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2017

A Prospective Evaluation of Ileocecal Valve Dysfunction and Intestinal Motility Derangements in Small Intestinal Bacterial Overgrowth

Chander Roland, B., Mullin, G. E., Passi, M., Zheng, X., Salem, A., Yolken, R. & Pasricha, P. J. Sep 4 2017 (Accepted/In press) In : Digestive Diseases and Sciences. p. 1-11 11 p.

Research output: Contribution to journalArticle

Ileocecal Valve
Gastrointestinal Motility
Lactulose
Hydrogen
Capsules

Association of cognitive function and liability to addiction with childhood herpesvirus infections: A prospective cohort study

Vanyukov, M. M., Nimgaonkar, V. L., Kirisci, L., Kirillova, G. P., Reynolds, M. D., Prasad, K., Tarter, R. E. & Yolken, R. H. Apr 19 2017 (Accepted/In press) In : Development and Psychopathology. p. 1-10 10 p.

Research output: Contribution to journalArticle

Herpesviridae Infections
Cognition
Substance-Related Disorders
Cohort Studies
Prospective Studies

Comparison of three cell-based drug screening platforms for HSV-1 infection

D'Aiuto, L., Williamson, K., Dimitrion, P., McNulty, J., Brown, C. E., Dokuburra, C. B., Nielsen, A. J., Lin, W. J., Piazza, P., Schurdak, M. E., Wood, J., Yolken, R. H., Kinchington, P. R., Bloom, D. C. & Nimgaonkar, V. L. Jun 1 2017 In : Antiviral Research. 142, p. 136-140 5 p.

Research output: Contribution to journalArticle

Preclinical Drug Evaluations
Human Herpesvirus 1
Virus Diseases
Induced Pluripotent Stem Cells
Acyclovir

Dynamic disorganization of synaptic NMDA receptors triggered by autoantibodies from psychotic patients

Jézéquel, J., Johansson, E. M., Dupuis, J. P., Rogemond, V., Gréa, H., Kellermayer, B., Hamdani, N., Le Guen, E., Rabu, C., Lepleux, M., Spatola, M., Mathias, E., Bouchet, D., Ramsey, A. J., Yolken, R. H., Tamouza, R., Dalmau, J., Honnorat, J., Leboyer, M. & Groc, L. Dec 1 2017 In : Nature Communications. 8, 1, 1791

Research output: Contribution to journalArticle

Neurotransmitter Receptor
N-Methyl-D-Aspartate Receptors
Autoantibodies
Healthy Volunteers
Neurons

Effects of cumulative Herpesviridae and Toxoplasma gondii infections on cognitive function in healthy, bipolar, and schizophrenia subjects

Hamdani, N., Daban-Huard, C., Godin, O., Laouamri, H., Jamain, S., Attiba, D., Delavest, M., Lépine, J. P., Le Corvoisier, P., Houenou, J., Richard, J. R., Yolken, R. H., Krishnamoorthy, R., Tamouza, R., Leboyer, M. & Dickerson, F. B. Jan 1 2017 In : Journal of Clinical Psychiatry. 78, 1, p. e18-e27

Research output: Contribution to journalArticle

Herpesviridae
Toxoplasmosis
Toxoplasma
Cognition
Schizophrenia

Emotion discrimination in humans: Its association with HSV-1 infection and its improvement with antiviral treatment

Bhatia, T., Wood, J., Iyengar, S., Narayanan, S. S., Beniwal, R. P., Prasad, K. M., Chen, K., Yolken, R. H., Dickerson, F., Gur, R. C., Gur, R. E., Deshpande, S. N. & Nimgaonkar, V. L. 2017 (Accepted/In press) In : Schizophrenia Research.

Research output: Contribution to journalArticle

Human Herpesvirus 1
Virus Diseases
Antiviral Agents
Emotions
Therapeutics
Toxoplasma
Psychotic Disorders
Schizophrenia
Psychiatry
Case-Control Studies

Infections and exposure to anti-infective agents and the risk of severe mental disorders: a nationwide study

Köhler, O., Petersen, L., Mors, O., Mortensen, P. B., Yolken, R. H., Gasse, C. & Benros, M. E. Feb 1 2017 In : Acta Psychiatrica Scandinavica. 135, 2, p. 97-105 9 p.

