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2018

Are pancreatic IPMN volumes measured on MRI images more reproducible than diameters? An assessment in a large single-institution cohort

Pandey, P., Pandey, A., Varzaneh, F. N., Ghasabeh, M. A., Fouladi, D., Khoshpouri, P., Shao, N., Zarghampour, M., Hruban, R. H., Canto, M., O’Broin-Lennon, A. M. & Kamel, I. R. Feb 5 2018 (Accepted/In press) In : European Radiology. p. 1-11 11 p.

Research output: Contribution to journalArticle

Observer Variation
Neoplasms
Radiologists

Detection and localization of surgically resectable cancers with a multi-analyte blood test

Cohen, J. D. , Li, L. , Wang, Y. , Thoburn, C. , Afsari, B. , Danilova, L. , Douville, C. , Javed, A. A. , Wong, F. , Mattox, A. , Hruban, R. H. , Wolfgang, C. L. , Goggins, M. G. , Molin, M. D. , Wang, T. L. , Roden, R. , Klein, A. P. , Ptak, J. , Dobbyn, L. , Schaefer, J. & 22 others Silliman, N., Popoli, M., Vogelstein, J. T., Browne, J. D., Schoen, R. E., Brand, R. E., Tie, J., Gibbs, P., Wong, H. L., Mansfield, A. S., Jen, J., Hanash, S. M., Falconi, M., Allen, P. J., Zhou, S., Bettegowda, C., Diaz, L. A., Tomasetti, C., Kinzler, K. W., Vogelstein, B., Lennon, A. M. & Papadopoulos, N. Feb 23 2018 In : Science. 359, 6378, p. 926-930 5 p.

Research output: Contribution to journalArticle

Hematologic Tests
Liver Neoplasms
Ovarian Neoplasms
Esophagus
Pancreas
Long Interspersed Nucleotide Elements
Aneuploidy
Neoplasms
Biopsy
Chromosomes

Development and Validation of a Multi-institutional Preoperative Nomogram for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas

Attiyeh, M. A., Fernández-Del Castillo, C., Al Efishat, M., Eaton, A. A., Gönen, M., Batts, R., Pergolini, I., Rezaee, N., Lillemoe, K. D., Ferrone, C. R., Mino-Kenudson, M., Weiss, M. J., Cameron, J. L., Hruban, R. H., D'Angelica, M. I., Dematteo, R. P., Kingham, T. P., Jarnagin, W. R., Wolfgang, C. L. & Allen, P. J. Jan 1 2018 In : Annals of Surgery. 267, 1, p. 157-163 7 p.

Research output: Contribution to journalArticle

Nomograms
Pancreatic Neoplasms
Neoplasms
Carcinoma
Unnecessary Procedures

Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers

Wang, Y. , Li, L. , Douville, C. , Cohen, J. D. , Yen, T. T. , Kinde, I. , Sundfelt, K. , Kjær, S. K. , Hruban, R. H. , Shih, I. M. , Wang, T. L. , Kurman, R. J. , Springer, S. , Ptak, J. , Popoli, M. , Schaefer, J. , Silliman, N. , Dobbyn, L. , Tanner, E. J. , Angarita, A. & 17 others Lycke, M., Jochumsen, K., Afsari, B., Danilova, L., Levine, D. A., Jardon, K., Zeng, X., Arseneau, J., Fu, L., Diaz, L. A., Karchin, R., Tomasetti, C., Kinzler, K. W., Vogelstein, B., Fader, A. N., Gilbert, L. & Papadopoulos, N. Mar 21 2018 In : Science translational medicine. 10, 433, 8793

Research output: Contribution to journalArticle

Papanicolaou Test
Endometrial Neoplasms
Ovarian Neoplasms
Biopsy
Confidence Intervals

Genome-Wide Somatic Copy Number Alterations and Mutations in High-Grade Pancreatic Intraepithelial Neoplasia

Hata, T., Suenaga, M., Marchionni, L., Macgregor-Das, A., Yu, J., Shindo, K., Tamura, K., Hruban, R. H. & Goggins, M. Jul 1 2018 In : American Journal of Pathology. 188, 7, p. 1723-1733 11 p.

Research output: Contribution to journalArticle

Genome
Mutation
Neoplasms
Adenocarcinoma
Single Nucleotide Polymorphism

Immunolabeling of Cleared Human Pancreata Provides Insights into Three-Dimensional Pancreatic Anatomy and Pathology

Noë, M., Rezaee, N., Asrani, K., Skaro, M., Groot, V. P., Wu, P. H., Olson, M. T., Hong, S. M., Kim, S. J., Weiss, M. J., Wolfgang, C. L., Makary, M. A., He, J., Cameron, J. L., Wirtz, D., Roberts, N. J., Offerhaus, G. J. A., Brosens, L. A. A., Wood, L. D. & Hruban, R. H. Jul 1 2018 In : American Journal of Pathology. 188, 7, p. 1530-1535 6 p.

