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2018

A coupled-clock system drives the automaticity of human sinoatrial nodal pacemaker cells

Tsutsui, K., Monfredi, O. J., Sirenko-Tagirova, S. G., Maltseva, L. A., Bychkov, R., Kim, M. S., Ziman, B. D., Tarasov, K. V., Tarasova, Y. S., Zhang, J., Wang, M., Maltsev, A. V., Brennan, J. A., Efimov, I. R., Stern, M. D., Maltsev, V. A. & Lakatta, E., Jun 12 2018, In : Science Signaling. 11, 534, eaap7608.

Research output: Contribution to journalArticle

Action Potentials
Cyclic AMP-Dependent Protein Kinases
Sinoatrial Node
Membrane Potentials
Adrenergic Receptors

Adipocytokine correlations with thyroid function and autoimmunity in euthyroid sardinians

Delitala, A. P., Steri, M., Fiorillo, E., Marongiu, M., Lakatta, E. G., Schlessinger, D. & Cucca, F., Nov 1 2018, In : Cytokine. 111, p. 189-193 5 p.

Research output: Contribution to journalArticle

Aldosterone, inactive matrix gla-protein, and large artery stiffness in hypertension

Chirinos, J. A., Sardana, M., Syed, A. A., Koppula, M. R., Varakantam, S., Vasim, I., Oldland, H. G., Phan, T. S., Drummen, N. E. A., Vermeer, C., Townsend, R. R., Akers, S. R., Wei, W., Lakatta, E. G. & Fedorova, O. V., Jan 1 2018, (Accepted/In press) In : Journal of the American Society of Hypertension.

Research output: Contribution to journalArticle

Aldosterone
Arteries
Hypertension
Pulse Wave Analysis
Thigh

Antibody to marinobufagenin reverses placenta-induced fibrosis of umbilical arteries in preeclampsia

Fedorova, O. V., Ishkaraeva, V. V., Grigorova, Y. N., Reznik, V. A., Kolodkin, N. I., Zazerskaya, I. E., Zernetkina, V., Agalakova, N. I., Tapilskaya, N. I., Adair, C. D., Lakatta, E. G. & Bagrov, A. Y., Aug 13 2018, In : International Journal of Molecular Sciences. 19, 8, 2377.

Research output: Contribution to journalArticle

fibrosis
Umbilical Arteries
Blood pressure
arteries
blood pressure

Association of arginine vasopressin with low atrial natriuretic peptide levels, left ventricular remodelling, and outcomes in adults with and without heart failure

Chirinos, J. A., Sardana, M., Oldland, G., Ansari, B., Lee, J., Hussain, A., Mustafa, A., Akers, S. R., Wei, W., Lakatta, E. G. & Fedorova, O. V., Oct 1 2018, In : ESC Heart Failure. 5, 5, p. 911-919 9 p.

Research output: Contribution to journalArticle

Ventricular Remodeling
Arginine Vasopressin
Atrial Natriuretic Factor
Heart Failure
Confidence Intervals

Basal Spontaneous Firing of Rabbit Sinoatrial Node Cells Is Regulated by Dual Activation of PDEs (Phosphodiesterases) 3 and 4

Vinogradova, T. M., Sirenko, S., Lukyanenko, Y. O., Yang, D., Tarasov, K. V., Lyashkov, A. E., Varghese, N. J., Li, Y., Chakir, K., Ziman, B. & Lakatta, E., Jun 1 2018, In : Circulation: Arrhythmia and Electrophysiology. 11, 6, e005896.

Research output: Contribution to journalArticle

Type 4 Cyclic Nucleotide Phosphodiesterase
Sinoatrial Node
Rabbits
Phosphoric Diester Hydrolases
Ryanodine Receptor Calcium Release Channel

Dietary sodium restriction reduces arterial stiffness, vascular TGF-β-dependent fibrosis and marinobufagenin in young normotensive rats

Grigorova, Y. N., Wei, W., Petrashevskaya, N., Zernetkina, V., Juhasz, O., Fenner, R., Gilbert, C., Lakatta, E., Shapiro, J. I., Bagrov, A. Y. & Fedorova, O. V., Oct 15 2018, In : International Journal of Molecular Sciences. 19, 10, 3168.

Research output: Contribution to journalArticle

Dietary Sodium
fibrosis
Vascular Stiffness
Transforming Growth Factor beta
rats
Sarcoplasmic Reticulum
Ion Channels
Ions
Rabbits
Calcium

Heterogeneity of calcium clock functions in dormant, dysrhythmically and rhythmically firing single pacemaker cells isolated from SA node

Kim, M. S., Maltsev, A. V., Monfredi, O., Maltseva, L. A., Wirth, A., Florio, M. C., Tsutsui, K., Riordon, D. R., Parsons, S. P., Tagirova, S., Ziman, B. D., Stern, M. D., Lakatta, E. & Maltsev, V. A., Sep 1 2018, In : Cell Calcium. 74, p. 168-179 12 p.

Research output: Contribution to journalArticle

Sinoatrial Node
Calcium
Receptors, Adrenergic, beta
Action Potentials
Diastole

Positive Feedback Mechanisms among Local Ca Releases, NCX, and ICaL Ignite Pacemaker Action Potentials

Lyashkov, A. E., Beahr, J., Lakatta, E. G., Yaniv, Y. & Maltsev, V. A., Mar 13 2018, In : Biophysical Journal. 114, 5, p. 1176-1189 14 p.

Research output: Contribution to journalArticle

Action Potentials
Membrane Potentials
Ryanodine Receptor Calcium Release Channel
Sarcoplasmic Reticulum
Noise

Reduced vasorin enhances angiotensin II signaling within the aging arterial wall

Pintus, G., Giordo, R., Wang, Y., Zhu, W., Kim, S. H., Zhang, L., Ni, L., Zhang, J., Telljohann, R., McGraw, K. R., Monticone, R. E., Ferris, C., Liu, L., Wang, M. & Lakatta, E. G., Jun 1 2018, In : Oncotarget. 9, 43, p. 27117-27132 16 p.