Research output: Contribution to journalArticle

Anti-Infective Agents
Mental Disorders
Infection
Mood Disorders
Schizophrenia

Neurodevelopment: The impact of nutrition and inflammation during adolescence in low-resource settings

Galler, J. R., Koethe, J. R. & Yolken, R. H. Apr 1 2017 In : Pediatrics. 139, p. S72-S84

Research output: Contribution to journalReview article

Inflammation
Malnutrition
Brain Diseases
Age Groups
Infection

Pathogen-mediated NMDA receptor autoimmunity and cellular barrier dysfunction in schizophrenia

Kannan, G., Gressitt, K. L., Yang, S., Stallings, C. R., Katsafanas, E., Schweinfurth, L. A., Savage, C. L. G., Adamos, M. B., Sweeney, K. M., Origoni, A. E., Khushalani, S., Bahn, S., Leweke, F. M., Dickerson, F. B., Yolken, R. H., Pletnikov, M. V. & Severance, E. G. Aug 1 2017 In : Translational Psychiatry. 7, 8, e1186

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Autoimmunity
Schizophrenia
Toxoplasma
Autoantibodies

Persistent herpesvirus infections and telomere attrition over 3 years in the whitehall II cohort

Dowd, J. B., Bosch, J. A., Steptoe, A., Jayabalasingham, B., Lin, J., Yolken, R. & Aiello, A. E. Sep 1 2017 In : Journal of Infectious Diseases. 216, 5, p. 565-572 8 p.

Research output: Contribution to journalArticle

Herpesviridae Infections
Telomere
Cytomegalovirus
Leukocytes
Human Herpesvirus 4

Schizophrenia and Infections: The Eyes Have It

Torrey, E. F. & Yolken, R. H. Mar 1 2017 In : Schizophrenia bulletin. 43, 2, p. 247-252 6 p.

Research output: Contribution to journalReview article

Eye Infections
Schizophrenia
Perceptual Distortion
Eye Abnormalities
Human Herpesvirus 3

Stability of Toxoplasma gondii: Antibody levels in schizophrenia

Yuksel, P., Kocazeybek, B., Ozdemir, A., Yolken, R. H. & Torrey, E. F. 2017 (Accepted/In press) In : Schizophrenia Research.

Research output: Contribution to journalArticle

Suicide attempts and markers of immune response in individuals with serious mental illness

Dickerson, F., Wilcox, H. C., Adamos, M., Katsafanas, E., Khushalani, S., Origoni, A., Savage, C., Schweinfurth, L., Stallings, C., Sweeney, K. & Yolken, R. Apr 1 2017 In : Journal of Psychiatric Research. 87, p. 37-43 7 p.

Research output: Contribution to journalArticle

Suicide
Biomarkers
Toxoplasma
Antibodies
Cytomegalovirus

The association between immune markers and recent suicide attempts in patients with serious mental illness: A pilot study

Dickerson, F., Adamos, M., Katsafanas, E., Khushalani, S., Origoni, A., Savage, C., Schweinfurth, L., Stallings, C., Sweeney, K., Alaedini, A., Uhde, M., Severance, E., Wilcox, H. C. & Yolken, R. Sep 1 2017 In : Psychiatry Research. 255, p. 8-12 5 p.

Research output: Contribution to journalArticle

Suicide
Biomarkers
Psychiatry
Inflammation
Schizophrenia

The association between toxoplasma and the psychosis continuum in a general population setting

Lindgren, M., Torniainen-Holm, M., Härkänen, T., Dickerson, F., Yolken, R. H. & Suvisaari, J. 2017 (Accepted/In press) In : Schizophrenia Research.

Research output: Contribution to journalArticle

Toxoplasma
Psychotic Disorders
Population
C-Reactive Protein
Interviews

To the editor: how statistics killed the cat: conclusion

Torrey, E. F. & Yolken, R. H. Jul 18 2017 (Accepted/In press) In : Psychological Medicine. p. 1 1 p.

