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2017

A Study of TNF Pathway Activation in Schizophrenia and Bipolar Disorder in Plasma and Brain Tissue

Hoseth, E. Z., Ueland, T., Dieset, I., Birnbaum, R., Shin, J. H., Kleinman, J. E., Hyde, T. M., Mørch, R. H., Hope, S., Lekva, T., Abraityte, A. J., Michelsen, A. E., Melle, I., Westlye, L. T., Ueland, T., Djurovic, S., Aukrust, P., Weinberger, D. R. & Andreassen, O. A. Jul 1 2017 In : Schizophrenia Bulletin. 43, 4, p. 881-890 10 p.

Research output: Research - peer-reviewArticle

Bipolar Disorder
Schizophrenia
Tumor Necrosis Factor-alpha
Brain
Disintegrins

DRD2 co-expression network and a related polygenic index predict imaging, behavioral and clinical phenotypes linked to schizophrenia

Pergola, G., Di Carlo, P., D'Ambrosio, E., Gelao, B., Fazio, L., Papalino, M., Monda, A., Scozia, G., Pietrangelo, B., Attrotto, M., Apud, J. A., Chen, Q., Mattay, V. S., Rampino, A., Caforio, G., Weinberger, D. R., Blasi, G. & Bertolino, A. 2017 In : Translational Psychiatry. 7, 1, e1006

Research output: Research - peer-reviewArticle

Schizophrenia
Phenotype
Short-Term Memory
Genes
Brain

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

McLaughlin, R. L. , Schijven, D. , Van Rheenen, W. , Van Eijk, K. R. , O'Brien, M. , Kahn, R. S. , Ophoff, R. A. , Goris, A. , Bradley, D. G. , Al-Chalabi, A. , Van Den Berg, L. H. , Luykx, J. J. , Hardiman, O. , Veldink, J. H. , Shatunov, A. , Dekker, A. M. , Diekstra, F. P. , Pulit, S. L. , Van Der Spek, R. A. A. , Van Doormaal, P. T. C. & 416 others Sproviero, W., Jones, A. R., Nicholson, G. A., Rowe, D. B., Pamphlett, R., Kiernan, M. C., Bauer, D., Kahlke, T., Williams, K., Eftimov, F., Fogh, I., Ticozzi, N., Lin, K., Millecamps, S., Salachas, F., Meininger, V., Carvalho, M. D., Pinto, S., Mora, J. S., Rojas-Garcyá, R., Polak, M., Chandran, S., Colville, S., Swingler, R., Morrison, K. E., Shaw, P. J., Hardy, J., Orrell, R. W., Pittman, A., Sidle, K., Fratta, P., Malaspina, A., Petri, S., Abdulla, S., Drepper, C., Sendtner, M., Meyer, T., Wiedau-Pazos, M., Lomen-Hoerth, C., Deerlin, V. M. V., Trojanowski, J. Q., Elman, L., McCluskey, L., Basak, N., Meitinger, T., Lichtner, P., Blagojevic-Radivojkov, M., Andres, C. R., Maurel, C., Bensimon, G., Landwehrmeyer, B., Brice, A., Payan, C. A. M., Saker-Delye, S., Durr, A., Wood, N., Tittmann, L., Lieb, W., Franke, A., Rietschel, M., Cichon, S., Nothen, M. M., Amouyel, P., Tzourio, C., Dartigues, J. F., Uitterlinden, A. G., Rivadeneira, F., Estrada, K., Hofman, A., Curtis, C., Derkooi, A. J. V., De Visser, M., Weber, M., Shaw, C. E., Smith, B. N., Pansarasa, O., Cereda, C., Bo, R. D., Comi, G. P., D'Alfonso, S., Bertolin, C., Soraru, G., Mazzini, L., Pensato, V., Gellera, C., Tiloca, C., Ratti, A., Calvo, A., Moglia, C., Brunetti, M., Arcuti, S., Capozzo, R., Zecca, C., Lunetta, C., Penco, S., Riva, N., Padovani, A., Filosto, M., Blair, I., Nigel Leigh, P., Casale, F., Chio, A., Beghi, E., Pupillo, E., Tortelli, R., Logroscino, G., Powell, J., Ludolph, A. C., Weishaupt, J. H., Robberecht, W., Damme, P. V., Brown, R. H., Glass, J., Landers, J. E., Andersen, P. M., Corcia, P., Vourc'H, P., Silani, V., Es, M. A. V., Pasterkamp, R. J., Lewis, C. M., Breen, G., Ripke, S., Neale, B. M., Corvin, A., Walters, J. T. R., Farh, K. H., Holmans, P. A., Lee, P., Bulik-Sullivan, B., Collier, D. A., Huang, H., Pers, T. H., Agartz, I., Agerbo, E., Albus, M., Alexander, M., Amin, F., Bacanu, S. A., Begemann, M., Belliveau, R. A., Bene, J., Bergen, S. E., Bevilacqua, E., Bigdeli, T. B., Black, D. W., Bruggeman, R., Buccola, N. G., Buckner, R. L., Byerley, W., Cahn, W., Cai, G., Campion, D., Cantor, R. M., Carr, V. J., Carrera, N., Catts, S. V., Chambert, K. D., Chan, R. C. K., Chan, R. Y. L., Chen, E. Y. H., Cheng, W., Cheung, E. F. C., Chong, S. A., Cloninger, C. R., Cohen, D., Cohen, N., Cormican, P., Craddock, N., Crowley, J. J., Curtis, D., Davidson, M., Davis, K. L., Degenhardt, F., Favero, J. D., Demontis, D., Dikeos, D., Dinan, T., Djurovic, S., Donohoe, G., Drapeau, E., Duan, J., Dudbridge, F., Durmishi, N., Eichhammer, P., Eriksson, J., Escott-Price, V., Essioux, L., Fanous, A. H., Farrell, M. S., Frank, J., Franke, L., Freedman, R., Freimer, N. B., Friedl, M., Friedman, J. I., Fromer, M., Genovese, G., Georgieva, L., Giegling, I., Giusti-Rodrýguez, P., Godard, S., Goldstein, J. I., Golimbet, V., Gopal, S., Gratten, J., De Haan, L., Hammer, C., Hamshere, M. L., Hansen, M., Hansen, T., Haroutunian, V., Hartmann, A. M., Henskens, F. A., Herms, S., Hirschhorn, J. N., Hoffmann, P., Hofman, A., Hollegaard, M. V., Hougaard, D. M., Ikeda, M., Joa, I., Julia, A., Kalaydjieva, L., Karachanak-Yankova, S., Karjalainen, J., Kavanagh, D., Keller, M. C., Kennedy, J. L., Khrunin, A., Kim, Y., Klovins, J., Knowles, J. A., Konte, B., Kucinskas, V., Kucinskiene, Z. A., Kuzelova-Ptackova, H., Kahler, A. K., Laurent, C., Lee, J., Hong Lee, S., Legge, S. E., Lerer, B., Li, M., Li, T., Liang, K. Y., Lieberman, J., Limborska, S., Loughland, C. M., Lubinski, J., Lonnqvist, J., MacEk, M., Magnusson, P. K. E., Maher, B. S., Maier, W., Mallet, J., Marsal, S., Mattheisen, M., Mattingsdal, M., McCarley, R. W., McDonald, C., McIntosh, A. M., Meier, S., Meijer, C. J., Melegh, B., Melle, I., Mesholam-Gately, R. I., Metspalu, A., Michie, P. T., Milani, L., Milanova, V., Mokrab, Y., Morris, D. W., Mors, O., Murphy, K. C., Murray, R. M., Myin-Germeys, I., Muller-Myhsok, B., Nelis, M., Nenadic, I., Nertney, D. A., Nestadt, G., Nicodemus, K. K., Nikitina-Zake, L., Nisenbaum, L., Nordin, A., O'Callaghan, E., O'Dushlaine, C., Anthony O'Neill, F., Oh, S. Y., Olincy, A., Olsen, L., Vanos, J., Pantelis, C., Papadimitriou, G. N., Papiol, S., Parkhomenko, E., Pato, M. T., Paunio, T., Pejovic-Milovancevic, M., Perkins, D. O., Pietilainen, O., Pimm, J., Pocklington, A. J., Price, A., Pulver, A. E., Purcell, S. M., Quested, D., Rasmussen, H. B., Reichenberg, A., Reimers, M. A., Richards, A. L., Roffman, J. L., Roussos, P., Ruderfer, D. M., Salomaa, V., Sanders, A. R., Schall, U., Schubert, C. R., Schulze, T. G., Schwab, S. G., Scolnick, E. M., Scott, R. J., Seidman, L. J., Shi, J., Sigurdsson, E., Silagadze, T., Silverman, J. M., Sim, K., Slominsky, P., Smoller, J. W., So, H. C., Spencer, C. C. A., Stah, E. A., Stefansson, H., Steinberg, S., Stogmann, E., Straub, R. E., Strengman, E., Strohmaier, J., Scott Stroup, T., Subramaniam, M., Suvisaari, J., Svrakic, D. M., Szatkiewicz, J. P., Söderman, E., Thirumalai, S., Toncheva, D., Tosato, S., Veijola, J., Waddington, J., Walsh, D., Wang, D., Wang, Q., Webb, B. T., Weiser, M., Wildenauer, D. B., Williams, N. M., Williams, S., Witt, S. H., Wolen, A. R., Wong, E. H. M., Wormley, B. K., Xi, H. S., Zai, C. C., Zheng, X., Zimprich, F., Wray, N. R., Stefansson, K., Visscher, P. M., Adolfsson, R., Andreassen, O. A., Blackwood, D. H. R., Bramon, E., Buxbaum, J. D., Børglum, A. D., Darvasi, A., Domenici, E., Ehrenreich, H., Esko, T., Gejman, P. V., Gil, M., Gurling, H., Hultman, C. M., Iwata, N., Jablensky, A. V., Jonsson, E. G., Kendler, K. S., Kirov, G., Knight, J., Lencz, T., Levinson, D. F., Li, Q. S., Liu, J., Malhotra, A. K., McCarrol, S. A., McQuillin, A., Moran, J. L., Mortensen, P. B., Mowry, B. J., Owen, M. J., Palotie, A., Pato, C. N., Petryshen, T. L., Posthuma, D., Riley, B. P., Rujescu, D., Sham, P. C., Sklar, P., Clair, D. S., Weinberger, D. R., Wendland, J. R., Werge, T., Daly, M. J., Sullivan, P. F. & O'Donovan, M. C. Mar 21 2017 In : Nature Communications. 8, 14774

