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Arterial Stiffness and Risk of Overall Heart Failure, Heart Failure with Preserved Ejection Fraction, and Heart Failure with Reduced Ejection Fraction: The Health ABC Study (Health, Aging, and Body Composition)

Pandey, A., Khan, H., Newman, A. B., Lakatta, E. G., Forman, D. E., Butler, J. & Berry, J. D. Feb 1 2017 In : Hypertension. 69, 2, p. 267-274 8 p.

Research output: Research - peer-reviewArticle

Vascular Stiffness
Body Composition
Heart Failure
Health
Pulse Wave Analysis

Causal effect of plasminogen activator inhibitor type 1 on coronary heart disease

Song, C. , Burgess, S. , Eicher, J. D. , O'Donnell, C. J. , Johnson, A. D. , Huang, J. , Sabater-Lleal, M. , Asselbergs, F. W. , Tregouet, D. , Shin, S. Y. , Ding, J. , Baumert, J. , Oudot-Mellakh, T. , Folkersen, L. , Smith, N. L. , Williams, S. M. , Ikram, M. A. , Kleber, M. E. , Becker, D. M. , Truong, V. & 472 others Mychaleckyj, J. C., Tang, W., Yang, Q., Sennblad, B., Moore, J. H., Williams, F. M. K., Dehghan, A., Silbernagel, G., Schrijvers, E. M. C., Smith, S., Karakas, M., Tofler, G. H., Silveira, A., Navis, G. J., Lohman, K., Chen, M. H., Peters, A., Goel, A., Hopewell, J. C., Chambers, J. C., Saleheen, D., Lundmark, P., Psaty, B. M., Strawbridge, R. J., Boehm, B. O., Carter, A. M., Meisinger, C., Peden, J. F., Bis, J. C., McKnight, B., Öhrvik, J., Taylor, K., Franzosi, M. G., Seedorf, U., Collins, R., Franco-Cereceda, A., Syvänen, A. C., Goodall, A. H., Yanek, L. R., Cushman, M., Müller-Nurasyid, M., Folsom, A. R., Basu, S., Matijevic, N., van Gilst, W. H., Kooner, J. S., Danesh, J., Clarke, R., Meigs, J. B., Kathiresan, S., Reilly, M. P., Klopp, N., Harris, T. B., Winkelmann, B. R., Grant, P. J., Hillege, H. L., Watkins, H., Spector, T. D., Becker, L. C., Tracy, R. P., März, W., Uitterlinden, A. G., Eriksson, P., Cambien, F., Morange, P. E., Koenig, W., Soranzo, N., van der Harst, P., Liu, Y., Hamsten, A., Ehret, G. B., Munroe, P. B., Rice, K. M., Bochud, M., Chasman, D. I., Smith, A. V., Tobin, M. D., Verwoert, G. C., Hwang, S. J., Pihur, V., Vollenweider, P., O'Reilly, P. F., Amin, N., Bragg-Gresham, J. L., Teumer, A., Glazer, N. L., Launer, L., Zhao, J. H., Aulchenko, Y., Heath, S., Sõber, S., Parsa, A., Luan, J., Arora, P., Zhang, F., Lucas, G., Hicks, A. A., Jackson, A. U., Tanaka, T., Wild, S. H., Rudan, I., Igl, W., Milaneschi, Y., Parker, A. N., Fava, C., Fox, E. R., Kumari, M., Go, M. J., Linda Kao, W. H., Sjögren, M., Vinay, D. G., Alexander, M., Tabara, Y., Shaw-Hawkins, S., Whincup, P. H., Shi, G., Kuusisto, J., Tayo, B., Seielstad, M., Sim, X., Nguyen, K. D. H., Lehtimäki, T., Matullo, G., Wu, Y., Gaunt, T. R., Onland-Moret, N. C., Cooper, M. N., Platou, C. G. P., Org, E., Hardy, R., Dahgam, S., Palmen, J., Vitart, V., Braund, P. S., Kuznetsova, T., Uiterwaal, C. S. P. M., Adeyemo, A., Palmas, W., Campbell, H., Ludwig, B., Tomaszewski, M., Tzoulaki, I., Palmer, N. D., Aspelund, T., Garcia, M., Chang, Y. P. C., O'Connell, J. R., Steinle, N. I., Grobbee, D. E., Arking, D. E., Kardia, S. L., Morrison, A. C., Hernandez, D., Najjar, S., McArdle, W. L., Hadley, D., Brown, M. J., Connell, J. M., Hingorani, A. D., Day, I. N. M., Lawlor, D. A., Beilby, J. P., Lawrence, R. W., Ongen, H., Dreisbach, A. W., Li, Y., Young, J. H., Kähönen, M., Viikari, J., Adair, L. S., Lee, N. R., Olden, M., Pattaro, C., Hoffman Bolton, J. A., Köttgen, A., Bergmann, S., Mooser, V., Chaturvedi, N., Frayling, T. M., Islam, M., Jafar, T. H., Erdmann, J., Kulkarni, S. R., Bornstein, S. R., Grässler, J., Groop, L., Voight, B. F., Kettunen, J., Howard, P., Taylor, A., Guarrera, S., Ricceri, F., Emilsson, V., Plump, A., Barroso, I., Khaw, K. T., Weder, A. B., Hunt, S. C., Sun, Y. V., Bergman, R. N., Collins, F. S., Bonnycastle, L. L., Scott, L. J., Stringham, H. M., Peltonen, L., Perola, M., Vartiainen, E., Brand, S. M., Staessen, J. A., Wang, T. J., Burton, P. R., Artigas, M. S., Dong, Y., Snieder, H., Wang, X., Zhu, H., Lohman, K. K., Rudock, M. E., Heckbert, S. R., Wiggins, K. L., Doumatey, A., Shriner, D., Veldre, G., Viigimaa, M., Kinra, S., Prabhakaran, D., Tripathy, V., Langefeld, C. D., Rosengren, A., Thelle, D. S., Corsi, A. M., Singleton, A., Forrester, T., Hilton, G., McKenzie, C. A., Salako, T., Iwai, N., Kita, Y., Ogihara, T., Ohkubo, T., Okamura, T., Ueshima, H., Umemura, S., Eyheramendy, S., Meitinger, T., Wichmann, H. E., Cho, Y. S., Kim, H. L., Lee, J. Y., Scott, J., Sehmi, J. S., Zhang, W., Hedblad, B., Nilsson, P., Smith, G. D., Wong, A., Narisu, N., Stančáková, A., Raffel, L. J., Yao, J., Schwartz, S. M., Arfan Ikram, M., Longstreth, W. T., Mosley, T. H., Seshadri, S., Shrine, N. R. G., Wain, L. V., Morken, M. A., Swift, A. J., Laitinen, J., Prokopenko, I., Zitting, P., Cooper, J. A., Humphries, S. E., Rasheed, A., Bakker, S. J. L., Janipalli, C. S., Mani, K. R., Yajnik, C. S., Mattace-Raso, F. U. S., Oostra, B. A., Demirkan, A., Isaacs, A., Rivadeneira, F., Lakatta, E. G., Orru, M., Scuteri, A., Ala-Korpela, M., Kangas, A. J., Lyytikäinen, L. P., Soininen, P., Tukiainen, T., Würtz, P., Ong, R. T. H., Dörr, M., Kroemer, H. K., Völker, U., Völzke, H., Galan, P., Hercberg, S., Lathrop, M., Zelenika, D., Deloukas, P., Mangino, M., Zhai, G., Meschia, J. F., Nalls, M. A., Sharma, P., Terzic, J., Kumar, M. V. K., Denniff, M., Zukowska-Szczechowska, E., Wagenknecht, L. E., Fowkes, F. G. R., Charchar, F. J., Schwarz, P. E. H., Hayward, C., Guo, X., Rotimi, C., Bots, M. L., Brand, E., Samani, N. J., Polasek, O., Talmud, P. J., Nyberg, F., Kuh, D., Laan, M., Hveem, K., Palmer, L. J., van der Schouw, Y. T., Casas, J. P., Mohlke, K. L., Vineis, P., Raitakari, O., Ganesh, S. K., Wong, T. Y., Shyong Tai, E., Cooper, R. S., Laakso, M., Rao, D. C., Morris, R. W., Dominiczak, A. F., Kivimaki, M., Marmot, M. G., Miki, T., Chandak, G. R., Coresh, J., Navis, G., Salomaa, V., Han, B. G., Zhu, X., Melander, O., Ridker, P. M., Bandinelli, S., Gyllensten, U. B., Wright, A. F., Wilson, J. F., Ferrucci, L., Farrall, M., Tuomilehto, J., Pramstaller, P. P., Elosua, R., Sijbrands, E. J. G., Altshuler, D., Loos, R. J. F., Gieger, C., Meneton, P., Wareham, N. J., Gudnason, V., Rotter, J. I., Rettig, R., Uda, M., Strachan, D. P., Witteman, J. C. M., Hartikainen, A. L., Beckmann, J. S., Boerwinkle, E., Vasan, R. S., Boehnke, M., Larson, M. G., Järvelin, M. R., Abecasis, G. R., Chakravarti, A., Elliott, P., van Duijn, C. M., Newton-Cheh, C., Levy, D., Caulfield, M. J., Johnson, T., van der Lugt, A., Shuldiner, A. R., Hofman, A., Kraja, A. T., Uitterlinden, A., Ziegler, A., Newman, A. B., Schillert, A., Oostra, B., Thorsson, B., Mitchell, B. D., Fox, C. S., White, C. C., Ballantyne, C., Duijn, C. V., Herrington, D. M., O'Leary, D. H., Siscovick, D. S., Couper, D. J., Halperin, E., Stoegerer, E. M., Ernst, F., Krestin, G. P., Homuth, G., Heiss, G., Usala, G., Eiriksdottir, G., Shen, H., Erich Wichmann, H., Schmidt, H., Borecki, I. B., Markus, H. S., Witteman, J., Lüdemann, J., Huffman, J. E., Murabito, J. M., Thiery, J., Seissler, J., Massaro, J. M., Polak, J. F., Cunningham, J., North, K., Petrovic, K. E., Rice, K., Adrienne Cupples, L., Bielak, L. F., Launer, L. J., Andrade, M. D., Feitosa, M. F., Kavousi, M., Sitzer, M., Oudkerk, M., Province, M. A., Nalls, M., Franceschini, N., Peyser, P. A., Wolf, P. A., Zhang, Q., Wild, P. S., Schnabel, R. B., D'Agostino, R. B., Chilukoti, R. K., Schmidt, R., Sanna, S., Demissie, S., Sigurdsson, S., Blankenberg, S., Bevan, S., Elias-Smale, S. E., Zeller, T., Illig, T., Münzel, T., Howard, T. D., Hoffmann, U., Schminke, U., Nambi, V., Post, W. S., Rathmann, W., Li, X., Cheng, Y. C., CHARGE Consortium Hemostatic Factor Working Group, ICBP Consortium & CHARGE Consortium Subclinical Working Group Jun 1 2017 In : Journal of the American Heart Association. 6, 6, e004918