Research output: Contribution to journalArticle

Pancreas
Anatomy
Pathology
Pancreatic Neoplasms
Paraffin

Implications of the Pattern of Disease Recurrence on Survival Following Pancreatectomy for Pancreatic Ductal Adenocarcinoma

Groot, V. P., Gemenetzis, G., Blair, A. B., Ding, D., Javed, A. A., Burkhart, R. A., Yu, J., Borel Rinkes, I. H., Molenaar, I. Q., Cameron, J. L., Fishman, E. K., Hruban, R. H., Weiss, M. J., Wolfgang, C. L. & He, J. Jun 14 2018 (Accepted/In press) In : Annals of Surgical Oncology. p. 1-9 9 p.

Research output: Contribution to journalArticle

Pancreatectomy
Adenocarcinoma
Recurrence
Survival
Neoadjuvant Therapy

Lessons learned from 29 lymphoepithelial cysts of the pancreas: Institutional experience and review of the literature

Groot, V. P., Thakker, S. S., Gemenetzis, G., Noë, M., Javed, A. A., Burkhart, R. A., Noveiry, B. B., Cameron, J. L., Weiss, M. J., VandenBussche, C. J., Fishman, E. K., Hruban, R. H., Wolfgang, C. L., Lennon, A. M. & He, J. Jan 1 2018 (Accepted/In press) In : HPB.

Research output: Contribution to journalArticle

Cysts
Pancreas
Fine Needle Biopsy
Pancreatic Cyst
Unnecessary Procedures

Long-term analysis of 2 prospective studies that incorporate mitomycin C into an adjuvant chemoradiation regimen for pancreatic and periampullary cancers

Schunke, K. J., Rosati, L. M., Zahurak, M., Herman, J. M., Narang, A. K., Usach, I., Klein, A. P., Yeo, C. J., Korman, L. T., Hruban, R. H., Cameron, J. L., Laheru, D. A. & Abrams, R. A. Jan 1 2018 (Accepted/In press) In : Advances in Radiation Oncology.

Research output: Contribution to journalArticle

Mitomycin
Pancreatic Neoplasms
Fluorouracil
Prospective Studies
Survival

Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer

Tamura, K. , Yu, J. , Hata, T. , Suenaga, M. , Shindo, K. , Abe, T. , MacGregor-Das, A. , Borges, M. , Wolfgang, C. L. , Weiss, M. J. , He, J. , Canto, M. I. , Petersen, G. M. , Gallinger, S. , Syngal, S. , Brand, R. E. , Rustgi, A. , Olson, S. H. , Stoffel, E. , Cote, M. L. & 13 others Zogopoulos, G., Potash, J. B., Goes, F. S., McCombie, R. W., Zandi, P. P., Pirooznia, M., Kramer, M., Parla, J., Eshleman, J. R., Roberts, N. J., Hruban, R. H., Klein, A. P. & Goggins, M. May 1 2018 In : Proceedings of the National Academy of Sciences of the United States of America. 115, 18, p. 4767-4772 6 p.

Research output: Contribution to journalArticle

Carboxypeptidases A
Pancreatic Neoplasms
Endoplasmic Reticulum Stress
Mutation
Enzymes

New Developments in the Molecular Mechanisms of Pancreatic Tumorigenesis

Felsenstein, M., Hruban, R. H. & Wood, L. D. Jan 1 2018 In : Advances in Anatomic Pathology. 25, 2, p. 131-142 12 p.

Research output: Contribution to journalReview article

Pancreatic Neoplasms
Carcinogenesis
Clonal Evolution
Explosions
Patient Care

Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy

Springer, S. U. , Chen, C. H. , Del Carmen Rodriguez Pena, M. , Li, L. , Douville, C. , Wang, Y. , Cohen, J. D. , Taheri, D. , Silliman, N. , Schaefer, J. , Ptak, J. , Dobbyn, L. , Papoli, M. , Kinde, I. , Afsari, B. , Tregnago, A. C. , Bezerra, S. M. , Vandenbussche, C. , Fujita, K. , Ertoy, D. & 20 others Cunha, I. W., Yu, L., Bivalacqua, T. J., Grollman, A. P., Diaz, L. A., Karchin, R., Danilova, L., Huang, C. Y., Shun, C. T., Turesky, R. J., Yun, B. H., Rosenquist, T. A., Pu, Y. S., Hruban, R. H., Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., Dickman, K. G. & Netto, G. J. Mar 20 2018 In : eLife. 7, e32143

Research output: Contribution to journalArticle

Aneuploidy
Urinary Bladder Neoplasms
Cell Biology
Mutation
Neoplasm DNA

Pancreatic neuroendocrine tumor: review of heterogeneous spectrum of CT appearance

Lee, N. J., Hruban, R. H. & Fishman, E. K. Mar 28 2018 (Accepted/In press) In : Abdominal Radiology. p. 1-10 10 p.

