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  • 2019
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  • Janice E Clements
2017

Brain macrophages in simian immunodeficiency virus-infected, antiretroviral-suppressed macaques: A functional latent reservoir

Avalos, C. R., Abreu, C. M., Queen, S. E., Li, M., Price, S., Shirk, E. N., Engle, E. L., Forsyth, E., Bullock, B. T., Gabhann, F. M., Wietgrefe, S. W., Haase, A. T., Zink, M. C., Mankowski, J. L., Clements, J. E. & Gama, L., Jul 1 2017, In : mBio. 8, 4, e01186-17.

Research output: Contribution to journalArticle

2019

CCR2 signaling selectively regulates IFN-α: Role of β-arrestin 2 in IFNAR1 internalization

Williams, D., Askew, L. C., Jones, E. & Clements, J. E., Jan 1 2019, In : Journal of Immunology. 202, 1, p. 105-118 14 p.

Research output: Contribution to journalArticle

HIV persistence in the central nervous system during antiretroviral therapy: Evidence and implications

Spudich, S. & Clements, J. E., Dec 1 2019, In : AIDS. 33, p. S103-S106

Research output: Contribution to journalEditorial

A Quantitative Approach to SIV Functional Latency in Brain Macrophages

Abreu, C., Shirk, E. N., Queen, S. E., Mankowski, J. L., Gama, L. & Clements, J. E., Mar 15 2019, In : Journal of Neuroimmune Pharmacology. 14, 1, p. 23-32 10 p.

Research output: Contribution to journalReview article

2017

An SIV/macaque model targeted to study HIV-associated neurocognitive disorders

Beck, S., Queen, S. E., Pate, K., Mangus, L., Abreu, C. M., Gama, L., Witwer, K. W., Adams, R. J., Zink, M. C., Clements, J. E. & Mankowski, J. L., Oct 3 2017, (Accepted/In press) In : Journal of NeuroVirology. p. 1-9 9 p.

Research output: Contribution to journalArticle

2018

Lymphocyte-Dominant Encephalitis and Meningitis in Simian Immunodeficiency Virus–Infected Macaques Receiving Antiretroviral Therapy

Mangus, L., Beck, S., Queen, S. E., Brill, S. A., Shirk, E. N., Pate, K., Muth, D. C., Adams, R. J., Gama, L., Clements, J. E. & Mankowski, J. L., Jan 1 2018, In : American Journal of Pathology. 188, 1, p. 125-134 10 p.

Research output: Contribution to journalArticle

2019

Myeloid and CD4 T cells comprise the latent reservoir in antiretroviral therapy-suppressed SIVmac251-infected macaques

Abreu, C. M., Veenhuis, R. T., Avalos, C. R., Graham, S., Parrilla, D. R., Ferreira, E. A., Queen, S. E., Shirk, E. N., Bullock, B. T., Li, M., Metcalf Pate, K. A., Beck, S. E., Mangus, L. M., Mankowski, J. L., Gabhann, F. M., O’Connor, S. L., Gama, L. & Clementsa, J. E., Jan 1 2019, In : mBio. 10, 4, e01659-19.

Research output: Contribution to journalArticle

Open Access

Infectious virus persists in CD4+ T cells and macrophages in antiretroviral therapy-suppressed simian immunodeficiency virus-infected macaques

Abreu, C. M., Veenhuis, R. T., Avalos, C. R., Graham, S., Queen, S. E., Shirk, E. N., Bullock, B. T., Li, M., Metcalf Pate, K. A., Beck, S. E., Mangus, L. M., Mankowski, J. L., Clements, J. E. & Gama, L., Jan 1 2019, In : Journal of virology. 93, 15, e00065-19.