Research output: Research - peer-reviewArticle

Plasminogen Activator Inhibitor 1
Coronary Disease
Odds Ratio
Mendelian Randomization Analysis
Genome-Wide Association Study

Computer algorithms for automated detection and analysis of local Ca2+ releases in spontaneously beating cardiac pacemaker cells

Maltsev, A. V., Parsons, S. P., Kim, M. S., Tsutsui, K., Stern, M. D., Lakatta, E. G., Maltsev, V. A. & Monfredi, O. Jul 1 2017 In : PLoS ONE. 12, 7, e0179419

Research output: Research - peer-reviewArticle

cells
Pacemakers
Noise
Affine transforms
Biophysics

Hemodynamic determinants of the short-term blood pressure variability: Differential roles of arterial stiffness and wave reflection

Hsu, P. F., Cheng, H. M., Sung, S. H., Chuang, S. Y., Lakatta, E. G., Yin, F. C. P., Chou, P. & Chen, C. H. 2017 In : American Journal of Hypertension. 30, 3, p. 256-263 8 p.

Research output: Research - peer-reviewArticle

Vascular Stiffness
Hemodynamics
Blood Pressure
Pulse Wave Analysis
Thigh

Longitudinal Association between Serum Uric Acid and Arterial Stiffness: Results from the Baltimore Longitudinal Study of Aging

Canepa, M., Viazzi, F., Strait, J. B., Ameri, P., Pontremoli, R., Brunelli, C., Studenski, S., Ferrucci, L., Lakatta, E. G. & Alghatrif, M. Feb 1 2017 In : Hypertension. 69, 2, p. 228-235 8 p.

