , Runarsson, A. , Berndsen, B. , Gur, R. C. , Moore, T. M. , Perry, R. T. , Fugman, D. , Sabunciyan, S. , Yolken, R. H. , Hyde, T. M. , Kleinman, J. E. , Sobell, J. L. , Pato, C. N. , Pato, M. T. & 7 others Go, R. C., Nimgaonkar, V., Weinberger, D. R., Braff, D., Gur, R. E., Fallin, M. D. & Feinberg, A. P. May 1 2016 In : JAMA Psychiatry. 73, 5, p. 506-514 9 p.

Research output: Contribution to journalArticle

DNA Methylation
Schizophrenia
Genome
Endophenotypes
African Americans

Automated quality assessment of structural magnetic resonance brain images based on a supervised machine learning algorithm

Pizarro, R. A., Cheng, X., Barnett, A., Lemaitre, H., Verchinski, B. A., Goldman, A. L., Xiao, E., Luo, Q., Berman, K. F., Callicott, J. H., Weinberger, D. R. & Mattay, V. S. Dec 19 2016 In : Frontiers in Neuroinformatics. 10, 52

Research output: Contribution to journalArticle

Magnetic resonance
Magnetic resonance imaging
Learning algorithms
Learning systems
Brain

Behavioral, neurophysiological, and synaptic impairment in a transgenic neuregulin1 (NRG1-IV) murine schizophrenia model

Papaleo, F., Yang, F., Paterson, C., Palumbo, S., Carr, G. V., Wang, Y., Floyd, K., Huang, W., Thomas, C. J., Chen, J., Weinberger, D. R. & Law, A. J. Apr 27 2016 In : Journal of Neuroscience. 36, 17, p. 4859-4875 17 p.

Research output: Contribution to journalArticle

Neuregulin-1
Schizophrenia
Sensory Gating
Neurobiology
Social Behavior
Catechol O-Methyltransferase
Phencyclidine
Memory Disorders
Transgenic Mice
Brain

Differential response to risperidone in schizophrenia patients by KCNH2Genotype and drug metabolizer status

Heide, J., Zhang, F., Bigos, K. L., Mann, S. A., Carr, V. J., Weickert, C. S., Green, M. J., Weinberger, D. R. & Vandenberg, J. I. Jan 1 2016 In : American Journal of Psychiatry. 173, 1, p. 53-59 7 p.

Research output: Contribution to journalArticle

Risperidone
Schizophrenia
Antipsychotic Agents
Protein Isoforms
Genotype

Dissociating Bottom-Up and Top-Down Mechanisms in the Cortico-Limbic System during Emotion Processing

Comte, M., Schön, D., Coull, J. T., Reynaud, E., Khalfa, S., Belzeaux, R., Ibrahim, E. C., Guedj, E., Blin, O., Weinberger, D. R. & Fakra, E. Jan 1 2016 In : Cerebral Cortex. 26, 1, p. 144-155 12 p.

Research output: Contribution to journalArticle

Limbic System
Prefrontal Cortex
Gyrus Cinguli
Emotions
Amygdala

Dynamic regulation of RNA editing in human brain development and disease

Hwang, T., Park, C. K., Leung, A. K. L., Gao, Y., Hyde, T. M., Kleinman, J. E., Rajpurohit, A., Tao, R., Shin, J. H. & Weinberger, D. R. Aug 1 2016 In : Nature Neuroscience. 19, 8, p. 1093-1099 7 p.

Research output: Contribution to journalArticle

RNA Editing
Brain Diseases
Human Development
RNA
Gene Ontology

Editorial overview: Neurobiology of disease

Selkoe, D. J. & Weinberger, D. R. Feb 1 2016 In : Current Opinion in Neurobiology. 36, p. v-vii

Research output: Contribution to journalEditorial

Tauopathies
tau Proteins
alpha-Synuclein
Neurobiology
Genome-Wide Association Study

Estimating changing contexts in schizophrenia

Kaplan, C. M., Saha, D., Molina, J. L., Hockeimer, W. D., Postell, E. M., Apud, J. A., Weinberger, D. R. & Tan, H. Y. Jul 1 2016 In : Brain. 139, 7, p. 2082-2095 14 p.

Research output: Contribution to journalArticle

Prefrontal Cortex
Schizophrenia
Delusions
Mesencephalon
Uncertainty

Finding the elusive psychiatric "lesion" with 21st-century neuroanatomy: A note of caution

Weinberger, D. R. & Radulescu, E. Jan 1 2016 In : American Journal of Psychiatry. 173, 1, p. 27-33 7 p.

