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2017
Glioblastoma
Cytomegalovirus
Glioma
In Situ Hybridization
Real-Time Polymerase Chain Reaction
Image-Guided Biopsy
Amides
Glioma
Protons
Magnetic Resonance Spectroscopy

A mouse model of MYCN-driven retinoblastoma reveals MYCN-independent tumor reemergence

Wu, N., Jia, D., Bates, B., Basom, R., Eberhart, C. G. & MacPherson, D. Mar 1 2017 In : Journal of Clinical Investigation. 127, 3, p. 888-898 11 p.

Research output: Research - peer-reviewArticle

Retinoblastoma
Neoplasms
Genes
Anaplasia
Gene Amplification

An immunocompetent mouse model of human glioblastoma

Semenkow, S., Li, S., Kahlert, U. D., Raabe, E. H., Xu, J., Arnold, A., Janowski, M., Oh, B. C., Brandacher, G., Bulte, J. W. M., Eberhart, C. G. & Walczak, P. Sep 1 2017 In : Oncotarget. 8, 37, p. 61072-61082 11 p.

Research output: Research - peer-reviewArticle

Glioblastoma
Neoplasms
Precision Medicine
Heterologous Transplantation
Adaptive Immunity

Delayed Superficial Migration of Retained Hyaluronic Acid Years Following Periocular Injection

Chang, J. R., Baharestani, S., Salek, S. S., Piluek, W. J., Eberhart, C. G. & McCulley, T. J. May 1 2017 In : Ophthalmic Plastic and Reconstructive Surgery. 33, 3S, p. S116-S118

Research output: Research - peer-reviewArticle

Intraocular Injections
Hyaluronic Acid
Injections
Hyaluronoglucosaminidase
Cosmetics

HIF-1α- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy

Mangraviti, A. , Raghavan, T. , Volpin, F. , Skuli, N. , Gullotti, D. , Zhou, J. , Asnaghi, L. , Sankey, E. , Liu, A. , Wang, Y. , Lee, D. H. , Gorelick, N. , Serra, R. , Peters, M. , Schriefer, D. , Delaspre, F. , Rodriguez, F. J. , Eberhart, C. G. , Brem, H. , Olivi, A. & 1 others Tyler, B. Dec 1 2017 In : Scientific Reports. 7, 1, 14978

Research output: Research - peer-reviewArticle

Acriflavine
Brain Neoplasms
Survival
Neoplasms
Therapeutics

Hypoxia inhibits growth, proliferation, and increases response to chemotherapy in retinoblastoma cells

Yang, Q., Tripathy, A., Yu, W., Eberhart, C. G. & Asnaghi, L. Sep 1 2017 In : Experimental Eye Research. 162, p. 48-61 14 p.

Research output: Research - peer-reviewArticle

Retinoblastoma
Drug Therapy
Growth
Hypoxia
Glycolysis

Intertumoral Heterogeneity within Medulloblastoma Subgroups

Cavalli, F. M. G. , Remke, M. , Rampasek, L. , Peacock, J. , Shih, D. J. H. , Luu, B. , Garzia, L. , Torchia, J. , Nor, C. , Morrissy, A. S. , Agnihotri, S. , Thompson, Y. Y. , Kuzan-Fischer, C. M. , Farooq, H. , Isaev, K. , Daniels, C. , Cho, B. K. , Kim, S. K. , Wang, K. C. , Lee, J. Y. & 75 others Grajkowska, W. A., Perek-Polnik, M., Vasiljevic, A., Faure-Conter, C., Jouvet, A., Giannini, C., Nageswara Rao, A. A., Li, K. K. W., Ng, H. K., Eberhart, C. G., Pollack, I. F., Hamilton, R. L., Gillespie, G. Y., Olson, J. M., Leary, S., Weiss, W. A., Lach, B., Chambless, L. B., Thompson, R. C., Cooper, M. K., Vibhakar, R., Hauser, P., van Veelen, M. L. C., Kros, J. M., French, P. J., Ra, Y. S., Kumabe, T., López-Aguilar, E., Zitterbart, K., Sterba, J., Finocchiaro, G., Massimino, M., Van Meir, E. G., Osuka, S., Shofuda, T., Klekner, A., Zollo, M., Leonard, J. R., Rubin, J. B., Jabado, N., Albrecht, S., Mora, J., Van Meter, T. E., Jung, S., Moore, A. S., Hallahan, A. R., Chan, J. A., Tirapelli, D. P. C., Carlotti, C. G., Fouladi, M., Pimentel, J., Faria, C. C., Saad, A. G., Massimi, L., Liau, L. M., Wheeler, H., Nakamura, H., Elbabaa, S. K., Perezpeña-Diazconti, M., Chico Ponce de León, F., Robinson, S., Zapotocky, M., Lassaletta, A., Huang, A., Hawkins, C. E., Tabori, U., Bouffet, E., Bartels, U., Dirks, P. B., Rutka, J. T., Bader, G. D., Reimand, J., Goldenberg, A., Ramaswamy, V. & Taylor, M. D. Jun 12 2017 In : Cancer Cell. 31, 6, p. 737-754.e6