Research output: Research - peer-reviewArticle

Baltimore
Vascular Stiffness
Uric Acid
Longitudinal Studies
Serum

Lower mitochondrial energy production of the thigh muscles in patients with low-normal ankle-brachial index

AlGhatrif, M., Zane, A., Oberdier, M., Canepa, M., Studenski, S., Simonsick, E., Spencer, R. G., Fishbein, K., Reiter, D., Lakatta, E. G., McDermott, M. M. & Ferrucci, L. Sep 1 2017 In : Journal of the American Heart Association. 6, 9, e006604

Research output: Research - peer-reviewArticle

Ankle Brachial Index
Thigh
Muscles
Phosphocreatine
Exercise

Spontaneous, local diastolic subsarcolemmal calcium releases in single, isolated guinea-pig sinoatrial nodal cells

Sirenko, S. G., Yang, D., Maltseva, L. A., Kim, M. S., Lakatta, E. G. & Maltsev, V. A. Sep 1 2017 In : PLoS ONE. 12, 9, e0185222

Research output: Research - peer-reviewArticle

guinea pigs
calcium
cells
Guinea Pigs
Calcium

The Pressure of Aging

AlGhatrif, M., Wang, M., Fedorova, O. V., Bagrov, A. Y. & Lakatta, E. G. Jan 1 2017 In : Medical Clinics of North America. 101, 1, p. 81-101 21 p.

Research output: Research - peer-reviewReview article

Blood Pressure
Pressure
Pulse Wave Analysis
Hemodynamics
Hypertension

The Systematic Evaluation of Identifying the Infarct Related Artery Utilizing Cardiac Magnetic Resonance in Patients Presenting with ST-Elevation Myocardial Infarction

Hamo, C. E., Klem, I., Rao, S. V., Songco, V., Najjar, S., Lakatta, E. G., Raman, S. V., Harrington, R. A. & Heitner, J. F. Jan 1 2017 In : PLoS ONE. 12, 1, e0169108

Research output: Research - peer-reviewArticle

Magnetic Resonance Spectroscopy
Arteries
ST Elevation Myocardial Infarction
infarction
myocardial infarction
2016

52 Genetic Loci Influencing Myocardial Mass

van der Harst, P. , van Setten, J. , Verweij, N. , Vogler, G. , Franke, L. , Maurano, M. T. , Wang, X. , Mateo Leach, I. , Eijgelsheim, M. , Sotoodehnia, N. , Hayward, C. , Sorice, R. , Meirelles, O. , Lyytikäinen, L. P. , Polašek, O. , Tanaka, T. , Arking, D. E. , Ulivi, S. , Trompet, S. , Müller-Nurasyid, M. & 140 others Smith, A. V., Dörr, M., Kerr, K. F., Magnani, J. W., Del Greco M., F., Zhang, W., Nolte, I. M., Silva, C. T., Padmanabhan, S., Tragante, V., Esko, T., Abecasis, G. R., Adriaens, M. E., Andersen, K., Barnett, P., Bis, J. C., Bodmer, R., Buckley, B. M., Campbell, H., Cannon, M. V., Chakravarti, A., Chen, L. Y., Delitala, A., Devereux, R. B., Doevendans, P. A., Dominiczak, A. F., Ferrucci, L., Ford, I., Gieger, C., Harris, T. B., Haugen, E., Heinig, M., Hernandez, D. G., Hillege, H. L., Hirschhorn, J. N., Hofman, A., Hubner, N., Hwang, S. J., Iorio, A., Kähönen, M., Kellis, M., Kolcic, I., Kooner, I. K., Kooner, J. S., Kors, J. A., Lakatta, E. G., Lage, K., Launer, L. J., Levy, D., Lundby, A., Macfarlane, P. W., May, D., Meitinger, T., Metspalu, A., Nappo, S., Naitza, S., Neph, S., Nord, A. S., Nutile, T., Okin, P. M., Olsen, J. V., Oostra, B. A., Penninger, J. M., Pennacchio, L. A., Pers, T. H., Perz, S., Peters, A., Pinto, Y. M., Pfeufer, A., Pilia, M. G., Pramstaller, P. P., Prins, B. P., Raitakari, O. T., Raychaudhuri, S., Rice, K. M., Rossin, E. J., Rotter, J. I., Schafer, S., Schlessinger, D., Schmidt, C. O., Sehmi, J., Silljé, H. H. W., Sinagra, G., Sinner, M. F., Slowikowski, K., Soliman, E. Z., Spector, T. D., Spiering, W., Stamatoyannopoulos, J. A., Stolk, R. P., Strauch, K., Tan, S. T., Tarasov, K. V., Trinh, B., Uitterlinden, A. G., van den Boogaard, M., van Duijn, C. M., van Gilst, W. H., Viikari, J. S., Visscher, P. M., Vitart, V., Völker, U., Waldenberger, M., Weichenberger, C. X., Westra, H. J., Wijmenga, C., Wolffenbuttel, B. H., Yang, J., Bezzina, C. R., Munroe, P. B., Snieder, H., Wright, A. F., Rudan, I., Boyer, L. A., Asselbergs, F. W., van Veldhuisen, D. J., Stricker, B. H., Psaty, B. M., Ciullo, M., Sanna, S., Lehtimäki, T., Wilson, J. F., Bandinelli, S., Alonso, A., Gasparini, P., Jukema, J. W., Kääb, S., Gudnason, V., Felix, S. B., Heckbert, S. R., de Boer, R. A., Newton-Cheh, C., Hicks, A. A., Chambers, J. C., Jamshidi, Y., Visel, A., Christoffels, V. M., Isaacs, A., Samani, N. J. & de Bakker, P. I. W. Sep 27 2016 In : Journal of the American College of Cardiology. 68, 13, p. 1435-1448 14 p.