Research output: Research - peer-reviewArticle

Amyotrophic Lateral Sclerosis
Schizophrenia
schizophrenia
Genes
genome

GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium

Trampush, J. W. , Yang, M. L. Z. , Yu, J. , Knowles, E. , Davies, G. , Liewald, D. C. , Starr, J. M. , Djurovic, S. , Melle, I. , Sundet, K. , Christoforou, A. , Reinvang, I. , DeRosse, P. , Lundervold, A. J. , Steen, V. M. , Espeseth, T. , Räikkönen, K. , Widen, E. , Palotie, A. , Eriksson, J. G. & 46 others Giegling, I., Konte, B., Roussos, P., Giakoumaki, S., Burdick, K. E., Payton, A., Ollier, W., Horan, M., Chiba-Falek, O., Attix, D. K., Need, A. C., Cirulli, E. T., Voineskos, A. N., Stefanis, N. C., Avramopoulos, D., Hatzimanolis, A., Arking, D. E., Smyrnis, N., Bilder, R. M., Freimer, N. A., Cannon, T. D., London, E., Poldrack, R. A., Sabb, F. W., Congdon, E., Conley, E. D., Scult, M. A., Dickinson, D., Straub, R. E., Donohoe, G., Morris, D., Corvin, A., Gill, M., Hariri, A. R., Weinberger, D. R., Pendleton, N., Bitsios, P., Rujescu, D., Lahti, J., Le Hellard, S., Keller, M. C., Andreassen, O. A., Deary, I. J., Glahn, D. C., Malhotra, A. K. & Lencz, T. Jan 17 2017 (Accepted/In press) In : Molecular Psychiatry.

Research output: Research - peer-reviewArticle

Genetic Loci
Genome-Wide Association Study
Genomics
Cognition
Single Nucleotide Polymorphism

Illuminating the dark road from schizophrenia genetic associations to disease mechanisms

Li, M. & Weinberger, D. R. Mar 1 2017 In : National Science Review. 4, 2, p. 240-251 12 p., nww065

Research output: Research - peer-reviewReview article

Schizophrenia
Genome-Wide Association Study
Epidemiologic Methods
Drug Discovery
Neurosciences

Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network

McConnell, M. J. , Moran, J. V. , Abyzov, A. , Akbarian, S. , Bae, T. , Cortes-Ciriano, I. , Erwin, J. A. , Fasching, L. , Flasch, D. A. , Freed, D. , Ganz, J. , Jaffe, A. E. , Kwan, K. Y. , Kwon, M. , Lodato, M. A. , Mills, R. E. , Paquola, A. C. M. , Rodin, R. E. , Rosenbluh, C. , Sestan, N. & 20 others Sherman, M. A., Shin, J. H., Song, S., Straub, R. E., Thorpe, J., Weinberger, D. R., Urban, A. E., Zhou, B., Gage, F. H., Lehner, T., Senthil, G., Walsh, C. A., Chess, A., Courchesne, E., Gleeson, J. G., Kidd, J. M., Park, P. J., Pevsner, J., Vaccarino, F. M. & Brain Somatic Mosaicism Network Apr 28 2017 In : Science. 356, 6336, 395

Research output: Research - peer-reviewArticle

Mosaicism
Brain Diseases
Genome
Brain
Neurons

Neanderthal-Derived Genetic Variation Shapes Modern Human Cranium and Brain

Gregory, M. D., Kippenhan, J. S., Eisenberg, D. P., Kohn, P. D., Dickinson, D., Mattay, V. S., Chen, Q., Weinberger, D. R., Saad, Z. S. & Berman, K. F. Dec 1 2017 In : Scientific Reports. 7, 1, 6308

Research output: Research - peer-reviewArticle

Neanderthals
Skull
Brain
Occipital Bone
Parietal Bone

New repeat polymorphism in the AKT1 gene predicts striatal dopamine D2/D3 receptor availability and stimulant-induced dopamine release in the healthy human brain

Shumay, E., Wiers, C. E., Shokri-Kojori, E., Kim, S. W., Hodgkinson, C. A., Sun, H., Tomasi, D., Wong, C. T., Weinberger, D. R., Wang, G. J., Fowler, J. S. & Volkow, N. D. May 10 2017 In : Journal of Neuroscience. 37, 19, p. 4982-4991 10 p.

