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2017

Arterial Stiffness and Risk of Overall Heart Failure, Heart Failure with Preserved Ejection Fraction, and Heart Failure with Reduced Ejection Fraction: The Health ABC Study (Health, Aging, and Body Composition)

Pandey, A., Khan, H., Newman, A. B., Lakatta, E. G., Forman, D. E., Butler, J. & Berry, J. D. Feb 1 2017 In : Hypertension. 69, 2, p. 267-274 8 p.

Research output: Contribution to journalArticle

Vascular Stiffness
Pulse Wave Analysis
Body Composition
Thigh
Heart Failure

Causal effect of plasminogen activator inhibitor type 1 on coronary heart disease

CHARGE Consortium Hemostatic Factor Working Group, ICBP Consortium & CHARGE Consortium Subclinical Working Group Jun 1 2017 In : Journal of the American Heart Association. 6, 6, e004918

Research output: Contribution to journalArticle

Plasminogen Activator Inhibitor 1
Coronary Disease
Odds Ratio
Mendelian Randomization Analysis
Genome-Wide Association Study

Computer algorithms for automated detection and analysis of local Ca2+ releases in spontaneously beating cardiac pacemaker cells

Maltsev, A. V., Parsons, S. P., Kim, M. S., Tsutsui, K., Stern, M. D., Lakatta, E. G., Maltsev, V. A. & Monfredi, O. Jul 1 2017 In : PLoS ONE. 12, 7, e0179419

Research output: Contribution to journalArticle

Pacemakers
cells
Noise
Affine transforms
Biophysics

Hemodynamic determinants of the short-term blood pressure variability: Differential roles of arterial stiffness and wave reflection

Hsu, P. F., Cheng, H. M., Sung, S. H., Chuang, S. Y., Lakatta, E. G., Yin, F. C. P., Chou, P. & Chen, C. H. 2017 In : American Journal of Hypertension. 30, 3, p. 256-263 8 p.

Research output: Contribution to journalArticle

Vascular Stiffness
Pulse Wave Analysis
Hemodynamics
Thigh
Blood Pressure

Longitudinal Association between Serum Uric Acid and Arterial Stiffness: Results from the Baltimore Longitudinal Study of Aging

Canepa, M., Viazzi, F., Strait, J. B., Ameri, P., Pontremoli, R., Brunelli, C., Studenski, S., Ferrucci, L., Lakatta, E. G. & Alghatrif, M. Feb 1 2017 In : Hypertension. 69, 2, p. 228-235 8 p.

Research output: Contribution to journalArticle

Baltimore
Vascular Stiffness
Uric Acid
Longitudinal Studies
Serum

Lower mitochondrial energy production of the thigh muscles in patients with low-normal ankle-brachial index

AlGhatrif, M., Zane, A., Oberdier, M., Canepa, M., Studenski, S., Simonsick, E., Spencer, R. G., Fishbein, K., Reiter, D., Lakatta, E. G., McDermott, M. M. & Ferrucci, L. Sep 1 2017 In : Journal of the American Heart Association. 6, 9, e006604

Research output: Contribution to journalArticle

Ankle Brachial Index
Thigh
Muscles
Phosphocreatine
Exercise

Mammalian γ2 AMPK regulates intrinsic heart rate

Yavari, A. , Bellahcene, M. , Bucchi, A. , Sirenko, S. , Pinter, K. , Herring, N. , Jung, J. J. , Tarasov, K. V. , Sharpe, E. J. , Wolfien, M. , Czibik, G. , Steeples, V. , Ghaffari, S. , Nguyen, C. , Stockenhuber, A. , Clair, J. R. S. , Rimmbach, C. , Okamoto, Y. , Yang, D. , Wang, M. & 30 others Ziman, B. D., Moen, J. M., Riordon, D. R., Ramirez, C., Paina, M., Lee, J., Zhang, J., Ahmet, I., Matt, M. G., Tarasova, Y. S., Baban, DI., Sahgal, N., Lockstone, H., Puliyadi, R., De Bono, J., Siggs, O. M., Gomes, J., Muskett, H., Maguire, M. L., Beglov, Y., Kelly, M., Dos Santos, P. P. N., Bright, N. J., Woods, A., Gehmlich, K., Isackson, H., Douglas, G., Ferguson, D. J. P., Schneider, J. E. & Lakatta, E. G. Dec 1 2017 In : Nature Communications. 8, 1, 1258

