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2017

Abdominal schwannomas: review of imaging findings and pathology

Lee, N. J., Hruban, R. H. & Fishman, E. K. Mar 6 2017 (Accepted/In press) In : Abdominal Radiology. p. 1-7 7 p.

Research output: Contribution to journalArticle

Neurilemmoma
Pathology
Neoplasms
Differential Diagnosis

Accuracy of apparent diffusion coefficient in differentiating pancreatic neuroendocrine tumour from intrapancreatic accessory spleen

Pandey, A., Pandey, P., Ghasabeh, M. A., Varzaneh, F. N., Khoshpouri, P., Shao, N., Pour, M. Z., Fouladi, D. F., Hruban, R. H., O’Broin-Lennon, A. M. & Kamel, I. R. Nov 13 2017 (Accepted/In press) In : European Radiology. p. 1-8 8 p.

Research output: Contribution to journalArticle

Neuroendocrine Tumors
Spleen
Unnecessary Procedures
Pancreatectomy
ROC Curve

Alterations of type II classical cadherin, cadherin-10 (CDH10), is associated with pancreatic ductal adenocarcinomas

Jinawath, N., Shiao, M. S., Norris, A., Murphy, K., Klein, A. P., Yonescu, R., Iacobuzio-Donahue, C., Meeker, A., Jinawath, A., Yeo, C. J., Eshleman, J. R., Hruban, R. H., Brody, J. R., Griffin, C. A. & Harada, S. May 1 2017 In : Genes Chromosomes and Cancer. 56, 5, p. 427-435 9 p.

Research output: Contribution to journalArticle

Cadherins
Adenocarcinoma
Loss of Heterozygosity
Pancreatic Neoplasms
Carcinogenesis
Telomere Homeostasis
Neuroendocrine Tumors
Fine Needle Biopsy
Telomere
Neoplasms

Alternative lengthening of telomeres in primary pancreatic neuroendocrine tumors is associated with aggressive clinical behavior and poor survival

Kim, J. Y., Brosnan-Cashman, J. A., An, S., Kim, S. J., Song, K. B., Kim, M. S., Kim, M. J., Hwang, D. W., Meeker, A. K., Yu, E., Kim, S. C., Hruban, R. H., Heaphy, C. M. & Hong, S. M. Mar 15 2017 In : Clinical Cancer Research. 23, 6, p. 1598-1606 9 p.

Research output: Contribution to journalArticle

Telomere Homeostasis
Neuroendocrine Tumors
Survival
Neoplasm Metastasis
Recurrence

A Novel Absorbable Radiopaque Hydrogel Spacer to Separate the Head of the Pancreas and Duodenum in Radiation Therapy for Pancreatic Cancer

Rao, A. D. , Feng, Z. , Shin, E. J. , He, J. , Waters, K. M. , Coquia, S. , DeJong, R. , Rosati, L. M. , Su, L. , Li, D. , Jackson, J. , Clark, S. , Schultz, J. , Hutchings, D. , Kim, S. H. , Hruban, R. H. , DeWeese, T. L. , Wong, J. , Narang, A. , Herman, J. M. & 1 others Ding, K. 2017 (Accepted/In press) In : International Journal of Radiation Oncology Biology Physics.

Research output: Contribution to journalArticle

pancreas
Hydrogel
Pancreatic Neoplasms
Duodenum
spacers

A novel approach for selecting combination clinical markers of pathology applied to a large retrospective cohort of surgically resected pancreatic cysts

Masica, D. L. , Molin, M. D. , Wolfgang, C. L. , Tomita, T. , Ostovaneh, M. R. , Blackford, A. , Moran, R. A. , Law, J. K. , Barkley, T. , Goggins, M. , Canto, M. I. , Pittman, M. , Eshleman, J. R. , Ali, S. Z. , Fishman, E. K. , Kamel, I. R. , Raman, S. P. , Zaheer, A. , Ahuja, N. , Makary, M. A. & 16 others Weiss, M. J., Hirose, K., Cameron, J. L., Rezaee, N., He, J., Ahn, Y. J., Wu, W., Wang, Y., Springer, S., Diaz, L. L., Papadopoulos, N., Hruban, R. H., Kinzler, K. W., Vogelstein, B., Karchin, R. & Lennon, A. M. 2017 In : Journal of the American Medical Informatics Association. 24, 1, p. 145-152 8 p.

