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2017
Glioblastoma
Cytomegalovirus
Glioma
In Situ Hybridization
Real-Time Polymerase Chain Reaction
Image-Guided Biopsy
Amides
Glioma
Protons
Magnetic Resonance Spectroscopy

A mouse model of MYCN-driven retinoblastoma reveals MYCN-independent tumor reemergence

Wu, N., Jia, D., Bates, B., Basom, R., Eberhart, C. G. & MacPherson, D., Mar 1 2017, In : Journal of Clinical Investigation. 127, 3, p. 888-898 11 p.

Research output: Contribution to journalArticle

Retinoblastoma
Neoplasms
Anaplasia
Gene Amplification
Tumor Suppressor Genes

An immunocompetent mouse model of human glioblastoma

Semenkow, S., Li, S., Kahlert, U. D., Raabe, E. H., Xu, J., Arnold, A., Janowski, M., Oh, B. C., Brandacher, G., Bulte, J. W. M., Eberhart, C. G. & Walczak, P., Sep 1 2017, In : Oncotarget. 8, 37, p. 61072-61082 11 p.

Research output: Contribution to journalArticle

Glioblastoma
Neoplasms
Precision Medicine
Heterologous Transplantation
Adaptive Immunity

Delayed Superficial Migration of Retained Hyaluronic Acid Years Following Periocular Injection

Chang, J. R., Baharestani, S., Salek, S. S., Piluek, W. J., Eberhart, C. G. & McCulley, T. J., May 1 2017, In : Ophthalmic Plastic and Reconstructive Surgery. 33, 3S, p. S116-S118

Research output: Contribution to journalArticle

Intraocular Injections
Hyaluronic Acid
Injections
Hyaluronoglucosaminidase
Cosmetics

Discriminating MGMT promoter methylation status in patients with glioblastoma employing amide proton transfer-weighted MRI metrics

Jiang, S., Rui, Q., Wang, Y., Heo, H. Y., Zou, T., Yu, H., Zhang, Y., Wang, X., Du, Y., Wen, X., Chen, F., Wang, J., Eberhart, C. G., Zhou, J. & Wen, Z., Dec 12 2017, (Accepted/In press) In : European Radiology. p. 1-9 9 p.

Research output: Contribution to journalArticle

Methyltransferases
Glioblastoma
Amides
Methylation
Protons
Hemophagocytic Lymphohistiocytosis
Uvea
Trabecular Meshwork
Vision Disorders
Virus Diseases

HIF-1α- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy

Mangraviti, A. , Raghavan, T. , Volpin, F. , Skuli, N. , Gullotti, D. , Zhou, J. , Asnaghi, L. , Sankey, E. , Liu, A. , Wang, Y. , Lee, D. H. , Gorelick, N. , Serra, R. , Peters, M. , Schriefer, D. , Delaspre, F. , Rodriguez, F. J. , Eberhart, C. G. , Brem, H. , Olivi, A. & 1 others Tyler, B., Dec 1 2017, In : Scientific Reports. 7, 1, 14978

Research output: Contribution to journalArticle

Acriflavine
Brain Neoplasms
Survival
Neoplasms
Glioma

Hypoxia inhibits growth, proliferation, and increases response to chemotherapy in retinoblastoma cells

Yang, Q., Tripathy, A., Yu, W., Eberhart, C. G. & Asnaghi, L., Sep 1 2017, In : Experimental Eye Research. 162, p. 48-61 14 p.

Research output: Contribution to journalArticle

Retinoblastoma
Drug Therapy
Growth
Glycolysis
Protein-Lysine 6-Oxidase

Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy

Hu, J. , Dziumbla, S. , Lin, J. , Bibli, S. I. , Zukunft, S. , De Mos, J. , Awwad, K. , Frömel, T. , Jungmann, A. , Devraj, K. , Cheng, Z. , Wang, L. , Fauser, S. , Eberhart, C. G. , Sodhi, A. , Hammock, B. D. , Liebner, S. , Müller, O. J. , Glaubitz, C. , Hammes, H. P. & 2 others Popp, R. & Fleming, I., Dec 14 2017, In : Nature. 552, 7684, p. 248-252 5 p.