Research output: Contribution to journalArticle

Neuroendocrine Tumors
Pancreatic Neoplasms
Pancreas
Urine
Pancreatic Neoplasms
Radiotherapy
Radiation
Drug Therapy
Adenocarcinoma

Simple Detection of Telomere Fusions in Pancreatic Cancer, Intraductal Papillary Mucinous Neoplasm, and Pancreatic Cyst Fluid

Hata, T., Dal Molin, M., McGregor-Das, A., Song, T. J., Wolfgang, C., Eshleman, J. R., Hruban, R. H. & Goggins, M. Jan 1 2018 In : Journal of Molecular Diagnostics. 20, 1, p. 46-55 10 p.

Research output: Contribution to journalArticle

Pancreatic Cyst
Cyst Fluid
Telomere
Pancreatic Neoplasms
Neoplasms

Smad4 Loss Correlates with Higher Rates of Local and Distant Failure in Pancreatic Adenocarcinoma Patients Receiving Adjuvant Chemoradiation

Herman, J. M., Jabbour, S. K., Lin, S. H., Deek, M. P., Hsu, C. C., Fishman, E. K., Kim, S., Cameron, J. L., Chekmareva, M., Laheru, D. A., Narang, A. K., Pawlik, T. M., Hruban, R. H., Wolfgang, C. L. & Iacobuzio-Donahue, C. A. Feb 1 2018 In : Pancreas. 47, 2, p. 208-212 5 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Recurrence
Confidence Intervals
Survival
Tumor Suppressor Genes

Transcriptional alterations in hereditary and sporadic nonfunctioning pancreatic neuroendocrine tumors according to genotype

Keutgen, X. M., Kumar, S., Gara, S., Boufraqech, M., Agarwal, S., Hruban, R. H., Nilubol, N., Quezado, M., Finney, R., Cam, M. & Kebebew, E. Feb 1 2018 In : Cancer. 124, 3, p. 636-647 12 p.

Research output: Contribution to journalArticle

von Hippel-Lindau Disease
Multiple Endocrine Neoplasia Type 1
Neuroendocrine Tumors
Pancreas
Genotype

Whole-exome sequencing of duodenal neuroendocrine tumors in patients with neurofibromatosis type 1

Noë, M., Pea, A., Luchini, C., Felsenstein, M., Barbi, S., Bhaijee, F., Yonescu, R., Ning, Y., Adsay, N. V., Zamboni, G., Lawlor, R. T., Scarpa, A., Offerhaus, G. J. A., Brosens, L. A. A., Hruban, R. H., Roberts, N. J. & Wood, L. D. May 30 2018 (Accepted/In press) In : Modern Pathology. p. 1-7 7 p.

Research output: Contribution to journalArticle

Exome
Neurofibromatosis 1
Neuroendocrine Tumors
Chromosomes, Human, Pair 22
Neoplasms
2017

Abdominal schwannomas: review of imaging findings and pathology

Lee, N. J., Hruban, R. H. & Fishman, E. K. Mar 6 2017 (Accepted/In press) In : Abdominal Radiology. p. 1-7 7 p.

Research output: Contribution to journalArticle

Neurilemmoma
Pathology
Neoplasms
Differential Diagnosis

Accuracy of apparent diffusion coefficient in differentiating pancreatic neuroendocrine tumour from intrapancreatic accessory spleen

Pandey, A., Pandey, P., Ghasabeh, M. A., Varzaneh, F. N., Khoshpouri, P., Shao, N., Pour, M. Z., Fouladi, D. F., Hruban, R. H., O’Broin-Lennon, A. M. & Kamel, I. R. Nov 13 2017 (Accepted/In press) In : European Radiology. p. 1-8 8 p.

Research output: Contribution to journalArticle

Neuroendocrine Tumors
Spleen
Unnecessary Procedures
Pancreatectomy
ROC Curve

Alterations of type II classical cadherin, cadherin-10 (CDH10), is associated with pancreatic ductal adenocarcinomas

Jinawath, N., Shiao, M. S., Norris, A., Murphy, K., Klein, A. P., Yonescu, R., Iacobuzio-Donahue, C., Meeker, A., Jinawath, A., Yeo, C. J., Eshleman, J. R., Hruban, R. H., Brody, J. R., Griffin, C. A. & Harada, S. May 1 2017 In : Genes Chromosomes and Cancer. 56, 5, p. 427-435 9 p.

Research output: Contribution to journalArticle

Cadherins
Adenocarcinoma
Loss of Heterozygosity
Pancreatic Neoplasms
Carcinogenesis
Telomere Homeostasis
Neuroendocrine Tumors
Fine Needle Biopsy
Telomere
Neoplasms

Alternative lengthening of telomeres in primary pancreatic neuroendocrine tumors is associated with aggressive clinical behavior and poor survival

Kim, J. Y., Brosnan-Cashman, J. A., An, S., Kim, S. J., Song, K. B., Kim, M. S., Kim, M. J., Hwang, D. W., Meeker, A. K., Yu, E., Kim, S. C., Hruban, R. H., Heaphy, C. M. & Hong, S. M. Mar 15 2017 In : Clinical Cancer Research. 23, 6, p. 1598-1606 9 p.