Research output: Contribution to journalArticle

Vascular Smooth Muscle
Angiotensin II
Smooth Muscle Myocytes
Matrix Metalloproteinases
Cell Wall

Segment-specific associations between local haemodynamic and imaging markers of early atherosclerosis at the carotid artery: an in vivo human study

Gallo, D., Bijari, P. B., Morbiducci, U., Qiao, Y., Xie, Y. J., Etesami, M., Habets, D., Lakatta, E. G., Wasserman, B. A. & Steinman, D. A., Oct 10 2018, In : Journal of the Royal Society, Interface. 15, 147

Research output: Contribution to journalArticle

Common Carotid Artery
Hemodynamics
Carotid Arteries
Shear stress
Atherosclerosis

TGFβ1 reinforces arterial aging in the vascular smooth muscle cell through a long-range regulation of the cytoskeletal stiffness

Zhu, W., Kim, B. C., Wang, M., Huang, J., Isak, A., Bexiga, N. M., Monticone, R., Ha, T., Lakatta, E. & An, S., Dec 1 2018, In : Scientific Reports. 8, 1, 2668.

Research output: Contribution to journalArticle

Transforming Growth Factors
Vascular Smooth Muscle
Smooth Muscle Myocytes
Thoracic Aorta
Actin Cytoskeleton

The reality of getting old

Lakatta, E., Sep 1 2018, In : Nature Reviews Cardiology. 15, 9, p. 499-500 2 p.

Research output: Contribution to journalComment/debate

Life Expectancy
Cardiology
Research

Unique Ca2+-cycling protein abundance and regulation sustains local Ca2+ releases and spontaneous firing of rabbit sinoatrial node cells

Vinogradova, T. M., Sirenko, S. T. & Lakatta, E., Aug 1 2018, In : International Journal of Molecular Sciences. 19, 8, 2173.

Research output: Contribution to journalReview article

sarcoplasmic reticulum
Sinoatrial Node
rabbits
Depolarization
Sarcoplasmic Reticulum
2017

Arterial Stiffness and Risk of Overall Heart Failure, Heart Failure with Preserved Ejection Fraction, and Heart Failure with Reduced Ejection Fraction: The Health ABC Study (Health, Aging, and Body Composition)

Pandey, A., Khan, H., Newman, A. B., Lakatta, E. G., Forman, D. E., Butler, J. & Berry, J. D., Feb 1 2017, In : Hypertension. 69, 2, p. 267-274 8 p.

Research output: Contribution to journalArticle

Vascular Stiffness
Pulse Wave Analysis
Body Composition
Thigh
Heart Failure

Causal effect of plasminogen activator inhibitor type 1 on coronary heart disease

CHARGE Consortium Hemostatic Factor Working Group, ICBP Consortium & CHARGE Consortium Subclinical Working Group, Jun 1 2017, In : Journal of the American Heart Association. 6, 6, e004918.

Research output: Contribution to journalArticle

Plasminogen Activator Inhibitor 1
Coronary Disease
Odds Ratio
Mendelian Randomization Analysis
Genome-Wide Association Study

Computer algorithms for automated detection and analysis of local Ca2+ releases in spontaneously beating cardiac pacemaker cells

Maltsev, A. V., Parsons, S. P., Kim, M. S., Tsutsui, K., Stern, M. D., Lakatta, E., Maltsev, V. A. & Monfredi, O., Jul 1 2017, In : PLoS One. 12, 7, e0179419.

Research output: Contribution to journalArticle

Pacemakers
cells
Noise
Affine transforms
Biophysics

Hemodynamic determinants of the short-term blood pressure variability: Differential roles of arterial stiffness and wave reflection

Hsu, P. F., Cheng, H. M., Sung, S. H., Chuang, S. Y., Lakatta, E., Yin, F. C. P., Chou, P. & Chen, C. H., 2017, In : American Journal of Hypertension. 30, 3, p. 256-263 8 p.

Research output: Contribution to journalArticle

Vascular Stiffness
Pulse Wave Analysis
Hemodynamics
Thigh
Blood Pressure

Longitudinal Association between Serum Uric Acid and Arterial Stiffness: Results from the Baltimore Longitudinal Study of Aging

Canepa, M., Viazzi, F., Strait, J. B., Ameri, P., Pontremoli, R., Brunelli, C., Studenski, S., Ferrucci, L., Lakatta, E. & AlGhatrif, M., Feb 1 2017, In : Hypertension. 69, 2, p. 228-235 8 p.

Research output: Contribution to journalArticle

Baltimore
Vascular Stiffness
Uric Acid
Longitudinal Studies
Serum

Lower mitochondrial energy production of the thigh muscles in patients with low-normal ankle-brachial index

AlGhatrif, M., Zane, A., Oberdier, M., Canepa, M., Studenski, S., Simonsick, E. M., Spencer, R. G., Fishbein, K., Reiter, D., Lakatta, E., McDermott, M. M. & Ferrucci, L., Sep 1 2017, In : Journal of the American Heart Association. 6, 9, e006604.

Research output: Contribution to journalArticle

Ankle Brachial Index
Thigh
Muscles
Phosphocreatine
Exercise

Mammalian γ2 AMPK regulates intrinsic heart rate

Yavari, A., Bellahcene, M., Bucchi, A., Sirenko, S., Pinter, K., Herring, N., Jung, J. J., Tarasov, K. V., Sharpe, E. J., Wolfien, M., Czibik, G., Steeples, V., Ghaffari, S., Nguyen, C., Stockenhuber, A., Clair, J. R. S., Rimmbach, C., Okamoto, Y., Yang, D., Wang, M. & 44 othersZiman, B. D., Moen, J. M., Riordon, D. R., Ramirez, C., Paina, M., Lee, J., Zhang, J., Ahmet, I., Matt, M. G., Tarasova, Y. S., Baban, DI., Sahgal, N., Lockstone, H., Puliyadi, R., De Bono, J., Siggs, O. M., Gomes, J., Muskett, H., Maguire, M. L., Beglov, Y., Kelly, M., Dos Santos, P. P. N., Bright, N. J., Woods, A., Gehmlich, K., Isackson, H., Douglas, G., Ferguson, D. J. P., Schneider, J. E., Tinker, A., Wolkenhauer, O., Channon, K. M., Cornall, R. J., Sternick, E. B., Paterson, D. J., Redwood, C. S., Carling, D., Proenza, C., David, R., Baruscotti, M., DIfrancesco, D., Lakatta, E. G., Watkins, H. & Ashrafian, H., Dec 1 2017, In : Nature Communications. 8, 1, 1258.