Research output: Contribution to journalArticle

Epoxide Hydrolases
Diabetic Retinopathy
Pericytes
Blood Vessels
Retina

Intertumoral Heterogeneity within Medulloblastoma Subgroups

Cavalli, F. M. G. , Remke, M. , Rampasek, L. , Peacock, J. , Shih, D. J. H. , Luu, B. , Garzia, L. , Torchia, J. , Nor, C. , Morrissy, A. S. , Agnihotri, S. , Thompson, Y. Y. , Kuzan-Fischer, C. M. , Farooq, H. , Isaev, K. , Daniels, C. , Cho, B. K. , Kim, S. K. , Wang, K. C. , Lee, J. Y. & 75 others Grajkowska, W. A., Perek-Polnik, M., Vasiljevic, A., Faure-Conter, C., Jouvet, A., Giannini, C., Nageswara Rao, A. A., Li, K. K. W., Ng, H. K., Eberhart, C. G., Pollack, I. F., Hamilton, R. L., Gillespie, G. Y., Olson, J. M., Leary, S., Weiss, W. A., Lach, B., Chambless, L. B., Thompson, R. C., Cooper, M. K., Vibhakar, R., Hauser, P., van Veelen, M. L. C., Kros, J. M., French, P. J., Ra, Y. S., Kumabe, T., López-Aguilar, E., Zitterbart, K., Sterba, J., Finocchiaro, G., Massimino, M., Van Meir, E. G., Osuka, S., Shofuda, T., Klekner, A., Zollo, M., Leonard, J. R., Rubin, J. B., Jabado, N., Albrecht, S., Mora, J., Van Meter, T. E., Jung, S., Moore, A. S., Hallahan, A. R., Chan, J. A., Tirapelli, D. P. C., Carlotti, C. G., Fouladi, M., Pimentel, J., Faria, C. C., Saad, A. G., Massimi, L., Liau, L. M., Wheeler, H., Nakamura, H., Elbabaa, S. K., Perezpeña-Diazconti, M., Chico Ponce de León, F., Robinson, S., Zapotocky, M., Lassaletta, A., Huang, A., Hawkins, C. E., Tabori, U., Bouffet, E., Bartels, U., Dirks, P. B., Rutka, J. T., Bader, G. D., Reimand, J., Goldenberg, A., Ramaswamy, V. & Taylor, M. D., Jun 12 2017, In : Cancer Cell. 31, 6, p. 737-754.e6

Research output: Contribution to journalArticle

Medulloblastoma
DNA Methylation
Cluster Analysis
Clinical Trials
Genome

Melanoma subtypes demonstrate distinct PD-L1 expression profiles

Kaunitz, G. J., Cottrell, T. R., Lilo, M., Muthappan, V., Esandrio, J., Berry, S., Xu, H., Ogurtsova, A., Anders, R. A., Fischer, A. H., Kraft, S., Gerstenblith, M. R., Thompson, C. L., Honda, K., Cuda, J. D., Eberhart, C. G., Handa, J. T., Lipson, E. J. & Taube, J. M., Sep 1 2017, In : Laboratory Investigation. 97, 9, p. 1063-1071 9 p.

Research output: Contribution to journalArticle

Melanoma
Solar System
Tumor-Infiltrating Lymphocytes
Tumor Microenvironment
Extremities

mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma

Wu, C. C., Hou, S., Orr, B. A., Kuo, B. R., Youn, Y. H., Ong, T., Roth, F., Eberhart, C. G., Robinson, G. W., Solecki, D. J., Taketo, M. M., Gilbertson, R. J., Roussel, M. F. & Han, Y. G., Dec 18 2017, In : Developmental Cell. 43, 6, p. 673-688.e5

Research output: Contribution to journalArticle

Medulloblastoma
Hedgehogs
Sirolimus
Growth and Development
Cerebellum

Predicting IDH mutation status in grade II gliomas using amide proton transfer-weighted (APTw) MRI

Jiang, S., Zou, T., Eberhart, C. G., Villalobos, M. A. V., Heo, H. Y., Zhang, Y., Wang, Y., Wang, X., Yu, H., Du, Y., van Zijl, P. C. M., Wen, Z. & Zhou, J., Sep 1 2017, In : Magnetic Resonance in Medicine. 78, 3, p. 1100-1109 10 p.