Research output: Research - peer-reviewArticle

Medulloblastoma
DNA Methylation
Cluster Analysis
Clinical Trials
Genome

Melanoma subtypes demonstrate distinct PD-L1 expression profiles

Kaunitz, G. J., Cottrell, T. R., Lilo, M., Muthappan, V., Esandrio, J., Berry, S., Xu, H., Ogurtsova, A., Anders, R. A., Fischer, A. H., Kraft, S., Gerstenblith, M. R., Thompson, C. L., Honda, K., Cuda, J. D., Eberhart, C. G., Handa, J. T., Lipson, E. J. & Taube, J. M. Sep 1 2017 In : Laboratory Investigation. 97, 9, p. 1063-1071 9 p.

Research output: Research - peer-reviewArticle

Melanoma
Solar System
Extremities
Skin
Tumor-Infiltrating Lymphocytes

Predicting IDH mutation status in grade II gliomas using amide proton transfer-weighted (APTw) MRI

Jiang, S., Zou, T., Eberhart, C. G., Villalobos, M. A. V., Heo, H. Y., Zhang, Y., Wang, Y., Wang, X., Yu, H., Du, Y., van Zijl, P. C. M., Wen, Z. & Zhou, J. Sep 1 2017 In : Magnetic Resonance in Medicine. 78, 3, p. 1100-1109 10 p.

Research output: Research - peer-reviewArticle

Isocitrate Dehydrogenase
Amides
Glioma
Protons
Mutation

Rabbit model of human gliomas: Implications for intra-arterial drug delivery

Qin, H., Janowski, M., Pearl, M. S., Malysz-Cymborska, I., Li, S., Eberhart, C. G. & Walczak, P. Jan 1 2017 In : PLoS ONE. 12, 1, e0169656

Research output: Research - peer-reviewArticle

Glioma
Rabbits
Pharmaceutical Preparations
rabbits
drugs

Strategies to enhance the distribution of nanotherapeutics in the brain

Zhang, C., Mastorakos, P., Sobral, M., Berry, S., Song, E., Nance, E., Eberhart, C. G., Hanes, J. & Suk, J. S. 2017 (Accepted/In press) In : Journal of Controlled Release.

Research output: Research - peer-reviewArticle

Nanoparticles
Brain
Convection
Therapeutics
Blood-Brain Barrier

The dual mTOR kinase inhibitor TAK228 inhibits tumorigenicity and enhances radiosensitization in diffuse intrinsic pontine glioma

Miyahara, H., Yadavilli, S., Natsumeda, M., Rubens, J. A., Rodgers, L., Kambhampati, M., Taylor, I. C., Kaur, H., Asnaghi, L., Eberhart, C. G., Warren, K. E., Nazarian, J. & Raabe, E. H. Aug 1 2017 In : Cancer Letters. 400, p. 110-116 7 p.

Research output: Research - peer-reviewArticle

Glioma
Phosphotransferases
mechanistic target of rapamycin complex 1
TOR complex 2
Apoptosis

The TORC1/2 inhibitor TAK228 sensitizes atypical teratoid rhabdoid tumors to cisplatin-induced cytotoxicity

Rubens, J. A., Wang, S. Z., Price, A., Weingart, M. F., Allen, S. J., Orr, B. A., Eberhart, C. G. & Raabe, E. H. Oct 1 2017 In : Neuro-Oncology. 19, 10, p. 1361-1371 11 p.