Research output: Contribution to journalArticle

physiological responses
homeostasis
heart rate
enzyme activity
mammals

Prognostic utility of morning blood pressure surge for 20-year all- cause and cardiovascular mortalities: Results of a community-based study

Cheng, H. M., Wu, C. L., Sung, S. H., Lee, J. C., Kario, K., Chiang, C. E., Huang, C. J., Hsu, P. F., Chuang, S. Y., Lakatta, E. G., Yin, F. C. P., Chou, P. & Chen, C. H. Dec 1 2017 In : Journal of the American Heart Association. 6, 12, e007667

Research output: Contribution to journalArticle

Sleep
Blood Pressure
Mortality
Confidence Intervals
Proportional Hazards Models

Spontaneous, local diastolic subsarcolemmal calcium releases in single, isolated guinea-pig sinoatrial nodal cells

Sirenko, S. G., Yang, D., Maltseva, L. A., Kim, M. S., Lakatta, E. G. & Maltsev, V. A. Sep 1 2017 In : PLoS ONE. 12, 9, e0185222

Research output: Contribution to journalArticle

guinea pigs
Guinea Pigs
Calcium
calcium
cells

The Pressure of Aging

AlGhatrif, M., Wang, M., Fedorova, O. V., Bagrov, A. Y. & Lakatta, E. G. Jan 1 2017 In : Medical Clinics of North America. 101, 1, p. 81-101 21 p.

Research output: Contribution to journalReview article

Blood Pressure
Pressure
Pulse Wave Analysis
Hemodynamics
Hypertension

The Systematic Evaluation of Identifying the Infarct Related Artery Utilizing Cardiac Magnetic Resonance in Patients Presenting with ST-Elevation Myocardial Infarction

Hamo, C. E., Klem, I., Rao, S. V., Songco, V., Najjar, S., Lakatta, E. G., Raman, S. V., Harrington, R. A. & Heitner, J. F. Jan 1 2017 In : PLoS ONE. 12, 1, e0169108

Research output: Contribution to journalArticle

infarction
myocardial infarction
Magnetic resonance
arteries
Magnetic Resonance Spectroscopy
2016

52 Genetic Loci Influencing Myocardial Mass

van der Harst, P. , van Setten, J. , Verweij, N. , Vogler, G. , Franke, L. , Maurano, M. T. , Wang, X. , Mateo Leach, I. , Eijgelsheim, M. , Sotoodehnia, N. , Hayward, C. , Sorice, R. , Meirelles, O. , Lyytikäinen, L. P. , Polašek, O. , Tanaka, T. , Arking, D. E. , Ulivi, S. , Trompet, S. , Müller-Nurasyid, M. & 30 others Smith, A. V., Dörr, M., Kerr, K. F., Magnani, J. W., Del Greco M., F., Zhang, W., Nolte, I. M., Silva, C. T., Padmanabhan, S., Tragante, V., Esko, T., Abecasis, G. R., Adriaens, M. E., Andersen, K., Barnett, P., Bis, J. C., Bodmer, R., Buckley, B. M., Campbell, H., Cannon, M. V., Chakravarti, A., Chen, L. Y., Delitala, A., Devereux, R. B., Doevendans, P. A., Dominiczak, A. F., Ferrucci, L., Ford, I., Gieger, C. & Lakatta, E. G. Sep 27 2016 In : Journal of the American College of Cardiology. 68, 13, p. 1435-1448 14 p.

Research output: Contribution to journalArticle

Genetic Loci
Cardiomegaly
Meta-Analysis
Myocardium
Histone Code

AGE-RAGE signal generates a specific NF-Κ B RelA "barcode" that directs collagen i expression

Peng, Y., Kim, J. M., Park, H. S., Yang, A., Islam, C., Lakatta, E. G. & Lin, L. Jan 5 2016 In : Scientific Reports. 6, 18822

Research output: Contribution to journalArticle

Collagen
NF-kappa B
Advanced Glycosylation End Products
Post Translational Protein Processing
Phosphorylation

Aortic Fibrosis, Induced by High Salt Intake in the Absence of Hypertensive Response, Is Reduced by a Monoclonal Antibody to Marinobufagenin

Grigorova, Y. N., Juhasz, O., Zernetkina, V., Fishbein, K. W., Lakatta, E. G., Fedorova, O. V. & Bagrov, A. Y. May 1 2016 In : American Journal of Hypertension. 29, 5, p. 641-646 6 p.