Research output: Contribution to journalArticle

Pancreatic Cyst
Clinical Pathology
Biomarkers
Sensitivity and Specificity
Serous Cystadenoma

A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer

Mello, S. S., Valente, L. J., Raj, N., Seoane, J. A., Flowers, B. M., McClendon, J., Bieging-Rolett, K. T., Lee, J., Ivanochko, D., Kozak, M. M., Chang, D. T., Longacre, T. A., Koong, A. C., Arrowsmith, C. H., Kim, S. K., Vogel, H., Wood, L. D., Hruban, R. H., Curtis, C. & Attardi, L. D. Oct 9 2017 In : Cancer Cell. 32, 4, p. 460-473.e6

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Neoplasms
p53 Genes
Transcriptional Activation
Mutation

A rare case of esophageal metastasis from pancreatic ductal adenocarcinoma: A case report and literature review

Rosati, L. M., Kummerlowe, M. N., Poling, J., Hacker-Prietz, A., Narang, A. K., Shin, E. J., Le, D. T., Fishman, E. K., Hruban, R. H., Yang, S. C., Weiss, M. J. & Herman, J. M. Jan 1 2017 In : Oncotarget. 8, 59, p. 100942-100950 9 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Neoplasm Metastasis
oxaliplatin
irinotecan
Radiotherapy

Classification, morphology, molecular pathogenesis, and outcome of premalignant lesions of the pancreas

Pittman, M. E., Rao, R. & Hruban, R. H. Dec 1 2017 In : Archives of Pathology and Laboratory Medicine. 141, 12, p. 1606-1614 9 p.

Research output: Contribution to journalArticle

Neoplasm Invasiveness
Pancreatic Ductal Carcinoma
Precancerous Conditions
Carcinoma in Situ
Pancreatic Neoplasms

Classification of pancreatic cysts in computed tomography images using a random forest and convolutional neural network ensemble

Dmitriev, K., Kaufman, A. E., Javed, A. A., Hruban, R. H., Fishman, E. K., Lennon, A. M. & Saltz, J. H. 2017 Medical Image Computing and Computer Assisted Intervention − MICCAI 2017 - 20th International Conference, Proceedings. Springer Verlag, Vol. 10435 LNCS, p. 150-158 9 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 10435 LNCS)

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Neural Network Ensemble
Random Forest
Computed Tomography
Tomography
Neural networks

Deleterious germline mutations in patients with apparently sporadic pancreatic adenocarcinoma

Shindo, K. , Yu, J. , Suenaga, M. , Fesharakizadeh, S. , Cho, C. , Macgregor-Das, A. , Siddiqui, A. , Witmer, P. D. , Tamura, K. , Song, T. J. , Almario, J. A. N. , Brant, A. , Borges, M. , Ford, M. , Barkley, T. , He, J. , Weiss, M. J. , Wolfgang, C. L. , Roberts, N. J. , Hruban, R. H. & 2 others Klein, A. P. & Goggins, M. Oct 20 2017 In : Journal of Clinical Oncology. 35, 30, p. 3382-3390 9 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Adenocarcinoma
Pancreatic Neoplasms
Neoplasm Genes
Neoplasms

Duodenal and Ampullary Carcinoid Tumors: Size Predicts Necessity for Lymphadenectomy

Dogeas, E., Cameron, J. L., Wolfgang, C. L., Hirose, K., Hruban, R. H., Makary, M. A., Pawlik, T. A. & Choti, M. A. Aug 1 2017 In : Journal of Gastrointestinal Surgery. 21, 8, p. 1262-1269 8 p.

Research output: Contribution to journalArticle

Carcinoid Tumor
Lymph Node Excision
Lymph Nodes
Neoplasms
Pancreaticoduodenectomy

Duodenal Involvement is an Independent Prognostic Factor for Patients with Surgically Resected Pancreatic Ductal Adenocarcinoma

Dal Molin, M., Blackford, A. L., Siddiqui, A., Brant, A., Cho, C., Rezaee, N., Yu, J., He, J., Weiss, M., Hruban, R. H., Wolfgang, C. & Goggins, M. Apr 24 2017 (Accepted/In press) In : Annals of Surgical Oncology. p. 1-8 8 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Neoplasms
Confidence Intervals
Common Bile Duct
Pancreas

Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4

Hosoda, W. , Chianchiano, P. , Griffin, J. F. , Pittman, M. E. , Brosens, L. A. A. , Noë, M. , Yu, J. , Shindo, K. , Suenaga, M. , Rezaee, N. , Yonescu, R. , Ning, Y. , Albores-Saavedra, J. , Yoshizawa, N. , Harada, K. , Yoshizawa, A. , Hanada, K. , Yonehara, S. , Shimizu, M. , Uehara, T. & 6 others Samra, J. S., Gill, A. J., Wolfgang, C. L., Goggins, M. G., Hruban, R. H. & Wood, L. D. May 1 2017 In : Journal of Pathology. 242, 1, p. 16-23 8 p.