Research output: Research - peer-reviewArticle

Cisplatin
Typical Teratoid Rhabdoid Tumor
mechanistic target of rapamycin complex 1
Atypical Teratoid Tumor
Sirolimus
2016

Alterations in cellular metabolome after pharmacological inhibition of Notch in glioblastoma cells

Kahlert, U. D., Cheng, M., Koch, K., Marchionni, L., Fan, X., Raabe, E. H., Maciaczyk, J., Glunde, K. & Eberhart, C. G. Mar 1 2016 In : International Journal of Cancer. 138, 5, p. 1246-1255 10 p.

Research output: Research - peer-reviewArticle

Metabolome
Glioblastoma
Glutamic Acid
Pharmacology
Glutaminase

Altered gene expression in conjunctival squamous cell carcinoma

Mahale, A., Alkatan, H., Alwadani, S., Othman, M., Suarez, M. J., Price, A., Al-Hussain, H., Jastaneiah, S., Yu, W., Maktabi, A., Deepak, E. P., Eberhart, C. G. & Asnaghi, L. Feb 26 2016 (Accepted/In press) In : Modern Pathology.

Research output: Research - peer-reviewArticle

Matrix Metalloproteinases
Squamous Cell Carcinoma
Gene Expression
Clusterin
Carcinoma in Situ

Convection enhanced delivery of cisplatin-loaded brain penetrating nanoparticles cures malignant glioma in rats

Zhang, C., Nance, E. A., Mastorakos, P., Chisholm, J., Berry, S., Eberhart, C., Tyler, B., Brem, H., Suk, J. S. & Hanes, J. Dec 5 2016 (Accepted/In press) In : Journal of Controlled Release.

Research output: Research - peer-reviewArticle

Convection
Glioma
Nanoparticles
Cisplatin
Brain

Divergent clonal selection dominates medulloblastoma at recurrence

Morrissy, A. S. , Garzia, L. , Shih, D. J. H. , Zuyderduyn, S. , Huang, X. , Skowron, P. , Remke, M. , Cavalli, F. M. G. , Ramaswamy, V. , Lindsay, P. E. , Jelveh, S. , Donovan, L. K. , Wang, X. , Luu, B. , Zayne, K. , Li, Y. , Mayoh, C. , Thiessen, N. , Mercier, E. , Mungall, K. L. & 118 others Ma, Y., Tse, K., Zeng, T., Shumansky, K., Roth, A. J. L., Shah, S., Farooq, H., Kijima, N., Holgado, B. L., Lee, J. J. Y., Matan-Lithwick, S., Liu, J., Mack, S. C., Manno, A., Michealraj, K. A., Nor, C., Peacock, J., Qin, L., Reimand, J., Rolider, A., Thompson, Y. Y., Wu, X., Pugh, T., Ally, A., Bilenky, M., Butterfield, Y. S. N., Carlsen, R., Cheng, Y., Chuah, E., Corbett, R. D., Dhalla, N., He, A., Lee, D., Li, H. I., Long, W., Mayo, M., Plettner, P., Qian, J. Q., Schein, J. E., Tam, A., Wong, T., Birol, I., Zhao, Y., Faria, C. C., Pimentel, J., Nunes, S., Shalaby, T., Grotzer, M., Pollack, I. F., Hamilton, R. L., Li, X. N., Bendel, A. E., Fults, D. W., Walter, A. W., Kumabe, T., Tominaga, T., Collins, V. P., Cho, Y. J., Hoffman, C., Lyden, D., Wisoff, J. H., Garvin, J. H., Stearns, D. S., Massimi, L., Schüller, U., Sterba, J., Zitterbart, K., Puget, S., Ayrault, O., Dunn, S. E., Tirapelli, D. P. C., Carlotti, C. G., Wheeler, H., Hallahan, A. R., Ingram, W., MacDonald, T. J., Olson, J. J., Van Meir, E. G., Lee, J. Y., Wang, K. C., Kim, S. K., Cho, B. K., Pietsch, T., Fleischhack, G., Tippelt, S., Ra, Y. S., Bailey, S., Lindsey, J. C., Clifford, S. C., Eberhart, C. G., Cooper, M. K., Packer, R. J., Massimino, M., Garre, M. L., Bartels, U., Tabori, U., Hawkins, C. E., Dirks, P., Bouffet, E., Rutka, J. T., Wechsler-Reya, R. J., Weiss, W. A., Collier, L. S., Dupuy, A. J., Korshunov, A., Jones, D. T. W., Kool, M., Northcott, P. A., Pfister, S. M., Largaespada, D. A., Mungall, A. J., Moore, R. A., Jabado, N., Bader, G. D., Jones, S. J. M., Malkin, D., Marra, M. A. & Taylor, M. D. Jan 21 2016 In : Nature. 529, 7586, p. 351-357 7 p.