Research output: Contribution to journalArticle

Fibrosis
Salts
Monoclonal Antibodies
Nitroprusside
Blood Pressure

A rat carotid balloon injury model to test anti-vascular remodeling therapeutics

Petrasheskaya, N., Tae, H. J., Ahmet, I., Talan, M. I., Lakatta, E. G. & Lin, L. Sep 19 2016 In : Journal of Visualized Experiments. 2016, 115, e53777

Research output: Contribution to journalArticle

Balloons
Rats
Wounds and Injuries
Pharmaceutical Preparations
Ultrasonography

Ca2 +/calmodulin-activated phosphodiesterase 1A is highly expressed in rabbit cardiac sinoatrial nodal cells and regulates pacemaker function

Lukyanenko, Y. O., Younes, A., Lyashkov, A. E., Tarasov, K. V., Riordon, D. R., Lee, J., Sirenko, S. G., Kobrinsky, E., Ziman, B., Tarasova, Y. S., Juhaszova, M., Sollott, S. J., Graham, D. R. & Lakatta, E. G. Sep 1 2016 In : Journal of Molecular and Cellular Cardiology. 98, p. 73-82 10 p.

Research output: Contribution to journalArticle

Type 1 Cyclic Nucleotide Phosphodiesterases
Rabbits
Calmodulin
Lipids
Phosphoric Diester Hydrolases

Camkii-dependent phosphorylation regulates basal cardiac pacemaker function via modulation of local ca2+ releases

Li, Y., Sirenko, S., Riordon, D. R., Yang, D., Spurgeon, H., Lakatta, E. G. & Vinogradova, T. M. Sep 1 2016 In : American Journal of Physiology - Heart and Circulatory Physiology. 311, 3, p. H532-H544

Research output: Contribution to journalArticle

Sinoatrial Node
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Phosphorylation
Ryanodine Receptor Calcium Release Channel
Muscle Cells

Deterioration of autonomic neuronal receptor signaling and mechanisms intrinsic to heart pacemaker cells contribute to age-associated alterations in heart rate variability in vivo

Yaniv, Y., Ahmet, I., Tsutsui, K., Behar, J., Moen, J. M., Okamoto, Y., Guiriba, T. R., Liu, J., Bychkov, R. & Lakatta, E. G. Aug 1 2016 In : Aging Cell. 15, 4, p. 716-724 9 p.

Research output: Contribution to journalArticle

Heart Rate
Phosphoric Diester Hydrolases
Atropine
Propranolol
Electrocardiography

Electrochemical Na+ and Ca2+gradients drive coupled-clock regulation of automaticity of isolated rabbit sinoatrial nodal pacemaker cells

Sirenko, S. G., Maltsev, V. A., Yaniv, Y., Bychkov, R., Yaeger, D., Vinogradova, T., Spurgeon, H. A. & Lakatta, E. G. Jul 1 2016 In : American Journal of Physiology - Heart and Circulatory Physiology. 311, 1, p. H251-H267

Research output: Contribution to journalArticle

Action Potentials
Rabbits
Ion Channels
Digitalis Glycosides
Ions

Gender specific profiles of white coat and masked hypertension impacts on arterial structure and function in the SardiNIA study

Scuteri, A., Morrell, C. H., Orru', M., Alghatrif, M., Saba, P. S., Terracciano, A., Ferreli, L. A. P., Loi, F., Marongiu, M., Pilia, M. G., Delitala, A., Tarasov, K. V., Schlessinger, D., Ganau, A., Cucca, F. & Lakatta, E. G. Aug 15 2016 In : International Journal of Cardiology. 217, p. 92-98 7 p.