Research output: Research - peer-reviewArticle

Dopamine D3 Receptors
Corpus Striatum
Dopamine D2 Receptors
Dopamine
Brain

Novel genetic loci associated with hippocampal volume

Hibar, D. P. , Adams, H. H. H. , Jahanshad, N. , Chauhan, G. , Stein, J. L. , Hofer, E. , Renteria, M. E. , Bis, J. C. , Arias-Vasquez, A. , Ikram, M. K. , Desrivières, S. , Vernooij, M. W. , Abramovic, L. , Alhusaini, S. , Amin, N. , Andersson, M. , Arfanakis, K. , Aribisala, B. S. , Armstrong, N. J. , Athanasiu, L. & 312 others Axelsson, T., Beecham, A. H., Beiser, A., Bernard, M., Blanton, S. H., Bohlken, M. M., Boks, M. P., Bralten, J., Brickman, A. M., Carmichael, O., Chakravarty, M. M., Chen, Q., Ching, C. R. K., Chouraki, V., Cuellar-Partida, G., Crivello, F., Den Braber, A., Doan, N. T., Ehrlich, S., Giddaluru, S., Goldman, A. L., Gottesman, R. F., Grimm, O., Griswold, M. E., Guadalupe, T., Gutman, B. A., Hass, J., Haukvik, U. K., Hoehn, D., Holmes, A. J., Hoogman, M., Janowitz, D., Jia, T., Jørgensen, K. N., Karbalai, N., Kasperaviciute, D., Kim, S., Klein, M., Kraemer, B., Lee, P. H., Liewald, D. C. M., Lopez, L. M., Luciano, M., MacAre, C., Marquand, A. F., Matarin, M., Mather, K. A., Mattheisen, M., McKay, D. R., Milaneschi, Y., Muñoz Maniega, S., Nho, K., Nugent, A. C., Nyquist, P., Loohuis, L. M. O., Oosterlaan, J., Papmeyer, M., Pirpamer, L., Pütz, B., Ramasamy, A., Richards, J. S., Risacher, S. L., Roiz-Santiañez, R., Rommelse, N., Ropele, S., Rose, E. J., Royle, N. A., Rundek, T., Sämann, P. G., Saremi, A., Satizabal, C. L., Schmaal, L., Schork, A. J., Shen, L., Shin, J., Shumskaya, E., Smith, A. V., Sprooten, E., Strike, L. T., Teumer, A., Tordesillas-Gutierrez, D., Toro, R., Trabzuni, D., Trompet, S., Vaidya, D., Van Der Grond, J., Van Der Lee, S. J., Van Der Meer, D., Van Donkelaar, M. M. J., Van Eijk, K. R., Van Erp, T. G. M., Van Rooij, D., Walton, E., Westlye, L. T., Whelan, C. D., Windham, B. G., Winkler, A. M., Wittfeld, K., Woldehawariat, G., Wolf, C., Wolfers, T., Yanek, L. R., Yang, J., Zijdenbos, A., Zwiers, M. P., Agartz, I., Almasy, L., Ames, D., Amouyel, P., Andreassen, O. A., Arepalli, S., Assareh, A. A., Barral, S., Bastin, M. E., Becker, D. M., Becker, J. T., Bennett, D. A., Blangero, J., Van Bokhoven, H., Boomsma, D. I., Brodaty, H., Brouwer, R. M., Brunner, H. G., Buckner, R. L., Buitelaar, J. K., Bulayeva, K. B., Cahn, W., Calhoun, V. D., Cannon, D. M., Cavalleri, G. L., Cheng, C. Y., Cichon, S., Cookson, M. R., Corvin, A., Crespo-Facorro, B., Curran, J. E., Czisch, M., Dale, A. M., Davies, G. E., De Craen, A. J. M., De Geus, E. J. C., De Jager, P. L., De Zubicaray, G. I., Deary, I. J., Debette, S., Decarli, C., Delanty, N., Depondt, C., Destefano, A., Dillman, A., Djurovic, S., Donohoe, G., Drevets, W. C., Duggirala, R., Dyer, T. D., Enzinger, C., Erk, S., Espeseth, T., Fedko, I. O., Fernández, G., Ferrucci, L., Fisher, S. E., Fleischman, D. A., Ford, I., Fornage, M., Foroud, T. M., Fox, P. T., Francks, C., Fukunaga, M., Gibbs, J. R., Glahn, D. C., Gollub, R. L., Göring, H. H. H., Green, R. C., Gruber, O., Gudnason, V., Guelfi, S., Håberg, A. K., Hansell, N. K., Hardy, J., Hartman, C. A., Hashimoto, R., Hegenscheid, K., Heinz, A., Le Hellard, S., Hernandez, D. G., Heslenfeld, D. J., Ho, B. C., Hoekstra, P. J., Hoffmann, W., Hofman, A., Holsboer, F., Homuth, G., Hosten, N., Hottenga, J. J., Huentelman, M., Pol, H. E. H., Ikeda, M., Jack, C. R., Jenkinson, M., Johnson, R., Jönsson, E. G., Jukema, J. W., Kahn, R. S., Kanai, R., Kloszewska, I., Knopman, D. S., Kochunov, P., Kwok, J. B., Lawrie, S. M., Lemaître, H., Liu, X., Longo, D. L., Lopez, O. L., Lovestone, S., Martinez, O., Martinot, J. L., Mattay, V. S., McDonald, C., McIntosh, A. M., McMahon, F. J., McMahon, K. L., Mecocci, P., Melle, I., Meyer-Lindenberg, A., Mohnke, S., Montgomery, G. W., Morris, D. W., Mosley, T. H., Mühleisen, T. W., Müller-Myhsok, B., Nalls, M. A., Nauck, M., Nichols, T. E., Niessen, W. J., Nöthen, M. M., Nyberg, L., Ohi, K., Olvera, R. L., Ophoff, R. A., Pandolfo, M., Paus, T., Pausova, Z., Penninx, B. W. J. H., Pike, G. B., Potkin, S. G., Psaty, B. M., Reppermund, S., Rietschel, M., Roffman, J. L., Romanczuk-Seiferth, N., Rotter, J. I., Ryten, M., Sacco, R. L., Sachdev, P. S., Saykin, A. J., Schmidt, R., Schmidt, H., Schofield, P. R., Sigursson, S., Simmons, A., Singleton, A., Sisodiya, S. M., Smith, C., Smoller, J. W., Soininen, H., Steen, V. M., Stott, D. J., Sussmann, J. E., Thalamuthu, A., Toga, A. W., Traynor, B. J., Troncoso, J., Tsolaki, M., Tzourio, C., Uitterlinden, A. G., Hernández, M. C. V., Van Der Brug, M., Van Der Lugt, A., Van Der Wee, N. J. A., Van Haren, N. E. M., Van 'T Ent, D., Van Tol, M. J., Vardarajan, B. N., Vellas, B., Veltman, D. J., Völzke, H., Walter, H., Wardlaw, J. M., Wassink, T. H., Weale, M. E., Weinberger, D. R., Weiner, M. W., Wen, W., Westman, E., White, T., Wong, T. Y., Wright, C. B., Zielke, R. H., Zonderman, A. B., Martin, N. G., Van Duijn, C. M., Wright, M. J., Longstreth, W. T., Schumann, G., Grabe, H. J., Franke, B., Launer, L. J., Medland, S. E., Seshadri, S., Thompson, P. M. & Ikram, M. A. Jan 18 2017 In : Nature Communications. 8, 13624

Research output: Research - peer-reviewArticle

Genetic Loci
Hippocampus
Genes
loci
Episodic Memory

QSVA framework for RNA quality correction in differential expression analysis

Jaffe, A. E., Tao, R., Norris, A. L., Kealhofer, M., Nellore, A., Shin, J. H., Kim, D., Jia, Y., Hyde, T. M., Kleinman, J. E., Straub, R. E., Leek, J. T. & Weinberger, D. R. Jul 3 2017 In : Proceedings of the National Academy of Sciences of the United States of America. 114, 27, p. 7130-7135 6 p.

Research output: Research - peer-reviewArticle

RNA
RNA Sequence Analysis
Brain
Social Adjustment
RNA Stability
Neuregulins
Brain Diseases
Human Development
Mood Disorders
Protein Isoforms

World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia–a short version for primary care

Hasan, A. , Falkai, P. , Wobrock, T. , Lieberman, J. , Glenthøj, B. , Gattaz, W. F. , Thibaut, F. , Möller, H. J. , Carlo Altamura, A. , Andreasen, N. , Barnes, T. R. E. , Emin Ceylan, M. , Ollivier, J. C. , Crow, T. , Danaci, A. E. , David, A. , Davidson, M. , Deakin, B. , Elkis, H. , Farde, L. & 29 others Gaebel, W., Gallhofer, B., Gerlach, J., Hirsch, S. R., Hojaij, C. R., Hwang, M., Hwo, H. G., Jablensky, A. V., Jarema, M., Kane, J., Kojima, T., Larach, V., Lieberman, J., McGorry, P., Meltzer, H., Möller, H. J., Mosolov, S., Moussaoui, D., Olié, J. P., Palha, A. P., Sarandöl, A., Sato, M., Sauer, H., Schooler, N., Taneli, B., von Knorring, L., Weinberger, D., Yamawaki, S. & WFSBP Task Force on Treatment Guidelines for Schizophrenia Apr 3 2017 In : International Journal of Psychiatry in Clinical Practice. 21, 2, p. 82-90 9 p.

Research output: Research - peer-reviewReview article

Biological Psychiatry
Primary Health Care
Schizophrenia
Guidelines
Therapeutics
2016

A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus

Li, M., Jaffe, A. E., Straub, R. E., Tao, R., Shin, J. H., Wang, Y., Chen, Q., Li, C., Jia, Y., Ohi, K., Maher, B. J., Brandon, N. J., Cross, A., Chenoweth, J. G., Hoeppner, D. J., Wei, H., Hyde, T. M., McKay, R., Kleinman, J. E. & Weinberger, D. R. Jun 1 2016 In : Nature Medicine. 22, 6, p. 649-656 8 p.