Research output: Contribution to journalArticle

Mutation
Neoplasms
Adenocarcinoma
Exome
Genes

Hypermutation In Pancreatic Cancer

Humphris, J. L. , Patch, A. M. , Nones, K. , Bailey, P. J. , Johns, A. L. , McKay, S. , Chang, D. K. , Miller, D. K. , Pajic, M. , Kassahn, K. S. , Quinn, M. C. J. , Bruxner, T. J. C. , Christ, A. N. , Harliwong, I. , Idrisoglu, S. , Manning, S. , Nourse, C. , Nourbakhsh, E. , Stone, A. , Wilson, P. J. & 31 others Anderson, M., Fink, J. L., Holmes, O., Kazakoff, S., Leonard, C., Newell, F., Waddell, N., Wood, S., Mead, R. S., Xu, Q., Wu, J., Pinese, M., Cowley, M. J., Jones, M. D., Nagrial, A. M., Chin, V. T., Chantrill, L. A., Mawson, A., Chou, A., Scarlett, C. J., Pinho, A. V., Rooman, I., Giry-Laterriere, M., Samra, J. S., Hruban, R. H., Maitra, A., Iacobuzio-Donahue, C. A., Schulick, R. D., Wolfgang, C. L., Eshleman, J. R. & Australian Pancreatic Cancer Genome Initiative Jan 1 2017 In : Gastroenterology. 152, 1, p. 68-74.e2

Research output: Contribution to journalArticle

Pancreatic Neoplasms
DNA Repair
Mutation
Immunotherapy
Patient Selection

IL2RG, identified as overexpressed by RNA-seq profiling of pancreatic intraepithelial neoplasia, mediates pancreatic cancer growth

Ayars, M., O'Sullivan, E., Macgregor-Das, A., Shindo, K., Kim, H., Borges, M., Yu, J., Hruban, R. H. & Goggins, M. 2017 In : Oncotarget. 8, 48, p. 83370-83383 14 p.

Research output: Contribution to journalArticle

Interleukin Receptor Common gamma Subunit
Pancreatic Neoplasms
RNA
Pancreatic Ducts
Growth

Immunohistochemical Characterization of the Origins of Metastatic Well-differentiated Neuroendocrine Tumors to the Liver

Yang, Z., Klimstra, D. S., Hruban, R. H. & Tang, L. H. 2017 In : American Journal of Surgical Pathology. 41, 7, p. 915-922 8 p.

Research output: Contribution to journalArticle

Neuroendocrine Tumors
Liver
Bile Ducts
Rectum
Lung

Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma

Raphael, B. J. , Hruban, R. H. , Aguirre, A. J. , Moffitt, R. A. , Yeh, J. J. , Stewart, C. , Robertson, A. G. , Cherniack, A. D. , Gupta, M. , Getz, G. , Gabriel, S. B. , Meyerson, M. , Cibulskis, C. , Fei, S. S. , Hinoue, T. , Shen, H. , Laird, P. W. , Ling, S. , Lu, Y. , Mills, G. B. & 30 others Akbani, R., Loher, P., Londin, E. R., Rigoutsos, I., Telonis, A. G., Gibb, E. A., Goldenberg, A., Mezlini, A. M., Hoadley, K. A., Collisson, E., Lander, E., Murray, B. A., Hess, J., Rosenberg, M., Bergelson, L., Zhang, H., Cho, J., Tiao, G., Kim, J., Livitz, D., Leshchiner, I., Reardon, B., Van Allen, E., Kamburov, A., Beroukhim, R., Saksena, G., Schumacher, S. E., Noble, M. S., Heiman, D. I. & Gehlenborg, N. Aug 14 2017 In : Cancer Cell. 32, 2, p. 185-203.e13

Research output: Contribution to journalArticle

Adenocarcinoma
Mutation
Exome
Neoplasms
Untranslated RNA

Intraductal Papillary Mucinous Neoplasm of the Pancreas in Young Patients: Tumor Biology, Clinical Features, and Survival Outcomes