Research output: Contribution to journalArticle

Isocitrate Dehydrogenase
Amides
Glioma
Protons
Mutation

Rabbit model of human gliomas: Implications for intra-arterial drug delivery

Qin, H., Janowski, M., Pearl, M. S., Malysz-Cymborska, I., Li, S., Eberhart, C. G. & Walczak, P., Jan 1 2017, In : PLoS One. 12, 1, e0169656

Research output: Contribution to journalArticle

Drug delivery
Glioma
Tumors
rabbits
Rabbits

Strategies to enhance the distribution of nanotherapeutics in the brain

Zhang, C., Mastorakos, P., Sobral, M., Berry, S., Song, E., Nance, E., Eberhart, C. G., Hanes, J. & Suk, J. S., 2017, (Accepted/In press) In : Journal of Controlled Release.

Research output: Contribution to journalArticle

Nanoparticles
Convection
Brain
Blood-Brain Barrier
Extracellular Matrix

The dual mTOR kinase inhibitor TAK228 inhibits tumorigenicity and enhances radiosensitization in diffuse intrinsic pontine glioma

Miyahara, H., Yadavilli, S., Natsumeda, M., Rubens, J. A., Rodgers, L., Kambhampati, M., Taylor, I. C., Kaur, H., Asnaghi, L., Eberhart, C. G., Warren, K. E., Nazarian, J. & Raabe, E. H., Aug 1 2017, In : Cancer Letters. 400, p. 110-116 7 p.

Research output: Contribution to journalArticle

Glioma
Phosphotransferases
Brain Stem Neoplasms
Apoptosis
S 6

The TORC1/2 inhibitor TAK228 sensitizes atypical teratoid rhabdoid tumors to cisplatin-induced cytotoxicity

Rubens, J. A., Wang, S. Z., Price, A., Weingart, M. F., Allen, S. J., Orr, B. A., Eberhart, C. G. & Raabe, E. H., Oct 1 2017, In : Neuro-Oncology. 19, 10, p. 1361-1371 11 p.

Research output: Contribution to journalArticle

Cisplatin
Sirolimus
Heterografts
Apoptosis
Neoplasms
2016

Alterations in cellular metabolome after pharmacological inhibition of Notch in glioblastoma cells

Kahlert, U. D., Cheng, M., Koch, K., Marchionni, L., Fan, X., Raabe, E. H., Maciaczyk, J., Glunde, K. & Eberhart, C. G., Mar 1 2016, In : International Journal of Cancer. 138, 5, p. 1246-1255 10 p.

Research output: Contribution to journalArticle

Metabolome
Glioblastoma
Glutamic Acid
Pharmacology
Glutaminase

Altered gene expression in conjunctival squamous cell carcinoma

Mahale, A., Alkatan, H., Alwadani, S., Othman, M., Suarez, M. J., Price, A., Al-Hussain, H., Jastaneiah, S., Yu, W., Maktabi, A., Deepak, E. P., Eberhart, C. G. & Asnaghi, L., Feb 26 2016, (Accepted/In press) In : Modern Pathology.

Research output: Contribution to journalArticle

Matrix Metalloproteinases
Squamous Cell Carcinoma
Clusterin
Gene Expression
Carcinoma in Situ

Convection enhanced delivery of cisplatin-loaded brain penetrating nanoparticles cures malignant glioma in rats

Zhang, C., Nance, E. A., Mastorakos, P., Chisholm, J., Berry, S., Eberhart, C., Tyler, B., Brem, H., Suk, J. S. & Hanes, J., Dec 5 2016, (Accepted/In press) In : Journal of Controlled Release.