Research output: Contribution to journalArticle

Masked Hypertension
White Coat Hypertension
Italy
Ambulatory Blood Pressure Monitoring
Common Carotid Artery

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Pattaro, C. , Teumer, A. , Gorski, M. , Chu, A. Y. , Li, M. , Mijatovic, V. , Garnaas, M. , Tin, A. , Sorice, R. , Li, Y. , Taliun, D. , Olden, M. , Foster, M. , Yang, Q. , Chen, M. H. , Pers, T. H. , Johnson, A. D. , Ko, Y. A. , Fuchsberger, C. , Tayo, B. & 30 others Nalls, M., Feitosa, M. F., Isaacs, A., Dehghan, A., D'Adamo, P., Adeyemo, A., Dieffenbach, A. K., Zonderman, A. B., Nolte, I. M., Van Der Most, P. J., Wright, A. F., Shuldiner, A. R., Morrison, A. C., Hofman, A., Smith, A. V., Dreisbach, A. W., Franke, A., Uitterlinden, A. G., Metspalu, A., Tonjes, A., Lupo, A., Robino, A., Johansson, Å., Demirkan, A., Ehret, G. B., Coresh, J., Arking, D. E., Chakravarti, A., Lakatta, E. G. & Young, J. H. Jan 21 2016 In : Nature Communications. 7, 10023

Research output: Contribution to journalArticle

kidneys
loci
Glomerular Filtration Rate
Kidney
cells

High short-term blood pressure variability predicts long-term cardiovascular mortality in untreated hypertensives but not in normotensives

Hsu, P. F., Cheng, H. M., Wu, C. H., Sung, S. H., Chuang, S. Y., Lakatta, E. G., Yin, F. C. P., Chou, P. & Chen, C. H. 2016 In : American Journal of Hypertension. 29, 7, p. 806-813 8 p.

Research output: Contribution to journalArticle

Blood Pressure
Mortality
Confidence Intervals
Ambulatory Blood Pressure Monitoring
Hypertension
Dietary Supplements
Heart Failure
Diet
Pulse Wave Analysis
Vascular Stiffness

Mouse RAGE variant 4 is a dominant membrane receptor that does not shed to generate soluble RAGE

Peng, Y., Horwitz, N., Lakatta, E. G. & Lin, L. Sep 1 2016 In : PLoS ONE. 11, 9, e0153657

Research output: Contribution to journalArticle

Cell membranes
Protein Isoforms
Endosomes
Cell Membrane
Membranes

Pharmacological Strategies to Retard Cardiovascular Aging

Alfaras, I., Di Germanio, C., Bernier, M., Csiszar, A., Ungvari, Z., Lakatta, E. G. & De Cabo, R. May 13 2016 In : Circulation Research. 118, 10, p. 1626-1642 17 p.

Research output: Contribution to journalReview article

Cardiovascular Diseases
Pharmacology
Cardiovascular System
Hypercholesterolemia
Hyperglycemia

Prognostic significance of mechanical biomarkers derived from pulse wave analysis for predicting long-term cardiovascular mortality in two population-based cohorts

Cheng, H. M., Chuang, S. Y., Wang, J. J., Shih, Y. T., Wang, H. N., Huang, C. J., Huang, J. T., Sung, S. H., Lakatta, E. G., Yin, F. C. P., Chou, P., Yeh, C. J., Bai, C. H., Pan, W. H. & Chen, C. H. Jul 15 2016 In : International Journal of Cardiology. 215, p. 388-395 8 p.

Research output: Contribution to journalArticle

Pulse Wave Analysis
Biomarkers
Mortality
Population
Cardiovascular Diseases

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Ehret, G. B. , Ferreira, T. , Chasman, D. I. , Jackson, A. U. , Schmidt, E. M. , Johnson, T. , Thorleifsson, G. , Luan, JA. , Donnelly, L. A. , Kanoni, S. , Petersen, A. K. , Pihur, V. , Strawbridge, R. J. , Shungin, D. , Hughes, M. F. , Meirelles, O. , Kaakinen, M. , Bouatia-Naji, N. , Kristiansson, K. , Shah, S. & 30 others Kleber, M. E., Guo, X., Lyytikäinen, L. P., Fava, C., Eriksson, N., Nolte, I. M., Magnusson, P. K., Salfati, E. L., Rallidis, L. S., Theusch, E., Smith, A. J. P., Folkersen, L., Witkowska, K., Pers, T. H., Joehanes, R., Kim, S. K., Lataniotis, L., Jansen, R., Johnson, A. D., Warren, H., Kim, Y. J., Zhao, W., Wu, Y., Tayo, B. O., Bochud, M., Absher, D., Arking, D. E., Vaidya, D., Lakatta, E. G. & Chakravarti, A. Oct 1 2016 In : Nature Genetics. 48, 10, p. 1171-1184 14 p.