Research output: Research - peer-reviewArticle

Medulloblastoma
Recurrence
Neoplasms
Therapeutics
Image-Guided Radiotherapy

Establishment and biological characterization of a panel of glioblastoma multiforme (GBM) and GBM variant oncosphere cell lines

Binder, Z. A., Wilson, K. M., Salmasi, V., Orr, B. A., Eberhart, C. G., Siu, I. M., Lim, M., Weingart, J. D., Quinones-Hinojosa, A., Bettegowda, C., Kassam, A. B., Olivi, A., Brem, H., Riggins, G. J. & Gallia, G. L. Mar 1 2016 In : PLoS One. 11, 3, e0150271

Research output: Research - peer-reviewArticle

oncospheres
cell lines
neoplasms
Glioblastoma
Cell Line

Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma

Hu, K., Babapoor-Farrokhran, S., Rodrigues, M., Deshpande, M., Puchner, B., Kashiwabuchi, F., Hassan, S. J., Asnaghi, L., Handa, J. T., Merbs, S., Eberhart, C. G., Semenza, G. L., Montaner, S. & Sodhi, A. 2016 In : Oncotarget. 7, 7, p. 7816-7828 13 p.

Research output: Research - peer-reviewArticle

Hypoxia-Inducible Factor 1
Vascular Endothelial Growth Factor A
Up-Regulation
Phenotype
Uveal melanoma

Multiple cilia suppress tumour formation

Eberhart, C. Mar 30 2016 In : Nature Cell Biology. 18, 4, p. 368-369 2 p.

Research output: Research - peer-reviewShort survey

MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism

Bandopadhayay, P. , Ramkissoon, L. A. , Jain, P. , Bergthold, G. , Wala, J. , Zeid, R. , Schumacher, S. E. , Urbanski, L. , O'Rourke, R. , Gibson, W. J. , Pelton, K. , Ramkissoon, S. H. , Han, H. J. , Zhu, Y. , Choudhari, N. , Silva, A. , Boucher, K. , Henn, R. E. , Kang, Y. J. , Knoff, D. & 42 others Paolella, B. R., Gladden-Young, A., Varlet, P., Pages, M., Horowitz, P. M., Federation, A., Malkin, H., Tracy, A. A., Seepo, S., Ducar, M., Van Hummelen, P., Santi, M., Buccoliero, A. M., Scagnet, M., Bowers, D. C., Giannini, C., Puget, S., Hawkins, C., Tabori, U., Klekner, A., Bognar, L., Burger, P. C., Eberhart, C., Rodriguez, F. J., Hill, D. A., Mueller, S., Haas-Kogan, D. A., Phillips, J. J., Santagata, S., Stiles, C. D., Bradner, J. E., Jabado, N., Goren, A., Grill, J., Ligon, A. H., Goumnerova, L., Waanders, A. J., Storm, P. B., Kieran, M. W., Ligon, K. L., Beroukhim, R. & Resnick, A. C. Mar 1 2016 In : Nature Genetics. 48, 3, p. 273-282 10 p.

Research output: Research - peer-reviewArticle

Glioma
Pediatrics
Neoplasms
Epigenomics
Carcinogenesis

Somatic cell transfer of c-Myc and Bcl-2 induces large-cell anaplastic medulloblastomas in mice

Jenkins, N. C., Rao, G., Eberhart, C. G., Pedone, C. A., Dubuc, A. M. & Fults, D. W. Feb 1 2016 In : Journal of Neuro-Oncology. 126, 3, p. 415-424 10 p.

Research output: Research - peer-reviewArticle

Medulloblastoma
Neoplasms
Brain Neoplasms
Stem Cells
Therapeutics

Somatic mutations of DICER1 and KMT2D are frequent in intraocular medulloepitheliomas

Sahm, F., Jakobiec, F. A., Meyer, J., Schrimpf, D., Eberhart, C. G., Hovestadt, V., Capper, D., Lambo, S., Ryzhova, M., Schüller, U., Zheludkova, O., Kumirova, E., Lichter, P., von Deimling, A., Jones, D. T. W., Pfister, S. M., Kool, M. & Korshunov, A. 2016 (Accepted/In press) In : Genes Chromosomes and Cancer.