Research output: Research - peer-reviewArticle

Genetic Loci
Cardiomegaly
Meta-Analysis
Myocardium
Genes

AGE-RAGE signal generates a specific NF-Κ B RelA "barcode" that directs collagen i expression

Peng, Y., Kim, J. M., Park, H. S., Yang, A., Islam, C., Lakatta, E. G. & Lin, L. Jan 5 2016 In : Scientific Reports. 6, 18822

Research output: Research - peer-reviewArticle

Collagen
NF-kappa B
Advanced Glycosylation End Products
Post Translational Protein Processing
Phosphorylation

Aortic Fibrosis, Induced by High Salt Intake in the Absence of Hypertensive Response, Is Reduced by a Monoclonal Antibody to Marinobufagenin

Grigorova, Y. N., Juhasz, O., Zernetkina, V., Fishbein, K. W., Lakatta, E. G., Fedorova, O. V. & Bagrov, A. Y. May 1 2016 In : American Journal of Hypertension. 29, 5, p. 641-646 6 p.

Research output: Research - peer-reviewArticle

Fibrosis
Salts
Monoclonal Antibodies
marinobufagenin
Blood Pressure

A rat carotid balloon injury model to test anti-vascular remodeling therapeutics

Petrasheskaya, N., Tae, H. J., Ahmet, I., Talan, M. I., Lakatta, E. G. & Lin, L. Sep 19 2016 In : Journal of Visualized Experiments. 2016, 115, e53777

Research output: Research - peer-reviewArticle

Wounds and Injuries
Therapeutics
Vascular Remodeling
Balloons
Rats

Ca2 +/calmodulin-activated phosphodiesterase 1A is highly expressed in rabbit cardiac sinoatrial nodal cells and regulates pacemaker function

Lukyanenko, Y. O., Younes, A., Lyashkov, A. E., Tarasov, K. V., Riordon, D. R., Lee, J., Sirenko, S. G., Kobrinsky, E., Ziman, B., Tarasova, Y. S., Juhaszova, M., Sollott, S. J., Graham, D. R. & Lakatta, E. G. Sep 1 2016 In : Journal of Molecular and Cellular Cardiology. 98, p. 73-82 10 p.

Research output: Research - peer-reviewArticle

Type 1 Cyclic Nucleotide Phosphodiesterases
Rabbits
Lipids
Calmodulin
Phosphoric Diester Hydrolases

Camkii-dependent phosphorylation regulates basal cardiac pacemaker function via modulation of local ca2+ releases

Li, Y., Sirenko, S., Riordon, D. R., Yang, D., Spurgeon, H., Lakatta, E. G. & Vinogradova, T. M. Sep 1 2016 In : American Journal of Physiology - Heart and Circulatory Physiology. 311, 3, p. H532-H544

Research output: Research - peer-reviewArticle

Phosphorylation
Sinoatrial Node
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Ryanodine Receptor Calcium Release Channel
phospholamban

Deterioration of autonomic neuronal receptor signaling and mechanisms intrinsic to heart pacemaker cells contribute to age-associated alterations in heart rate variability in vivo

Yaniv, Y., Ahmet, I., Tsutsui, K., Behar, J., Moen, J. M., Okamoto, Y., Guiriba, T. R., Liu, J., Bychkov, R. & Lakatta, E. G. Aug 1 2016 In : Aging Cell. 15, 4, p. 716-724 9 p.

Research output: Research - peer-reviewArticle

Heart Rate
Phosphoric Diester Hydrolases
Atropine
Propranolol
Electrocardiography

Electrochemical Na+ and Ca2+gradients drive coupled-clock regulation of automaticity of isolated rabbit sinoatrial nodal pacemaker cells

Sirenko, S. G., Maltsev, V. A., Yaniv, Y., Bychkov, R., Yaeger, D., Vinogradova, T., Spurgeon, H. A. & Lakatta, E. G. Jul 1 2016 In : American Journal of Physiology - Heart and Circulatory Physiology. 311, 1, p. H251-H267

Research output: Research - peer-reviewArticle

Action Potentials
Rabbits
Ion Channels
Ions
Digitalis Glycosides

Gender specific profiles of white coat and masked hypertension impacts on arterial structure and function in the SardiNIA study

Scuteri, A., Morrell, C. H., Orru', M., Alghatrif, M., Saba, P. S., Terracciano, A., Ferreli, L. A. P., Loi, F., Marongiu, M., Pilia, M. G., Delitala, A., Tarasov, K. V., Schlessinger, D., Ganau, A., Cucca, F. & Lakatta, E. G. Aug 15 2016 In : International Journal of Cardiology. 217, p. 92-98 7 p.

Research output: Research - peer-reviewArticle

Masked Hypertension
White Coat Hypertension
Italy
Ambulatory Blood Pressure Monitoring
Common Carotid Artery