Research output: Contribution to journalArticle

Convection
Glioma
Nanoparticles
Cisplatin
Brain

Divergent clonal selection dominates medulloblastoma at recurrence

Morrissy, A. S. , Garzia, L. , Shih, D. J. H. , Zuyderduyn, S. , Huang, X. , Skowron, P. , Remke, M. , Cavalli, F. M. G. , Ramaswamy, V. , Lindsay, P. E. , Jelveh, S. , Donovan, L. K. , Wang, X. , Luu, B. , Zayne, K. , Li, Y. , Mayoh, C. , Thiessen, N. , Mercier, E. , Mungall, K. L. & 118 others Ma, Y., Tse, K., Zeng, T., Shumansky, K., Roth, A. J. L., Shah, S., Farooq, H., Kijima, N., Holgado, B. L., Lee, J. J. Y., Matan-Lithwick, S., Liu, J., Mack, S. C., Manno, A., Michealraj, K. A., Nor, C., Peacock, J., Qin, L., Reimand, J., Rolider, A., Thompson, Y. Y., Wu, X., Pugh, T., Ally, A., Bilenky, M., Butterfield, Y. S. N., Carlsen, R., Cheng, Y., Chuah, E., Corbett, R. D., Dhalla, N., He, A., Lee, D., Li, H. I., Long, W., Mayo, M., Plettner, P., Qian, J. Q., Schein, J. E., Tam, A., Wong, T., Birol, I., Zhao, Y., Faria, C. C., Pimentel, J., Nunes, S., Shalaby, T., Grotzer, M., Pollack, I. F., Hamilton, R. L., Li, X. N., Bendel, A. E., Fults, D. W., Walter, A. W., Kumabe, T., Tominaga, T., Collins, V. P., Cho, Y. J., Hoffman, C., Lyden, D., Wisoff, J. H., Garvin, J. H., Stearns, D. S., Massimi, L., Schüller, U., Sterba, J., Zitterbart, K., Puget, S., Ayrault, O., Dunn, S. E., Tirapelli, D. P. C., Carlotti, C. G., Wheeler, H., Hallahan, A. R., Ingram, W., MacDonald, T. J., Olson, J. J., Van Meir, E. G., Lee, J. Y., Wang, K. C., Kim, S. K., Cho, B. K., Pietsch, T., Fleischhack, G., Tippelt, S., Ra, Y. S., Bailey, S., Lindsey, J. C., Clifford, S. C., Eberhart, C. G., Cooper, M. K., Packer, R. J., Massimino, M., Garre, M. L., Bartels, U., Tabori, U., Hawkins, C. E., Dirks, P., Bouffet, E., Rutka, J. T., Wechsler-Reya, R. J., Weiss, W. A., Collier, L. S., Dupuy, A. J., Korshunov, A., Jones, D. T. W., Kool, M., Northcott, P. A., Pfister, S. M., Largaespada, D. A., Mungall, A. J., Moore, R. A., Jabado, N., Bader, G. D., Jones, S. J. M., Malkin, D., Marra, M. A. & Taylor, M. D., Jan 21 2016, In : Nature. 529, 7586, p. 351-357 7 p.

Research output: Contribution to journalArticle

Medulloblastoma
Recurrence
Image-Guided Radiotherapy
Neoplasms
Therapeutics

Establishment and biological characterization of a panel of glioblastoma multiforme (GBM) and GBM variant oncosphere cell lines

Binder, Z. A., Wilson, K. M., Salmasi, V., Orr, B. A., Eberhart, C. G., Siu, I. M., Lim, M., Weingart, J. D., Quinones-Hinojosa, A., Bettegowda, C., Kassam, A. B., Olivi, A., Brem, H., Riggins, G. J. & Gallia, G. L., Mar 1 2016, In : PLoS One. 11, 3, e0150271

Research output: Contribution to journalArticle

oncospheres
Glioblastoma
Tumors
Cells
cell lines

Expression of p16 and p53 in intraepithelial periocular sebaceous carcinoma

Bell, W. R., Singh, K., Anand Rajan, K. D. & Eberhart, C. G., Jan 1 2016, In : Ocular Oncology and Pathology. 2, 2, p. 71-75 5 p.

Research output: Contribution to journalArticle

Carcinoma in Situ
Carcinoma
Neoplasms
Conjunctiva
Immunohistochemistry

Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma

Hu, K., Babapoor-Farrokhran, S., Rodrigues, M., Deshpande, M., Puchner, B., Kashiwabuchi, F., Hassan, S. J., Asnaghi, L., Handa, J. T., Merbs, S., Eberhart, C. G., Semenza, G. L., Montaner, S. & Sodhi, A., 2016, In : Oncotarget. 7, 7, p. 7816-7828 13 p.

Research output: Contribution to journalArticle

Hypoxia-Inducible Factor 1
Vascular Endothelial Growth Factor A
Up-Regulation
Phenotype
Uveal melanoma

Multiple cilia suppress tumour formation

Eberhart, C., Mar 30 2016, In : Nature Cell Biology. 18, 4, p. 368-369 2 p.