Research output: Contribution to journalArticle

Blood Pressure
Single Nucleotide Polymorphism
Kidney
Blood Vessels
Endothelial Cells

The relationship between the metabolic syndrome and arterial wall thickness: A mosaic still to be interpreted

Scuteri, A., Franco, O. H., Völzke, H., Shin, M. H., Kweon, S. S., Rietzschel, E., Ryliškytė, L., Strazhesko, I., Chen, C. H., Lakatta, E. G. & Nilsson, P. M. Dec 1 2016 In : Atherosclerosis. 255, p. 11-16 6 p.

Research output: Contribution to journalArticle

Abdominal Obesity
Hypertension
Arteries
Cholesterol
Carotid Arteries
2015

Cardiovascular disease and aging

Rabinovitch, P., Chiao, Y. A., Dai, D. F., Lakatta, E. & Ungvari, Z. Jan 1 2015 Advances in Geroscience. Springer International Publishing, p. 121-160 40 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cardiovascular Diseases
Aging of materials
Disease
Cardiovascular system
Cardiovascular System

From two competing oscillators to one coupled-clock pacemaker cell system

Yaniv, Y., Lakatta, E. G. & Maltsev, V. A. 2015 In : Frontiers in Physiology. 6, FEB, 28

Research output: Contribution to journalShort survey

Action Potentials
Ion Channels
Electrophysiology
Sarcoplasmic Reticulum
Mammals

Marinobufagenin-induced vascular fibrosis is a likely target for mineralocorticoid antagonists

Fedorova, O. V., Emelianov, I. V., Bagrov, K. A., Grigorova, Y. N., Wei, W., Juhasz, O., Frolova, E. V., Marshall, C. A., Lakatta, E. G., Konradi, A. O. & Bagrov, A. Y. Aug 11 2015 In : Journal of Hypertension. 33, 8, p. 1602-1610 9 p.

Research output: Contribution to journalArticle

Mineralocorticoid Receptor Antagonists
Blood Vessels
Fibrosis
Spironolactone
Canrenone

Matrix metalloproteinases promote arterial remodeling in aging, hypertension, and atherosclerosis

Wang, M., Kim, S. H., Monticone, R. E. & Lakatta, E. G. Apr 20 2015 In : Hypertension. 65, 4, p. 698-703 6 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinases
Disease Progression
Atherosclerosis
Arteries
Hypertension

Metabolic syndrome across Europe: Different clusters of risk factors

Scuteri, A., Laurent, S., Cucca, F., Cockcroft, J., Cunha, P. G., Mañas, L. R., Raso, F. U. M., Muiesan, M. L., Ryliškyte, L., Rietzschel, E., Strait, J., Vlachopoulos, C., Völzke, H., Lakatta, E. G., Nilsson, P. M. & Metabolic Syndrome and Arteries Research (MARE) Consortium Apr 15 2015 In : European Journal of Preventive Cardiology. 22, 4, p. 486-491 6 p.

Research output: Contribution to journalArticle

Italy
Sweden
Spain
Germany
Lithuania

No evidence of association between subclinical thyroid disorders and common carotid intima medial thickness or atherosclerotic plaque

Delitala, A. P., Filigheddu, F., Orrù, M., AlGhatrif, M., Steri, M., Pilia, M. G., Scuteri, A., Lobina, M., Piras, M. G., Delitala, G., Lakatta, E. G., Schlessinger, D. & Cucca, F. Dec 1 2015 In : Nutrition, Metabolism and Cardiovascular Diseases. 25, 12, p. 1104-1110 7 p.

Research output: Contribution to journalArticle

Carotid Intima-Media Thickness
Atherosclerotic Plaques
Thyroid Gland
Carotid Artery Diseases
Thyroid Hormones

Plasma level of the endogenous sodium pump ligand marinobufagenin is related to the salt-sensitivity in men

Fedorova, O. V., Lakatta, E. G., Bagrov, A. Y. & Melander, O. Mar 6 2015 In : Journal of Hypertension. 33, 3, p. 534-541 8 p.