Research output: Contribution to journalArticle

Prognostic utility of morning blood pressure surge for 20-year all- cause and cardiovascular mortalities: Results of a community-based study

Cheng, H. M., Wu, C. L., Sung, S. H., Lee, J. C., Kario, K., Chiang, C. E., Huang, C. J., Hsu, P. F., Chuang, S. Y., Lakatta, E., Yin, F. C. P., Chou, P. & Chen, C. H., Dec 1 2017, In : Journal of the American Heart Association. 6, 12, e007667.

Research output: Contribution to journalArticle

Sleep
Blood Pressure
Mortality
Confidence Intervals
Proportional Hazards Models

Spontaneous, local diastolic subsarcolemmal calcium releases in single, isolated guinea-pig sinoatrial nodal cells

Sirenko, S. G., Yang, D., Maltseva, L. A., Kim, M. S., Lakatta, E. G. & Maltsev, V. A., Sep 1 2017, In : PLoS One. 12, 9, e0185222.

Research output: Contribution to journalArticle

guinea pigs
Guinea Pigs
Calcium
calcium
cells

The Pressure of Aging

AlGhatrif, M., Wang, M., Fedorova, O. V., Bagrov, A. Y. & Lakatta, E. G., Jan 1 2017, In : Medical Clinics of North America. 101, 1, p. 81-101 21 p.

Research output: Contribution to journalReview article

Blood Pressure
Pressure
Pulse Wave Analysis
Hemodynamics
Hypertension

The Systematic Evaluation of Identifying the Infarct Related Artery Utilizing Cardiac Magnetic Resonance in Patients Presenting with ST-Elevation Myocardial Infarction

Hamo, C. E., Klem, I., Rao, S. V., Songco, V., Najjar, S., Lakatta, E. G., Raman, S. V., Harrington, R. A. & Heitner, J. F., Jan 1 2017, In : PLoS One. 12, 1, e0169108.

Research output: Contribution to journalArticle

infarction
myocardial infarction
Magnetic resonance
arteries
Magnetic Resonance Spectroscopy
2016

52 Genetic Loci Influencing Myocardial Mass

van der Harst, P., van Setten, J., Verweij, N., Vogler, G., Franke, L., Maurano, M. T., Wang, X., Mateo Leach, I., Eijgelsheim, M., Sotoodehnia, N., Hayward, C., Sorice, R., Meirelles, O., Lyytikäinen, L. P., Polašek, O., Tanaka, T., Arking, D. E., Ulivi, S., Trompet, S., Müller-Nurasyid, M. & 140 othersSmith, A. V., Dörr, M., Kerr, K. F., Magnani, J. W., Del Greco M., F., Zhang, W., Nolte, I. M., Silva, C. T., Padmanabhan, S., Tragante, V., Esko, T., Abecasis, G. R., Adriaens, M. E., Andersen, K., Barnett, P., Bis, J. C., Bodmer, R., Buckley, B. M., Campbell, H., Cannon, M. V., Chakravarti, A., Chen, L. Y., Delitala, A., Devereux, R. B., Doevendans, P. A., Dominiczak, A. F., Ferrucci, L., Ford, I., Gieger, C., Harris, T. B., Haugen, E., Heinig, M., Hernandez, D. G., Hillege, H. L., Hirschhorn, J. N., Hofman, A., Hubner, N., Hwang, S. J., Iorio, A., Kähönen, M., Kellis, M., Kolcic, I., Kooner, I. K., Kooner, J. S., Kors, J. A., Lakatta, E. G., Lage, K., Launer, L. J., Levy, D., Lundby, A., Macfarlane, P. W., May, D., Meitinger, T., Metspalu, A., Nappo, S., Naitza, S., Neph, S., Nord, A. S., Nutile, T., Okin, P. M., Olsen, J. V., Oostra, B. A., Penninger, J. M., Pennacchio, L. A., Pers, T. H., Perz, S., Peters, A., Pinto, Y. M., Pfeufer, A., Pilia, M. G., Pramstaller, P. P., Prins, B. P., Raitakari, O. T., Raychaudhuri, S., Rice, K. M., Rossin, E. J., Rotter, J. I., Schafer, S., Schlessinger, D., Schmidt, C. O., Sehmi, J., Silljé, H. H. W., Sinagra, G., Sinner, M. F., Slowikowski, K., Soliman, E. Z., Spector, T. D., Spiering, W., Stamatoyannopoulos, J. A., Stolk, R. P., Strauch, K., Tan, S. T., Tarasov, K. V., Trinh, B., Uitterlinden, A. G., van den Boogaard, M., van Duijn, C. M., van Gilst, W. H., Viikari, J. S., Visscher, P. M., Vitart, V., Völker, U., Waldenberger, M., Weichenberger, C. X., Westra, H. J., Wijmenga, C., Wolffenbuttel, B. H., Yang, J., Bezzina, C. R., Munroe, P. B., Snieder, H., Wright, A. F., Rudan, I., Boyer, L. A., Asselbergs, F. W., van Veldhuisen, D. J., Stricker, B. H., Psaty, B. M., Ciullo, M., Sanna, S., Lehtimäki, T., Wilson, J. F., Bandinelli, S., Alonso, A., Gasparini, P., Jukema, J. W., Kääb, S., Gudnason, V., Felix, S. B., Heckbert, S. R., de Boer, R. A., Newton-Cheh, C., Hicks, A. A., Chambers, J. C., Jamshidi, Y., Visel, A., Christoffels, V. M., Isaacs, A., Samani, N. J. & de Bakker, P. I. W., Sep 27 2016, In : Journal of the American College of Cardiology. 68, 13, p. 1435-1448 14 p.