Research output: Contribution to journalArticle

Cats

To the Editor: How statistics killed the cat

Torrey, E. F. & Yolken, R. H. May 4 2017 (Accepted/In press) In : Psychological Medicine. p. 1 1 p.

Research output: Contribution to journalArticle

Cats

Toxoplasma gondii infection and common mental disorders in the Finnish general population

Suvisaari, J., Torniainen-Holm, M., Lindgren, M., Härkänen, T. & Yolken, R. H. Dec 1 2017 In : Journal of Affective Disorders. 223, p. 20-25 6 p.

Research output: Contribution to journalArticle

Toxoplasmosis
Toxoplasma
Mental Disorders
Anxiety Disorders
Population
2016

Analysis of microbiota in first episode psychosis identifies preliminary associations with symptom severity and treatment response

Schwarz, E., Maukonen, J., Hyytiäinen, T., Kieseppä, T., Orešič, M., Sabunciyan, S., Mantere, O., Saarela, M., Yolken, R. & Suvisaari, J. Dec 19 2016 (Accepted/In press) In : Schizophrenia Research.

Research output: Contribution to journalArticle

Microbiota
Psychotic Disorders
Lactobacillus
Mental Disorders
Therapeutics

Anti-NMDA receptor autoantibodies and associated neurobehavioral pathology in mice are dependent on age of first exposure to Toxoplasma gondii

Kannan, G., Crawford, J. A., Yang, C. X., Gressitt, K. L., Ihenatu, C., Krasnova, I. N., Cadet, J. L., Yolken, R. H., Severance, E. G. & Pletnikov, M. V. Jul 1 2016 In : Neurobiology of Disease. 91, p. 307-314 8 p.

Research output: Contribution to journalArticle

Toxoplasma
N-Methyl-D-Aspartate Receptors
Autoantibodies
Pathology
Dizocilpine Maleate

Association of Depressed Mood With Herpes Simplex Virus-2 Immunoglobulin-G Levels in Pregnancy

Hsu, P. C., Yolken, R. H., Postolache, T. T., Beckie, T. M., Munro, C. L. & Groer, M. W. Aug 3 2016 (Accepted/In press) In : Psychosomatic Medicine.

Research output: Contribution to journalArticle

Human Herpesvirus 2
Immunoglobulin G
Pregnancy
Herpes Genitalis
Marital Status

Association of DNA methylation differences with schizophrenia in an epigenome-wide association study

Montano, C. , Taub, M. A. , Jaffe, A. , Briem, E. , Feinberg, J. I. , Trygvadottir, R. , Idrizi, A. , Runarsson, A. , Berndsen, B. , Gur, R. C. , Moore, T. M. , Perry, R. T. , Fugman, D. , Sabunciyan, S. , Yolken, R. H. , Hyde, T. M. , Kleinman, J. E. , Sobell, J. L. , Pato, C. N. , Pato, M. T. & 7 others Go, R. C., Nimgaonkar, V., Weinberger, D. R., Braff, D., Gur, R. E., Fallin, M. D. & Feinberg, A. P. May 1 2016 In : JAMA Psychiatry. 73, 5, p. 506-514 9 p.

Research output: Contribution to journalArticle

DNA Methylation
Schizophrenia
Genome
Endophenotypes
African Americans

Autism with intellectual disability is associated with increased levels of maternal cytokines and chemokines during gestation

Jones, K. L., Croen, L. A., Yoshida, C. K., Heuer, L., Hansen, R., Zerbo, O., DeLorenze, G. N., Kharrazi, M., Yolken, R., Ashwood, P. & van de Water, J. May 24 2016 (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Autistic Disorder
Chemokines
Intellectual Disability
Mothers
Cytokines
Toxoplasmosis
Cysts
Antibodies
Infection
Toxoplasma

Cerebral complement C1q activation in chronic Toxoplasma infection

Xiao, J., Li, Y., Gressitt, K. L., He, H., Kannan, G., Schultz, T. L., Svezhova, N., Carruthers, V. B., Pletnikov, M. V., Yolken, R. H. & Severance, E. G. Feb 17 2016 (Accepted/In press) In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

Complement C1q
Complement Activation
Toxoplasma
Cysts
Brain

Enol ethers as carbonyl surrogates in a modification of the Povarov synthesis of 3-aryl quinolines and their anti-Toxoplasma activity

Brown, C. E., McNulty, J., Bordón, C., Yolken, R. & Jones-Brando, L. 2016 In : Organic and Biomolecular Chemistry. 14, 25, p. 5951-5955 5 p.

