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  • Stephen B Baylin
2017

Evolution of neoantigen landscape during immune checkpoint blockade in non-small cell lung cancer

Anagnostou, V., Smith, K. N., Forde, P. M., Niknafs, N., Bhattacharya, R., White, J., Zhang, T., Adleff, V., Phallen, J., Wali, N., Hruban, C., Guthrie, V. B., Rodgers, K., Naidoo, J., Kang, H., Sharfman, W., Georgiades, C., Verde, F., Illei, P., Li, Q. K. & 9 others, Gabrielson, E., Brock, M. V., Zahnow, C. A., Baylin, S. B., Scharpf, R. B., Brahmer, J. R., Karchin, R., Pardoll, D. M. & Velculescu, V. E., Mar 2017, In : Cancer discovery. 7, 3, p. 264-276 13 p.

Research output: Contribution to journalArticle

2016

Combining epigenetic and immunotherapy to combat cancer

Chiappinelli, K. B., Zahnow, C., Ahuja, N. & Baylin, S. B., Apr 1 2016, In : Cancer Research. 76, 7, p. 1683-1689 7 p.

Research output: Contribution to journalArticle

2017

Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells

Cai, Y., Tsai, H. C., Yen, R. W. C., Zhang, Y. W., Kong, X., Wang, W., Xia, L. & Baylin, S. B., Apr 2017, In : Genome research. 27, 4, p. 533-544 12 p.

Research output: Contribution to journalArticle

Epigenetic Therapy Ties MYC Depletion to Reversing Immune Evasion and Treating Lung Cancer

Topper, M. J., Vaz, M., Chiappinelli, K. B., DeStefano Shields, C. E., Niknafs, N., Yen, R. W. C., Wenzel, A., Hicks, J., Ballew, M., Stone, M., Tran, P. T., Zahnow, C. A., Hellmann, M. D., Anagnostou, V., Strissel, P. L., Strick, R., Velculescu, V. E. & Baylin, S. B., Nov 30 2017, In : Cell. 171, 6, p. 1284-1300.e21

Research output: Contribution to journalArticle

2018

A phase I trial of a guadecitabine (SGI-110) and irinotecan in metastatic colorectal cancer patients previously exposed to irinotecan

Lee, V., Wang, J., Zahurak, M., Gootjes, E., Verheul, H. M., Parkinson, R., Kerner, Z., Sharma, A., Rosner, G., De Jesus-Acosta, A., Laheru, D., Le, D. T., Oganesian, A., Lilly, E., Brown, T., Jones, P., Baylin, S., Ahuja, N. & Azad, N., Dec 15 2018, In : Clinical Cancer Research. 24, 24, p. 6160-6167 8 p.

Research output: Contribution to journalArticle

2016

Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents – A Potential Therapy for Cancer

Muvarak, N. E., Chowdhury, K., Xia, L., Robert, C., Choi, E. Y., Cai, Y., Bellani, M., Zou, Y., Singh, Z. N., Duong, V. H., Rutherford, T., Nagaria, P., Bentzen, S. M., Seidman, M. M., Baer, M. R., Lapidus, R. G., Baylin, S. B. & Rassool, F. V., Oct 10 2016, In : Cancer cell. 30, 4, p. 637-650 14 p.

Research output: Contribution to journalArticle

2017

Early detection of lung cancer using DNA promoter hypermethylation in plasma and sputum

Hulbert, A., Jusue-Torres, I., Stark, A., Chen, C., Rodgers, K., Lee, B., Griffin, C., Yang, A., Huang, P., Wrangle, J., Belinsky, S. A., Wang, T. H., Yang, S. C., Baylin, S. B., Brock, M. V. & Herman, J. G., Apr 15 2017, In : Clinical Cancer Research. 23, 8, p. 1998-2005 8 p.

Research output: Contribution to journalArticle

2016

Epigenetic determinants of cancer

Baylin, S. B. & Jones, P. A., Sep 1 2016, In : Cold Spring Harbor perspectives in biology. 8, 9, a019505.

Research output: Contribution to journalArticle

2018

Oncogenic Signaling Pathways in The Cancer Genome Atlas

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 321-337.e10

Research output: Contribution to journalArticle

2019

Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties

Kong, X., Chen, J., Xie, W., Brown, S. M., Cai, Y., Wu, K., Fan, D., Nie, Y., Yegnasubramanian, S., Tiedemann, R. L., Tao, Y., Chiu Yen, R. W., Topper, M. J., Zahnow, C. A., Easwaran, H., Rothbart, S. B., Xia, L. & Baylin, S. B., Apr 15 2019, In : Cancer cell. 35, 4, p. 633-648.e7

Research output: Contribution to journalArticle

2016

Tankyrase inhibition promotes a stable human naïve pluripotent state with improved functionality

Zimmerlin, L., Park, T. S., Huo, J. S., Verma, K., Pather, S. R., Talbot, C. C., Agarwal, J., Steppan, D., Zhang, Y. W., Considine, M., Guo, H., Zhong, X., Gutierrez, C., Cope, L., Canto-Soler, M. V., Friedman, A. D., Baylin, S. B. & Zambidis, E. T., Dec 1 2016, In : Development (Cambridge). 143, 23, p. 4368-4380 13 p.