Research output: Research - peer-reviewArticle

Schizophrenia
Protein Isoforms
Genes
Polymorphism
Association reactions

Altering the course of schizophrenia: progress and perspectives

Millan, M. J. , Andrieux, A. , Bartzokis, G. , Cadenhead, K. , Dazzan, P. , Fusar-Poli, P. , Gallinat, J. , Giedd, J. , Grayson, D. R. , Heinrichs, M. , Kahn, R. , Krebs, M. O. , Leboyer, M. , Lewis, D. , Marin, O. , Marin, P. , Meyer-Lindenberg, A. , McGorry, P. , McGuire, P. , Owen, M. J. & 7 others Patterson, P., Sawa, A., Spedding, M., Uhlhaas, P., Vaccarino, F., Wahlestedt, C. & Weinberger, D. Mar 4 2016 (Accepted/In press) In : Nature Reviews Drug Discovery.

Research output: Research - peer-reviewArticle

Schizophrenia
Psychotic Disorders
Psychiatry
Rodentia
Drug Therapy

Association of DNA methylation differences with schizophrenia in an epigenome-wide association study

Montano, C. , Taub, M. A. , Jaffe, A. , Briem, E. , Feinberg, J. I. , Trygvadottir, R. , Idrizi, A. , Runarsson, A. , Berndsen, B. , Gur, R. C. , Moore, T. M. , Perry, R. T. , Fugman, D. , Sabunciyan, S. , Yolken, R. H. , Hyde, T. M. , Kleinman, J. E. , Sobell, J. L. , Pato, C. N. , Pato, M. T. & 7 others Go, R. C., Nimgaonkar, V., Weinberger, D. R., Braff, D., Gur, R. E., Fallin, M. D. & Feinberg, A. P. May 1 2016 In : JAMA Psychiatry. 73, 5, p. 506-514 9 p.

Research output: Research - peer-reviewArticle

DNA Methylation
Schizophrenia
Genome
Endophenotypes
African Americans

Automated quality assessment of structural magnetic resonance brain images based on a supervised machine learning algorithm

Pizarro, R. A., Cheng, X., Barnett, A., Lemaitre, H., Verchinski, B. A., Goldman, A. L., Xiao, E., Luo, Q., Berman, K. F., Callicott, J. H., Weinberger, D. R. & Mattay, V. S. Dec 19 2016 In : Frontiers in Neuroinformatics. 10, 52

Research output: Research - peer-reviewArticle

Magnetic resonance
Magnetic resonance imaging
Learning algorithms
Learning systems
Brain

Behavioral, neurophysiological, and synaptic impairment in a transgenic neuregulin1 (NRG1-IV) murine schizophrenia model

Papaleo, F., Yang, F., Paterson, C., Palumbo, S., Carr, G. V., Wang, Y., Floyd, K., Huang, W., Thomas, C. J., Chen, J., Weinberger, D. R. & Law, A. J. Apr 27 2016 In : Journal of Neuroscience. 36, 17, p. 4859-4875 17 p.

Research output: Research - peer-reviewArticle

Neuregulin-1
Schizophrenia
Sensory Gating
Genes
Neurobiology
Catechol O-Methyltransferase
Phencyclidine
Memory Disorders
Transgenic Mice
Brain

Differential response to risperidone in schizophrenia patients by KCNH2Genotype and drug metabolizer status

Heide, J., Zhang, F., Bigos, K. L., Mann, S. A., Carr, V. J., Weickert, C. S., Green, M. J., Weinberger, D. R. & Vandenberg, J. I. Jan 1 2016 In : American Journal of Psychiatry. 173, 1, p. 53-59 7 p.

Research output: Research - peer-reviewArticle

Risperidone
Schizophrenia
Pharmaceutical Preparations
Antipsychotic Agents
Protein Isoforms

Dissociating Bottom-Up and Top-Down Mechanisms in the Cortico-Limbic System during Emotion Processing

Comte, M., Schön, D., Coull, J. T., Reynaud, E., Khalfa, S., Belzeaux, R., Ibrahim, E. C., Guedj, E., Blin, O., Weinberger, D. R. & Fakra, E. Jan 1 2016 In : Cerebral Cortex. 26, 1, p. 144-155 12 p.

Research output: Research - peer-reviewArticle

Limbic System
Prefrontal Cortex
Emotions
Gyrus Cinguli
Amygdala

Dynamic regulation of RNA editing in human brain development and disease

Hwang, T., Park, C. K., Leung, A. K. L., Gao, Y., Hyde, T. M., Kleinman, J. E., Rajpurohit, A., Tao, R., Shin, J. H. & Weinberger, D. R. Aug 1 2016 In : Nature Neuroscience. 19, 8, p. 1093-1099 7 p.

Research output: Research - peer-reviewArticle

RNA Editing
Brain Diseases
Human Development
RNA
Brain

Editorial overview: Neurobiology of disease

Selkoe, D. J. & Weinberger, D. R. Feb 1 2016 In : Current Opinion in Neurobiology. 36, p. v-vii

Research output: Research - peer-reviewEditorial

Estimating changing contexts in schizophrenia

Kaplan, C. M., Saha, D., Molina, J. L., Hockeimer, W. D., Postell, E. M., Apud, J. A., Weinberger, D. R. & Tan, H. Y. Jul 1 2016 In : Brain. 139, 7, p. 2082-2095 14 p.

Research output: Research - peer-reviewArticle

Schizophrenia
Prefrontal Cortex
Delusions
Experiment
Mesencephalon

Finding the elusive psychiatric "lesion" with 21st-century neuroanatomy: A note of caution

Weinberger, D. R. & Radulescu, E. Jan 1 2016 In : American Journal of Psychiatry. 173, 1, p. 27-33 7 p.

Research output: Research - peer-reviewReview article

Neuroanatomy
Artifacts
Psychiatry
Diffusion Tensor Imaging
Psychotropic Drugs

GAD2 alternative transcripts in the human prefrontal cortex, and in schizophrenia and affective disorders

Davis, K. N., Tao, R., Li, C., Gao, Y., Gondré-Lewis, M. C., Lipska, B. K., Shin, J. H., Xie, B., Ye, T., Weinberger, D. R., Kleinman, J. E. & Hyde, T. M. Feb 1 2016 In : PLoS ONE. 11, 2, e0148558

Research output: Research - peer-reviewArticle

Prefrontal Cortex
Mood Disorders
Schizophrenia
prefrontal cortex
schizophrenia

Genetic Disruption of Arc/Arg3.1 in Mice Causes Alterations in Dopamine and Neurobehavioral Phenotypes Related to Schizophrenia

Managò, F., Mereu, M., Mastwal, S., Mastrogiacomo, R., Scheggia, D., Emanuele, M., De Luca, M. A., Weinberger, D. R., Wang, K. H. & Papaleo, F. Aug 23 2016 In : Cell Reports. 16, 8, p. 2116-2128 13 p.

Research output: Research - peer-reviewArticle

Cytoskeleton
Dopamine
Schizophrenia
Phenotype
Proteins

Genetic risk mechanisms of posttraumatic stress disorder in the human brain

Bharadwaj, R. A., Jaffe, A. E., Chen, Q., Deep-Soboslay, A., Goldman, A. L., Mighdoll, M. I., Cotoia, J. A., Brandtjen, A. C., Shin, J., Hyde, T. M., Mattay, V. S., Weinberger, D. R. & Kleinman, J. E. 2016 (Accepted/In press) In : Journal of Neuroscience Research.

Research output: Research - peer-reviewArticle

Post-Traumatic Stress Disorders
Brain
Genotype
Gene Expression
Amygdala

Genomic structure and expression of the human serotonin 2A receptor gene (HTR2A) locus: Identification of novel HTR2A and antisense (HTR2A-AS1) exons

Ruble, C. L., Smith, R. M., Calley, J., Munsie, L., Airey, D. C., Gao, Y., Shin, J. H., Hyde, T. M., Straub, R. E., Weinberger, D. R. & Nisenbaum, L. K. Jan 6 2016 In : BMC Genetics. 17, 1, 16

Research output: Research - peer-reviewArticle

Receptor, Serotonin, 5-HT2A
Exons
Genes
Single Nucleotide Polymorphism
Protein Isoforms

Genotype-Dependent Effects of COMT Inhibition on Cognitive Function in a Highly Specific, Novel Mouse Model of Altered COMT Activity

Barkus, C., Korn, C., Stumpenhorst, K., Laatikainen, L. M., Ballard, D., Lee, S., Sharp, T., Harrison, P. J., Bannerman, D. M., Weinberger, D. R., Chen, J. & Tunbridge, E. M. Dec 1 2016 In : Neuropsychopharmacology. 41, 13, p. 3060-3069 10 p.

Research output: Research - peer-reviewArticle

Catechol O-Methyltransferase
Cognition
Genotype
Inhibition (Psychology)
Dopamine

Impact of a cis-associated gene expression SNP on chromosome 20q11.22 on bipolar disorder susceptibility, hippocampal structure and cognitive performance

Li, M. , Luo, X. J. , Landén, M. , Bergen, S. E. , Hultman, C. M. , Li, X. , Zhang, W. , Yao, Y. G. , Zhang, C. , Liu, J. , Mattheisen, M. , Cichon, S. , Mühleisen, T. W. , Degenhardt, F. A. , Nöthen, M. M. , Schulze, T. G. , Grigoroiu-Serbanescu, M. , Li, H. , Fuller, C. K. , Chen, C. & 25 others Dong, Q., Chen, C., Jamain, S., Leboyer, M., Bellivier, F., Etain, B., Kahn, J. P., Henry, C., Preisig, M., Kutalik, Z., Castelao, E., Wright, A., Mitchell, P. B., Fullerton, J. M., Schofield, P. R., Montgomery, G. W., Medland, S. E., Gordon, S. D., Martin, N. G., Rietschel, M., Liu, C., Kleinman, J. E., Hyde, T. M., Weinberger, D. R. & Su, B. Feb 1 2016 In : British Journal of Psychiatry. 208, 2, p. 128-137 10 p.

Research output: Research - peer-reviewArticle

Bipolar Disorder
Single Nucleotide Polymorphism
Chromosomes
Gene Expression
Quantitative Trait Loci

Invalid assumptions in clustering analyses of category fluency data: Reply to Sung, Gordon and Schretlen (2015)

Verheyen, S., Voorspoels, W., Longenecker, J., Weinberger, D. R., Elvevåg, B. & Storms, G. Feb 1 2016 In : Cortex. 75, p. 255-259 5 p.

Research output: Research - peer-reviewComment/debate

KCNH2-3.1 expression impairs cognition and alters neuronal function in a model of molecular pathology associated with schizophrenia

Carr, G. V., Chen, J., Yang, F., Ren, M., Yuan, P., Tian, Q., Bebensee, A., Zhang, G. Y., Du, J., Glineburg, P., Xun, R., Akhile, O., Akuma, D., Pickel, J., Barrow, J. C., Papaleo, F. & Weinberger, D. R. Nov 1 2016 In : Molecular Psychiatry. 21, 11, p. 1517-1526 10 p.

Research output: Research - peer-reviewArticle

Molecular Pathology
Cognition
Transgenic Mice
Schizophrenia
Prefrontal Cortex

Leveraging Genomic Annotations and Pleiotropic Enrichment for Improved Replication Rates in Schizophrenia GWAS

Wang, Y. , Thompson, W. K. , Schork, A. J. , Holland, D. , Chen, C. H. , Bettella, F. , Desikan, R. S. , Li, W. , Witoelar, A. , Zuber, V. , Devor, A. , Nöthen, M. M. , Rietschel, M. , Chen, Q. , Werge, T. , Cichon, S. , Weinberger, D. R. , Djurovic, S. , O’Donovan, M. , Visscher, P. M. & 4 others Andreassen, O. A., Dale, A. M., Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium & Enhancing Neuro Imaging Genetics through Meta Analysis Consortium 2016 In : PLoS Genetics. 12, 1, e1005803

Research output: Research - peer-reviewArticle

genomics
genome-wide association study
schizophrenia
genome
rate

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

Jo, J. , Xiao, Y. , Sun, A. X. , Cukuroglu, E. , Tran, H. D. , Göke, J. , Tan, Z. Y. , Saw, T. Y. , Tan, C. P. , Lokman, H. , Lee, Y. , Kim, D. , Ko, H. S. , Kim, S. O. , Park, J. H. , Cho, N. J. , Hyde, T. M. , Kleinman, J. E. , Shin, J. H. , Weinberger, D. R. & 3 others Tan, E. K., Je, H. S. & Ng, H. H. Aug 4 2016 In : Cell Stem Cell. 19, 2, p. 248-257 10 p.

Research output: Research - peer-reviewArticle

Organoids
Pluripotent Stem Cells
Mesencephalon
Neurons
neuromelanin

No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study

Johnson, E. C. , Bjelland, D. W. , Howrigan, D. P. , Abdellaoui, A. , Breen, G. , Borglum, A. , Cichon, S. , Degenhardt, F. , Forstner, A. J. , Frank, J. , Genovese, G. , Heilmann-Heimbach, S. , Herms, S. , Hoffman, P. , Maier, W. , Mattheisen, M. , Morris, D. , Mowry, B. , Müller-Mhysok, B. , Neale, B. & 298 others Nenadic, I., Nöthen, M. M., O’Dushlaine, C., Rietschel, M., Ruderfer, D. M., Rujescu, D., Schulze, T. G., Simonson, M. A., Stahl, E., Strohmaier, J., Witt, S. H., Ripke, S., Neale, B. M., Corvin, A., Walters, J. T. R., Farh, K. H., Holmans, P. A., Lee, P., Bulik-Sullivan, B., Collier, D. A., Huang, H., Pers, T. H., Agartz, I., Agerbo, E., Albus, M., Alexander, M., Amin, F., Bacanu, S. A., Begemann, M., Belliveau, R. A., Bene, J., Bergen, S. E., Bevilacqua, E., Bigdeli, T. B., Black, D. W., Bruggeman, R., Buccola, N. G., Buckner, R. L., Byerley, W., Cahn, W., Cai, G., Campion, D., Cantor, R. M., Carr, V. J., Carrera, N., Catts, S. V., Chambert, K. D., Chan, R. C. K., Chen, R. Y. L., Chen, E. Y. H., Cheng, W., Cheung, E. F. C., Chong, S. A., Robert Cloninger, C., Cohen, D., Cohen, N., Cormican, P., Craddock, N., Crowley, J. J., Curtis, D., Davidson, M., Davis, K. L., Del Favero, J., Demontis, D., Dikeos, D., Dinan, T., Djurovic, S., Donohoe, G., Drapeau, E., Duan, J., Dudbridge, F., Durmishi, N., Eichhammer, P., Eriksson, J., Escott-Price, V., Essioux, L., Fanous, A. H., Farrell, M. S., Franke, L., Freedman, R., Freimer, N. B., Friedl, M., Friedman, J. I., Fromer, M., Georgieva, L., Giegling, I., Giusti-Rodríguez, P., Godard, S., Goldstein, J. I., Golimbet, V., Gopal, S., Gratten, J., de Haan, L., Hammer, C., Hamshere, M. L., Hansen, M., Hansen, T., Haroutunian, V., Hartmann, A. M., Henskens, F. A., Hirschhorn, J. N., Hoffmann, P., Hofman, A., Hollegaard, M. V., Hougaard, D. M., Ikeda, M., Joa, I., Julià, A., Kahn, R. S., Kalaydjieva, L., Karachanak-Yankova, S., Karjalainen, J., Kavanagh, D., Kennedy, J. L., Khrunin, A., Kim, Y., Klovins, J., Knowles, J. A., Konte, B., Kucinskas, V., Kucinskiene, Z. A., Kuzelova-Ptackova, H., Kähler, A. K., Laurent, C., Chee Keong, J. L., Hong Lee, S., Legge, S. E., Lerer, B., Li, M., Li, T., Liang, K. Y., Lieberman, J., Limborska, S., Loughland, C. M., Lubinski, J., Lönnqvist, J., Macek, M., Magnusson, P. K. E., Maher, B. S., Mallet, J., Marsal, S., Mattingsdal, M., McCarley, R. W., McDonald, C., McIntosh, A. M., Meier, S., Meijer, C. J., Melegh, B., Melle, I., Mesholam-Gately, R. I., Metspalu, A., Michie, P. T., Milani, L., Milanova, V., Mokrab, Y., Morris, D. W., Mors, O., Murphy, K. C., Murray, R. M., Myin-Germeys, I., Müller-Myhsok, B., Nelis, M., Nertney, D. A., Nestadt, G., Nicodemus, K. K., Nikitina-Zake, L., Nisenbaum, L., Nordin, A., O'Callaghan, E., O'Dushlaine, C., Anthony O'Neill, F., Oh, S. Y., Olincy, A., Olsen, L., Van Os, J., Pantelis, C., Papadimitriou, G. N., Papiol, S., Parkhomenko, E., Pato, M. T., Paunio, T., Pejovic-Milovancevic, M., Perkins, D. O., Pietiläinen, O., Pimm, J., Pocklington, A. J., Powell, J., Price, A., Pulver, A. E., Purcell, S. M., Quested, D., Rasmussen, H. B., Reichenberg, A., Reimers, M. A., Richards, A. L., Roffman, J. L., Roussos, P., Salomaa, V., Sanders, A. R., Schall, U., Schubert, C. R., Schwab, S. G., Scolnick, E. M., Scott, R. J., Seidman, L. J., Shi, J., Sigurdsson, E., Silagadze, T., Silverman, J. M., Sim, K., Slominsky, P., Smoller, J. W., So, H. C., Spencer, C. C. A., Stahl, E. A., Stefansson, H., Steinberg, S., Stogmann, E., Straub, R. E., Strengman, E., Scott Stroup, T., Subramaniam, M., Suvisaari, J., Svrakic, D. M., Szatkiewicz, J. P., Söderman, E., Thirumalai, S., Toncheva, D., Tosato, S., Veijola, J., Waddington, J., Walsh, D., Wang, D., Wang, Q., Webb, B. T., Weiser, M., Wildenauer, D. B., Williams, N. M., Williams, S., Wolen, A. R., Wong, E. H. M., Wormley, B. K., Xi, H. S., Zai, C. C., Zheng, X., Zimprich, F., Wray, N. R., Stefansson, K., Visscher, P. M., Adolfsson, R., Andreassen, O. A., Blackwood, D. H. R., Bramon, E., Buxbaum, J. D., Børglum, A. D., Darvasi, A., Domenici, E., Ehrenreich, H., Esko, T., Gejman, P. V., Gill, M., Gurling, H., Hultman, C. M., Iwata, N., Jablensky, A. V., Jönsson, E. G., Kendler, K. S., Kirov, G., Knight, J., Lencz, T., Levinson, D. F., Li, Q. S., Liu, J., Malhotra, A. K., McCarroll, S. A., McQuillin, A., Moran, J. L., Mortensen, P. B., Mowry, B. J., Nöthen, M. M., Ophoff, R. A., Owen, M. J., Palotie, A., Pato, C. N., Petryshen, T. L., Posthuma, D., Riley, B. P., Sham, P. C., Sklar, P., Clair, D. S., Weinberger, D. R., Wendland, J. R., Werge, T., Daly, M. J., O'Donovan, M. C., Sullivan, P. F., Keller, M. C. & Schizophrenia Working Group of the Psychiatric Genomics Consortium Oct 1 2016 In : PLoS Genetics. 12, 10, e1006343