Research output: Contribution to journalArticle

Telomere Homeostasis
Neuroendocrine Tumors
Survival
Neoplasm Metastasis
Recurrence

A Novel Absorbable Radiopaque Hydrogel Spacer to Separate the Head of the Pancreas and Duodenum in Radiation Therapy for Pancreatic Cancer

Rao, A. D. , Feng, Z. , Shin, E. J. , He, J. , Waters, K. M. , Coquia, S. , DeJong, R. , Rosati, L. M. , Su, L. , Li, D. , Jackson, J. , Clark, S. , Schultz, J. , Hutchings, D. , Kim, S. H. , Hruban, R. H. , DeWeese, T. L. , Wong, J. , Narang, A. , Herman, J. M. & 1 others Ding, K. 2017 (Accepted/In press) In : International Journal of Radiation Oncology Biology Physics.

Research output: Contribution to journalArticle

pancreas
Hydrogel
Pancreatic Neoplasms
Duodenum
spacers

A novel approach for selecting combination clinical markers of pathology applied to a large retrospective cohort of surgically resected pancreatic cysts

Masica, D. L. , Molin, M. D. , Wolfgang, C. L. , Tomita, T. , Ostovaneh, M. R. , Blackford, A. , Moran, R. A. , Law, J. K. , Barkley, T. , Goggins, M. , Canto, M. I. , Pittman, M. , Eshleman, J. R. , Ali, S. Z. , Fishman, E. K. , Kamel, I. R. , Raman, S. P. , Zaheer, A. , Ahuja, N. , Makary, M. A. & 16 others Weiss, M. J., Hirose, K., Cameron, J. L., Rezaee, N., He, J., Ahn, Y. J., Wu, W., Wang, Y., Springer, S., Diaz, L. L., Papadopoulos, N., Hruban, R. H., Kinzler, K. W., Vogelstein, B., Karchin, R. & Lennon, A. M. 2017 In : Journal of the American Medical Informatics Association. 24, 1, p. 145-152 8 p.

Research output: Contribution to journalArticle

Pancreatic Cyst
Clinical Pathology
Biomarkers
Sensitivity and Specificity
Serous Cystadenoma

A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer

Mello, S. S., Valente, L. J., Raj, N., Seoane, J. A., Flowers, B. M., McClendon, J., Bieging-Rolett, K. T., Lee, J., Ivanochko, D., Kozak, M. M., Chang, D. T., Longacre, T. A., Koong, A. C., Arrowsmith, C. H., Kim, S. K., Vogel, H., Wood, L. D., Hruban, R. H., Curtis, C. & Attardi, L. D. Oct 9 2017 In : Cancer Cell. 32, 4, p. 460-473.e6

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Neoplasms
p53 Genes
Transcriptional Activation
Mutation

A rare case of esophageal metastasis from pancreatic ductal adenocarcinoma: A case report and literature review

Rosati, L. M., Kummerlowe, M. N., Poling, J., Hacker-Prietz, A., Narang, A. K., Shin, E. J., Le, D. T., Fishman, E. K., Hruban, R. H., Yang, S. C., Weiss, M. J. & Herman, J. M. Jan 1 2017 In : Oncotarget. 8, 59, p. 100942-100950 9 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Neoplasm Metastasis
oxaliplatin
irinotecan
Radiotherapy

Classification, morphology, molecular pathogenesis, and outcome of premalignant lesions of the pancreas

Pittman, M. E., Rao, R. & Hruban, R. H. Dec 1 2017 In : Archives of Pathology and Laboratory Medicine. 141, 12, p. 1606-1614 9 p.

Research output: Contribution to journalArticle

Neoplasm Invasiveness
Pancreatic Ductal Carcinoma
Precancerous Conditions
Carcinoma in Situ
Pancreatic Neoplasms

Classification of pancreatic cysts in computed tomography images using a random forest and convolutional neural network ensemble

Dmitriev, K., Kaufman, A. E., Javed, A. A., Hruban, R. H., Fishman, E. K., Lennon, A. M. & Saltz, J. H. 2017 Medical Image Computing and Computer Assisted Intervention − MICCAI 2017 - 20th International Conference, Proceedings. Springer Verlag, Vol. 10435 LNCS, p. 150-158 9 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 10435 LNCS)

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Neural Network Ensemble
Random Forest
Computed Tomography
Tomography
Neural networks

Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers

Cohen, J. D. , Javed, A. A. , Thoburn, C. , Wong, F. , Tie, J. , Gibbs, P. , Schmidt, C. M. , Yip-Schneider, M. T. , Allen, P. J. , Schattner, M. , Brand, R. E. , Singhi, A. D. , Petersen, G. M. , Hong, S. M. , Kim, S. C. , Falconi, M. , Doglioni, C. , Weiss, M. J. , Ahuja, N. , He, J. & 20 others Makary, M. A., Maitra, A., Hanash, S. M., Dal Molin, M., Wang, Y., Li, L., Ptak, J., Dobbyn, L., Schaefer, J., Silliman, N., Popoli, M., Goggins, M. G., Hruban, R. H., Wolfgang, C. L., Klein, A. P., Tomasetti, C., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Lennon, A. M. Sep 19 2017 In : Proceedings of the National Academy of Sciences of the United States of America. 114, 38, p. 10202-10207 6 p.

Research output: Contribution to journalArticle

Deleterious germline mutations in patients with apparently sporadic pancreatic adenocarcinoma

Shindo, K. , Yu, J. , Suenaga, M. , Fesharakizadeh, S. , Cho, C. , Macgregor-Das, A. , Siddiqui, A. , Witmer, P. D. , Tamura, K. , Song, T. J. , Almario, J. A. N. , Brant, A. , Borges, M. , Ford, M. , Barkley, T. , He, J. , Weiss, M. J. , Wolfgang, C. L. , Roberts, N. J. , Hruban, R. H. & 2 others Klein, A. P. & Goggins, M. Oct 20 2017 In : Journal of Clinical Oncology. 35, 30, p. 3382-3390 9 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Adenocarcinoma
Pancreatic Neoplasms
Neoplasm Genes
Neoplasms

Duodenal and Ampullary Carcinoid Tumors: Size Predicts Necessity for Lymphadenectomy

Dogeas, E., Cameron, J. L., Wolfgang, C. L., Hirose, K., Hruban, R. H., Makary, M. A., Pawlik, T. A. & Choti, M. A. Aug 1 2017 In : Journal of Gastrointestinal Surgery. 21, 8, p. 1262-1269 8 p.

Research output: Contribution to journalArticle

Carcinoid Tumor
Lymph Node Excision
Lymph Nodes
Neoplasms
Pancreaticoduodenectomy

Duodenal Involvement is an Independent Prognostic Factor for Patients with Surgically Resected Pancreatic Ductal Adenocarcinoma

Dal Molin, M., Blackford, A. L., Siddiqui, A., Brant, A., Cho, C., Rezaee, N., Yu, J., He, J., Weiss, M., Hruban, R. H., Wolfgang, C. & Goggins, M. Apr 24 2017 (Accepted/In press) In : Annals of Surgical Oncology. p. 1-8 8 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Neoplasms
Confidence Intervals
Common Bile Duct
Pancreas
Pancreas
Stomach
Tomography
Gastrointestinal Stromal Tumors
Differential Diagnosis

Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4

Hosoda, W. , Chianchiano, P. , Griffin, J. F. , Pittman, M. E. , Brosens, L. A. A. , Noë, M. , Yu, J. , Shindo, K. , Suenaga, M. , Rezaee, N. , Yonescu, R. , Ning, Y. , Albores-Saavedra, J. , Yoshizawa, N. , Harada, K. , Yoshizawa, A. , Hanada, K. , Yonehara, S. , Shimizu, M. , Uehara, T. & 6 others Samra, J. S., Gill, A. J., Wolfgang, C. L., Goggins, M. G., Hruban, R. H. & Wood, L. D. May 1 2017 In : Journal of Pathology. 242, 1, p. 16-23 8 p.

Research output: Contribution to journalArticle

Mutation
Neoplasms
Adenocarcinoma
Exome
Genes

Hypermutation In Pancreatic Cancer

Humphris, J. L. , Patch, A. M. , Nones, K. , Bailey, P. J. , Johns, A. L. , McKay, S. , Chang, D. K. , Miller, D. K. , Pajic, M. , Kassahn, K. S. , Quinn, M. C. J. , Bruxner, T. J. C. , Christ, A. N. , Harliwong, I. , Idrisoglu, S. , Manning, S. , Nourse, C. , Nourbakhsh, E. , Stone, A. , Wilson, P. J. & 31 others Anderson, M., Fink, J. L., Holmes, O., Kazakoff, S., Leonard, C., Newell, F., Waddell, N., Wood, S., Mead, R. S., Xu, Q., Wu, J., Pinese, M., Cowley, M. J., Jones, M. D., Nagrial, A. M., Chin, V. T., Chantrill, L. A., Mawson, A., Chou, A., Scarlett, C. J., Pinho, A. V., Rooman, I., Giry-Laterriere, M., Samra, J. S., Hruban, R. H., Maitra, A., Iacobuzio-Donahue, C. A., Schulick, R. D., Wolfgang, C. L., Eshleman, J. R. & Australian Pancreatic Cancer Genome Initiative Jan 1 2017 In : Gastroenterology. 152, 1, p. 68-74.e2

Research output: Contribution to journalArticle

Pancreatic Neoplasms
DNA Repair
Mutation
Immunotherapy
Patient Selection

IL2RG, identified as overexpressed by RNA-seq profiling of pancreatic intraepithelial neoplasia, mediates pancreatic cancer growth

Ayars, M., O'Sullivan, E., Macgregor-Das, A., Shindo, K., Kim, H., Borges, M., Yu, J., Hruban, R. H. & Goggins, M. 2017 In : Oncotarget. 8, 48, p. 83370-83383 14 p.