Morales-Oyarvide, V., Mino-Kenudson, M., Ferrone, C. R., Warshaw, A. L., Lillemoe, K. D., Sahani, D. V., Pergolini, I., Attiyeh, M. A., Al Efishat, M., Rezaee, N., Hruban, R. H., He, J., Weiss, M. J., Allen, P. J., Wolfgang, C. L. & Fernández-Del Castillo, C. Oct 18 2017 (Accepted/In press) In : Journal of Gastrointestinal Surgery. p. 1-9 9 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Survival
Neoplasms
Carcinoma, Intraductal, Noninfiltrating
Pancreatic Ducts

Lack of association between the pancreatitis risk allele CEL-HYB and pancreatic cancer

Shindo, K., Yu, J., Suenaga, M., Fesharakizadeh, S., Tamura, K., Almario, J. A. N., Brant, A., Borges, M., Siddiqui, A., Datta, L., Wolfgang, C. L., Hruban, R. H., Klein, A. P. & Goggins, M. Feb 7 2017 In : Oncotarget. 8, 31, p. 50824-50831 8 p.

Research output: Contribution to journalArticle

Lipase
Pancreatic Neoplasms
Pancreatitis
Esters
Alleles

Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer

Makohon-Moore, A. P., Zhang, M., Reiter, J. G., Bozic, I., Allen, B., Kundu, D., Chatterjee, K., Wong, F., Jiao, Y., Kohutek, Z. A., Hong, J., Attiyeh, M., Javier, B., Wood, L. D., Hruban, R. H., Nowak, M. A., Papadopoulos, N., Kinzler, K. W., Vogelstein, B. & Iacobuzio-Donahue, C. A. Jan 16 2017 (Accepted/In press) In : Nature Genetics.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Neoplasm Metastasis
Mutation
Genes
Genome

Long-term survival benefit of upfront chemotherapy in patients with newly diagnosed borderline resectable pancreatic cancer

Shrestha, B. , Sun, Y. , Faisal, F. , Kim, V. , Soares, K. , Blair, A. , Herman, J. M. , Narang, A. , Dholakia, A. S. , Rosati, L. , Hacker-Prietz, A. , Chen, L. , Laheru, D. A. , De Jesus-Acosta, A. , Le, D. T. , Donehower, R. , Azad, N. , Diaz, L. A. , Murphy, A. , Lee, V. & 11 others Fishman, E. K., Hruban, R. H., Liang, T., Cameron, J. L., Makary, M., Weiss, M. J., Ahuja, N., He, J., Wolfgang, C. L., Huang, C. Y. & Zheng, L. Jul 1 2017 In : Cancer Medicine. 6, 7, p. 1552-1562 11 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Drug Therapy
Neoadjuvant Therapy
Survival
Adenocarcinoma

Lost in translation: Returning germline genetic results in genome-scale cancer research

Johns, A. L. , McKay, S. H. , Humphris, J. L. , Pinese, M. , Chantrill, L. A. , Mead, R. S. , Tucker, K. , Andrews, L. , Goodwin, A. , Leonard, C. , High, H. A. , Nones, K. , Waddell, N. , Patch, A. M. , Merrett, N. D. , Pavlakis, N. , Kassahn, K. S. , Samra, J. S. , Miller, D. K. , Chang, D. K. & 31 others Pajic, M., Pearson, J. V., Grimmond, S. M., Waddell, N., Zeps, N., Gill, A. J., Biankin, A. V., Johns, A. L., Gill, A. J., Chang, D. K., McKay, S. H., Chantrill, L. A., Chin, V. T., Chou, A., Humphris, J. L., Pajic, M., Steinmann, A., Arshi, M., Drury, A., Froio, D., Morgan, A., Timpson, P., Hermann, D., Vennin, C., Warren, S., Pinese, M., Wu, J., Pinho, A. V., Hruban, R. H., Wolfgang, C. L. & Australian Pancreatic Cancer Genome Initiative Apr 28 2017 In : Genome Medicine. 9, 1, 41

Research output: Contribution to journalArticle

Genome
Pancreatic Neoplasms
Research
Neoplasms
Genes

Multi-Institutional Validation Study of Pancreatic Cyst Fluid Protein Analysis for Prediction of High-Risk Intraductal Papillary Mucinous Neoplasms of the Pancreas

Al Efishat, M. A. , Attiyeh, M. F. , Eaton, A. A. , Gönen, M. , Prosser, D. , Lokshin, A. E. , Castillo, C. F. D. , Lillemoe, K. D. , Ferrone, C. R. , Pergolini, I. , Mino-Kenudson, M. , Rezaee, N. , Dal Molin, M. , Weiss, M. J. , Cameron, J. L. , Hruban, R. H. , D’Angelica, M. I. , Kingham, P. P. , DeMatteo, R. P. , Jarnagin, W. R. & 2 others Wolfgang, C. L. & Allen, P. J. Jul 11 2017 (Accepted/In press) In : Annals of Surgery.