Research output: Research - peer-reviewArticle

Primitive Neuroectodermal Tumors
Mutation
Neoplasms
Genome
Genes

Subepidermal Calcified Nodules of the Eyelid Differ in Children and Adults

AlWadani, S., Suarez, M. J., Kass, J. J., MacQuaid, E., Edward, D. P., Alkatan, H. & Eberhart, C. Jul 29 2016 (Accepted/In press) In : Ophthalmic Plastic and Reconstructive Surgery.

Research output: Research - peer-reviewArticle

Eyelids
Foreign-Body Reaction
Inflammation
Calcinosis
Gout

Targeting Notch Signaling and Autophagy Increases Cytotoxicity in Glioblastoma Neurospheres

Natsumeda, M., Maitani, K., Liu, Y., Miyahara, H., Kaur, H., Chu, Q., Zhang, H., D. Kahlert, U. & Eberhart, C. G. Nov 1 2016 In : Brain Pathology. 26, 6, p. 713-723 11 p.

Research output: Research - peer-reviewArticle

Autophagy
Glioblastoma
Glioma
Stem Cells
MRK 003

Targeting Notch signaling as a novel therapy for retinoblastoma

Asnaghi, L., Tripathy, A., Yang, Q., Kaur, H., Hanaford, A., Yu, W. & Eberhart, C. G. 2016 In : Oncotarget. 7, 43, p. 70028-70044 17 p.

Research output: Research - peer-reviewArticle

Retinoblastoma
Therapeutics
Small Interfering RNA
Down-Regulation
Growth

Therapeutic impact of cytoreductive surgery and irradiation of posterior fossa ependymoma in the molecular era: A retrospective multicohort analysis

Ramaswamy, V. , Hielscher, T. , Mack, S. C. , Lassaletta, A. , Lin, T. , Pajtler, K. W. , Jones, D. T. W. , Luu, B. , Cavalli, F. M. G. , Aldape, K. , Remke, M. , Mynarek, M. , Rutkowski, S. , Gururangan, S. , McLendon, R. E. , Lipp, E. S. , Dunham, C. , Hukin, J. , Eisenstat, D. D. , Fulton, D. & 95 others Van Landeghem, F. K. H., Santi, M., Van Veelen, M. L. C., Van Meir, E. G., Osuka, S., Fan, X., Muraszko, K. M., Tirapelli, D. P. C., Oba-Shinjo, S. M., Marie, S. K. N., Carlotti, C. G., Lee, J. Y., Rao, A. A. N., Giannini, C., Faria, C. C., Nunes, S., Mora, J., Hamilton, R. L., Hauser, P., Jabado, N., Petrecca, K., Jung, S., Massimi, L., Zollo, M., Cinalli, G., Bognár, L., Klekner, A., Hortobágyi, T., Leary, S., Ermoian, R. P., Olson, J. M., Leonard, J. R., Gardner, C., Grajkowska, W. A., Chambless, L. B., Cain, J., Eberhart, C. G., Ahsan, S., Massimino, M., Giangaspero, F., Buttarelli, F. R., Packer, R. J., Emery, L., Yong, W. H., Soto, H., Liau, L. M., Everson, R., Grossbach, A., Shalaby, T., Grotzer, M., Karajannis, M. A., Zagzag, D., Wheeler, H., Von Hoff, K., Alonso, M. M., Tuñon, T., Schüller, U., Zitterbart, K., Sterba, J., Chan, J. A., Guzman, M., Elbabaa, S. K., Colman, H., Dhall, G., Fisher, P. G., Fouladi, M., Gajjar, A., Goldman, S., Hwang, E., Kool, M., Ladha, H., Vera-Bolanos, E., Wani, K., Lieberman, F., Mikkelsen, T., Omuro, A. M., Pollack, I. F., Prados, M., Robins, H. I., Soffietti, R., Wu, J., Metellus, P., Tabori, U., Bartels, U., Bouffet, E., Hawkins, C. E., Rutka, J. T., Dirks, P., Pfister, S. M., Merchant, T. E., Gilbert, M. R., Armstrong, T. S., Korshunov, A., Ellison, D. W. & Taylor, M. D. Jul 20 2016 In : Journal of Clinical Oncology. 34, 21, p. 2468-2477 10 p.