Research output: Contribution to journalReview article

Neuroanatomy
Artifacts
Psychiatry
Diffusion Tensor Imaging
Psychotropic Drugs

GAD2 alternative transcripts in the human prefrontal cortex, and in schizophrenia and affective disorders

Davis, K. N., Tao, R., Li, C., Gao, Y., Gondré-Lewis, M. C., Lipska, B. K., Shin, J. H., Xie, B., Ye, T., Weinberger, D. R., Kleinman, J. E. & Hyde, T. M. Feb 1 2016 In : PLoS ONE. 11, 2, e0148558

Research output: Contribution to journalArticle

Prefrontal Cortex
Mood Disorders
gamma-Aminobutyric Acid
Schizophrenia
gamma-aminobutyric acid

Genetic Disruption of Arc/Arg3.1 in Mice Causes Alterations in Dopamine and Neurobehavioral Phenotypes Related to Schizophrenia

Managò, F., Mereu, M., Mastwal, S., Mastrogiacomo, R., Scheggia, D., Emanuele, M., De Luca, M. A., Weinberger, D. R., Wang, K. H. & Papaleo, F. Aug 23 2016 In : Cell Reports. 16, 8, p. 2116-2128 13 p.

Research output: Contribution to journalArticle

Cytoskeleton
Dopamine
Schizophrenia
Phenotype
Proteins

Genetic risk mechanisms of posttraumatic stress disorder in the human brain

Bharadwaj, R. A., Jaffe, A. E., Chen, Q., Deep-Soboslay, A., Goldman, A. L., Mighdoll, M. I., Cotoia, J. A., Brandtjen, A. C., Shin, J., Hyde, T. M., Mattay, V. S., Weinberger, D. R. & Kleinman, J. E. 2016 (Accepted/In press) In : Journal of Neuroscience Research.

Research output: Contribution to journalArticle

Post-Traumatic Stress Disorders
Amygdala
Prefrontal Cortex
Genotype
Brain

Genomic structure and expression of the human serotonin 2A receptor gene (HTR2A) locus: Identification of novel HTR2A and antisense (HTR2A-AS1) exons

Ruble, C. L., Smith, R. M., Calley, J., Munsie, L., Airey, D. C., Gao, Y., Shin, J. H., Hyde, T. M., Straub, R. E., Weinberger, D. R. & Nisenbaum, L. K. Jan 6 2016 In : BMC Genetics. 17, 1, 16

Research output: Contribution to journalArticle

Receptor, Serotonin, 5-HT2A
Exons
Single Nucleotide Polymorphism
Genes
RNA Isoforms

Genotype-Dependent Effects of COMT Inhibition on Cognitive Function in a Highly Specific, Novel Mouse Model of Altered COMT Activity

Barkus, C., Korn, C., Stumpenhorst, K., Laatikainen, L. M., Ballard, D., Lee, S., Sharp, T., Harrison, P. J., Bannerman, D. M., Weinberger, D. R., Chen, J. & Tunbridge, E. M. Dec 1 2016 In : Neuropsychopharmacology. 41, 13, p. 3060-3069 10 p.

Research output: Contribution to journalArticle

Catechol O-Methyltransferase
Cognition
Genotype
Dopamine
Anxiety

Impact of a cis-associated gene expression SNP on chromosome 20q11.22 on bipolar disorder susceptibility, hippocampal structure and cognitive performance

Li, M. , Luo, X. J. , Landén, M. , Bergen, S. E. , Hultman, C. M. , Li, X. , Zhang, W. , Yao, Y. G. , Zhang, C. , Liu, J. , Mattheisen, M. , Cichon, S. , Mühleisen, T. W. , Degenhardt, F. A. , Nöthen, M. M. , Schulze, T. G. , Grigoroiu-Serbanescu, M. , Li, H. , Fuller, C. K. , Chen, C. & 25 others Dong, Q., Chen, C., Jamain, S., Leboyer, M., Bellivier, F., Etain, B., Kahn, J. P., Henry, C., Preisig, M., Kutalik, Z., Castelao, E., Wright, A., Mitchell, P. B., Fullerton, J. M., Schofield, P. R., Montgomery, G. W., Medland, S. E., Gordon, S. D., Martin, N. G., Rietschel, M., Liu, C., Kleinman, J. E., Hyde, T. M., Weinberger, D. R. & Su, B. Feb 1 2016 In : British Journal of Psychiatry. 208, 2, p. 128-137 10 p.

Research output: Contribution to journalArticle

Bipolar Disorder
Single Nucleotide Polymorphism
Chromosomes
Gene Expression
Quantitative Trait Loci