Research output: Contribution to journalArticle

Quinolines
Ethers
quinoline
Toxoplasma
ethers

Hepatitis C virus antibody titers associated with cognitive dysfunction in an asymptomatic community-based sample

Ibrahim, I., Salah, H., El Sayed, H., Mansour, H., Eissa, A., Wood, J., Fathi, W., Tobar, S., Gur, R. C., Gur, R. E., Dickerson, F., Yolken, R. H., El Bahaey, W. & Nimgaonkar, V. Sep 13 2016 In : Journal of Clinical and Experimental Neuropsychology. 38, 8, p. 861-868 8 p.

Research output: Contribution to journalArticle

Hepatitis C Antibodies
Viral Load
Hepacivirus
Substance-Related Disorders
Cognition

Immuno-psychiatry: An agenda for clinical practice and innovative research

Leboyer, M., Berk, M., Yolken, R. H., Tamouza, R., Kupfer, D. & Groc, L. Oct 28 2016 In : BMC Medicine. 14, 1, 173

Research output: Contribution to journalArticle

Psychiatry
Biomarkers
Research
Translational Medical Research
Mood Disorders

Individuals hospitalized with acute mania have increased exposure to antimicrobial medications

Yolken, R., Adamos, M., Katsafanas, E., Khushalani, S., Origoni, A., Savage, C., Schweinfurth, L., Stallings, C., Sweeney, K. & Dickerson, F. Aug 1 2016 In : Bipolar Disorders. 18, 5, p. 404-409 6 p.

Research output: Contribution to journalArticle

Bipolar Disorder
Prescriptions
Bacterial Infections
Psychiatry
Anti-Bacterial Agents

Infection and characterization of Toxoplasma gondii in human induced neurons from patients with brain disorders and healthy controls

Passeri, E., Jones-Brando, L., Bordón, C., Sengupta, S., Wilson, A. M., Primerano, A., Rapoport, J. L., Ishizuka, K., Kano, S. I., Yolken, R. H. & Sawa, A. Feb 1 2016 In : Microbes and Infection. 18, 2, p. 153-158 6 p.

Research output: Contribution to journalArticle

Toxoplasmosis
Toxoplasma
Brain Diseases
Neurons
Childhood Schizophrenia

Infection and inflammation in schizophrenia and bipolar disorder

Tanaka, T., Matsuda, T., Hayes, L. N., Yang, S., Rodriguez, K., Severance, E. G., Yolken, R. H., Sawa, A. & Eaton, W. W. Jul 28 2016 (Accepted/In press) In : Neuroscience Research.

Research output: Contribution to journalArticle

Bipolar Disorder
Schizophrenia
Inflammation
Immunoglobulin Isotypes
Infection

Inflammatory Markers in Recent Onset Psychosis and Chronic Schizophrenia

Dickerson, F., Stallings, C., Origoni, A., Schroeder, J., Katsafanas, E., Schweinfurth, L., Savage, C., Khushalani, S. & Yolken, R. Jan 1 2016 In : Schizophrenia Bulletin. 42, 1, p. 134-141 8 p.

Research output: Contribution to journalArticle

Psychotic Disorders
Schizophrenia
Inflammation
Innate Immunity
Gliadin

IPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections

McNulty, J., D'Aiuto, L., Zhi, Y., McClain, L., Zepeda-Velázquez, C., Ler, S., Jenkins, H. A., Yee, M. B., Piazza, P., Yolken, R. H., Kinchington, P. R. & Nimgaonkar, V. L. Jan 14 2016 In : ACS Medicinal Chemistry Letters. 7, 1, p. 46-50 5 p.