Research output: Contribution to journalArticle

Interleukin Receptor Common gamma Subunit
Pancreatic Neoplasms
RNA
Pancreatic Ducts
Growth

Immunohistochemical Characterization of the Origins of Metastatic Well-differentiated Neuroendocrine Tumors to the Liver

Yang, Z., Klimstra, D. S., Hruban, R. H. & Tang, L. H. 2017 In : American Journal of Surgical Pathology. 41, 7, p. 915-922 8 p.

Research output: Contribution to journalArticle

Neuroendocrine Tumors
Liver
Bile Ducts
Rectum
Lung

Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma

Raphael, B. J. , Hruban, R. H. , Aguirre, A. J. , Moffitt, R. A. , Yeh, J. J. , Stewart, C. , Robertson, A. G. , Cherniack, A. D. , Gupta, M. , Getz, G. , Gabriel, S. B. , Meyerson, M. , Cibulskis, C. , Fei, S. S. , Hinoue, T. , Shen, H. , Laird, P. W. , Ling, S. , Lu, Y. , Mills, G. B. & 251 others Akbani, R., Loher, P., Londin, E. R., Rigoutsos, I., Telonis, A. G., Gibb, E. A., Goldenberg, A., Mezlini, A. M., Hoadley, K. A., Collisson, E., Lander, E., Murray, B. A., Hess, J., Rosenberg, M., Bergelson, L., Zhang, H., Cho, J., Tiao, G., Kim, J., Livitz, D., Leshchiner, I., Reardon, B., Van Allen, E., Kamburov, A., Beroukhim, R., Saksena, G., Schumacher, S. E., Noble, M. S., Heiman, D. I., Gehlenborg, N., Kim, J., Lawrence, M. S., Adsay, V., Petersen, G., Klimstra, D., Bardeesy, N., Leiserson, M. D. M., Bowlby, R., Kasaian, K., Birol, I., Mungall, K. L., Sadeghi, S., Weinstein, J. N., Spellman, P. T., Liu, Y., Amundadottir, L. T., Tepper, J., Singhi, A. D., Dhir, R., Paul, D., Smyrk, T., Zhang, L., Kim, P., Bowen, J., Frick, J., Gastier-Foster, J. M., Gerken, M., Lau, K., Leraas, K. M., Lichtenberg, T. M., Ramirez, N. C., Renkel, J., Sherman, M., Wise, L., Yena, P., Zmuda, E., Shih, J., Ally, A., Balasundaram, M., Carlsen, R., Chu, A., Chuah, E., Clarke, A., Dhalla, N., Holt, R. A., Jones, S. J. M., Lee, D., Ma, Y., Marra, M. A., Mayo, M., Moore, R. A., Mungall, A. J., Schein, J. E., Sipahimalani, P., Tam, A., Thiessen, N., Tse, K., Wong, T., Brooks, D., Auman, J. T., Balu, S., Bodenheimer, T., Hayes, D. N., Hoyle, A. P., Jefferys, S. R., Jones, C. D., Meng, S., Mieczkowski, P. A., Mose, L. E., Perou, C. M., Perou, A. H., Roach, J., Shi, Y., Simons, J. V., Skelly, T., Soloway, M. G., Tan, D., Veluvolu, U., Parker, J. S., Wilkerson, M. D., Korkut, A., Senbabaoglu, Y., Burch, P., McWilliams, R., Chaffee, K., Oberg, A., Zhang, W., Gingras, M. C., Wheeler, D. A., Xi, L., Albert, M., Bartlett, J., Sekhon, H., Stephen, Y., Howard, Z., Judy, M., Breggia, A., Shroff, R. T., Chudamani, S., Liu, J., Lolla, L., Naresh, R., Pihl, T., Sun, Q., Wan, Y., Wu, Y., Jennifer, S., Roggin, K., Becker, K. F., Behera, M., Bennett, J., Boice, L., Burks, E., Carlotti Junior, C. G., Chabot, J., Pretti da Cunha Tirapelli, D., Sebastião dos Santos, J., Dubina, M., Eschbacher, J., Huang, M., Huelsenbeck-Dill, L., Jenkins, R., Karpov, A., Kemp, R., Lyadov, V., Maithel, S., Manikhas, G., Montgomery, E., Noushmehr, H., Osunkoya, A., Owonikoko, T., Paklina, O., Potapova, O., Ramalingam, S., Rathmell, W. K., Rieger-Christ, K., Saller, C., Setdikova, G., Shabunin, A., Sica, G., Su, T., Sullivan, T., Swanson, P., Tarvin, K., Tavobilov, M., Thorne, L. B., Urbanski, S., Voronina, O., Wang, T., Crain, D., Curley, E., Gardner, J., Mallery, D., Morris, S., Paulauskis, J., Penny, R., Shelton, C., Shelton, T., Janssen, K. P., Bathe, O., Bahary, N., Slotta-Huspenina, J., Johns, A., Hibshoosh, H., Hwang, R. F., Sepulveda, A., Radenbaugh, A., Baylin, S. B., Berrios, M., Bootwalla, M. S., Holbrook, A., Lai, P. H., Maglinte, D. T., Mahurkar, S., Triche, T. J., Van Den Berg, D. J., Weisenberger, D. J., Chin, L., Kucherlapati, R., Kucherlapati, M., Pantazi, A., Park, P., Saksena, G., Voet, D., Lin, P., Frazer, S., Defreitas, T., Meier, S., Chin, L., Kwon, S. Y., Kim, Y. H., Park, S. J., Han, S. S., Kim, S. H., Kim, H., Furth, E., Tempero, M., Sander, C., Biankin, A., Chang, D., Bailey, P., Gill, A., Kench, J., Grimmond, S., Johns, A., Cancer Genome Initiative (APGI, A. P., Postier, R., Zuna, R., Sicotte, H., Demchok, J. A., Ferguson, M. L., Hutter, C. M., Mills Shaw, K. R., Sheth, M., Sofia, H. J., Tarnuzzer, R., Wang, Z., Yang, L., Zhang, J. J., Felau, I. & Zenklusen, J. C. Aug 14 2017 In : Cancer Cell. 32, 2, p. 185-203.e13