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Pattaro, C. , Teumer, A. , Gorski, M. , Chu, A. Y. , Li, M. , Mijatovic, V. , Garnaas, M. , Tin, A. , Sorice, R. , Li, Y. , Taliun, D. , Olden, M. , Foster, M. , Yang, Q. , Chen, M. H. , Pers, T. H. , Johnson, A. D. , Ko, Y. A. , Fuchsberger, C. , Tayo, B. & 678 others Nalls, M., Feitosa, M. F., Isaacs, A., Dehghan, A., D'Adamo, P., Adeyemo, A., Dieffenbach, A. K., Zonderman, A. B., Nolte, I. M., Van Der Most, P. J., Wright, A. F., Shuldiner, A. R., Morrison, A. C., Hofman, A., Smith, A. V., Dreisbach, A. W., Franke, A., Uitterlinden, A. G., Metspalu, A., Tonjes, A., Lupo, A., Robino, A., Johansson, Å., Demirkan, A., Kollerits, B., Freedman, B. I., Ponte, B., Oostra, B. A., Paulweber, B., Krämer, B. K., Mitchell, B. D., Buckley, B. M., Peralta, C. A., Hayward, C., Helmer, C., Rotimi, C. N., Shaffer, C. M., Müller, C., Sala, C., Van Duijn, C. M., Saint-Pierre, A., Ackermann, D., Shriner, D., Ruggiero, D., Toniolo, D., Lu, Y., Cusi, D., Czamara, D., Ellinghaus, D., Siscovick, D. S., Ruderfer, D., Gieger, C., Grallert, H., Rochtchina, E., Atkinson, E. J., Holliday, E. G., Boerwinkle, E., Salvi, E., Bottinger, E. P., Murgia, F., Rivadeneira, F., Ernst, F., Kronenberg, F., Hu, F. B., Navis, G. J., Curhan, G. C., Ehret, G. B., Homuth, G., Coassin, S., Thun, G. A., Pistis, G., Gambaro, G., Malerba, G., Montgomery, G. W., Eiriksdottir, G., Jacobs, G., Li, G., Wichmann, H. E., Campbell, H., Schmidt, H., Wallaschofski, H., Völzke, H., Brenner, H., Kroemer, H. K., Kramer, H., Lin, H., Leach, I. M., Ford, I., Guessous, I., Rudan, I., Prokopenko, I., Borecki, I., Heid, I. M., Kolcic, I., Persico, I., Jukema, J. W., Wilson, J. F., Felix, J. F., Divers, J., Lambert, J. C., Stafford, J. M., Gaspoz, J. M., Smith, J. A., Faul, J. D., Wang, J. J., Ding, J., Hirschhorn, J. N., Attia, J., Whitfield, J. B., Chalmers, J., Viikari, J., Coresh, J., Denny, J. C., Karjalainen, J., Fernandes, J. K., Endlich, K., Butterbach, K., Keene, K. L., Lohman, K., Portas, L., Launer, L. 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B., Watzinger, N., Aragam, J., Zweiker, R., Lind, L., Rodeheffer, R. J., Greiser, K. H., Deckers, J. W., Stritzke, J., Ingelsson, E., Kullo, I., Haerting, J., Reffelmann, T., Redfield, M. M., Werdan, K., Mitchell, G. F., Arnett, D. K., Gottdiener, J. S., Blettner, M., Friedrich, N., Kovacs, P., Wild, P. S., Froguel, P., Rettig, R., Mägi, R., Biffar, R., Schmidt, R., Middelberg, R. P. S., Carroll, R. J., Penninx, B. W., Scott, R. J., Katz, R., Sedaghat, S., Wild, S. H., Kardia, S. L. R., Ulivi, S., Hwang, S. J., Enroth, S., Kloiber, S., Trompet, S., Stengel, B., Hancock, S. J., Turner, S. T., Rosas, S. E., Stracke, S., Harris, T. B., Zeller, T., Zemunik, T., Lehtimäki, T., Illig, T., Aspelund, T., Nikopensius, T., Esko, T., Tanaka, T., Gyllensten, U., Völker, U., Emilsson, V., Vitart, V., Aalto, V., Gudnason, V., Chouraki, V., Chen, W. M., Igl, W., März, W., Koenig, W., Lieb, W., Loos, R. J. F., Liu, Y., Snieder, H., Pramstaller, P. P., Parsa, A., O'Connell, J. R., Susztak, K., Hamet, P., Tremblay, J., De Boer, I. H., Böger, C. A., Goessling, W., Chasman, D. I., Köttgen, A., Kao, W. H. L. & Fox, C. S. Jan 21 2016 In : Nature Communications. 7, 10023

Research output: Research - peer-reviewArticle

kidneys
loci
cells
Kidney
Glomerular Filtration Rate

High short-term blood pressure variability predicts long-term cardiovascular mortality in untreated hypertensives but not in normotensives

Hsu, P. F., Cheng, H. M., Wu, C. H., Sung, S. H., Chuang, S. Y., Lakatta, E. G., Yin, F. C. P., Chou, P. & Chen, C. H. 2016 In : American Journal of Hypertension. 29, 7, p. 806-813 8 p.

Research output: Research - peer-reviewArticle

Blood Pressure
Mortality
Confidence Intervals
Ambulatory Blood Pressure Monitoring
Hypertension
Dietary Supplements
Heart Failure
resveratrol
Diet
Pulse Wave Analysis

Mouse RAGE variant 4 is a dominant membrane receptor that does not shed to generate soluble RAGE

Peng, Y., Horwitz, N., Lakatta, E. G. & Lin, L. Sep 1 2016 In : PLoS ONE. 11, 9, e0153657

Research output: Research - peer-reviewArticle

Protein Isoforms
Cell Membrane
Membranes
Advanced Glycosylation End Product-Specific Receptor
Mouse Ager protein

Pharmacological Strategies to Retard Cardiovascular Aging

Alfaras, I., Di Germanio, C., Bernier, M., Csiszar, A., Ungvari, Z., Lakatta, E. G. & De Cabo, R. May 13 2016 In : Circulation Research. 118, 10, p. 1626-1642 17 p.

Research output: Research - peer-reviewReview article

Cardiovascular Diseases
Pharmacology
Cardiovascular System
Hypercholesterolemia
Hyperglycemia

Prognostic significance of mechanical biomarkers derived from pulse wave analysis for predicting long-term cardiovascular mortality in two population-based cohorts

Cheng, H. M., Chuang, S. Y., Wang, J. J., Shih, Y. T., Wang, H. N., Huang, C. J., Huang, J. T., Sung, S. H., Lakatta, E. G., Yin, F. C. P., Chou, P., Yeh, C. J., Bai, C. H., Pan, W. H. & Chen, C. H. Jul 15 2016 In : International Journal of Cardiology. 215, p. 388-395 8 p.