Research output: Contribution to journalArticle

Erratum: Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses (Cell (2015) 152 (974-986))

Chiappinelli, K. B., Strissel, P. L., Desrichard, A., Li, H., Henke, C., Akman, B., Hein, A., Rote, N. S., Cope, L. M., Snyder, A., Makarov, V., Budhu, S., Slamon, D. J., Wolchok, J. D., Pardoll, D. M., Beckmann, M. W., Zahnow, C. A., Merghoub, T., Chan, T. A., Baylin, S. B. & 1 others, Strick, R., Feb 25 2016, In : Cell. 164, 5, 1 p.

Research output: Contribution to journalComment/debate

IGFBP-3 gene methylation in primary tumor predicts recurrence of stage II colorectal cancers

Fu, T., Pappou, E. P., Guzzetta, A. A., De Freitas Calmon, M., Sun, L., Herrera, A., Li, F., Wolfgang, C. L., Baylin, S. B., Iacobuzio-Donahue, C. A., Tong, W. & Ahuja, N., Jan 1 2016, In : Annals of surgery. 263, 2, p. 337-344 8 p.

Research output: Contribution to journalArticle

Unraveling the molecular pathways of DNA-methylation inhibitors: human endogenous retroviruses induce the innate immune response in tumors

Strick, R., Strissel, P. L., Baylin, S. B. & Chiappinelli, K. B., Apr 25 2016, (Accepted/In press) In : OncoImmunology.

Research output: Contribution to journalArticle

2017

Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress

Zhang, Y., Wang, Z., Xie, W., Cai, Y., Xia, L., Easwaran, H., Luo, J., Yen, R-W., Li, Y. & Baylin, S. B., Jan 19 2017, In : Molecular Cell. 65, 2, p. 323-335 13 p.

Research output: Contribution to journalArticle

2016

Mismatch repair proteins recruit DNA methyltransferase 1 to sites of oxidative DNA damage

Ding, N., Bonham, E. M., Hannon, B. E., Amick, T. R., Baylin, S. B. & O'Hagan, H. M., Jun 1 2016, In : Journal of Molecular Cell Biology. 8, 3, p. 244-254 11 p.

Research output: Contribution to journalArticle

2018

Reply to Haffner et al. DNA hypomethylation renders tumors more immunogenic

Stone, M. L., Chiappinelli, K. B., Li, H., Murphy, L. M., Travers, M. E., Topper, M. J., Mathios, D., Lim, M., Shih, I. M., Wang, T. L., Hung, C. F., Bhargava, V., Wiehagen, K. R., Cowley, G. S., Bachman, K. E., Strick, R., Strissel, P. L., Baylin, S. B. & Zahnow, C. A., Sep 11 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 37, p. E8583-E8584

Research output: Contribution to journalLetter

2017

Hypomethylating agents synergize with irinotecan to improve response to chemotherapy in colorectal cancer cells

Sharma, A., Vatapalli, R., Abdelfatah, E., McMahon, K. W., Kerner, Z., Guzzetta, A. A., Singh, J., Zahnow, C., Baylin, S. B., Yerram, S., Hu, Y., Azad, N. & Ahuja, N., Apr 2017, In : PloS one. 12, 4, e0176139.

Research output: Contribution to journalArticle

2016

Tumors with unmethylated MLH1 and the CpG island methylator phenotype are associated with a poor prognosis in stage II colorectal cancer patients

Fu, T., Liu, Y., Li, K., Wan, W., Pappou, E. P., Iacobuzio-Donahue, C. A., Kerner, Z., Baylin, S. B., Wolfgang, C. L. & Ahuja, N., Jan 1 2016, In : Oncotarget. 7, 52, p. 86480-86489 10 p.

Research output: Contribution to journalArticle

Open Access

Comprehensive pan-genomic characterization of adrenocortical carcinoma

The Cancer Genome Atlas Research Network, May 9 2016, In : Cancer cell. 29, 5, p. 723-736 14 p.