Research output: Contribution to journalShort survey

Notch1 Receptor
Choroid Plexus Neoplasms
Hedgehog Proteins
Cilia
Cell Proliferation

MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism

Bandopadhayay, P. , Ramkissoon, L. A. , Jain, P. , Bergthold, G. , Wala, J. , Zeid, R. , Schumacher, S. E. , Urbanski, L. , O'Rourke, R. , Gibson, W. J. , Pelton, K. , Ramkissoon, S. H. , Han, H. J. , Zhu, Y. , Choudhari, N. , Silva, A. , Boucher, K. , Henn, R. E. , Kang, Y. J. , Knoff, D. & 42 others Paolella, B. R., Gladden-Young, A., Varlet, P., Pages, M., Horowitz, P. M., Federation, A., Malkin, H., Tracy, A. A., Seepo, S., Ducar, M., Van Hummelen, P., Santi, M., Buccoliero, A. M., Scagnet, M., Bowers, D. C., Giannini, C., Puget, S., Hawkins, C., Tabori, U., Klekner, A., Bognar, L., Burger, P. C., Eberhart, C., Rodriguez, F. J., Hill, D. A., Mueller, S., Haas-Kogan, D. A., Phillips, J. J., Santagata, S., Stiles, C. D., Bradner, J. E., Jabado, N., Goren, A., Grill, J., Ligon, A. H., Goumnerova, L., Waanders, A. J., Storm, P. B., Kieran, M. W., Ligon, K. L., Beroukhim, R. & Resnick, A. C., Mar 1 2016, In : Nature Genetics. 48, 3, p. 273-282 10 p.

Research output: Contribution to journalArticle

Glioma
Pediatrics
Epigenomics
Neoplasms
Carcinogenesis

Somatic cell transfer of c-Myc and Bcl-2 induces large-cell anaplastic medulloblastomas in mice

Jenkins, N. C., Rao, G., Eberhart, C. G., Pedone, C. A., Dubuc, A. M. & Fults, D. W., Feb 1 2016, In : Journal of Neuro-Oncology. 126, 3, p. 415-424 10 p.

Research output: Contribution to journalArticle

Medulloblastoma
Neoplasms
Brain Neoplasms
Stem Cells
Nestin

Somatic mutations of DICER1 and KMT2D are frequent in intraocular medulloepitheliomas

Sahm, F., Jakobiec, F. A., Meyer, J., Schrimpf, D., Eberhart, C. G., Hovestadt, V., Capper, D., Lambo, S., Ryzhova, M., Schüller, U., Zheludkova, O., Kumirova, E., Lichter, P., von Deimling, A., Jones, D. T. W., Pfister, S. M., Kool, M. & Korshunov, A., 2016, (Accepted/In press) In : Genes Chromosomes and Cancer.

Research output: Contribution to journalArticle

Primitive Neuroectodermal Tumors
Mutation
Neoplasms
Neuroepithelial Neoplasms
Genome

Subepidermal Calcified Nodules of the Eyelid Differ in Children and Adults

AlWadani, S., Suarez, M. J., Kass, J. J., MacQuaid, E., Edward, D. P., Alkatan, H. & Eberhart, C., Jul 29 2016, (Accepted/In press) In : Ophthalmic Plastic and Reconstructive Surgery.

Research output: Contribution to journalArticle

Eyelids
Foreign-Body Reaction
Inflammation
Calcinosis
Gout

Targeting Notch Signaling and Autophagy Increases Cytotoxicity in Glioblastoma Neurospheres

Natsumeda, M., Maitani, K., Liu, Y., Miyahara, H., Kaur, H., Chu, Q., Zhang, H., D. Kahlert, U. & Eberhart, C. G., Nov 1 2016, In : Brain Pathology. 26, 6, p. 713-723 11 p.

Research output: Contribution to journalArticle

Autophagy
Glioblastoma
Glioma
Stem Cells
Amyloid Precursor Protein Secretases

Targeting Notch signaling as a novel therapy for retinoblastoma

Asnaghi, L., Tripathy, A., Yang, Q., Kaur, H., Hanaford, A., Yu, W. & Eberhart, C. G., 2016, In : Oncotarget. 7, 43, p. 70028-70044 17 p.