Research output: Research - peer-reviewArticle

Ependymoma
Therapeutics
Radiotherapy
Biomarkers
Radiation

The transcriptional modulator HMGA2 promotes stemness and tumorigenicity in glioblastoma

Kaur, H., Ali, S. Z., Huey, L., Hütt-Cabezas, M., Taylor, I., Mao, X. G., Weingart, M., Chu, Q., Rodriguez, F. J., Eberhart, C. G. & Raabe, E. H. Jul 10 2016 In : Cancer Letters. 377, 1, p. 55-64 10 p.

Research output: Research - peer-reviewArticle

AT-Hook Motifs
Glioblastoma
Therapeutics
Stem Cell Factor
Neoplastic Stem Cells
2015

Analysis of varicella-zoster virus in temporal arteries biopsy positive and negative for giant cell arteritis

Nagel, M. A. , White, T. , Khmeleva, N. , Rempel, A. , Boyer, P. J. , Bennett, J. L. , Haller, A. , Lear-Kaul, K. , Kandasmy, B. , Amato, M. , Wood, E. , Durairaj, V. , Fogt, F. , Tamhankar, M. A. , Grossniklaus, H. E. , Poppiti, R. J. , Bockelman, B. , Keyvani, K. , Pollak, L. , Mendlovic, S. & 7 others Fowkes, M., Eberhart, C. G., Buttmann, M., Toyka, K. V., Meyer-Ter-Vehn, T., Petursdottir, V. & Gilden, D. Nov 1 2015 In : JAMA Neurology. 72, 11, p. 1281-1287 7 p.

Research output: Research - peer-reviewArticle

Temporal Arteries
Giant Cell Arteritis
Human Herpesvirus 3
Biopsy
Antigens

Clinicopathologic implications of NF1 gene alterations in diffuse gliomas

Vizcaíno, M. A., Shah, S., Eberhart, C. G. & Rodriguez, F. J. Sep 1 2015 In : Human Pathology. 46, 9, p. 1323-1330 8 p.

Research output: Research - peer-reviewArticle

Glioblastoma
Glioma
Genes
Neoplasms
Atlases

Comparative integrated molecular analysis of intraocular medulloepitheliomas and central nervous system embryonal tumors with multilayered rosettes confirms that they are distinct nosologic entities

Korshunov, A., Jakobiec, F. A., Eberhart, C. G., Hovestadt, V., Capper, D., Jones, D. T. W., Sturm, D., Stagner, A. M., Edward, D. P., Eagle, R. C., Proia, A. D., Koch, A., Ryzhova, M., Ektova, A., Schüller, U., Zheludkova, O., Lichter, P., von Deimling, A., Pfister, S. M. & Kool, M. Dec 1 2015 In : Neuropathology. 35, 6, p. 538-544 7 p.

Research output: Research - peer-reviewArticle

Primitive Neuroectodermal Tumors
Central Nervous System Neoplasms
Neoplasms
Eye Neoplasms
Epigenomics

Corticosteroid-loaded biodegradable nanoparticles for prevention of corneal allograft rejection in rats

Pan, Q., Xu, Q., Boylan, N. J., Lamb, N. W., Emmert, D. G., Yang, J. C., Tang, L., Heflin, T., Alwadani, S., Eberhart, C. G., Stark, W. J. & Hanes, J. Mar 10 2015 In : Journal of Controlled Release. 201, p. 32-40 9 p.

Research output: Research - peer-reviewArticle

Graft Rejection
Nanoparticles
Allografts
Adrenal Cortex Hormones
Rejection (Psychology)

Differential DNA methylation identified in the blood and retina of AMD patients

Oliver, V. F., Jaffe, A. E., Song, J., Wang, G., Zhang, P., Branham, K. E., Swaroop, A., Eberhart, C. G., Zack, D. J., Qian, J. & Merbs, S. L. Jan 1 2015 In : Epigenetics. 10, 8, p. 698-707 10 p.

Research output: Research - peer-reviewArticle

Macular Degeneration
DNA Methylation
Retina
Epigenomics
Methylation

Disrupting LIN28 in atypical teratoid rhabdoid tumors reveals the importance of the mitogen activated protein kinase pathway as a therapeutic target

Weingart, M. F., Roth, J. J., Hutt-Cabezas, M., Busse, T. M., Kaur, H., Price, A., Maynard, R., Rubens, J., Taylor, I., Mao, X. G., Xu, J., Kuwahara, Y., Allen, S. J., Erdreich-Epstein, A., Weissman, B. E., Orr, B. A., Eberhart, C. G., Biegel, J. A. & Raabe, E. H. 2015 In : Oncotarget. 6, 5, p. 3165-3177 13 p.