Research output: Contribution to journalArticle

Genetic Loci
Cardiomegaly
Meta-Analysis
Myocardium
Histone Code

AGE-RAGE signal generates a specific NF-Κ B RelA "barcode" that directs collagen i expression

Peng, Y., Kim, J. M., Park, H. S., Yang, A., Islam, C., Lakatta, E. & Lin, L., Jan 5 2016, In : Scientific Reports. 6, 18822.

Research output: Contribution to journalArticle

Collagen
NF-kappa B
Advanced Glycosylation End Products
Post Translational Protein Processing
Phosphorylation

Aortic Fibrosis, Induced by High Salt Intake in the Absence of Hypertensive Response, Is Reduced by a Monoclonal Antibody to Marinobufagenin

Grigorova, Y. N., Juhasz, O., Zernetkina, V., Fishbein, K. W., Lakatta, E. G., Fedorova, O. V. & Bagrov, A. Y., May 1 2016, In : American Journal of Hypertension. 29, 5, p. 641-646 6 p.

Research output: Contribution to journalArticle

Fibrosis
Salts
Monoclonal Antibodies
Nitroprusside
Blood Pressure

A rat carotid balloon injury model to test anti-vascular remodeling therapeutics

Petrasheskaya, N., Tae, H. J., Ahmet, I., Talan, M. I., Lakatta, E. G. & Lin, L., Sep 19 2016, In : Journal of Visualized Experiments. 2016, 115, e53777.

Research output: Contribution to journalArticle

Balloons
Rats
Wounds and Injuries
Pharmaceutical Preparations
Ultrasonography

Ca2 +/calmodulin-activated phosphodiesterase 1A is highly expressed in rabbit cardiac sinoatrial nodal cells and regulates pacemaker function

Lukyanenko, Y. O., Younes, A., Lyashkov, A. E., Tarasov, K. V., Riordon, D. R., Lee, J., Sirenko, S. G., Kobrinsky, E., Ziman, B., Tarasova, Y. S., Juhaszova, M., Sollott, S. J., Graham, D. & Lakatta, E., Sep 1 2016, In : Journal of Molecular and Cellular Cardiology. 98, p. 73-82 10 p.

Research output: Contribution to journalArticle

Type 1 Cyclic Nucleotide Phosphodiesterases
Rabbits
Calmodulin
Lipids
Phosphoric Diester Hydrolases

Camkii-dependent phosphorylation regulates basal cardiac pacemaker function via modulation of local ca2+ releases

Li, Y., Sirenko, S., Riordon, D. R., Yang, D., Spurgeon, H., Lakatta, E. & Vinogradova, T. M., Sep 1 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 311, 3, p. H532-H544

Research output: Contribution to journalArticle

Sinoatrial Node
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Phosphorylation
Ryanodine Receptor Calcium Release Channel
Muscle Cells

Deterioration of autonomic neuronal receptor signaling and mechanisms intrinsic to heart pacemaker cells contribute to age-associated alterations in heart rate variability in vivo

Yaniv, Y., Ahmet, I., Tsutsui, K., Behar, J., Moen, J. M., Okamoto, Y., Guiriba, T. R., Liu, J., Bychkov, R. & Lakatta, E. G., Aug 1 2016, In : Aging Cell. 15, 4, p. 716-724 9 p.

Research output: Contribution to journalArticle

Heart Rate
Phosphoric Diester Hydrolases
Atropine
Propranolol
Electrocardiography

Electrochemical Na+ and Ca2+gradients drive coupled-clock regulation of automaticity of isolated rabbit sinoatrial nodal pacemaker cells

Sirenko, S. G., Maltsev, V. A., Yaniv, Y., Bychkov, R., Yaeger, D., Vinogradova, T., Spurgeon, H. A. & Lakatta, E., Jul 1 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 311, 1, p. H251-H267

Research output: Contribution to journalArticle

Action Potentials
Rabbits
Ion Channels
Digitalis Glycosides
Ions

Gender specific profiles of white coat and masked hypertension impacts on arterial structure and function in the SardiNIA study

Scuteri, A., Morrell, C. H., Orru', M., Alghatrif, M., Saba, P. S., Terracciano, A., Ferreli, L. A. P., Loi, F., Marongiu, M., Pilia, M. G., Delitala, A., Tarasov, K. V., Schlessinger, D., Ganau, A., Cucca, F. & Lakatta, E. G., Aug 15 2016, In : International Journal of Cardiology. 217, p. 92-98 7 p.

Research output: Contribution to journalArticle

Masked Hypertension
White Coat Hypertension
Italy
Ambulatory Blood Pressure Monitoring
Common Carotid Artery