Research output: Research - peer-reviewArticle

inbreeding
genome
effect
homozygosity
schizophrenia

Novel genetic loci underlying human intracranial volume identified through genome-wide association

Adams, H. H. H. , Hibar, D. P. , Chouraki, V. , Stein, J. L. , Nyquist, P. A. , Rentería, M. E. , Trompet, S. , Arias-Vasquez, A. , Seshadri, S. , Desrivières, S. , Beecham, A. H. , Jahanshad, N. , Wittfeld, K. , van der Lee, S. J. , Abramovic, L. , Alhusaini, S. , Amin, N. , Andersson, M. , Arfanakis, K. , Aribisala, B. S. & 322 others Armstrong, N. J., Athanasiu, L., Axelsson, T., Beiser, A., Bernard, M., Bis, J. C., Blanken, L. M. E., Blanton, S. H., Bohlken, M. M., Boks, M. P., Bralten, J., Brickman, A. M., Carmichael, O., Chakravarty, M. M., Chauhan, G., Chen, Q., Ching, C. R. K., Cuellar-Partida, G., Braber, A. D., Doan, N. T., Ehrlich, S., Filippi, I., Ge, T., Giddaluru, S., Goldman, A. L., Gottesman, R. F., Greven, C. U., Grimm, O., Griswold, M. E., Guadalupe, T., Hass, J., Haukvik, U. K., Hilal, S., Hofer, E., Hoehn, D., Holmes, A. J., Hoogman, M., Janowitz, D., Jia, T., Kasperaviciute, D., Kim, S., Klein, M., Kraemer, B., Lee, P. H., Liao, J., Liewald, D. C. M., Lopez, L. M., Luciano, M., Macare, C., Marquand, A., Matarin, M., Mather, K. A., Mattheisen, M., Mazoyer, B., McKay, D. R., McWhirter, R., Milaneschi, Y., Mirza-Schreiber, N., Muetzel, R. L., Maniega, S. M., Nho, K., Nugent, A. C., Loohuis, L. M. O., Oosterlaan, J., Papmeyer, M., Pappa, I., Pirpamer, L., Pudas, S., Pütz, B., Rajan, K. B., Ramasamy, A., Richards, J. S., Risacher, S. L., Roiz-Santiañez, R., Rommelse, N., Rose, E. J., Royle, N. A., Rundek, T., Sämann, P. G., Satizabal, C. L., Schmaal, L., Schork, A. J., Shen, L., Shin, J., Shumskaya, E., Smith, A. V., Sprooten, E., Strike, L. T., Teumer, A., Thomson, R., Tordesillas-Gutierrez, D., Toro, R., Trabzuni, D., Vaidya, D., van der Grond, J., van der Meer, D., van Donkelaar, M. M. J., van Eijk, K. R., van Erp, T. G. M., van Rooij, D., Walton, E., Westlye, L. T., Whelan, C. D., Windham, B. G., Winkler, A. M., Woldehawariat, G., Wolf, C., Wolfers, T., Xu, B., Yanek, L. R., Yang, J., Zijdenbos, A., Zwiers, M. P., Agartz, I., Aggarwal, N. T., Almasy, L., Ames, D., Amouyel, P., Andreassen, O. A., Arepalli, S., Assareh, A. A., Barral, S., Bastin, M. E., Becker, D. M., Becker, J. T., Bennett, D. A., Blangero, J., van Bokhoven, H., Boomsma, D. I., Brodaty, H., Brouwer, R. M., Brunner, H. G., Buckner, R. L., Buitelaar, J. K., Bulayeva, K. B., Cahn, W., Calhoun, V. D., Cannon, D. M., Cavalleri, G. L., Chen, C., Cheng, C. Y., Cichon, S., Cookson, M. R., Corvin, A., Crespo-Facorro, B., Curran, J. E., Czisch, M., Dale, A. M., Davies, G. E., de Geus, E. J. C., de Jager, P. L., de Zubicaray, G. I., Delanty, N., Depondt, C., DeStefano, A. L., Dillman, A., Djurovic, S., Donohoe, G., Drevets, W. C., Duggirala, R., Dyer, T. D., Erk, S., Espeseth, T., Evans, D. A., Fedko, I. O., Fernández, G., Ferrucci, L., Fisher, S. E., Fleischman, D. A., Ford, I., Foroud, T. M., Fox, P. T., Francks, C., Fukunaga, M., Gibbs, J. R., Glahn, D. C., Gollub, R. L., Göring, H. H. H., Grabe, H. J., Green, R. C., Gruber, O., Gudnason, V., Guelfi, S., Hansell, N. K., Hardy, J., Hartman, C. A., Hashimoto, R., Hegenscheid, K., Heinz, A., Le Hellard, S., Hernandez, D. G., Heslenfeld, D. J., Ho, B. C., Hoekstra, P. J., Hoffmann, W., Hofman, A., Holsboer, F., Homuth, G., Hosten, N., Hottenga, J. J., Pol, H. E. H., Ikeda, M., Ikram, M. K., Jr, C. R. J., Jenkinson, M., Johnson, R., Jönsson, E. G., Jukema, J. W., Kahn, R. S., Kanai, R., Kloszewska, I., Knopman, D. S., Kochunov, P., Kwok, J. B., Lawrie, S. M., Lemaître, H., Liu, X., Longo, D. L., Jr, W. T. L., Lopez, O. L., Lovestone, S., Martinez, O., Martinot, J. L., Mattay, V. S., McDonald, C., McIntosh, A. M., McMahon, K. L., McMahon, F. J., Mecocci, P., Melle, I., Meyer-Lindenberg, A., Mohnke, S., Montgomery, G. W., Morris, D. W., Mosley, T. H., Mühleisen, T. W., Müller-Myhsok, B., Nalls, M. A., Nauck, M., Nichols, T. E., Niessen, W. J., Nöthen, M. M., Nyberg, L., Ohi, K., Olvera, R. L., Ophoff, R. A., Pandolfo, M., Paus, T., Pausova, Z., Penninx, B. W. J. H., Pike, G. B., Potkin, S. G., Psaty, B. M., Reppermund, S., Rietschel, M., Roffman, J. L., Romanczuk-Seiferth, N., Rotter, J. I., Ryten, M., Sacco, R. L., Sachdev, P. S., Saykin, A. J., Schmidt, R., Schofield, P. R., Sigurdsson, S., Simmons, A., Singleton, A., Sisodiya, S. M., Smith, C., Smoller, J. W., Soininen, H., Srikanth, V., Steen, V. M., Stott, D. J., Sussmann, J. E., Thalamuthu, A., Tiemeier, H., Toga, A. W., Traynor, B. J., Troncoso, J., Turner, J. A., Tzourio, C., Uitterlinden, A. G., Hernández, M. C. V., van der Brug, M., van der Lugt, A., van der Wee, N. J. A., van Duijn, C. M., van Haren, N. E. M., van ′t Ent, D., van Tol, M. J., Vardarajan, B. N., Veltman, D. J., Vernooij, M. W., Völzke, H., Walter, H., Wardlaw, J. M., Wassink, T. H., Weale, M. E., Weinberger, D. R., Weiner, M. W., Wen, W., Westman, E., White, T., Wong, T. Y., Wright, C. B., Zielke, H. R., Zonderman, A. B., Deary, I. J., DeCarli, C., Schmidt, H., Martin, N. G., de Craen, A. J. M., Wright, M. J., Launer, L. J., Schumann, G., Fornage, M., Franke, B., Debette, S., Medland, S. E., Ikram, M. A. & Thompson, P. M. Oct 3 2016 (Accepted/In press) In : Nature Neuroscience.