Research output: Research - peer-reviewArticle

Mitogen-Activated Protein Kinases
Therapeutics
Typical Teratoid Rhabdoid Tumor
Atypical Teratoid Tumor
Neoplasms

Disrupting NOTCH Slows Diffuse Intrinsic Pontine Glioma Growth, Enhances Radiation Sensitivity, and Shows Combinatorial Efficacy With Bromodomain Inhibition

Taylor, I. C., Hütt-Cabezas, M., Brandt, W. D., Kambhampati, M., Nazarian, J., Chang, H. T., Warren, K. E., Eberhart, C. G. & Raabe, E. H. Aug 31 2015 In : Journal of Neuropathology and Experimental Neurology. 74, 8, p. 778-790 13 p.

Research output: Research - peer-reviewArticle

Radiation Tolerance
Glioma
Growth
MRK 003
Therapeutics

DNMT-dependent suppression of microRNA regulates the induction of GBM tumor-propagating phenotype by Oct4 and Sox2

Lopez-Bertoni, H., Lal, B., Li, A., Caplan, M., Guerrero-Cázares, H., Eberhart, C. G., Quiñones-Hinojosa, A., Glas, M., Scheffler, B., Laterra, J. & Li, Y. Jul 23 2015 In : Oncogene. 34, 30, p. 3994-4004 11 p.

Research output: Research - peer-reviewArticle

Transferases
MicroRNAs
Phenotype
DNA
Neoplasms

EMT-associated factors promote invasive properties of uveal melanoma cells

Asnaghi, L., Gezgin, G., Tripathy, A., Handa, J. T., Merbs, S. L., van der Velden, P. A., Jager, M. J., Harbour, J. W. & Eberhart, C. G. Aug 25 2015 In : Molecular Vision. 21, p. 919-929 11 p.

Research output: Research - peer-reviewArticle

Epithelial-Mesenchymal Transition
Uveal melanoma
Neoplasms
Down-Regulation
Growth

EphrinB2 controls vessel pruning through STAT1-JNK3 signalling

Salvucci, O., Ohnuki, H., Maric, D., Hou, X., Li, X., Yoon, S. O., Segarra, M., Eberhart, C. G., Acker-Palmer, A. & Tosato, G. 2015 In : Nature Communications. 6, 6576

Research output: Research - peer-reviewArticle

Cell Death
Endothelial Cells
Endothelial cells
Cell death
vessels

First human case of fungal keratitis caused by a putatively novel species of lophotrichus

Eghrari, A. O., Gibas, C., Watkins, T., Vahedi, S., Lee, R., Houle, E., Suarez, M. J., Eberhart, C., Sutton, D. A., Wiederhold, N. P., Sikder, S. & Zhang, S. X. Sep 1 2015 In : Journal of Clinical Microbiology. 53, 9, p. 3063-3067 5 p.

Research output: Research - peer-reviewArticle

Keratitis
Cornea
Dogs
Anti-Bacterial Agents
Infection

Genetic profiling by single-nucleotide polymorphism-based array analysis defines three distinct subtypes of orbital meningioma

Ho, C. Y., Mosier, S., Safneck, J., Salomao, D. R., Miller, N. R., Eberhart, C. G., Gocke, C. D., Batista, D. A. S. & Rodriguez, F. J. Mar 1 2015 In : Brain Pathology. 25, 2, p. 193-201 9 p.

Research output: Research - peer-reviewArticle

Meningioma
Single Nucleotide Polymorphism
Optic Nerve
Neoplasms
Chromosomes

Highly PEGylated DNA Nanoparticles Provide Uniform and Widespread Gene Transfer in the Brain

Mastorakos, P., Zhang, C., Berry, S., Oh, Y., Lee, S., Eberhart, C. G., Woodworth, G. F., Suk, J. S. & Hanes, J. May 1 2015 In : Advanced healthcare materials. 4, 7, p. 1023-1033 11 p.

Research output: Research - peer-reviewArticle

Gene transfer
Brain
Genes
Nanoparticles
DNA

Intraocular tuberculosis presenting as a large anterior chamber mass

Ostheimer, T. A., Dunn, J. P., Eberhart, C. G. & Burkholder, B. M. Feb 1 2015 In : Ocular Immunology and Inflammation. 23, 1, p. 100-101 2 p.