Research output: Contribution to journalArticle

Herpesviridae Infections
Human Herpesvirus 1
Virus Diseases
Viruses
Assays

Maternal mid-pregnancy C-reactive protein and risk of autism spectrum disorders: The early markers for autism study

Zerbo, O., Traglia, M., Yoshida, C., Heuer, L. S., Ashwood, P., Delorenze, G. N., Hansen, R. L., Kharrazi, M., Van De Water, J., Yolken, R. H., Weiss, L. A. & Croen, L. A. Apr 1 2016 In : Translational Psychiatry. 6, 4, e783

Research output: Contribution to journalArticle

Pregnancy Proteins
Autistic Disorder
C-Reactive Protein
Mothers
Pregnancy

Prenatal and newborn immunoglobulin levels from mother-child pairs and risk of autism spectrum disorders

Grether, J. K., Ashwood, P., Van de Water, J., Yolken, R. H., Anderson, M. C., Torres, A. R., Westover, J. B., Sweeten, T., Hansen, R. L., Kharrazi, M. & Croen, L. A. 2016 In : Frontiers in Neuroscience. 10, MAY, 218

Research output: Contribution to journalArticle

Immunoglobulins
Mothers
Newborn Infant
Toxoplasmosis
Immunoglobulin G

Probiotic normalization of Candida albicans in schizophrenia: A randomized, placebo-controlled, longitudinal pilot study

Severance, E. G., Gressitt, K. L., Stallings, C. R., Katsafanas, E., Schweinfurth, L. A., Savage, C. L. G., Adamos, M. B., Sweeney, K. M., Origoni, A. E., Khushalani, S., Dickerson, F. B. & Yolken, R. H. Sep 2 2016 (Accepted/In press) In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

Probiotics
Candida albicans
Longitudinal Studies
Schizophrenia
Placebos

Role of Immune and Autoimmune Dysfunction in Schizophrenia

Severance, E. G. & Yolken, R. H. 2016 Handbook of Behavioral Neuroscience. Elsevier B.V., Vol. 23, p. 501-516 16 p. (Handbook of Behavioral Neuroscience; vol. 23)

Research output: Chapter in Book/Report/Conference proceedingChapter

Schizophrenia
Immune System Phenomena
Humoral Immunity
Autoimmunity
Innate Immunity

Shared immune and repair markers during experimental toxoplasma chronic brain infection and schizophrenia

Tomasik, J., Schultz, T. L., Kluge, W., Yolken, R. H., Bahn, S. & Carruthers, V. B. 2016 In : Schizophrenia Bulletin. 42, 2, p. 386-395 10 p.

Research output: Contribution to journalArticle

Toxoplasma
Schizophrenia
Biomarkers
Brain
Infection

The association among smoking, HSV-1 exposure, and cognitive functioning in schizophrenia, bipolar disorder, and non-psychiatric controls

Dickerson, F., Adamos, M. B., Katsafanas, E., Khushalani, S., Origoni, A., Savage, C. L. G., Schroeder, J., Schweinfurth, L. A. B., Stallings, C., Sweeney, K. & Yolken, R. Feb 18 2016 (Accepted/In press) In : Schizophrenia Research.

Research output: Contribution to journalArticle

Human Herpesvirus 1
Bipolar Disorder
Schizophrenia
Smoking
Linear Models

The gut microbiota and the emergence of autoimmunity: Relevance to major psychiatric disorders

Severance, E. G., Tveiten, D., Lindström, L. H., Yolken, R. H. & Reichelt, K. L. 2016 In : Current Pharmaceutical Design. 22, 40, p. 6076-6086 11 p.

Research output: Contribution to journalReview article

Autoimmunity
Psychiatry
Microbiota
Enteric Nervous System
Digestive System

The microbiome, immunity, and schizophrenia and bipolar disorder

Dickerson, F., Severance, E. & Yolken, R. Jul 25 2016 (Accepted/In press) In : Brain, Behavior, and Immunity.

Research output: Contribution to journalArticle

Microbiota
Bipolar Disorder
Immunity
Schizophrenia
Psychiatry

Total Synthesis of the Natural Product (+)-trans-Dihydronarciclasine via an Asymmetric Organocatalytic [3+3]-Cycloaddition and discovery of its potent anti-Zika Virus (ZIKV) Activity

Revu, O., Zepeda-Velázquez, C., Nielsen, A. J., McNulty, J., Yolken, R. H. & Jones-Brando, L. Jan 1 2016 In : ChemistrySelect. 1, 18, p. 5895-5899 5 p.