Research output: Research - peer-reviewArticle

Genetic Loci
Genome
Genes
Genome-Wide Association Study
Phosphatidylinositol 3-Kinases

Prefrontal GABA levels measured with magnetic resonance spectroscopy in patients with psychosis and unaffected siblings

Marenco, S., Meyer, C., Kuo, S., Van Der Veen, J. W., Shen, J., DeJong, K., Barnett, A. S., Apud, J. A., Dickinson, D., Weinberger, D. R. & Berman, K. F. May 1 2016 In : American Journal of Psychiatry. 173, 5, p. 527-534 8 p.

Research output: Research - peer-reviewArticle

Psychotic Disorders
gamma-Aminobutyric Acid
Siblings
Magnetic Resonance Spectroscopy
Antipsychotic Agents

Regional variations in brain gyrification are associated with general cognitive ability in humans

Gregory, M. D., Kippenhan, J. S., Dickinson, D., Carrasco, J., Mattay, V. S., Weinberger, D. R. & Berman, K. F. May 23 2016 In : Current Biology. 26, 10, p. 1301-1305 5 p.

Research output: Research - peer-reviewArticle

Aptitude
Brain
brain
Intelligence
Gyrus Cinguli

Regulation of Brain-Derived Neurotrophic Factor Exocytosis and Gamma-Aminobutyric Acidergic Interneuron Synapse by the Schizophrenia Susceptibility Gene Dysbindin-1

Yuan, Q., Yang, F., Xiao, Y., Tan, S., Husain, N., Ren, M., Hu, Z., Martinowich, K., Ng, J. S., Kim, P. J., Han, W., Nagata, K. I., Weinberger, D. R. & Je, H. S. Aug 15 2016 In : Biological Psychiatry. 80, 4, p. 312-322 11 p.

Research output: Research - peer-reviewArticle

Brain-Derived Neurotrophic Factor
Exocytosis
Interneurons
Synapses
Schizophrenia

Seeking optimal region-of-interest (ROI) single-value summary measures for fMRI studies in imaging genetics

Tong, Y., Chen, Q., Nichols, T. E., Rasetti, R., Callicott, J. H., Berman, K. F., Weinberger, D. R. & Mattay, V. S. Mar 1 2016 In : PLoS ONE. 11, 3, e0151391

Research output: Research - peer-reviewArticle

magnetic resonance imaging
image analysis
genome
Genes
Imaging techniques

Strong Components of Epigenetic Memory in Cultured Human Fibroblasts Related to Site of Origin and Donor Age

Ivanov, N. A., Tao, R., Chenoweth, J. G., Brandtjen, A., Mighdoll, M. I., Genova, J. D., McKay, R. D., Jia, Y., Weinberger, D. R., Kleinman, J. E., Hyde, T. M. & Jaffe, A. E. Feb 1 2016 In : PLoS Genetics. 12, 2, e1005819

Research output: Research - peer-reviewArticle

Epigenomics
Fibroblasts
Tissue Donors
tissue
epigenetics

The impact of Val108/158Met polymorphism of catechol-O-methyltransferase on brain oscillations during working memory

Altamura, M., Elvevåg, B., Goldberg, T. E., Carver, F. W., Weinberger, D. R. & Coppola, R. Jan 1 2016 In : Neuroscience Letters. 610, p. 86-91 6 p.

Research output: Research - peer-reviewArticle

Catechol O-Methyltransferase
Short-Term Memory
Brain
Magnetoencephalography
Parietal Lobe
2015

A common polymorphism in SCN2A predicts general cognitive ability through effects on PFC physiology

Scult, M. A., Trampush, J. W., Zheng, F., Conley, E. D., Lencz, T., Malhotra, A. K., Dickinson, D., Weinberger, D. R. & Hariri, A. R. 2015 In : Journal of Cognitive Neuroscience. 27, 9, p. 1766-1774 9 p.

Research output: Research - peer-reviewArticle

Physiology
Cognitive Ability
Polymorphism
Aptitude
physiology

A variable number of tandem repeats in the 3′-untranslated region of the dopamine transporter modulates striatal function during working memory updating across the adult age span

Sambataro, F., Podell, J. E., Murty, V. P., Das, S., Kolachana, B., Goldberg, T. E., Weinberger, D. R. & Mattay, V. S. Aug 1 2015 In : European Journal of Neuroscience. 42, 3, p. 1912-1918 7 p.

Research output: Research - peer-reviewArticle

Corpus Striatum
Minisatellite Repeats
Dopamine Plasma Membrane Transport Proteins
3' Untranslated Regions
Short-Term Memory

BrainSeq: Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders

Schubert, C. R. , O'Donnell, P. , Quan, J. , Wendland, J. R. , Xi, H. S. , Winslow, A. R. , Domenici, E. , Essioux, L. , Kam-Thong, T. , Airey, D. C. , Calley, J. N. , Collier, D. A. , Wang, H. , Eastwood, B. , Ebert, P. , Liu, Y. , Nisenbaum, L. , Ruble, C. , Scherschel, J. , Smith, R. M. & 20 others Qian, H. R., Merchant, K., Didriksen, M., Matsumoto, M., Saito, T., Brandon, N. J., Cross, A. J., Wang, Q., Manji, H., Kolb, H., Furey, M., Drevets, W. C., Shin, J. H., Jaffe, A. E., Jia, Y., Straub, R. E., Deep-Soboslay, A., Hyde, T. M., Kleinman, J. E. & Weinberger, D. R. 2015 In : Neuron. 88, 6, p. 1078-1083 6 p.