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Pattaro, C., Teumer, A., Gorski, M., Chu, A. Y., Li, M., Mijatovic, V., Garnaas, M., Tin, A., Sorice, R., Li, Y., Taliun, D., Olden, M., Foster, M., Yang, Q., Chen, M. H., Pers, T. H., Johnson, A. D., Ko, Y. A., Fuchsberger, C., Tayo, B. & 678 othersNalls, M., Feitosa, M. F., Isaacs, A., Dehghan, A., D'Adamo, P., Adeyemo, A., Dieffenbach, A. K., Zonderman, A. B., Nolte, I. M., Van Der Most, P. J., Wright, A. F., Shuldiner, A. R., Morrison, A. C., Hofman, A., Smith, A. V., Dreisbach, A. W., Franke, A., Uitterlinden, A. G., Metspalu, A., Tonjes, A., Lupo, A., Robino, A., Johansson, Å., Demirkan, A., Kollerits, B., Freedman, B. I., Ponte, B., Oostra, B. A., Paulweber, B., Krämer, B. K., Mitchell, B. D., Buckley, B. M., Peralta, C. A., Hayward, C., Helmer, C., Rotimi, C. N., Shaffer, C. M., Müller, C., Sala, C., Van Duijn, C. M., Saint-Pierre, A., Ackermann, D., Shriner, D., Ruggiero, D., Toniolo, D., Lu, Y., Cusi, D., Czamara, D., Ellinghaus, D., Siscovick, D. S., Ruderfer, D., Gieger, C., Grallert, H., Rochtchina, E., Atkinson, E. J., Holliday, E. G., Boerwinkle, E., Salvi, E., Bottinger, E. P., Murgia, F., Rivadeneira, F., Ernst, F., Kronenberg, F., Hu, F. B., Navis, G. J., Curhan, G. C., Ehret, G. B., Homuth, G., Coassin, S., Thun, G. A., Pistis, G., Gambaro, G., Malerba, G., Montgomery, G. W., Eiriksdottir, G., Jacobs, G., Li, G., Wichmann, H. E., Campbell, H., Schmidt, H., Wallaschofski, H., Völzke, H., Brenner, H., Kroemer, H. K., Kramer, H., Lin, H., Leach, I. M., Ford, I., Guessous, I., Rudan, I., Prokopenko, I., Borecki, I., Heid, I. M., Kolcic, I., Persico, I., Jukema, J. W., Wilson, J. F., Felix, J. F., Divers, J., Lambert, J. C., Stafford, J. M., Gaspoz, J. M., Smith, J. A., Faul, J. D., Wang, J. J., Ding, J., Hirschhorn, J. N., Attia, J., Whitfield, J. B., Chalmers, J., Viikari, J., Coresh, J., Denny, J. C., Karjalainen, J., Fernandes, J. K., Endlich, K., Butterbach, K., Keene, K. L., Lohman, K., Portas, L., Launer, L. J., Lyytikäinen, L. P., Yengo, L., Franke, L., Ferrucci, L., Rose, L. M., Kedenko, L., Rao, M., Struchalin, M., Kleber, M. E., Cavalieri, M., Haun, M., Cornelis, M. C., Ciullo, M., Pirastu, M., De Andrade, M., McEvoy, M. A., Woodward, M., Adam, M., Cocca, M., Nauck, M., Imboden, M., Waldenberger, M., Pruijm, M., Metzger, M., Stumvoll, M., Evans, M. K., Sale, M. M., Kähönen, M., Boban, M., Bochud, M., Rheinberger, M., Verweij, N., Bouatia-Naji, N., Martin, N. G., Hastie, N., Probst-Hensch, N., Soranzo, N., Devuyst, O., Raitakari, O., Gottesman, O., Franco, O. H., Polasek, O., Gasparini, P., Munroe, P. B., Ridker, P. M., Mitchell, P., Muntner, P., Meisinger, C., Smit, J. H., Abecasis, G. R., Adair, L. S., Alexander, M., Altshuler, D., Amin, N., Arking, D. E., Arora, P., Aulchenko, Y., Bakker, S. J. L., Bandinelli, S., Barroso, I., Beckmann, J. S., Beilby, J. P., Bergman, R. N., Bergmann, S., Bis, J. C., Boehnke, M., Bonnycastle, L. L., Bornstein, S. R., Bots, M. L., Bragg-Gresham, J. L., Brand, S. M., Brand, E., Braund, P. S., Brown, M. J., Burton, P. R., Casas, J. P., Caulfield, M. J., Chakravarti, A., Chambers, J. C., Chandak, G. R., Chang, Y. P. C., Charchar, F. J., Chaturvedi, N., Cho, Y. S., Clarke, R., Collins, F. S., Collins, R., Connell, J. M., Cooper, J. A., Cooper, M. N., Cooper, R. S., Corsi, A. M., Dörr, M., Dahgam, S., Danesh, J., Smith, G. D., Day, I. N. M., Deloukas, P., Denniff, M., Dominiczak, A. F., Dong, Y., Doumatey, A., Elliott, P., Elosua, R., Erdmann, J., Eyheramendy, S., Farrall, M., Fava, C., Forrester, T., Fowkes, F. G. R., Fox, E. R., Frayling, T. M., Galan, P., Ganesh, S. K., Garcia, M., Gaunt, T. R., Glazer, N. L., Go, M. J., Goel, A., Grässler, J., Grobbee, D. E., Groop, L., Guarrera, S., Guo, X., Hadley, D., Hamsten, A., Han, B. G., Hardy, R., Hartikainen, A. L., Heath, S., Heckbert, S. R., Hedblad, B., Hercberg, S., Hernandez, D., Hicks, A. A., Hilton, G., Hingorani, A. D., Hoffman Bolton, J. A., Hopewell, J. C., Howard, P., Humphries, S. E., Hunt, S. C., Hveem, K., Ikram, M. A., Islam, M., Iwai, N., Jarvelin, M. R., Jackson, A. U., Jafar, T. H., Janipalli, C. S., Johnson, T., Kathiresan, S., Khaw, K. T., Kim, H. L., Kinra, S., Kita, Y., Kivimaki, M., Kooner, J. S., Kumar, M. J. K., Kuh, D., Kulkarni, S. R., Kumari, M., Kuusisto, J., Kuznetsova, T., Laakso, M., Laan, M., Laitinen, J., Lakatta, E. G., Langefeld, C. D., Larson, M. G., Lathrop, M., Lawlor, D. A., Lawrence, R. W., Lee, J. Y., Lee, N. R., Levy, D., Li, Y., Longstreth, W. T., Luan, J., Lucas, G., Ludwig, B., Mangino, M., Mani, K. R., Marmot, M. G., Mattace-Raso, F. U. S., Matullo, G., McArdle, W. L., McKenzie, C. A., Meitinger, T., Melander, O., Meneton, P., Meschia, J. F., Miki, T., Milaneschi, Y., Mohlke, K. L., Mooser, V., Morken, M. A., Morris, R. W., Mosley, T. H., Najjar, S., Narisu, N., Newton-Cheh, C., Nguyen, K. D. H., Nilsson, P., Nyberg, F., O'Donnell, C. J., Ogihara, T., Ohkubo, T., Okamura, T., Ong, R. T. H., Ongen, H., Onland-Moret, N. C., O'Reilly, P. F., Org, E., Orru, M., Palmas, W., Palmen, J., Palmer, L. J., Palmer, N. D., Parker, A. N., Peden, J. F., Peltonen, L., Perola, M., Pihur, V., Platou, C. G. P., Plump, A., Prabhakaran, D., Psaty, B. M., Raffel, L. J., Rao, D. C., Rasheed, A., Ricceri, F., Rice, K. M., Rosengren, A., Rotter, J. I., Rudock, M. E., Sõber, S., Salako, T., Saleheen, D., Salomaa, V., Samani, N. J., Schwartz, S. M., Schwarz, P. E. H., Scott, L. J., Scott, J., Scuteri, A., Sehmi, J. S., Seielstad, M., Seshadri, S., Sharma, P., Shaw-Hawkins, S., Shi, G., Shrine, N. R. G., Sijbrands, E. J. G., Sim, X., Singleton, A., Sjögren, M., Smith, N. L., Artigas, M. S., Spector, T. D., Staessen, J. A., Stancakova, A., Steinle, N. I., Strachan, D. P., Stringham, H. M., Sun, Y. V., Swift, A. J., Tabara, Y., Tai, E. S., Talmud, P. J., Taylor, A., Terzic, J., Thelle, D. S., Tobin, M. D., Tomaszewski, M., Tripathy, V., Tuomilehto, J., Tzoulaki, I., Uda, M., Ueshima, H., Uiterwaal, C. S. P. M., Umemura, S., Van Der Harst, P., Van Der Schouw, Y. T., Van Gilst, W. H., Vartiainen, E., Vasan, R. S., Veldre, G., Verwoert, G. C., Viigimaa, M., Vinay, D. G., Vineis, P., Voight, B. F., Vollenweider, P., Wagenknecht, L. E., Wain, L. V., Wang, X., Wang, T. J., Wareham, N. J., Watkins, H., Weder, A. B., Whincup, P. H., Wiggins, K. L., Witteman, J. C. M., Wong, A., Wu, Y., Yajnik, C. S., Yao, J., Young, J. H., Zelenika, D., Zhai, G., Zhang, W., Zhang, F., Zhao, J. H., Zhu, H., Zhu, X., Zitting, P., Zukowska-Szczechowska, E., Okada, Y., Wu, J. Y., Gu, D., Takeuchi, F., Takahashi, A., Maeda, S., Tsunoda, T., Chen, P., Lim, S. C., Wong, T. Y., Liu, J., Young, T. L., Aung, T., Teo, Y. Y., Kim, Y. J., Kang, D., Chen, C. H., Tsai, F. J., Chang, L. C., Fann, S. J. C., Mei, H., Hixson, J. E., Chen, S., Katsuya, T., Isono, M., Albrecht, E., Yamamoto, K., Kubo, M., Nakamura, Y., Kamatani, N., Kato, N., He, J., Chen, Y. T., Tanaka, T., Reilly, M. P., Schunkert, H., Assimes, T. L., Hall, A., Hengstenberg, C., König, I. R., Laaksonen, R., McPherson, R., Thompson, J. R., Thorsteinsdottir, U., Ziegler, A., Absher, D., Chen, L., Cupples, L. A., Halperin, E., Li, M., Musunuru, K., Preuss, M., Schillert, A., Thorleifsson, G., Wells, G. A., Holm, H., Roberts, R., Stewart, A. F. R., Fortmann, S., Go, A., Hlatky, M., Iribarren, C., Knowles, J., Myers, R., Quertermous, T., Sidney, S., Risch, N., Tang, H., Blankenberg, S., Schnabel, R., Sinning, C., Lackner, K. J., Tiret, L., Nicaud, V., Cambien, F., Bickel, C., Rupprecht, H. J., Perret, C., Proust, C., Münzel, T. F., Barbalic, M., Chen, I. Y. D., Demissie-Banjaw, S., Folsom, A., Lumley, T., Marciante, K., Taylor, K. D., Volcik, K., Gretarsdottir, S., Gulcher, J. R., Kong, A., Stefansson, K., Thorgeirsson, G., Andersen, K., Fischer, M., Grosshennig, A., Linsel-Nitschke, P., Stark, K., Schreiber, S., Aherrahrou, Z., Bruse, P., Doering, A., Klopp, N., Diemert, P., Loley, C., Medack, A., Nahrstedt, J., Peters, A., Wagner, A. K., Willenborg, C., Böhm, B. O., Dobnig, H., Grammer, T. B., Hoffmann, M. M., Meinitzer, A., Winkelmann, B. R., Pilz, S., Renner, W., Scharnagl, H., Stojakovic, T., Tomaschitz, A., Winkler, K., Guiducci, C., Burtt, N., Gabriel, S. B., Dandona, S., Jarinova, O., Qu, L., Wilensky, R., Matthai, W., Hakonarson, H. H., Devaney, J., Burnett, M. S., Pichard, A. D., Kent, K. M., Satler, L., Lindsay, J. M., Waksman, R., Knouff, C. W., Waterworth, D. M., Walker, M. C., Epstein, S. E., Rader, D. J., Nelson, C. P., Wright, B. J., Balmforth, A. J., Ball, S. G., Loehr, L. R., Rosamond, W. D., Benjamin, E., Haritunians, T., Couper, D., Murabito, J., Wang, Y. A., Stricker, B. H., Chang, P. P., Willerson, J. T., Felix, S. B., Watzinger, N., Aragam, J., Zweiker, R., Lind, L., Rodeheffer, R. J., Greiser, K. H., Deckers, J. W., Stritzke, J., Ingelsson, E., Kullo, I., Haerting, J., Reffelmann, T., Redfield, M. M., Werdan, K., Mitchell, G. F., Arnett, D. K., Gottdiener, J. S., Blettner, M., Friedrich, N., Kovacs, P., Wild, P. S., Froguel, P., Rettig, R., Mägi, R., Biffar, R., Schmidt, R., Middelberg, R. P. S., Carroll, R. J., Penninx, B. W., Scott, R. J., Katz, R., Sedaghat, S., Wild, S. H., Kardia, S. L. R., Ulivi, S., Hwang, S. J., Enroth, S., Kloiber, S., Trompet, S., Stengel, B., Hancock, S. J., Turner, S. T., Rosas, S. E., Stracke, S., Harris, T. B., Zeller, T., Zemunik, T., Lehtimäki, T., Illig, T., Aspelund, T., Nikopensius, T., Esko, T., Tanaka, T., Gyllensten, U., Völker, U., Emilsson, V., Vitart, V., Aalto, V., Gudnason, V., Chouraki, V., Chen, W. M., Igl, W., März, W., Koenig, W., Lieb, W., Loos, R. J. F., Liu, Y., Snieder, H., Pramstaller, P. P., Parsa, A., O'Connell, J. R., Susztak, K., Hamet, P., Tremblay, J., De Boer, I. H., Böger, C. A., Goessling, W., Chasman, D. I., Köttgen, A., Kao, W. H. L. & Fox, C. S., Jan 21 2016, In : Nature Communications. 7, 10023.