Research output: Contribution to journalArticle

Adenocarcinoma
Mutation
Exome
Neoplasms
Untranslated RNA

Intraductal Papillary Mucinous Neoplasm of the Pancreas in Young Patients: Tumor Biology, Clinical Features, and Survival Outcomes

Morales-Oyarvide, V., Mino-Kenudson, M., Ferrone, C. R., Warshaw, A. L., Lillemoe, K. D., Sahani, D. V., Pergolini, I., Attiyeh, M. A., Al Efishat, M., Rezaee, N., Hruban, R. H., He, J., Weiss, M. J., Allen, P. J., Wolfgang, C. L. & Fernández-Del Castillo, C. Oct 18 2017 (Accepted/In press) In : Journal of Gastrointestinal Surgery. p. 1-9 9 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Survival
Neoplasms
Carcinoma, Intraductal, Noninfiltrating
Pancreatic Ducts

Lack of association between the pancreatitis risk allele CEL-HYB and pancreatic cancer

Shindo, K., Yu, J., Suenaga, M., Fesharakizadeh, S., Tamura, K., Almario, J. A. N., Brant, A., Borges, M., Siddiqui, A., Datta, L., Wolfgang, C. L., Hruban, R. H., Klein, A. P. & Goggins, M. Feb 7 2017 In : Oncotarget. 8, 31, p. 50824-50831 8 p.

Research output: Contribution to journalArticle

Lipase
Pancreatic Neoplasms
Pancreatitis
Esters
Alleles

Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer

Makohon-Moore, A. P., Zhang, M., Reiter, J. G., Bozic, I., Allen, B., Kundu, D., Chatterjee, K., Wong, F., Jiao, Y., Kohutek, Z. A., Hong, J., Attiyeh, M., Javier, B., Wood, L. D., Hruban, R. H., Nowak, M. A., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Iacobuzio-Donahue, C. A. Jan 16 2017 (Accepted/In press) In : Nature Genetics.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Neoplasm Metastasis
Mutation
Genes
Genome

Long-term survival benefit of upfront chemotherapy in patients with newly diagnosed borderline resectable pancreatic cancer

Shrestha, B. , Sun, Y. , Faisal, F. , Kim, V. , Soares, K. , Blair, A. , Herman, J. M. , Narang, A. , Dholakia, A. S. , Rosati, L. , Hacker-Prietz, A. , Chen, L. , Laheru, D. A. , De Jesus-Acosta, A. , Le, D. T. , Donehower, R. , Azad, N. , Diaz, L. A. , Murphy, A. , Lee, V. & 11 others Fishman, E. K., Hruban, R. H., Liang, T., Cameron, J. L., Makary, M., Weiss, M. J., Ahuja, N., He, J., Wolfgang, C. L., Huang, C. Y. & Zheng, L. Jul 1 2017 In : Cancer Medicine. 6, 7, p. 1552-1562 11 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Drug Therapy
Neoadjuvant Therapy
Survival
Adenocarcinoma

