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  • 2019
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  • Ernesto I Freire
2017

A novel lipoate attachment enzyme is shared by Plasmodium and Chlamydia species

Afanador, G. A., Guerra, A. J., Swift, R. P., Rodriguez, R. E., Bartee, D., Matthews, K. A., Schön, A., Freire, E. I., Meyers, C. L. & Prigge, S. T., Nov 1 2017, In : Molecular Microbiology. 106, 3, p. 439-451 13 p.

Research output: Contribution to journalArticle

2016

Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition

Melillo, B., Liang, S., Park, J., Schön, A., Courter, J. R., Lalonde, J. M., Wendler, D. J., Princiotto, A. M., Seaman, M. S., Freire, E., Sodroski, J., Madani, N., Hendrickson, W. A. & Smith, A. B., Mar 10 2016, In : ACS Medicinal Chemistry Letters. 7, 3, p. 330-334 5 p.

Research output: Contribution to journalArticle

2019

Erratum to: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite (Nature Medicine, (2018), 24, 4, (408-416), 10.1038/nm.4512)

Kisalu, N. K., Idris, A. H., Weidle, C., Flores-Garcia, Y., Flynn, B. J., Sack, B. K., Murphy, S., Schön, A., Freire, E. I., Francica, J. R., Miller, A. B., Gregory, J., March, S., Liao, H. X., Haynes, B. F., Wiehe, K., Trama, A. M., Saunders, K. O., Gladden, M. A., Monroe, A. & 18 others, Bonsignori, M., Kanekiyo, M., Wheatley, A. K., McDermott, A. B., Farney, S. K., Chuang, G. Y., Zhang, B., Kc, N., Chakravarty, S., Kwong, P. D., Sinnis, P., Bhatia, S. N., Kappe, S. H. I., Sim, B. K. L., Hoffman, S. L., Zavala, F. P., Pancera, M. & Seder, R. A., Jan 1 2019, In : Nature Medicine. 25, 1, p. 188-189 2 p.

Research output: Contribution to journalComment/debate

2017

The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions

Herschhorn, A., Gu, C., Moraca, F., Ma, X., Farrell, M., Smith, A. B., Pancera, M., Kwong, P. D., Schön, A., Freire, E. I., Abrams, C., Blanchard, S. C., Mothes, W. & Sodroski, J. G., Dec 1 2017, In : Nature Communications. 8, 1, 1049.

Research output: Contribution to journalArticle

2016

Three easy pieces

Schön, A. & Freire, E., May 1 2016, In : Biochimica et Biophysica Acta - General Subjects. 1860, 5, p. 975-980 6 p.

Research output: Contribution to journalArticle

2018

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

Kisalu, N. K., Idris, A. H., Weidle, C., Flores-Garcia, Y., Flynn, B. J., Sack, B. K., Murphy, S., Schön, A., Freire, E. I., Francica, J. R., Miller, A. B., Gregory, J., March, S., Liao, H. X., Haynes, B. F., Wiehe, K., Trama, A. M., Saunders, K. O., Gladden, M. A., Monroe, A. & 18 others, Bonsignori, M., Kanekiyo, M., Wheatley, A. K., McDermott, A. B., Farney, S. K., Chuang, G. Y., Zhang, B., Kc, N., Chakravarty, S., Kwong, P. D., Sinnis, P., Bhatia, S. N., Kappe, S. H. I., Sim, B. K. L., Hoffman, S. L., Zavala, F. P., Pancera, M. & Seder, R. A., May 1 2018, In : Nature Medicine. 24, 4, p. 408-416 9 p.

Research output: Contribution to journalArticle

2016

Conformational stability and self-association equilibrium in biologics

Clarkson, B. R., Schön, A. & Freire, E., Jan 1 2016, In : Drug Discovery Today. 21, 2, p. 342-347 6 p.

Research output: Contribution to journalReview article

2018

Long term stability of a HIV-1 neutralizing monoclonal antibody using isothermal calorimetry

Clarkson, B. R., Chaudhuri, R., Schön, A., Cooper, J. W., Kueltzo, L. & Freire, E. I., Aug 1 2018, In : Analytical Biochemistry. 554, p. 61-69 9 p.

Research output: Contribution to journalArticle

2017

Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529

Pancera, M., Lai, Y. T., Bylund, T., Druz, A., Narpala, S., O'Dell, S., Schön, A., Bailer, R. T., Chuang, G. Y., Geng, H., Louder, M. K., Rawi, R., Soumana, D. I., Finzi, A., Herschhorn, A., Madani, N., Sodroski, J., Freire, E. I., Langley, D. R., Mascola, J. R. & 2 others, McDermott, A. B. & Kwong, P. D., Oct 1 2017, In : Nature Chemical Biology. 13, 10, p. 1115-1122 8 p.

Research output: Contribution to journalArticle

2016

Enthalpy screen of drug candidates

Schön, A. & Freire, E., Nov 15 2016, In : Analytical biochemistry. 513, p. 1-6 6 p.

Research output: Contribution to journalArticle

2018

SOSIP changes affect human immunodeficiency virus type 1 envelope glycoprotein conformation and CD4 engagement

Alsahafi, N., Anand, S. P., Castillo-Menendez, L., Verly, M. M., Medjahed, H., Prévost, J., Herschhorn, A., Richard, J., Schön, A., Melillo, B., Freire, E., Smith, A. B., Sodroski, J. & Finzia, A., Oct 1 2018, In : Journal of virology. 92, 19, e01080.

Research output: Contribution to journalArticle

Erratum: Publisher Correction: The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions (Nature communications (2017) 8 1 (1049))

Herschhorn, A., Gu, C., Moraca, F., Ma, X., Farrell, M., Smith, A. B., Pancera, M., Kwong, P. D., Schön, A., Freire, E. I., Abrams, C., Blanchard, S. C., Mothes, W. & Sodroski, J. G., Jan 8 2018, In : Nature Communications. 9, 1, 1 p.

Research output: Contribution to journalComment/debate

Isothermal calorimetry of a monoclonal antibody using a conventional differential scanning calorimeter

Clarkson, B. R. & Freire, E. I., Oct 1 2018, In : Analytical Biochemistry. 558, p. 50-52 3 p.

Research output: Contribution to journalArticle

2017

Temperature stability of proteins: Analysis of irreversible denaturation using isothermal calorimetry

Schön, A., Clarkson, B. R., Jaime, M. & Freire, E. I., Nov 1 2017, In : Proteins: Structure, Function and Bioinformatics. 85, 11, p. 2009-2016 8 p.

Research output: Contribution to journalArticle

2018

Bioinspired supramolecular engineering of self-assembling immunofibers for high affinity binding of immunoglobulin G

Li, Y., Lock, L. L., Wang, Y., Ou, S. H., Stern, D., Schön, A., Freire, E. I., Xu, X., Ghose, S., Li, Z. J. & Cui, H., Jan 1 2018, (Accepted/In press) In : Biomaterials.

Research output: Contribution to journalArticle