Research output: Contribution to journalArticle

Pancreatic Cyst
Cyst Fluid
Validation Studies
Pancreatic Neoplasms
Nomograms

Multiplex Proximity Ligation Assay to Identify Potential Prognostic Biomarkers for Improved Survival in Locally Advanced Pancreatic Cancer Patients Treated With Stereotactic Body Radiation Therapy

Rao, A. D. , Liu, Y. , von Eyben, R. , Hsu, C. C. , Hu, C. , Rosati, L. M. , Parekh, A. , Ng, K. , Hacker-Prietz, A. , Zheng, L. , Pawlik, T. M. , Laheru, D. A. , Jaffee, E. M. , Weiss, M. J. , Le, D. T. , Hruban, R. H. , De Jesus-Acosta, A. , Wolfgang, C. L. , Narang, A. K. , Chang, D. T. & 2 others Koong, A. C. & Herman, J. M. Jan 1 2017 (Accepted/In press) In : International Journal of Radiation Oncology Biology Physics.

Research output: Contribution to journalArticle

biomarkers
Pancreatic Neoplasms
Ligation
proximity
radiation therapy

Patients with McCune-Albright syndrome have a broad spectrum of abnormalities in the gastrointestinal tract and pancreas

Wood, L. D., Noë, M., Hackeng, W., Brosens, L. A. A., Bhaijee, F., Debeljak, M., Yu, J., Suenaga, M., Singhi, A. D., Zaheer, A., Boyce, A., Robinson, C., Eshleman, J. R., Goggins, M. G., Hruban, R. H., Collins, M. T., Lennon, A. M. & Montgomery, E. A. Feb 10 2017 (Accepted/In press) In : Virchows Archiv. p. 1-10 10 p.

Research output: Contribution to journalArticle

Polyostotic Fibrous Dysplasia
Gastrointestinal Tract
Pancreas
Polyps
Esophagogastric Junction
Pancreatectomy
Adenocarcinoma
Recurrence
Survival
Adjuvant Chemoradiotherapy

Predicting the grade of dysplasia of pancreatic cystic neoplasms using cyst fluid DNA methylation markers

Hata, T., Dal Molin, M., Hong, S. M., Tamura, K., Suenaga, M., Yu, J., Sedogawa, H., Weiss, M. J., Wolfgang, C. L., Lennon, A. M., Hruban, R. H. & Goggins, M. G. Jul 15 2017 In : Clinical Cancer Research. 23, 14, p. 3935-3944 10 p.

Research output: Contribution to journalArticle

Pancreatic Cyst
Cyst Fluid
DNA Methylation
Pancreatic Neoplasms
Genetic Markers

Reconstituting development of pancreatic intraepithelial neoplasia from primary human pancreas duct cells

Lee, J., Snyder, E. R., Liu, Y., Gu, X., Wang, J., Flowers, B. M., Kim, Y. J., Park, S., Szot, G. L., Hruban, R. H., Longacre, T. A. & Kim, S. K. Mar 8 2017 In : Nature Communications. 8, 14686

Research output: Contribution to journalArticle

pancreas
Peptide Hormones
Biomarkers
ducts
Gene expression

The many faces of pancreatic serous cystadenoma: Radiologic and pathologic correlation

Chu, L. C., Singhi, A. D., Haroun, R. R., Hruban, R. H. & Fishman, E. K. Mar 1 2017 In : Diagnostic and Interventional Imaging. 98, 3, p. 191-202 12 p.