Research output: Research - peer-reviewArticle

Pulse Wave Analysis
Biomarkers
Mortality
Population
Cardiovascular Diseases

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Ehret, G. B. , Ferreira, T. , Chasman, D. I. , Jackson, A. U. , Schmidt, E. M. , Johnson, T. , Thorleifsson, G. , Luan, J. A. , Donnelly, L. A. , Kanoni, S. , Petersen, A. K. , Pihur, V. , Strawbridge, R. J. , Shungin, D. , Hughes, M. F. , Meirelles, O. , Kaakinen, M. , Bouatia-Naji, N. , Kristiansson, K. , Shah, S. & 293 others Kleber, M. E., Guo, X., Lyytikäinen, L. P., Fava, C., Eriksson, N., Nolte, I. M., Magnusson, P. K., Salfati, E. L., Rallidis, L. S., Theusch, E., Smith, A. J. P., Folkersen, L., Witkowska, K., Pers, T. H., Joehanes, R., Kim, S. K., Lataniotis, L., Jansen, R., Johnson, A. D., Warren, H., Kim, Y. J., Zhao, W., Wu, Y., Tayo, B. O., Bochud, M., Absher, D., Adair, L. S., Amin, N., Arking, D. E., Axelsson, T., Baldassarre, D., Balkau, B., Bandinelli, S., Barnes, M. R., Barroso, I., Bevan, S., Bis, J. C., Bjornsdottir, G., Boehnke, M., Boerwinkle, E., Bonnycastle, L. L., Boomsma, D. I., Bornstein, S. R., Brown, M. J., Burnier, M., Cabrera, C. P., Chambers, J. C., Chang, I. S., Cheng, C. Y., Chines, P. S., Chung, R. H., Collins, F. S., Connell, J. M., Döring, A., Dallongeville, J., Danesh, J., De Faire, U., Delgado, G., Dominiczak, A. F., Doney, A. S. F., Drenos, F., Edkins, S., Eicher, J. D., Elosua, R., Enroth, S., Erdmann, J., Eriksson, P., Esko, T., Evangelou, E., Evans, A., Fall, T., Farrall, M., Felix, J. F., Ferrières, J., Ferrucci, L., Fornage, M., Forrester, T., Franceschini, N., Franco, O. H., Franco-Cereceda, A., Fraser, R. M., Ganesh, S. K., Gao, H., Gertow, K., Gianfagna, F., Gigante, B., Giulianini, F., Goel, A., Goodall, A. H., Goodarzi, M. O., Gorski, M., Gräßler, J., Groves, C. J., Gudnason, V., Gyllensten, U., Hallmans, G., Hartikainen, A. L., Hassinen, M., Havulinna, A. S., Hayward, C., Hercberg, S., Herzig, K. H., Hicks, A. A., Hingorani, A. D., Hirschhorn, J. N., Hofman, A., Holmen, J., Holmen, O. L., Hottenga, J. J., Howard, P., Hsiung, C. A., Hunt, S. C., Ikram, M. A., Illig, T., Iribarren, C., Jensen, R. A., Kähönen, M., Kang, H. M., Kathiresan, S., Keating, B. J., Khaw, K. T., Kim, Y. K., Kim, E., Kivimaki, M., Klopp, N., Kolovou, G., Komulainen, P., Kooner, J. S., Kosova, G., Krauss, R. M., Kuh, D., Kutalik, Z., Kuusisto, J., Kvaløy, K., Lakka, T. A., Lee, N. R., Lee, I. T., Lee, W. J., Levy, D., Li, X., Liang, K. W., Lin, H., Lin, L., Lindström, J., Lobbens, S., Männistö, S., Müller, G., Müller-Nurasyid, M., Mach, F., Markus, H. S., Marouli, E., McCarthy, M. I., McKenzie, C. A., Meneton, P., Menni, C., Metspalu, A., Mijatovic, V., Moilanen, L., Montasser, M. E., Morris, A. D., Morrison, A. C., Mulas, A., Nagaraja, R., Narisu, N., Nikus, K., O'Donnell, C. J., O'Reilly, P. F., Ong, K. K., Paccaud, F., Palmer, C. D., Parsa, A., Pedersen, N. L., Penninx, B. W., Perola, M., Peters, A., Poulter, N., Pramstaller, P. P., Psaty, B. M., Quertermous, T., Rao, D. C., Rasheed, A., Rayner, N. W., Renström, F., Rettig, R., Rice, K. M., Roberts, R., Rose, L. M., Rossouw, J., Samani, N. J., Sanna, S., Saramies, J., Schunkert, H., Sebert, S., Sheu, W. H. H., Shin, Y. A., Sim, X., Smit, J. H., Smith, A. V., Sosa, M. X., Spector, T. D., Stančáková, A., Stanton, A. V., Stirrups, K. E., Stringham, H. M., Sundstrom, J., Swift, A. J., Syvänen, A. C., Tai, E. S., Tanaka, T., Tarasov, K. V., Teumer, A., Thorsteinsdottir, U., Tobin, M. D., Tremoli, E., Uitterlinden, A. G., Uusitupa, M., Vaez, A., Vaidya, D., Van Duijn, C. M., Van Iperen, E. P. A., Vasan, R. S., Verwoert, G. C., Virtamo, J., Vitart, V., Voight, B. F., Vollenweider, P., Wagner, A., Wain, L. V., Wareham, N. J., Watkins, H., Weder, A. B., Westra, H. J., Wilks, R., Wilsgaard, T., Wilson, J. F., Wong, T. Y., Yang, T. P., Yao, J., Yengo, L., Zhang, W., Zhao, J. H., Zhu, X., Bovet, P., Cooper, R. S., Mohlke, K. L., Saleheen, D., Lee, J. Y., Elliott, P., Gierman, H. J., Willer, C. J., Franke, L., Hovingh, G. K., Taylor, K. D., Dedoussis, G., Sever, P., Wong, A., Lind, L., Assimes, T. L., Njølstad, I., Schwarz, P. E. H., Langenberg, C., Snieder, H., Caulfield, M. J., Melander, O., Laakso, M., Saltevo, J., Rauramaa, R., Tuomilehto, J., Ingelsson, E., Lehtimäki, T., Hveem, K., Palmas, W., März, W., Kumari, M., Salomaa, V., Chen, Y. D. I., Rotter, J. I., Froguel, P., Jarvelin, M. R., Lakatta, E. G., Kuulasmaa, K., Franks, P. W., Hamsten, A., Wichmann, H. E., Palmer, C. N. A., Stefansson, K., Ridker, P. M., Loos, R. J. F., Chakravarti, A., Deloukas, P., Morris, A. P., Newton-Cheh, C. & Munroe, P. B. Oct 1 2016 In : Nature Genetics. 48, 10, p. 1171-1184 14 p.

Research output: Research - peer-reviewArticle

Blood Pressure
Single Nucleotide Polymorphism
Kidney
Blood Vessels
Endothelial Cells

The relationship between the metabolic syndrome and arterial wall thickness: A mosaic still to be interpreted

Scuteri, A., Franco, O. H., Völzke, H., Shin, M. H., Kweon, S. S., Rietzschel, E., Ryliškytė, L., Strazhesko, I., Chen, C. H., Lakatta, E. G. & Nilsson, P. M. Dec 1 2016 In : Atherosclerosis. 255, p. 11-16 6 p.

Research output: Research - peer-reviewArticle

Abdominal Obesity
Hypertension
Arteries
Cholesterol
Carotid Arteries
2015

Cardiovascular disease and aging

Rabinovitch, P., Chiao, Y. A., Dai, D. F., Lakatta, E. & Ungvari, Z. Jan 1 2015 Advances in Geroscience. Springer International Publishing, p. 121-160 40 p.