Research output: Contribution to journalArticle

kidneys
loci
Glomerular Filtration Rate
Kidney
cells

High short-term blood pressure variability predicts long-term cardiovascular mortality in untreated hypertensives but not in normotensives

Hsu, P. F., Cheng, H. M., Wu, C. H., Sung, S. H., Chuang, S. Y., Lakatta, E. G., Yin, F. C. P., Chou, P. & Chen, C. H., 2016, In : American Journal of Hypertension. 29, 7, p. 806-813 8 p.

Research output: Contribution to journalArticle

Blood Pressure
Mortality
Confidence Intervals
Ambulatory Blood Pressure Monitoring
Hypertension
Dietary Supplements
Heart Failure
Diet
Pulse Wave Analysis
Vascular Stiffness

Mouse RAGE variant 4 is a dominant membrane receptor that does not shed to generate soluble RAGE

Peng, Y., Horwitz, N., Lakatta, E. G. & Lin, L., Sep 1 2016, In : PLoS One. 11, 9, e0153657.

Research output: Contribution to journalArticle

Cell membranes
Protein Isoforms
Endosomes
Cell Membrane
Membranes

Pharmacological Strategies to Retard Cardiovascular Aging

Alfaras, I., Di Germanio, C., Bernier, M., Csiszar, A., Ungvari, Z., Lakatta, E. & De Cabo, R., May 13 2016, In : Circulation Research. 118, 10, p. 1626-1642 17 p.

Research output: Contribution to journalReview article

Cardiovascular Diseases
Pharmacology
Cardiovascular System
Hypercholesterolemia
Hyperglycemia

Prognostic significance of mechanical biomarkers derived from pulse wave analysis for predicting long-term cardiovascular mortality in two population-based cohorts

Cheng, H. M., Chuang, S. Y., Wang, J. J., Shih, Y. T., Wang, H. N., Huang, C. J., Huang, J. T., Sung, S. H., Lakatta, E. G., Yin, F. C. P., Chou, P., Yeh, C. J., Bai, C. H., Pan, W. H. & Chen, C. H., Jul 15 2016, In : International Journal of Cardiology. 215, p. 388-395 8 p.

Research output: Contribution to journalArticle

Pulse Wave Analysis
Biomarkers
Mortality
Population
Cardiovascular Diseases

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Ehret, G. B., Ferreira, T., Chasman, D. I., Jackson, A. U., Schmidt, E. M., Johnson, T., Thorleifsson, G., Luan, JA., Donnelly, L. A., Kanoni, S., Petersen, A. K., Pihur, V., Strawbridge, R. J., Shungin, D., Hughes, M. F., Meirelles, O., Kaakinen, M., Bouatia-Naji, N., Kristiansson, K., Shah, S. & 293 othersKleber, M. E., Guo, X., Lyytikäinen, L. P., Fava, C., Eriksson, N., Nolte, I. M., Magnusson, P. K., Salfati, E. L., Rallidis, L. S., Theusch, E., Smith, A. J. P., Folkersen, L., Witkowska, K., Pers, T. H., Joehanes, R., Kim, S. K., Lataniotis, L., Jansen, R., Johnson, A. D., Warren, H., Kim, Y. J., Zhao, W., Wu, Y., Tayo, B. O., Bochud, M., Absher, D., Adair, L. S., Amin, N., Arking, D. E., Axelsson, T., Baldassarre, D., Balkau, B., Bandinelli, S., Barnes, M. R., Barroso, I., Bevan, S., Bis, J. C., Bjornsdottir, G., Boehnke, M., Boerwinkle, E., Bonnycastle, L. L., Boomsma, D. I., Bornstein, S. R., Brown, M. J., Burnier, M., Cabrera, C. P., Chambers, J. C., Chang, I. S., Cheng, C. Y., Chines, P. S., Chung, R. H., Collins, F. S., Connell, J. M., Döring, A., Dallongeville, J., Danesh, J., De Faire, U., Delgado, G., Dominiczak, A. F., Doney, A. S. F., Drenos, F., Edkins, S., Eicher, J. D., Elosua, R., Enroth, S., Erdmann, J., Eriksson, P., Esko, T., Evangelou, E., Evans, A., Fall, T., Farrall, M., Felix, J. F., Ferrières, J., Ferrucci, L., Fornage, M., Forrester, T., Franceschini, N., Franco, O. H., Franco-Cereceda, A., Fraser, R. M., Ganesh, S. K., Gao, H., Gertow, K., Gianfagna, F., Gigante, B., Giulianini, F., Goel, A., Goodall, A. H., Goodarzi, M. O., Gorski, M., Gräßler, J., Groves, C. J., Gudnason, V., Gyllensten, U., Hallmans, G., Hartikainen, A. L., Hassinen, M., Havulinna, A. S., Hayward, C., Hercberg, S., Herzig, K. H., Hicks, A. A., Hingorani, A. D., Hirschhorn, J. N., Hofman, A., Holmen, J., Holmen, O. L., Hottenga, J. J., Howard, P., Hsiung, C. A., Hunt, S. C., Ikram, M. A., Illig, T., Iribarren, C., Jensen, R. A., Kähönen, M., Kang, H. M., Kathiresan, S., Keating, B. J., Khaw, K. T., Kim, Y. K., Kim, E., Kivimaki, M., Klopp, N., Kolovou, G., Komulainen, P., Kooner, J. S., Kosova, G., Krauss, R. M., Kuh, D., Kutalik, Z., Kuusisto, J., Kvaløy, K., Lakka, T. A., Lee, N. R., Lee, I. T., Lee, W. J., Levy, D., Li, X., Liang, K. W., Lin, H., Lin, L., Lindström, J., Lobbens, S., Männistö, S., Müller, G., Müller-Nurasyid, M., Mach, F., Markus, H. S., Marouli, E., McCarthy, M. I., McKenzie, C. A., Meneton, P., Menni, C., Metspalu, A., Mijatovic, V., Moilanen, L., Montasser, M. E., Morris, A. D., Morrison, A. C., Mulas, A., Nagaraja, R., Narisu, N., Nikus, K., O'Donnell, C. J., O'Reilly, P. F., Ong, K. K., Paccaud, F., Palmer, C. D., Parsa, A., Pedersen, N. L., Penninx, B. W., Perola, M., Peters, A., Poulter, N., Pramstaller, P. P., Psaty, B. M., Quertermous, T., Rao, D. C., Rasheed, A., Rayner, N. W., Renström, F., Rettig, R., Rice, K. M., Roberts, R., Rose, L. M., Rossouw, J., Samani, N. J., Sanna, S., Saramies, J., Schunkert, H., Sebert, S., Sheu, W. H. H., Shin, Y. A., Sim, X., Smit, J. H., Smith, A. V., Sosa, M. X., Spector, T. D., Stančáková, A., Stanton, A. V., Stirrups, K. E., Stringham, H. M., Sundstrom, J., Swift, A. J., Syvänen, A. C., Tai, E. S., Tanaka, T., Tarasov, K. V., Teumer, A., Thorsteinsdottir, U., Tobin, M. D., Tremoli, E., Uitterlinden, A. G., Uusitupa, M., Vaez, A., Vaidya, D., Van Duijn, C. M., Van Iperen, E. P. A., Vasan, R. S., Verwoert, G. C., Virtamo, J., Vitart, V., Voight, B. F., Vollenweider, P., Wagner, A., Wain, L. V., Wareham, N. J., Watkins, H., Weder, A. B., Westra, H. J., Wilks, R., Wilsgaard, T., Wilson, J. F., Wong, T. Y., Yang, T. P., Yao, J., Yengo, L., Zhang, W., Zhao, J. H., Zhu, X., Bovet, P., Cooper, R. S., Mohlke, K. L., Saleheen, D., Lee, J. Y., Elliott, P., Gierman, H. J., Willer, C. J., Franke, L., Hovingh, G. K., Taylor, K. D., Dedoussis, G., Sever, P., Wong, A., Lind, L., Assimes, T. L., Njølstad, I., Schwarz, P. E. H., Langenberg, C., Snieder, H., Caulfield, M. J., Melander, O., Laakso, M., Saltevo, J., Rauramaa, R., Tuomilehto, J., Ingelsson, E., Lehtimäki, T., Hveem, K., Palmas, W., März, W., Kumari, M., Salomaa, V., Chen, Y. D. I., Rotter, J. I., Froguel, P., Jarvelin, M. R., Lakatta, E. G., Kuulasmaa, K., Franks, P. W., Hamsten, A., Wichmann, H. E., Palmer, C. N. A., Stefansson, K., Ridker, P. M., Loos, R. J. F., Chakravarti, A., Deloukas, P., Morris, A. P., Newton-Cheh, C. & Munroe, P. B., Oct 1 2016, In : Nature Genetics. 48, 10, p. 1171-1184 14 p.