Research output: Contribution to journalArticle

Sodium-Potassium-Exchanging ATPase
Salts
Ligands
Inbred Dahl Rats
marinobufagenin

Potential effects of intrinsic heart pacemaker cell mechanisms on dysrhythmic cardiac action potential firing

Yaniv, Y., Tsutsui, K. & Lakatta, E. G. 2015 In : Frontiers in Physiology. 6, FEB, 047

Research output: Contribution to journalArticle

Action Potentials
Sinoatrial Node
Cardiac Arrhythmias
Vagus Nerve
Brain

Real-time relationship between PKA biochemical signal network dynamics and increased action potential firing rate in heart pacemaker cells. Kinetics of PKA activation in heart pacemaker cells.

Yaniv, Y., Ganesan, A., Yang, D., Ziman, B. D., Lyashkov, A. E., Levchenko, A., Zhang, J. & Lakatta, E. G. Sep 1 2015 In : Journal of Molecular and Cellular Cardiology. 86, p. 168-178 11 p.

Research output: Contribution to journalArticle

Action Potentials
Heart Rate
Receptors, Adrenergic, beta
Phosphoric Diester Hydrolases
Phosphorylation

Recommendations for Improving and Standardizing Vascular Research on Arterial Stiffness: A Scientific Statement from the American Heart Association

Townsend, R. R., Wilkinson, I. B., Schiffrin, E. L., Avolio, A. P., Chirinos, J. A., Cockcroft, J. R., Heffernan, K. S., Lakatta, E. G., McEniery, C. M., Mitchell, G. F., Najjar, S. S., Nichols, W. W., Urbina, E. M. & Weber, T. Sep 14 2015 In : Hypertension. 66, 3, p. 698-722 25 p.

Research output: Contribution to journalArticle

Vascular Stiffness
Blood Vessels
Clinical Medicine
Research
Longitudinal Studies

Serum free thyroxine levels are positively associated with arterial stiffness in the SardiNIA study

Delitala, A. P., Orrù, M., Filigheddu, F., Pilia, M. G., Delitala, G., Ganau, A., Saba, P. S., Decandia, F., Scuteri, A., Marongiu, M., Lakatta, E. G., Strait, J. & Cucca, F. Apr 1 2015 In : Clinical Endocrinology. 82, 4, p. 592-597 6 p.

Research output: Contribution to journalArticle

Pulse Wave Analysis
Vascular Stiffness
Thyroxine
Italy
Thigh

Serum from calorie-restricted animals delays senescence and extends the lifespan of normal human fibroblasts in vitro

de Cabo, R., Liu, L., Ali, A., Price, N., Zhang, J., Wang, M., Lakatta, E. & Irusta, P. M. 2015 In : Aging. 7, 3, p. 152-166 15 p.

Research output: Contribution to journalArticle

Caloric Restriction
Cell Aging
Fibroblasts
Serum
Diploidy

So! What's aging? Is cardiovascular aging a disease?

Lakatta, E. G. Jun 1 2015 In : Journal of Molecular and Cellular Cardiology. 83, p. 1-13 13 p.

Research output: Contribution to journalArticle

Arteries
Clinical Medicine
Signs and Symptoms
Cardiovascular Diseases
Slavery

Synthesis of an Endogenous Steroidal Na Pump Inhibitor Marinobufagenin, Implicated in Human Cardiovascular Diseases, Is Initiated by CYP27A1 via Bile Acid Pathway

Fedorova, O. V., Zernetkina, V. I., Shilova, V. Y., Grigorova, Y. N., Juhasz, O., Wei, W., Marshall, C. A., Lakatta, E. G. & Bagrov, A. Y. Oct 1 2015 In : Circulation: Cardiovascular Genetics. 8, 5, p. 736-745 10 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Cardiovascular Diseases
Cholesterol Side-Chain Cleavage Enzyme
Trophoblasts
Small Interfering RNA

The Aging Arterial Wall

Wang, M., Monticone, R. E. & Lakatta, E. G. Sep 8 2015 Handbook of the Biology of Aging: Eighth Edition. Elsevier Inc., p. 359-389 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Atherosclerosis
Tunica Intima
Hypertension
Elastin
Cell Aging
Vascular Stiffness
Blood Pressure
Aorta
Dilatation
Hemodynamics

The end effector of circadian heart rate variation: The sinoatrial node pacemaker cell

Yaniv, Y. & Lakatta, E. G. 2015 In : BMB Reports. 48, 12, p. 677-684 8 p.