Research output: Contribution to journalArticle

Cycloaddition
Biological Products
Viruses
dihydronarciclasine
cinnamic aldehyde

Towards a blood-based diagnostic panel for bipolar disorder

Haenisch, F., Cooper, J. D., Reif, A., Kittel-Schneider, S., Steiner, J., Leweke, F. M., Rothermundt, M., van Beveren, N. J. M., Crespo-Facorro, B., Niebuhr, D. W., Cowan, D. N., Weber, N. S., Yolken, R. H., Penninx, B. W. J. H. & Bahn, S. Feb 1 2016 In : Brain, Behavior, and Immunity. 52, p. 49-57 9 p.

Research output: Contribution to journalArticle

Bipolar Disorder
Biomarkers
Diagnostic Errors
Area Under Curve
Routine Diagnostic Tests

Toxoplasma gondii—A Gastrointestinal Pathogen Associated with Human Brain Diseases

Severance, E. G., Xiao, J., Jones-Brando, L., Sabunciyan, S., Li, Y., Pletnikov, M., Prandovszky, E. & Yolken, R. 2016 International Review of Neurobiology. Academic Press Inc., Vol. 131, p. 143-163 21 p. (International Review of Neurobiology; vol. 131)

Research output: Chapter in Book/Report/Conference proceedingChapter

Toxoplasma
Brain Diseases
Oocysts
Infection
Cognition

Toxoplasmosis Titers and past Suicide Attempts Among Older Adolescents Initiating SSRI Treatment

Coryell, W., Yolken, R., Butcher, B., Burns, T., Dindo, L., Schlechte, J. & Calarge, C. Oct 1 2016 In : Archives of Suicide Research. 20, 4, p. 605-613 9 p.

Research output: Contribution to journalArticle

Toxoplasmosis
Suicide
History
Therapeutics
Risk-Taking

Widespread splicing of repetitive element loci into coding regions of gene transcripts

Darby, M. M., Leek, J. T., Langmead, B., Yolken, R. H. & Sabunciyan, S. Nov 15 2016 In : Human Molecular Genetics. 25, 22, p. 4962-4982 21 p.

Research output: Contribution to journalArticle

Prefrontal Cortex
Genes
Short Interspersed Nucleotide Elements
Untranslated Regions
RNA Sequence Analysis
2015

Association of DNA methylation with acute mania and inflammatory markers

Sabunciyan, S., Maher, B., Bahn, S., Dickerson, F. & Yolken, R. H. Jul 6 2015 In : PLoS One. 10, 7, e0132001

Research output: Contribution to journalArticle

DNA methylation
DNA Methylation
Bipolar Disorder
epigenetics
methylation

Beyond the association. Toxoplasma gondii in schizophrenia, bipolar disorder, and addiction: Systematic review and meta-analysis

Sutterland, A. L., Fond, G., Kuin, A., Koeter, M. W. J., Lutter, R., van Gool, T., Yolken, R., Szoke, A., Leboyer, M. & de Haan, L. Sep 1 2015 In : Acta Psychiatrica Scandinavica. 132, 3, p. 161-179 19 p.

Research output: Contribution to journalArticle

Toxoplasma
Bipolar Disorder
Meta-Analysis
Schizophrenia
Odds Ratio

Broad-spectrum non-nucleoside inhibitors of human herpesviruses

McClain, L., Zhi, Y., Cheng, H., Ghosh, A., Piazza, P., Yee, M. B., Kumar, S., Milosevic, J., Bloom, D. C., Arav-Boger, R., Kinchington, P. R., Yolken, R., Nimgaonkar, V. & D'Aiuto, L. Jun 29 2015 In : Antiviral Research. 121, p. 16-23 8 p.

Research output: Contribution to journalArticle

Acyclovir
Herpesviridae
Virus Diseases
Antiviral Agents
Human Herpesvirus 1