Research output: Contribution to journalArticle

Blood Pressure
Single Nucleotide Polymorphism
Kidney
Blood Vessels
Endothelial Cells

The relationship between the metabolic syndrome and arterial wall thickness: A mosaic still to be interpreted

Scuteri, A., Franco, O. H., Völzke, H., Shin, M. H., Kweon, S. S., Rietzschel, E., Ryliškytė, L., Strazhesko, I., Chen, C. H., Lakatta, E. G. & Lakatta, E., Dec 1 2016, In : Atherosclerosis. 255, p. 11-16 6 p.

Research output: Contribution to journalArticle

Abdominal Obesity
Hypertension
Arteries
Cholesterol
Carotid Arteries
2015

A meta-analysis of gene expression signatures of blood pressure and hypertension

International Consortium for Blood Pressure GWAS (ICBP) & Levy, D., Mar 1 2015, In : PLoS Genetics. 11, 3, p. e1005035

Research output: Contribution to journalArticle

hypertension
meta-analysis
Transcriptome
gene expression
blood pressure

Cardiovascular disease and aging

Rabinovitch, P., Chiao, Y. A., Dai, D. F., Lakatta, E. & Ungvari, Z., Jan 1 2015, Advances in Geroscience. Springer International Publishing, p. 121-160 40 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cardiovascular Diseases
Aging of materials
Disease
Cardiovascular system
Cardiovascular System

From two competing oscillators to one coupled-clock pacemaker cell system

Yaniv, Y., Lakatta, E. G. & Maltsev, V. A., 2015, In : Frontiers in Physiology. 6, FEB, 28.

Research output: Contribution to journalShort survey

Action Potentials
Ion Channels
Electrophysiology
Sarcoplasmic Reticulum
Mammals

Marinobufagenin-induced vascular fibrosis is a likely target for mineralocorticoid antagonists

Fedorova, O. V., Emelianov, I. V., Bagrov, K. A., Grigorova, Y. N., Wei, W., Juhasz, O., Frolova, E. V., Marshall, C. A., Lakatta, E., Konradi, A. O. & Bagrov, A. Y., Aug 11 2015, In : Journal of Hypertension. 33, 8, p. 1602-1610 9 p.

Research output: Contribution to journalArticle

Mineralocorticoid Receptor Antagonists
Blood Vessels
Fibrosis
Spironolactone
Canrenone

Matrix metalloproteinases promote arterial remodeling in aging, hypertension, and atherosclerosis

Wang, M., Kim, S. H., Monticone, R. E. & Lakatta, E., Apr 20 2015, In : Hypertension. 65, 4, p. 698-703 6 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinases
Disease Progression
Atherosclerosis
Arteries
Hypertension

Metabolic syndrome across Europe: Different clusters of risk factors

Metabolic Syndrome and Arteries Research (MARE) Consortium, Apr 15 2015, In : European Journal of Preventive Cardiology. 22, 4, p. 486-491 6 p.

Research output: Contribution to journalArticle

Italy
Sweden
Spain
Germany
Lithuania