Research output: Contribution to journalShort survey

Pacemakers
Sinoatrial Node
End effectors
Clocks
Heart Rate

Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart

Kaushik, G., Spenlehauer, A., Sessions, A. O., Trujillo, A. S., Fuhrmann, A., Fu, Z., Venkatraman, V., Pohl, D., Tuler, J., Wang, M., Lakatta, E. G., Ocorr, K., Bodmer, R., Bernstein, S. I., Van Eyk, J. E., Cammarato, A. & Engler, A. J. Jun 17 2015 In : Science Translational Medicine. 7, 292, 292ra99

Research output: Contribution to journalArticle

Vinculin
Cytoskeleton
Diptera
Myofibrils
Proteome
2014

Age-associated abnormalities of intrinsic automaticity of sinoatrial nodal cells are linked to deficient cAMP-PKA-Ca2+ signaling

Liu, J., Sirenko, S., Juhaszova, M., Sollott, S. J., Shukla, S., Yaniv, Y. & Lakatta, E. G. May 15 2014 In : American Journal of Physiology - Heart and Circulatory Physiology. 306, 10

Research output: Contribution to journalArticle

Heart Rate
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Ryanodine Receptor Calcium Release Channel
Sinoatrial Node
Phosphodiesterase Inhibitors

Aortic pulse wave velocity improves cardiovascular event prediction: An individual participant meta-analysis of prospective observational data from 17,635 subjects

Ben-Shlomo, Y. , Spears, M. , Boustred, C. , May, M. , Anderson, S. G. , Benjamin, E. J. , Boutouyrie, P. , Cameron, J. , Chen, C. H. , Cruickshank, J. K. , Hwang, S. J. , Lakatta, E. G. , Laurent, S. , Maldonado, J. , Mitchell, G. F. , Najjar, S. S. , Newman, A. B. , Ohishi, M. , Pannier, B. , Pereira, T. & 11 others Vasan, R. S., Shokawa, T., Sutton-Tyrell, K., Verbeke, F., Wang, K. L., Webb, D. J., Willum Hansen, T., Zoungas, S., McEniery, C. M., Cockcroft, J. R. & Wilkinson, I. B. Feb 25 2014 In : Journal of the American College of Cardiology. 63, 7, p. 636-646 11 p.

Research output: Contribution to journalArticle

Pulse Wave Analysis
Meta-Analysis
Cardiovascular Diseases
Confidence Intervals
Coronary Disease

Are personality traits associated with white-coat and masked hypertension?

Terracciano, A., Scuteri, A., Strait, J., Sutin, A. R., Meirelles, O., Marongiu, M., Orru, M., Grazia Pilia, M., Ferrucci, L., Cucca, F., Schlessinger, D. & Lakatta, E. Oct 1 2014 In : Journal of Hypertension. 32, 10, p. 1987-1992 6 p.

Research output: Contribution to journalArticle

Masked Hypertension
White Coat Hypertension
Antihypertensive Agents
Personality
Ambulatory Monitoring

Arterial stiffness and influences of the metabolic syndrome: A cross-countries study

Scuteri, A. , Cunha, P. G. , Rosei, E. A. , Badariere, J. , Bekaert, S. , Cockcroft, J. R. , Cotter, J. , Cucca, F. , De Buyzere, M. L. , De Meyer, T. , Ferrucci, L. , Franco, O. , Gale, N. , Gillebert, T. C. , Langlois, M. , Laucevicius, A. , Laurent, S. , Mattace Raso, F. U. S. , Morrell, C. H. , Muiesan, M. L. & 20 others Munnery, M. M., Navickas, R., Oliveira, P., Orru', M., Pilia, M. G., Rietzschel, E. R., Ryliskyte, L., Salvetti, M., Schlessinger, D., Sousa, N., Stefanadis, C., Strait, J., Van daele, C., Villa, I., Vlachopoulos, C., Witteman, J., Xaplanteris, P., Nilsson, P., Lakatta, E. G. & Hofman, A. 2014 In : Atherosclerosis. 233, 2, p. 654-660 7 p.

Research output: Contribution to journalArticle

Vascular Stiffness
Pulse Wave Analysis
Arteries
Oculocerebral hypopigmentation syndrome type Preus
Research