Research output: Contribution to journalArticle

Retinoblastoma
Therapeutics
Small Interfering RNA
Down-Regulation
Amyloid Precursor Protein Secretases

Therapeutic impact of cytoreductive surgery and irradiation of posterior fossa ependymoma in the molecular era: A retrospective multicohort analysis

Ramaswamy, V. , Hielscher, T. , Mack, S. C. , Lassaletta, A. , Lin, T. , Pajtler, K. W. , Jones, D. T. W. , Luu, B. , Cavalli, F. M. G. , Aldape, K. , Remke, M. , Mynarek, M. , Rutkowski, S. , Gururangan, S. , McLendon, R. E. , Lipp, E. S. , Dunham, C. , Hukin, J. , Eisenstat, D. D. , Fulton, D. & 95 others Van Landeghem, F. K. H., Santi, M., Van Veelen, M. L. C., Van Meir, E. G., Osuka, S., Fan, X., Muraszko, K. M., Tirapelli, D. P. C., Oba-Shinjo, S. M., Marie, S. K. N., Carlotti, C. G., Lee, J. Y., Rao, A. A. N., Giannini, C., Faria, C. C., Nunes, S., Mora, J., Hamilton, R. L., Hauser, P., Jabado, N., Petrecca, K., Jung, S., Massimi, L., Zollo, M., Cinalli, G., Bognár, L., Klekner, A., Hortobágyi, T., Leary, S., Ermoian, R. P., Olson, J. M., Leonard, J. R., Gardner, C., Grajkowska, W. A., Chambless, L. B., Cain, J., Eberhart, C. G., Ahsan, S., Massimino, M., Giangaspero, F., Buttarelli, F. R., Packer, R. J., Emery, L., Yong, W. H., Soto, H., Liau, L. M., Everson, R., Grossbach, A., Shalaby, T., Grotzer, M., Karajannis, M. A., Zagzag, D., Wheeler, H., Von Hoff, K., Alonso, M. M., Tuñon, T., Schüller, U., Zitterbart, K., Sterba, J., Chan, J. A., Guzman, M., Elbabaa, S. K., Colman, H., Dhall, G., Fisher, P. G., Fouladi, M., Gajjar, A., Goldman, S., Hwang, E., Kool, M., Ladha, H., Vera-Bolanos, E., Wani, K., Lieberman, F., Mikkelsen, T., Omuro, A. M., Pollack, I. F., Prados, M., Robins, H. I., Soffietti, R., Wu, J., Metellus, P., Tabori, U., Bartels, U., Bouffet, E., Hawkins, C. E., Rutka, J. T., Dirks, P., Pfister, S. M., Merchant, T. E., Gilbert, M. R., Armstrong, T. S., Korshunov, A., Ellison, D. W. & Taylor, M. D., Jul 20 2016, In : Journal of Clinical Oncology. 34, 21, p. 2468-2477 10 p.

Research output: Contribution to journalArticle

Ependymoma
Radiotherapy
Biomarkers
Radiation
Therapeutics

The transcriptional modulator HMGA2 promotes stemness and tumorigenicity in glioblastoma

Kaur, H., Ali, S. Z., Huey, L., Hütt-Cabezas, M., Taylor, I., Mao, X. G., Weingart, M., Chu, Q., Rodriguez, F. J., Eberhart, C. G. & Raabe, E. H., Jul 10 2016, In : Cancer Letters. 377, 1, p. 55-64 10 p.

Research output: Contribution to journalArticle

AT-Hook Motifs
Glioblastoma
Stem Cell Factor
Neoplastic Stem Cells
Tumor Cell Line
2015

Analysis of varicella-zoster virus in temporal arteries biopsy positive and negative for giant cell arteritis

Nagel, M. A. , White, T. , Khmeleva, N. , Rempel, A. , Boyer, P. J. , Bennett, J. L. , Haller, A. , Lear-Kaul, K. , Kandasmy, B. , Amato, M. , Wood, E. , Durairaj, V. , Fogt, F. , Tamhankar, M. A. , Grossniklaus, H. E. , Poppiti, R. J. , Bockelman, B. , Keyvani, K. , Pollak, L. , Mendlovic, S. & 7 others Fowkes, M., Eberhart, C. G., Buttmann, M., Toyka, K. V., Meyer-Ter-Vehn, T., Petursdottir, V. & Gilden, D., Nov 1 2015, In : JAMA Neurology. 72, 11, p. 1281-1287 7 p.