Research output: Contribution to journalArticle

Serous Cystadenoma
Tomography
Neoplasms

Transcriptional mechanisms of resistance to anti-PD-1 therapy

Ascierto, M. L. , Makohon-Moore, A. , Lipson, E. J. , Taube, J. M. , McMiller, T. L. , Berger, A. E. , Fan, J. , Kaunitz, G. J. , Cottrell, T. R. , Kohutek, Z. A. , Favorov, A. , Makarov, V. , Riaz, N. , Chan, T. A. , Cope, L. , Hruban, R. H. , Pardoll, D. M. , Taylor, B. S. , Solit, D. B. , Iacobuzio-Donahue, C. A. & 1 others Topalian, S. L. Jun 15 2017 In : Clinical Cancer Research. 23, 12, p. 3168-3180 13 p.

Research output: Contribution to journalArticle

Melanoma
Biomarkers
Clonal Evolution
Neoplasm Metastasis
Exome
2016

Ampullary Cancers Harbor ELF3 Tumor Suppressor Gene Mutations and Exhibit Frequent WNT Dysregulation

Gingras, M. C. , Covington, K. R. , Chang, D. K. , Donehower, L. A. , Gill, A. J. , Ittmann, M. M. , Creighton, C. J. , Johns, A. L. , Shinbrot, E. , Dewal, N. , Fisher, W. E. , Pilarsky, C. , Grützmann, R. , Overman, M. J. , Jamieson, N. B. , Van Buren, G. , Drummond, J. , Walker, K. , Hampton, O. A. , Xi, L. & 30 others Muzny, D. M., Doddapaneni, H., Lee, S. L., Bellair, M., Hu, J., Han, Y., Dinh, H. H., Dahdouli, M., Samra, J. S., Bailey, P., Waddell, N., Pearson, J. V., Harliwong, I., Wang, H., Aust, D., Oien, K. A., Hruban, R. H., Hodges, S. E., McElhany, A., Saengboonmee, C., Duthie, F. R., Grimmond, S. M., Biankin, A. V., Wheeler, D. A., Gibbs, R. A., Jones, M. D., Mawson, A., Scarlett, C. J., Eshleman, J. R. & Wolfgang, C. L. Feb 2 2016 In : Cell Reports. 14, 4, p. 907-919 13 p.

Research output: Contribution to journalArticle

Genetic Suppression
Ports and harbors
Tumor Suppressor Genes
Tumors
Adenocarcinoma

A robust nonlinear tissue-component discrimination method for computational pathology

Sarnecki, J. S., Burns, K. H., Wood, L. D., Waters, K. M., Hruban, R. H., Wirtz, D. & Wu, P. H. Apr 1 2016 In : Laboratory Investigation. 96, 4, p. 450-458 9 p.

Research output: Contribution to journalArticle

Pathology
Color
Tissue Fixation
Biomedical Research
Immunohistochemistry

Association of common susceptibility variants of pancreatic cancer in higher-risk patients: A PACGENE study

Childs, E. J., Chaffee, K. G., Gallinger, S., Syngal, S., Schwartz, A. G., Cote, M. L., Bondy, M. L., Hruban, R. H., Chanock, S. J., Hoover, R. N., Fuchs, C. S., Rider, D. N., Amundadottir, L. T., Stolzenberg-Solomon, R., Wolpin, B. M., Risch, H. A., Goggins, M. G., Petersen, G. M. & Klein, A. P. Jul 1 2016 In : Cancer Epidemiology Biomarkers and Prevention. 25, 7, p. 1185-1191 7 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Ovarian Neoplasms
Single Nucleotide Polymorphism
BRCA2 Gene
Breast Neoplasms

Circulating Tumor Cell Phenotype Predicts Recurrence and Survival in Pancreatic Adenocarcinoma

Poruk, K. E., Valero, V., Saunders, T., Blackford, A. L., Griffin, J. F., Poling, J., Hruban, R. H., Anders, R. A., Herman, J., Zheng, L., Rasheed, Z. A., Laheru, D. A., Ahuja, N., Weiss, M. J., Cameron, J. L., Goggins, M., Iacobuzio-Donahue, C. A., Wood, L. D. & Wolfgang, C. L. Jan 7 2016 (Accepted/In press) In : Annals of Surgery.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Adenocarcinoma
Phenotype
Recurrence
Survival

Current concepts in the diagnosis and pathobiology of intraepithelial neoplasia: A review by organ system

Voltaggio, L., Cimino-Mathews, A., Bishop, J. A., Argani, P., Cuda, J. D., Epstein, J. I., Hruban, R. H., Netto, G. J., Stoler, M. H., Taube, J. M., Vang, R., Westra, W. H. & Montgomery, E. A. Sep 1 2016 In : Ca-A Cancer Journal for Clinicians. 66, 5, p. 408-436 29 p.