Research output: Research - peer-reviewArticle

Lateral inhibition of Notch signaling in neoplastic cells

Lim, K. J., Brandt, W. D., Heth, J. A., Muraszko, K. M., Fan, X., Bar, E. E. & Eberhart, C. G. 2015 In : Oncotarget. 6, 3, p. 1666-1677 12 p.

Research output: Research - peer-reviewArticle

Ligands
Neoplasms
Glioblastoma
Pancreatic Carcinoma
Cultured Cells

Medulloblastoma subgroups remain stable across primary and metastatic compartments

Wang, X. , Dubuc, A. M. , Ramaswamy, V. , Mack, S. , Gendoo, D. M. A. , Remke, M. , Wu, X. , Garzia, L. , Luu, B. , Cavalli, F. , Peacock, J. , López, B. , Skowron, P. , Zagzag, D. , Lyden, D. , Hoffman, C. , Cho, Y. J. , Eberhart, C. , MacDonald, T. , Li, X. N. & 9 others Van Meter, T., Northcott, P. A., Haibe-Kains, B., Hawkins, C., Rutka, J. T., Bouffet, E., Pfister, S. M., Korshunov, A. & Taylor, M. D. 2015 In : Acta Neuropathologica. 129, 3, p. 449-457 9 p.

Research output: Research - peer-reviewArticle

Medulloblastoma
Gene Expression
Neoplasms
DNA Methylation
Transcriptome

MicroRNA profiling in intraocular medulloepitheliomas

Edward, D. P., Alkatan, H., Rafiq, Q., Eberhart, C., Al Mesfer, S., Ghazi, N., Al Safieh, L., Kondkar, A. A. & Abu Amero, K. K. Mar 25 2015 In : PLoS One. 10, 3, e0121706

Research output: Research - peer-reviewArticle

Primitive Neuroectodermal Tumors
MicroRNAs
microRNA
genes
Genes

Molecular pathways: Not a simple tube-the many functions of blood vessels

Orr, B. A. & Eberhart, C. G. Jan 1 2015 In : Clinical Cancer Research. 21, 1, p. 18-23 6 p.

Research output: Research - peer-reviewArticle

Blood Vessels
Neoplasms
Tumor Microenvironment
Neoplastic Stem Cells
Phenotype

Notch signaling activation in pediatric low-grade astrocytoma

Brandt, W. D., Schreck, K. C., Bar, E. E., Taylor, I., Marchionni, L., Raabe, E., Eberhart, C. G. & Rodriguez, F. J. Feb 2 2015 In : Journal of Neuropathology and Experimental Neurology. 74, 2, p. 121-131 11 p.

Research output: Research - peer-reviewArticle

Astrocytoma
Pediatrics
Neoplasms
Therapeutics
Amyloid Precursor Protein Secretases

Pharmacologic Wnt Inhibition Reduces Proliferation, Survival, and Clonogenicity of Glioblastoma Cells

Kahlert, U. D., Suwala, A. K., Koch, K., Natsumeda, M., Orr, B. A., Hayashi, M., Maciaczyk, J. & Eberhart, C. G. Sep 29 2015 In : Journal of Neuropathology and Experimental Neurology. 74, 9, p. 889-900 12 p.

Research output: Research - peer-reviewArticle

Glioblastoma
Survival
Wnt Signaling Pathway
Growth
LGK974

Prevalence and distribution of VZV in temporal arteries of patients with giant cell arteritis

Gilden, D. , White, T. , Khmeleva, N. , Heintzman, A. , Choe, A. , Boyer, P. J. , Grose, C. , Carpenter, J. E. , Rempel, A. , Bos, N. , Kandasamy, B. , Lear-Kaul, K. , Holmes, D. B. , Bennett, J. L. , Cohrs, R. J. , Mahalingam, R. , Mandava, N. , Eberhart, C. G. , Bockelman, B. , Poppiti, R. J. & 13 others Tamhankar, M. A., Fogt, F., Amato, M., Wood, E., Durairaj, V., Rasmussen, S., Petursdottir, V., Pollak, L., Mendlovic, S., Chatelain, D., Keyvani, K., Brueck, W. & Nagel, M. A. May 12 2015 In : Neurology. 84, 19, p. 1948-1955 8 p.

Research output: Research - peer-reviewArticle

Temporal Arteries
Giant Cell Arteritis
Human Herpesvirus 3
Antigens
Skeletal Muscle