Research output: Contribution to journalArticle

Temporal Arteries
Giant Cell Arteritis
Human Herpesvirus 3
Biopsy
Antigens

Clinicopathologic implications of NF1 gene alterations in diffuse gliomas

Vizcaíno, M. A., Shah, S., Eberhart, C. G. & Rodriguez, F. J., Sep 1 2015, In : Human Pathology. 46, 9, p. 1323-1330 8 p.

Research output: Contribution to journalArticle

Glioblastoma
Glioma
Genes
Atlases
Fluorescence In Situ Hybridization

Comparative integrated molecular analysis of intraocular medulloepitheliomas and central nervous system embryonal tumors with multilayered rosettes confirms that they are distinct nosologic entities

Korshunov, A., Jakobiec, F. A., Eberhart, C. G., Hovestadt, V., Capper, D., Jones, D. T. W., Sturm, D., Stagner, A. M., Edward, D. P., Eagle, R. C., Proia, A. D., Koch, A., Ryzhova, M., Ektova, A., Schüller, U., Zheludkova, O., Lichter, P., von Deimling, A., Pfister, S. M. & Kool, M., Dec 1 2015, In : Neuropathology. 35, 6, p. 538-544 7 p.

Research output: Contribution to journalArticle

Primitive Neuroectodermal Tumors
Central Nervous System Neoplasms
Neoplasms
Eye Neoplasms
Epigenomics

Corticosteroid-loaded biodegradable nanoparticles for prevention of corneal allograft rejection in rats

Pan, Q., Xu, Q., Boylan, N. J., Lamb, N. W., Emmert, D. G., Yang, J. C., Tang, L., Heflin, T., Alwadani, S., Eberhart, C. G., Stark, W. J. & Hanes, J., Mar 10 2015, In : Journal of Controlled Release. 201, p. 32-40 9 p.

Research output: Contribution to journalArticle

dexamethasone 21-phosphate
Graft Rejection
Nanoparticles
Allografts
Adrenal Cortex Hormones

Differential DNA methylation identified in the blood and retina of AMD patients

Oliver, V. F., Jaffe, A. E., Song, J., Wang, G., Zhang, P., Branham, K. E., Swaroop, A., Eberhart, C. G., Zack, D. J., Qian, J. & Merbs, S. L., Jan 1 2015, In : Epigenetics. 10, 8, p. 698-707 10 p.

Research output: Contribution to journalArticle

Macular Degeneration
DNA Methylation
Retina
Epigenomics
Methylation

Disrupting LIN28 in atypical teratoid rhabdoid tumors reveals the importance of the mitogen activated protein kinase pathway as a therapeutic target

Weingart, M. F., Roth, J. J., Hutt-Cabezas, M., Busse, T. M., Kaur, H., Price, A., Maynard, R., Rubens, J., Taylor, I., Mao, X. G., Xu, J., Kuwahara, Y., Allen, S. J., Erdreich-Epstein, A., Weissman, B. E., Orr, B. A., Eberhart, C. G., Biegel, J. A. & Raabe, E. H., 2015, In : Oncotarget. 6, 5, p. 3165-3177 13 p.

Research output: Contribution to journalArticle

Mitogen-Activated Protein Kinases
Tumor Cell Line
MicroRNAs
Therapeutics
Pediatrics

Disrupting NOTCH Slows Diffuse Intrinsic Pontine Glioma Growth, Enhances Radiation Sensitivity, and Shows Combinatorial Efficacy With Bromodomain Inhibition

Taylor, I. C., Hütt-Cabezas, M., Brandt, W. D., Kambhampati, M., Nazarian, J., Chang, H. T., Warren, K. E., Eberhart, C. G. & Raabe, E. H., Aug 31 2015, In : Journal of Neuropathology and Experimental Neurology. 74, 8, p. 778-790 13 p.

Research output: Contribution to journalArticle

Radiation Tolerance
Glioma
Growth
Amyloid Precursor Protein Secretases
Radiotherapy

DNMT-dependent suppression of microRNA regulates the induction of GBM tumor-propagating phenotype by Oct4 and Sox2

Lopez-Bertoni, H., Lal, B., Li, A., Caplan, M., Guerrero-Cázares, H., Eberhart, C. G., Quiñones-Hinojosa, A., Glas, M., Scheffler, B., Laterra, J. & Li, Y., Jul 23 2015, In : Oncogene. 34, 30, p. 3994-4004 11 p.