Research output: Contribution to journalReview article

Cervix Uteri
Skin
Paint
Terminology
Esophagus

Cyst fluid telomerase activity predicts the histologic grade of cystic neoplasms of the pancreas

Hata, T., Molin, M. D., Suenaga, M., Yu, J., Pittman, M., Weiss, M., Canto, M. I., Wolfgang, C., Lennon, A. M., Hruban, R. H. & Goggins, M. Oct 15 2016 In : Clinical Cancer Research. 22, 20, p. 5141-5151 11 p.

Research output: Contribution to journalArticle

Cyst Fluid
Telomerase
Pancreatic Neoplasms
Pancreatic Cyst
Cysts

Diffusion-Weighted Magnetic Resonance Imaging in Distinguishing Between Mucin-Producing and Serous Pancreatic Cysts

Pozzessere, C., Castaños Gutiérrez, S. L., Corona-Villalobos, C. P., Righi, L., Xu, C., Lennon, A. M., Wolfgang, C. L., Hruban, R. H., Goggins, M., Canto, M. I. & Kamel, I. R. Mar 29 2016 (Accepted/In press) In : Journal of Computer Assisted Tomography.

Research output: Contribution to journalArticle

Pancreatic Cyst
Diffusion Magnetic Resonance Imaging
Mucins
Cysts
ROC Curve

Digital next-generation sequencing identifies low-abundance mutations in pancreatic juice samples collected from the duodenum of patients with pancreatic cancer and intraductal papillary mucinous neoplasms

Yu, J., Sadakari, Y., Shindo, K., Suenaga, M., Brant, A., Almario, J. A. N., Borges, M., Barkley, T., Fesharakizadeh, S., Ford, M., Hruban, R. H., Shin, E. J., Lennon, A. M., Canto, M. I. & Goggins, M. Jul 18 2016 (Accepted/In press) In : Gut.

Research output: Contribution to journalArticle

Pancreatic Juice
Pancreatic Neoplasms
Duodenum
Secretin
Mutation

Distinct pathways of pathogenesis of intraductal oncocytic papillary neoplasms and intraductal papillary mucinous neoplasms of the pancreas

Basturk, O., Chung, S. M., Hruban, R. H., Adsay, N. V., Askan, G., Iacobuzio-Donahue, C., Balci, S., Zee, S. Y., Memis, B., Shia, J. & Klimstra, D. S. Sep 3 2016 (Accepted/In press) In : Virchows Archiv. p. 1-10 10 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Claudin-4
beta Catenin
Neoplasms
Paraffin

Erratum: Intraductal tubulopapillary neoplasms of the bile ducts: Clinicopathologic, immunohistochemical, and molecular analysis of 20 cases (Modern Pathology (2016) 29 (93))

Schlitter, A. M., Jang, K. T., Klöppel, G., Saka, B., Hong, S. M., Choi, H., Offerhaus, G. J., Hruban, R. H., Zen, Y., Konukiewitz, B., Regel, I., Allgäuer, M., Balci, S., Basturk, O., Reid, M. D., Esposito, I. & Adsay, V. Jan 1 2016 In : Modern Pathology. 29, 1, p. 93 1 p.

Research output: Contribution to journalArticle

Genomic analyses identify molecular subtypes of pancreatic cancer

Bailey, P. , Chang, D. K. , Nones, K. , Johns, A. L. , Patch, A. M. , Gingras, M. C. , Miller, D. K. , Christ, A. N. , Bruxner, T. J. C. , Quinn, M. C. , Nourse, C. , Murtaugh, L. C. , Harliwong, I. , Idrisoglu, S. , Manning, S. , Nourbakhsh, E. , Wani, S. , Fink, L. , Holmes, O. , Chin, V. & 31 others Anderson, M. J., Kazakoff, S., Leonard, C., Newell, F., Waddell, N., Wood, S., Xu, Q., Wilson, P. J., Cloonan, N., Kassahn, K. S., Taylor, D., Quek, K., Robertson, A., Pantano, L., Mincarelli, L., Sanchez, L. N., Evers, L., Wu, J., Pinese, M., Cowley, M. J., Jones, M. D., Colvin, E. K., Nagrial, A. M., Humphrey, E. S., Chantrill, L. A., Mawson, A., Humphris, J., Wolfgang, C. L., Eshleman, J. R., Hruban, R. H. & Australian Pancreatic Cancer Genome Initiative Mar 3 2016 In : Nature. 531, 7592, p. 47-52 6 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Gene Regulatory Networks
Neoplasms
Up-Regulation
Genes