Research output: Research - peer-reviewShort survey

Brain
Drive
Mood Disorders
Epigenomics
Biomedical Research

Common genetic variants influence human subcortical brain structures

Hibar, D. P. , Stein, J. L. , Renteria, M. E. , Arias-Vasquez, A. , Desrivières, S. , Jahanshad, N. , Toro, R. , Wittfeld, K. , Abramovic, L. , Andersson, M. , Aribisala, B. S. , Armstrong, N. J. , Bernard, M. , Bohlken, M. M. , Boks, M. P. , Bralten, J. , Brown, A. A. , Mallar Chakravarty, M. , Chen, Q. , Ching, C. R. K. & 267 others Cuellar-Partida, G., Den Braber, A., Giddaluru, S., Goldman, A. L., Grimm, O., Guadalupe, T., Hass, J., Woldehawariat, G., Holmes, A. J., Hoogman, M., Janowitz, D., Jia, T., Kim, S., Klein, M., Kraemer, B., Lee, P. H., Olde Loohuis, L. M., Luciano, M., MacAre, C., Mather, K. A., Mattheisen, M., Milaneschi, Y., Nho, K., Papmeyer, M., Ramasamy, A., Risacher, S. L., Roiz-Santiañez, R., Rose, E. J., Salami, A., Sämann, P. G., Schmaal, L., Schork, A. J., Shin, J., Strike, L. T., Teumer, A., Van Donkelaar, M. M. J., Van Eijk, K. R., Walters, R. K., Westlye, L. T., Whelan, C. D., Winkler, A. M., Zwiers, M. P., Alhusaini, S., Athanasiu, L., Ehrlich, S., Hakobjan, M. M. H., Hartberg, C. B., Haukvik, U. K., Heister, A. J. G. A. M., Hoehn, D., Kasperaviciute, D., Liewald, D. C. M., Lopez, L. M., Makkinje, R. R. R., Matarin, M., Naber, M. A. M., Reese McKay, D., Needham, M., Nugent, A. C., Pütz, B., Royle, N. A., Shen, L., Sprooten, E., Trabzuni, D., Van Der Marel, S. S. L., Van Hulzen, K. J. E., Walton, E., Wolf, C., Almasy, L., Ames, D., Arepalli, S., Assareh, A. A., Bastin, M. E., Brodaty, H., Bulayeva, K. B., Carless, M. A., Cichon, S., Corvin, A., Curran, J. E., Czisch, M., De Zubicaray, G. I., Dillman, A., Duggirala, R., Dyer, T. D., Erk, S., Fedko, I. O., Ferrucci, L., Foroud, T. M., Fox, P. T., Fukunaga, M., Raphael Gibbs, J., Göring, H. H. H., Green, R. C., Guelfi, S., Hansell, N. K., Hartman, C. A., Hegenscheid, K., Heinz, A., Hernandez, D. G., Heslenfeld, D. J., Hoekstra, P. J., Holsboer, F., Homuth, G., Hottenga, J. J., Ikeda, M., Jack, C. R., Jenkinson, M., Johnson, R., Kanai, R., Keil, M., Kent, J. W., Kochunov, P., Kwok, J. B., Lawrie, S. M., Liu, X., Longo, D. L., McMahon, K. L., Meisenzahl, E., Melle, I., Mohnke, S., Montgomery, G. W., Mostert, J. C., Mühleisen, T. W., Nalls, M. A., Nichols, T. E., Nilsson, L. G., Nöthen, M. M., Ohi, K., Olvera, R. L., Perez-Iglesias, R., Bruce Pike, G., Potkin, S. G., Reinvang, I., Reppermund, S., Rietschel, M., Romanczuk-Seiferth, N., Rosen, G. D., Rujescu, D., Schnell, K., Schofield, P. R., Smith, C., Steen, V. M., Sussmann, J. E., Thalamuthu, A., Toga, A. W., Traynor, B. J., Troncoso, J., Turner, J. A., Valdés Hernández, M. C., Van 'T Ent, D., Van Der Brug, M., Van Der Wee, N. J. A., Van Tol, M. J., Veltman, D. J., Wassink, T. H., Westman, E., Zielke, R. H., Zonderman, A. B., Ashbrook, D. G., Hager, R., Lu, L., McMahon, F. J., Morris, D. W., Williams, R. W., Brunner, H. G., Buckner, R. L., Buitelaar, J. K., Cahn, W., Calhoun, V. D., Cavalleri, G. L., Crespo-Facorro, B., Dale, A. M., Davies, G. E., Delanty, N., Depondt, C., Djurovic, S., Drevets, W. C., Espeseth, T., Gollub, R. L., Ho, B. C., Hoffmann, W., Hosten, N., Kahn, R. S., Le Hellard, S., Meyer-Lindenberg, A., Müller-Myhsok, B., Nauck, M., Nyberg, L., Pandolfo, M., Penninx, B. W. J. H., Roffman, J. L., Sisodiya, S. M., Smoller, J. W., Van Bokhoven, H., Van Haren, N. E. M., Völzke, H., Walter, H., Weiner, M. W., Wen, W., White, T., Agartz, I., Andreassen, O. A., Blangero, J., Boomsma, D. I., Brouwer, R. M., Cannon, D. M., Cookson, M. R., De Geus, E. J. C., Deary, I. J., Donohoe, G., Fernández, G., Fisher, S. E., Francks, C., Glahn, D. C., Grabe, H. J., Gruber, O., Hardy, J., Hashimoto, R., Hulshoff Pol, H. E., Jönsson, E. G., Kloszewska, I., Lovestone, S., Mattay, V. S., Mecocci, P., McDonald, C., McIntosh, A. M., Ophoff, R. A., Paus, T., Pausova, Z., Ryten, M., Sachdev, P. S., Saykin, A. J., Simmons, A., Singleton, A., Soininen, H., Wardlaw, J. M., Weale, M. E., Weinberger, D. R., Adams, H. H. H., Launer, L. J., Seiler, S., Schmidt, R., Chauhan, G., Satizabal, C. L., Becker, J. T., Yanek, L., Van Der Lee, S. J., Ebling, M., Fischl, B., Longstreth, W. T., Greve, D., Schmidt, H., Nyquist, P., Vinke, L. N., Van Duijn, C. M., Xue, L., Mazoyer, B., Bis, J. C., Gudnason, V., Seshadri, S., Ikram, M. A., Martin, N. G., Wright, M. J., Schumann, G., Franke, B., Thompson, P. M. & Medland, S. E. Apr 9 2015 In : Nature. 520, 7546, p. 224-229 6 p.

Research output: Research - peer-reviewArticle

Brain
Putamen
Developmental Genes
Transport Vesicles
Caudate Nucleus

COMT genetic reduction produces sexually divergent effects on cortical anatomy and working memory in mice and humans

Sannino, S., Gozzi, A., Cerasa, A., Piras, F., Scheggia, D., Managò, F., Damiano, M., Galbusera, A., Erickson, L. C., De Pietri Tonelli, D., Bifone, A., Tsaftaris, S. A., Caltagirone, C., Weinberger, D. R., Spalletta, G. & Papaleo, F. Sep 1 2015 In : Cerebral Cortex. 25, 9, p. 2529-2541 13 p.

Research output: Research - peer-reviewArticle

Catechol O-Methyltransferase
Short-Term Memory
Anatomy
Prefrontal Cortex
Brain

DEGS2 polymorphism associated with cognition in schizophrenia is associated with gene expression in brain

Ohi, K., Ursini, X., Li, M., Shin, J. H., Ye, T., Chen, Q., Tao, R., Kleinman, J. E., Hyde, T. M., Hashimoto, R. & Weinberger, D. R. May 26 2015 In : Translational Psychiatry. 5, 4, e550

Research output: Research - peer-reviewArticle

Cognition
Schizophrenia
Gene Expression
Brain
Genome-Wide Association Study

Developmental regulation of human cortex transcription and its clinical relevance at single base resolution

Jaffe, A. E., Shin, J., Collado-Torres, L., Leek, J. T., Tao, R., Li, C., Gao, Y., Jia, Y., Maher, B. J., Hyde, T. M., Kleinman, J. E. & Weinberger, D. R. Jan 1 2015 In : Nature Neuroscience. 18, 1, p. 154-161 8 p.

Research output: Research - peer-reviewArticle

Brain
Transcriptome
Gene Expression Profiling
Prefrontal Cortex
Chromatin