Research output: Contribution to journalArticle

Transferases
MicroRNAs
Phenotype
DNA
Neoplasms

EMT-associated factors promote invasive properties of uveal melanoma cells

Asnaghi, L., Gezgin, G., Tripathy, A., Handa, J. T., Merbs, S. L., van der Velden, P. A., Jager, M. J., Harbour, J. W. & Eberhart, C. G., Aug 25 2015, In : Molecular Vision. 21, p. 919-929 11 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Down-Regulation
Neoplasms
Growth
Messenger RNA

EphrinB2 controls vessel pruning through STAT1-JNK3 signalling

Salvucci, O., Ohnuki, H., Maric, D., Hou, X., Li, X., Yoon, S. O., Segarra, M., Eberhart, C. G., Acker-Palmer, A. & Tosato, G., 2015, In : Nature Communications. 6, 6576

Research output: Contribution to journalArticle

Endothelial cells
Cell death
vessels
Mitogen-Activated Protein Kinase 10
Cell Death

First human case of fungal keratitis caused by a putatively novel species of lophotrichus

Eghrari, A. O., Gibas, C., Watkins, T., Vahedi, S., Lee, R., Houle, E., Suarez, M. J., Eberhart, C., Sutton, D. A., Wiederhold, N. P., Sikder, S. & Zhang, S. X., Sep 1 2015, In : Journal of Clinical Microbiology. 53, 9, p. 3063-3067 5 p.

Research output: Contribution to journalArticle

Keratitis
Cornea
Dogs
Anti-Bacterial Agents
Infection

Genetic profiling by single-nucleotide polymorphism-based array analysis defines three distinct subtypes of orbital meningioma

Ho, C. Y., Mosier, S., Safneck, J., Salomao, D. R., Miller, N. R., Eberhart, C. G., Gocke, C. D., Batista, D. A. S. & Rodriguez, F. J., Mar 1 2015, In : Brain Pathology. 25, 2, p. 193-201 9 p.

Research output: Contribution to journalArticle

Meningioma
Single Nucleotide Polymorphism
Optic Nerve
Chromosomes
Optic Nerve Neoplasms

Highly PEGylated DNA Nanoparticles Provide Uniform and Widespread Gene Transfer in the Brain

Mastorakos, P., Zhang, C., Berry, S., Oh, Y., Lee, S., Eberhart, C. G., Woodworth, G. F., Suk, J. S. & Hanes, J., May 1 2015, In : Advanced healthcare materials. 4, 7, p. 1023-1033 11 p.

Research output: Contribution to journalArticle

Gene transfer
Nanoparticles
Brain
DNA
Genes

Intraocular tuberculosis presenting as a large anterior chamber mass

Ostheimer, T. A., Dunn, J. P., Eberhart, C. G. & Burkholder, B. M., Feb 1 2015, In : Ocular Immunology and Inflammation. 23, 1, p. 100-101 2 p.

Research output: Contribution to journalArticle

Ocular Tuberculosis
Crystalline Lens
Anterior Chamber
Tuberculosis
Differential Diagnosis

Lateral inhibition of Notch signaling in neoplastic cells

Lim, K. J., Brandt, W. D., Heth, J. A., Muraszko, K. M., Fan, X., Bar, E. E. & Eberhart, C. G., 2015, In : Oncotarget. 6, 3, p. 1666-1677 12 p.

Research output: Contribution to journalArticle

Ligands
Glioblastoma
Neoplasms
Cultured Cells
Oxygen

Medulloblastoma subgroups remain stable across primary and metastatic compartments

Wang, X. , Dubuc, A. M. , Ramaswamy, V. , Mack, S. , Gendoo, D. M. A. , Remke, M. , Wu, X. , Garzia, L. , Luu, B. , Cavalli, F. , Peacock, J. , López, B. , Skowron, P. , Zagzag, D. , Lyden, D. , Hoffman, C. , Cho, Y. J. , Eberhart, C. , MacDonald, T. , Li, X. N. & 9 others Van Meter, T., Northcott, P. A., Haibe-Kains, B., Hawkins, C., Rutka, J. T., Bouffet, E., Pfister, S. M., Korshunov, A. & Taylor, M. D., 2015, In : Acta Neuropathologica. 129, 3, p. 449-457 9 p.

Research output: Contribution to journalArticle

Medulloblastoma
Gene Expression
DNA Methylation
Transcriptome
Methylation