Genomic Sequencing Identifies ELF3 as a Driver of Ampullary Carcinoma

Yachida, S. , Wood, L. D. , Suzuki, M. , Takai, E. , Totoki, Y. , Kato, M. , Luchini, C. , Arai, Y. , Nakamura, H. , Hama, N. , Elzawahry, A. , Hosoda, F. , Shirota, T. , Morimoto, N. , Hori, K. , Funazaki, J. , Tanaka, H. , Morizane, C. , Okusaka, T. , Nara, S. & 20 others Shimada, K., Hiraoka, N., Taniguchi, H., Higuchi, R., Oshima, M., Okano, K., Hirono, S., Mizuma, M., Arihiro, K., Yamamoto, M., Unno, M., Yamaue, H., Weiss, M. J., Wolfgang, C. L., Furukawa, T., Nakagama, H., Vogelstein, B., Kiyono, T., Hruban, R. H. & Shibata, T. Feb 8 2016 In : Cancer Cell. 29, 2, p. 229-240 12 p.

Research output: Contribution to journalArticle

Carcinoma
Asian Americans
Genes
Exome
Phenotype

Germline mutations in Japanese familial pancreatic cancer patients

Takai, E., Yachida, S., Shimizu, K., Furuse, J., Kubo, E., Ohmoto, A., Suzuki, M., Hruban, R. H., Okusaka, T., Morizane, C. & Furukawa, T. 2016 In : Oncotarget. 7, 45, p. 74227-74235 9 p.

Research output: Contribution to journalArticle

Germ-Line Mutation
Pancreatic Neoplasms
Adenocarcinoma
Neoplasm Genes
Mutation
Adenocarcinoma
Neoplasms
Survival
Pancreatic Neoplasms

Longer course of induction chemotherapy followed by chemoradiation favors better survival outcomes for patients with locally advanced pancreatic cancer

Faisal, F., Tsai, H. L., Blackford, A., Olino, K., Xia, C., De Jesus-Acosta, A., Le, D. T., Cosgrove, D., Azad, N., Rasheed, Z., Diaz, L. A., Donehower, R., Laheru, D., Hruban, R. H., Fishman, E. K., Edil, B. H., Schulick, R., Wolfgang, C., Herman, J. & Zheng, L. 2016 In : American Journal of Clinical Oncology: Cancer Clinical Trials. 39, 1, p. 18-26 9 p.

Research output: Contribution to journalArticle

Induction Chemotherapy
Pancreatic Neoplasms
Survival
Incidence
Drug Therapy

Loss of Activin Receptor Type 1B Accelerates Development of Intraductal Papillary Mucinous Neoplasms in Mice with Activated KRAS

Qiu, W., Tang, S. M., Lee, S., Turk, A. T., Sireci, A. N., Qiu, A., Rose, C., Xie, C., Kitajewski, J., Wen, H. J., Crawford, H. C., Sims, P. A., Hruban, R. H., Remotti, H. E. & Su, G. H. Jan 1 2016 In : Gastroenterology. 150, 1, p. 218-228.e12

Research output: Contribution to journalArticle

Activin Receptors
Neoplasms
Activins
Carcinogenesis
Pancreas

Multi-institutional Validation Study of the American Joint Commission on Cancer (8th Edition) Changes for T and N Staging in Patients with Pancreatic Adenocarcinoma

Allen, P. J., Kuk, D., Castillo, C. F. D., Basturk, O., Wolfgang, C. L., Cameron, J. L., Lillemoe, K. D., Ferrone, C. R., Morales-Oyarvide, V., He, J., Weiss, M. J., Hruban, R. H., Gönen, M., Klimstra, D. S. & Mino-Kenudson, M. May 9 2016 (Accepted/In press) In : Annals of Surgery.

Research output: Contribution to journalArticle

Validation Studies
Adenocarcinoma
Joints
Neoplasms
Neoplasm Staging

Mutational spectrum of intraepithelial neoplasia in pancreatic heterotopia

Ma, C., Gocke, C. D., Hruban, R. H. & Belchis, D. A. Feb 1 2016 In : Human Pathology. 48, p. 117-121 5 p.

Research output: Contribution to journalArticle

Adenocarcinoma
Pancreatic Neoplasms
Mutation
Pancreas
Neoplasms