Research output: ResearchChapter

Cardiovascular Diseases
Disease
Aging of materials
Cardiovascular System
Population

From two competing oscillators to one coupled-clock pacemaker cell system

Yaniv, Y., Lakatta, E. G. & Maltsev, V. A. 2015 In : Frontiers in Physiology. 6, FEB, 28

Research output: Research - peer-reviewShort survey

Action Potentials
Ion Channels
Electrophysiology
Sarcoplasmic Reticulum
Mammals

Marinobufagenin-induced vascular fibrosis is a likely target for mineralocorticoid antagonists

Fedorova, O. V., Emelianov, I. V., Bagrov, K. A., Grigorova, Y. N., Wei, W., Juhasz, O., Frolova, E. V., Marshall, C. A., Lakatta, E. G., Konradi, A. O. & Bagrov, A. Y. Aug 11 2015 In : Journal of Hypertension. 33, 8, p. 1602-1610 9 p.

Research output: Research - peer-reviewArticle

Mineralocorticoid Receptor Antagonists
Blood Vessels
Fibrosis
marinobufagenin
Spironolactone

Matrix metalloproteinases promote arterial remodeling in aging, hypertension, and atherosclerosis

Wang, M., Kim, S. H., Monticone, R. E. & Lakatta, E. G. Apr 20 2015 In : Hypertension. 65, 4, p. 698-703 6 p.

Research output: Research - peer-reviewArticle

Metabolic syndrome across Europe: Different clusters of risk factors

Scuteri, A., Laurent, S., Cucca, F., Cockcroft, J., Cunha, P. G., Mañas, L. R., Raso, F. U. M., Muiesan, M. L., Ryliškyte, L., Rietzschel, E., Strait, J., Vlachopoulos, C., Völzke, H., Lakatta, E. G., Nilsson, P. M. & Metabolic Syndrome and Arteries Research (MARE) Consortium Apr 15 2015 In : European Journal of Preventive Cardiology. 22, 4, p. 486-491 6 p.

Research output: Research - peer-reviewArticle

Italy
Sweden
Spain
Germany
Glucose

No evidence of association between subclinical thyroid disorders and common carotid intima medial thickness or atherosclerotic plaque

Delitala, A. P., Filigheddu, F., Orrù, M., AlGhatrif, M., Steri, M., Pilia, M. G., Scuteri, A., Lobina, M., Piras, M. G., Delitala, G., Lakatta, E. G., Schlessinger, D. & Cucca, F. Dec 1 2015 In : Nutrition, Metabolism and Cardiovascular Diseases. 25, 12, p. 1104-1110 7 p.

Research output: Research - peer-reviewArticle

Carotid Intima-Media Thickness
Atherosclerotic Plaques
Thyroid Gland
Carotid Artery Diseases
Thyroid Hormones

Plasma level of the endogenous sodium pump ligand marinobufagenin is related to the salt-sensitivity in men

Fedorova, O. V., Lakatta, E. G., Bagrov, A. Y. & Melander, O. Mar 6 2015 In : Journal of Hypertension. 33, 3, p. 534-541 8 p.

Research output: Research - peer-reviewArticle

Sodium-Potassium-Exchanging ATPase
Salts
Ligands
marinobufagenin
Inbred Dahl Rats

Potential effects of intrinsic heart pacemaker cell mechanisms on dysrhythmic cardiac action potential firing

Yaniv, Y., Tsutsui, K. & Lakatta, E. G. 2015 In : Frontiers in Physiology. 6, FEB, 047

Research output: Research - peer-reviewArticle

Action Potentials
Sinoatrial Node
Cardiac Arrhythmias
Brain
Vagus Nerve

Real-time relationship between PKA biochemical signal network dynamics and increased action potential firing rate in heart pacemaker cells. Kinetics of PKA activation in heart pacemaker cells.

Yaniv, Y., Ganesan, A., Yang, D., Ziman, B. D., Lyashkov, A. E., Levchenko, A., Zhang, J. & Lakatta, E. G. Sep 1 2015 In : Journal of Molecular and Cellular Cardiology. 86, p. 168-178 11 p.

Research output: Research - peer-reviewArticle

Action Potentials
Heart Rate
Receptors, Adrenergic, beta
Phosphoric Diester Hydrolases
Phosphorylation

Recommendations for Improving and Standardizing Vascular Research on Arterial Stiffness: A Scientific Statement from the American Heart Association

Townsend, R. R., Wilkinson, I. B., Schiffrin, E. L., Avolio, A. P., Chirinos, J. A., Cockcroft, J. R., Heffernan, K. S., Lakatta, E. G., McEniery, C. M., Mitchell, G. F., Najjar, S. S., Nichols, W. W., Urbina, E. M. & Weber, T. Sep 14 2015 In : Hypertension. 66, 3, p. 698-722 25 p.

Research output: Research - peer-reviewArticle

Vascular Stiffness
Blood Vessels
Research
Clinical Medicine
Longitudinal Studies

Serum free thyroxine levels are positively associated with arterial stiffness in the SardiNIA study

Delitala, A. P., Orrù, M., Filigheddu, F., Pilia, M. G., Delitala, G., Ganau, A., Saba, P. S., Decandia, F., Scuteri, A., Marongiu, M., Lakatta, E. G., Strait, J. & Cucca, F. Apr 1 2015 In : Clinical Endocrinology. 82, 4, p. 592-597 6 p.

Research output: Research - peer-reviewArticle

Pulse Wave Analysis
Vascular Stiffness
Thyroxine
Italy
Serum

Serum from calorie-restricted animals delays senescence and extends the lifespan of normal human fibroblasts in vitro

de Cabo, R., Liu, L., Ali, A., Price, N., Zhang, J., Wang, M., Lakatta, E. & Irusta, P. M. 2015 In : Aging. 7, 3, p. 152-166 15 p.

Research output: Research - peer-reviewArticle

Caloric Restriction
Cell Aging
Fibroblasts
Serum
In Vitro Techniques

So! What's aging? Is cardiovascular aging a disease?

Lakatta, E. G. Jun 1 2015 In : Journal of Molecular and Cellular Cardiology. 83, p. 1-13 13 p.