Research output: Contribution to journalArticle

Open Access

Brain macrophages harbor latent, infectious simian immunodeficiency virus

Abreu, C., Shirk, E. N., Queen, S. E., Beck, S. E., Mangus, L. M., Pate, K. A. M., Mankowski, J. L., Gama, L. & Clements, J. E., Dec 1 2019, In : AIDS. 33, p. S181-S188

Research output: Contribution to journalArticle

2017

Mechanisms of CNS viral seeding by HIV+ CD14+ CD16+ monocytes: Establishment and reseeding of viral reservoirs contributing to HIV-associated neurocognitive disorders

Veenstra, M., León-Rivera, R., Li, M., Gama, L., Clements, J. E. & Berman, J. W., Sep 1 2017, In : mBio. 8, 5, e01280-17.

Research output: Contribution to journalArticle

2019

The Landscape of Persistent Viral Genomes in ART-Treated SIV, SHIV, and HIV-2 Infections

Bender, A. M., Simonetti, F. R., Kumar, M. R., Fray, E. J., Bruner, K. M., Timmons, A. E., Tai, K. Y., Jenike, K. M., Antar, A. A. R., Liu, P. T., Ho, Y-C., Raugi, D. N., Seydi, M., Gottlieb, G. S., Okoye, A. A., Del Prete, G. Q., Picker, L. J., Mankowski, J. L., Lifson, J. D., Siliciano, J. D. & 4 others, Laird, G. M., Barouch, D. H., Clements, J. E. & Siliciano, R. F., Jul 10 2019, In : Cell Host and Microbe. 26, 1, p. 73-85.e4

Research output: Contribution to journalArticle

CCR2 on Peripheral Blood CD14 + CD16 + Monocytes Correlates with Neuronal Damage, HIV-Associated Neurocognitive Disorders, and Peripheral HIV DNA: reseeding of CNS reservoirs?

Veenstra, M., Byrd, D. A., Inglese, M., Buyukturkoglu, K., Williams, D. W., Fleysher, L., Li, M., Gama, L., León-Rivera, R., Calderon, T. M., Clements, J. E., Morgello, S. & Berman, J. W., Mar 15 2019, In : Journal of Neuroimmune Pharmacology. 14, 1, p. 120-133 14 p.

Research output: Contribution to journalArticle

2016

Quantitation of productively infected monocytes and macrophages of simian immunodeficiency virus-infected macaques

Avalos, C. R., Price, S. L., Forsyth, E. R., Pin, J. N., Shirk, E. N., Bullock, B. T., Queen, S. E., Li, M., Gellerup, D., O'Connor, S. L., Zink, M. C., Mankowski, J. L., Gama, L. & Clements, J. E., Jun 1 2016, In : Journal of virology. 90, 12, p. 5643-5656 14 p.

Research output: Contribution to journalArticle

2018

SIV Latency in Macrophages in the CNS

Gama, L., Abreu, C., Shirk, E. N., Queen, S. E., Beck, S. E., Metcalf Pate, K. A., Bullock, B. T., Zink, M. C., Mankowski, J. L. & Clements, J. E., Jan 1 2018, Current Topics in Microbiology and Immunology. Springer Verlag, p. 111-130 20 p. (Current Topics in Microbiology and Immunology; vol. 417).

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

Splenic Damage during SIV Infection: Role of T-Cell Depletion and Macrophage Polarization and Infection

Williams, D., Engle, E. L., Shirk, E. N., Queen, S. E., Gama, L., Mankowski, J. L., Zink, M. C. & Clements, J. E., Aug 1 2016, In : American Journal of Pathology. 186, 8, p. 2068-2087 20 p.

Research output: Contribution to journalArticle

2017

HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via β-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation

Gannon, P. J., Akay-Espinoza, C., Yee, A. C., Briand, L. A., Erickson, M. A., Gelman, B. B., Gao, Y., Haughey, N. J., Zink, M. C., Clements, J. E., Kim, N. S., Van De Walle, G., Jensen, B. K., Vassar, R., Pierce, R. C., Gill, A. J., Kolson, D. L., Diehl, J. A., Mankowski, J. L. & Jordan-Sciutto, K. L., Jan 1 2017, In : American Journal of Pathology. 187, 1, p. 91-109 19 p.

Research output: Contribution to journalArticle