Lost in translation: Returning germline genetic results in genome-scale cancer research

Johns, A. L. , McKay, S. H. , Humphris, J. L. , Pinese, M. , Chantrill, L. A. , Mead, R. S. , Tucker, K. , Andrews, L. , Goodwin, A. , Leonard, C. , High, H. A. , Nones, K. , Waddell, N. , Patch, A. M. , Merrett, N. D. , Pavlakis, N. , Kassahn, K. S. , Samra, J. S. , Miller, D. K. , Chang, D. K. & 31 others Pajic, M., Pearson, J. V., Grimmond, S. M., Waddell, N., Zeps, N., Gill, A. J., Biankin, A. V., Johns, A. L., Gill, A. J., Chang, D. K., McKay, S. H., Chantrill, L. A., Chin, V. T., Chou, A., Humphris, J. L., Pajic, M., Steinmann, A., Arshi, M., Drury, A., Froio, D., Morgan, A., Timpson, P., Hermann, D., Vennin, C., Warren, S., Pinese, M., Wu, J., Pinho, A. V., Hruban, R. H., Wolfgang, C. L. & Australian Pancreatic Cancer Genome Initiative Apr 28 2017 In : Genome Medicine. 9, 1, 41

Research output: Contribution to journalArticle

Genome
Pancreatic Neoplasms
Research
Neoplasms
Genes

Multi-Institutional Validation Study of Pancreatic Cyst Fluid Protein Analysis for Prediction of High-Risk Intraductal Papillary Mucinous Neoplasms of the Pancreas

Al Efishat, M. A. , Attiyeh, M. F. , Eaton, A. A. , Gönen, M. , Prosser, D. , Lokshin, A. E. , Castillo, C. F. D. , Lillemoe, K. D. , Ferrone, C. R. , Pergolini, I. , Mino-Kenudson, M. , Rezaee, N. , Dal Molin, M. , Weiss, M. J. , Cameron, J. L. , Hruban, R. H. , D’Angelica, M. I. , Kingham, P. P. , DeMatteo, R. P. , Jarnagin, W. R. & 2 others Wolfgang, C. L. & Allen, P. J. Jul 11 2017 (Accepted/In press) In : Annals of Surgery.

Research output: Contribution to journalArticle

Pancreatic Cyst
Cyst Fluid
Validation Studies
Pancreatic Neoplasms
Nomograms

Multiplex Proximity Ligation Assay to Identify Potential Prognostic Biomarkers for Improved Survival in Locally Advanced Pancreatic Cancer Patients Treated With Stereotactic Body Radiation Therapy

Rao, A. D. , Liu, Y. , von Eyben, R. , Hsu, C. C. , Hu, C. , Rosati, L. M. , Parekh, A. , Ng, K. , Hacker-Prietz, A. , Zheng, L. , Pawlik, T. M. , Laheru, D. A. , Jaffee, E. M. , Weiss, M. J. , Le, D. T. , Hruban, R. H. , De Jesus-Acosta, A. , Wolfgang, C. L. , Narang, A. K. , Chang, D. T. & 2 others Koong, A. C. & Herman, J. M. Jan 1 2017 (Accepted/In press) In : International Journal of Radiation Oncology Biology Physics.

Research output: Contribution to journalArticle

biomarkers
Pancreatic Neoplasms
Ligation
proximity
radiation therapy

Patients with McCune-Albright syndrome have a broad spectrum of abnormalities in the gastrointestinal tract and pancreas

Wood, L. D., Noë, M., Hackeng, W., Brosens, L. A. A., Bhaijee, F., Debeljak, M., Yu, J., Suenaga, M., Singhi, A. D., Zaheer, A., Boyce, A., Robinson, C., Eshleman, J. R., Goggins, M. G., Hruban, R. H., Collins, M. T., Lennon, A. M. & Montgomery, E. A. Feb 10 2017 (Accepted/In press) In : Virchows Archiv. p. 1-10 10 p.

Research output: Contribution to journalArticle

Polyostotic Fibrous Dysplasia
Gastrointestinal Tract
Pancreas
Polyps
Esophagogastric Junction
Pancreatectomy
Adenocarcinoma
Recurrence
Survival
Adjuvant Chemoradiotherapy

Predicting the grade of dysplasia of pancreatic cystic neoplasms using cyst fluid DNA methylation markers

Hata, T., Dal Molin, M., Hong, S. M., Tamura, K., Suenaga, M., Yu, J., Sedogawa, H., Weiss, M. J., Wolfgang, C. L., Lennon, A. M., Hruban, R. H. & Goggins, M. G. Jul 15 2017 In : Clinical Cancer Research. 23, 14, p. 3935-3944 10 p.

Research output: Contribution to journalArticle

Pancreatic Cyst
Cyst Fluid
DNA Methylation
Pancreatic Neoplasms
Genetic Markers