Research output: Research - peer-reviewArticle

Arteries
Clinical Medicine
Signs and Symptoms
Cardiovascular Diseases
Inflammation

Synthesis of an Endogenous Steroidal Na Pump Inhibitor Marinobufagenin, Implicated in Human Cardiovascular Diseases, Is Initiated by CYP27A1 via Bile Acid Pathway

Fedorova, O. V., Zernetkina, V. I., Shilova, V. Y., Grigorova, Y. N., Juhasz, O., Wei, W., Marshall, C. A., Lakatta, E. G. & Bagrov, A. Y. Oct 1 2015 In : Circulation: Cardiovascular Genetics. 8, 5, p. 736-745 10 p.

Research output: Research - peer-reviewArticle

Bile Acids and Salts
Cardiovascular Diseases
marinobufagenin
Cholesterol Side-Chain Cleavage Enzyme
Trophoblasts

The Aging Arterial Wall

Wang, M., Monticone, R. E. & Lakatta, E. G. Sep 8 2015 Handbook of the Biology of Aging: Eighth Edition. Elsevier Inc., p. 359-389 31 p.

Research output: ResearchChapter

Atherosclerosis
Hypertension
Tunica Intima
Elastin
Cell Aging
Vascular Stiffness
Blood Pressure
Aorta
Dilatation
Hemodynamics

The end effector of circadian heart rate variation: The sinoatrial node pacemaker cell

Yaniv, Y. & Lakatta, E. G. 2015 In : BMB Reports. 48, 12, p. 677-684 8 p.

Research output: Research - peer-reviewShort survey

Pacemakers
End effectors
Clocks
Sinoatrial Node
Heart Rate

Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart

Kaushik, G., Spenlehauer, A., Sessions, A. O., Trujillo, A. S., Fuhrmann, A., Fu, Z., Venkatraman, V., Pohl, D., Tuler, J., Wang, M., Lakatta, E. G., Ocorr, K., Bodmer, R., Bernstein, S. I., Van Eyk, J. E., Cammarato, A. & Engler, A. J. Jun 17 2015 In : Science Translational Medicine. 7, 292, 292ra99

Research output: Research - peer-reviewArticle

Vinculin
Cytoskeleton
Diptera
Therapeutics
Myofibrils
2014

Age-associated abnormalities of intrinsic automaticity of sinoatrial nodal cells are linked to deficient cAMP-PKA-Ca2+ signaling

Liu, J., Sirenko, S., Juhaszova, M., Sollott, S. J., Shukla, S., Yaniv, Y. & Lakatta, E. G. May 15 2014 In : American Journal of Physiology - Heart and Circulatory Physiology. 306, 10

Research output: Research - peer-reviewArticle

Heart Rate
Membranes
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Ryanodine Receptor Calcium Release Channel
Sinoatrial Node

Aortic pulse wave velocity improves cardiovascular event prediction: An individual participant meta-analysis of prospective observational data from 17,635 subjects

Ben-Shlomo, Y. , Spears, M. , Boustred, C. , May, M. , Anderson, S. G. , Benjamin, E. J. , Boutouyrie, P. , Cameron, J. , Chen, C. H. , Cruickshank, J. K. , Hwang, S. J. , Lakatta, E. G. , Laurent, S. , Maldonado, J. , Mitchell, G. F. , Najjar, S. S. , Newman, A. B. , Ohishi, M. , Pannier, B. , Pereira, T. & 11 others Vasan, R. S., Shokawa, T., Sutton-Tyrell, K., Verbeke, F., Wang, K. L., Webb, D. J., Willum Hansen, T., Zoungas, S., McEniery, C. M., Cockcroft, J. R. & Wilkinson, I. B. Feb 25 2014 In : Journal of the American College of Cardiology. 63, 7, p. 636-646 11 p.

Research output: Research - peer-reviewArticle

Pulse Wave Analysis
Meta-Analysis
Cardiovascular Diseases
Confidence Intervals
Coronary Disease

Are personality traits associated with white-coat and masked hypertension?

Terracciano, A., Scuteri, A., Strait, J., Sutin, A. R., Meirelles, O., Marongiu, M., Orru, M., Grazia Pilia, M., Ferrucci, L., Cucca, F., Schlessinger, D. & Lakatta, E. Oct 1 2014 In : Journal of Hypertension. 32, 10, p. 1987-1992 6 p.

Research output: Research - peer-reviewArticle

Masked Hypertension
White Coat Hypertension
Antihypertensive Agents
Personality
Anxiety

Arterial stiffness and influences of the metabolic syndrome: A cross-countries study

Scuteri, A. , Cunha, P. G. , Rosei, E. A. , Badariere, J. , Bekaert, S. , Cockcroft, J. R. , Cotter, J. , Cucca, F. , De Buyzere, M. L. , De Meyer, T. , Ferrucci, L. , Franco, O. , Gale, N. , Gillebert, T. C. , Langlois, M. , Laucevicius, A. , Laurent, S. , Mattace Raso, F. U. S. , Morrell, C. H. , Muiesan, M. L. & 20 others Munnery, M. M., Navickas, R., Oliveira, P., Orru', M., Pilia, M. G., Rietzschel, E. R., Ryliskyte, L., Salvetti, M., Schlessinger, D., Sousa, N., Stefanadis, C., Strait, J., Van daele, C., Villa, I., Vlachopoulos, C., Witteman, J., Xaplanteris, P., Nilsson, P., Lakatta, E. G. & Hofman, A. 2014 In : Atherosclerosis. 233, 2, p. 654-660 7 p.

Research output: Research - peer-reviewArticle

Vascular Stiffness
Oculocerebral hypopigmentation syndrome type Preus
Arteries
Pulse Wave Analysis
Research

Biophysical characterization of the underappreciated and important relationship between heart rate variability and heart rate

Monfredi, O., Lyashkov, A. E., Johnsen, A. B., Inada, S., Schneider, H., Wang, R., Nirmalan, M., Wisloff, U., Maltsev, V. A., Lakatta, E. G., Zhang, H. & Boyett, M. R. 2014 In : Hypertension. 64, 6, p. 1334-1343 10 p.

Research output: Research - peer-reviewArticle

Heart Rate
Autonomic Pathways
Morbidity
Mortality
Fetal Distress

Changes in the heart that accompany advancing age: Humans to molecules

Lakatta, E. G., Spurgeon, H. A. & Janczewski, A. M. Jan 1 2014 Aging and Heart Failure: Mechanisms and Management. Springer New York, p. 319-337 19 p.

Research output: ResearchChapter

Excitation Contraction Coupling
Clinical Medicine
Receptors, Adrenergic, beta
Sarcoplasmic Reticulum
Cardiology