Research output: Contribution to journalArticle

2017

Integrated Molecular Characterization of Uterine Carcinosarcoma

Cherniack, A. D., Shen, H., Walter, V., Stewart, C., Murray, B. A., Bowlby, R., Hu, X., Ling, S., Soslow, R. A., Broaddus, R. R., Zuna, R. E., Robertson, G., Laird, P. W., Kucherlapati, R., Mills, G. B., Akbani, R., Ally, A., Auman, J. T., Balasundaram, M., Balu, S. & 130 others, Baylin, S. B., Beroukhim, R., Bodenheimer, T., Bogomolniy, F., Boice, L., Bootwalla, M. S., Bowen, J., Broaddus, R., Brooks, D., Carlsen, R., Cho, J., Chuah, E., Chudamani, S., Cibulskis, K., Cline, M., Dao, F., David, M., Demchok, J. A., Dhalla, N., Dowdy, S., Felau, I., Ferguson, M. L., Frazer, S., Frick, J., Gabriel, S., Gastier-Foster, J. M., Gehlenborg, N., Gerken, M., Getz, G., Gupta, M., Haussler, D., Hayes, D. N., Heiman, D. I., Hess, J., Hoadley, K. A., Hoffmann, R., Holt, R. A., Hoyle, A. P., Huang, M., Hutter, C. M., Jefferys, S. R., Jones, S. J. M., Jones, C. D., Kanchi, R. S., Kandoth, C., Kasaian, K., Kerr, S., Kim, J., Lai, P. H., Lander, E., Lawrence, M. S., Lee, D., Leraas, K. M., Leshchiner, I., Levine, D. A., Lichtenberg, T. M., Lin, P., Liu, J., Liu, W., Liu, Y., Lolla, L., Lu, Y., Ma, Y., Maglinte, D. T., Marra, M. A., Mayo, M., Meng, S., Meyerson, M., Mieczkowski, P. A., Moore, R. A., Mose, L. E., Mungall, A. J., Mungall, K., Naresh, R., Noble, M. S., Olvera, N., Parker, J. S., Perou, C. M., Perou, A. H., Pihl, T., Radenbaugh, A. J., Ramirez, N. C., Rathmell, W. K., Roach, J., Robertson, A. G., Sadeghi, S., Saksena, G., Salvesen, H. B., Schein, J. E., Schumacher, S. E., Sheth, M., Shi, Y., Shih, J., Simons, J. V., Sipahimalani, P., Skelly, T., Sofia, H. J., Soloway, M. G., Sougnez, C., Sun, C., Tam, A., Tan, D., Tarnuzzer, R., Thiessen, N., Thorne, L. B., Tse, K., Tseng, J., Van Den Berg, D. J., Veluvolu, U., Verhaak, R. G. W., Voet, D., von Bismarck, A., Wan, Y., Wang, Z., Wang, C., Weinstein, J. N., Weisenberger, D. J., Wilkerson, M. D., Winterhoff, B., Wise, L., Wong, T., Wu, Y., Yang, L., Zenklusen, J. C., Zhang, J. J., Zhang, H., Zhang, W., Zhu, J. C., Zmuda, E. & Zhang, J., Mar 13 2017, In : Cancer cell. 31, 3, p. 411-423 13 p.

Research output: Contribution to journalArticle

2019

DNA methyltransferase inhibitors induce a BRCAness phenotype that sensitizes NSCLC to PARP inhibitor and ionizing radiation

Abbotts, R., Topper, M. J., Biondi, C., Fontaine, D., Goswami, R., Stojanovic, L., Choi, E. Y., McLaughlin, L., Kogan, A. A., Xia, L., Lapidus, R., Mahmood, J., Baylin, S. B. & Rassool, F. V., Nov 5 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 45, p. 22609-22618 10 p.

Research output: Contribution to journalArticle

Open Access
2018

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 181-193.e7

Research output: Contribution to journalArticle

Pathogenic Germline Variants in 10,389 Adult Cancers

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 355-370.e14

Research output: Contribution to journalArticle

2016

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

Ceccarelli, M., Barthel, F. P., Malta, T. M., Sabedot, T. S., Salama, S. R., Murray, B. A., Morozova, O., Newton, Y., Radenbaugh, A., Pagnotta, S. M., Anjum, S., Wang, J., Manyam, G., Zoppoli, P., Ling, S., Rao, A. A., Grifford, M., Cherniack, A. D., Zhang, H., Poisson, L. & 188 others, Carlotti, C. G., Tirapelli, D. P. D. C., Rao, A., Mikkelsen, T., Lau, C. C., Yung, W. K. A., Rabadan, R., Huse, J., Brat, D. J., Lehman, N. L., Barnholtz-Sloan, J. S., Zheng, S., Hess, K., Rao, G., Meyerson, M., Beroukhim, R., Cooper, L., Akbani, R., Wrensch, M., Haussler, D., Aldape, K. D., Laird, P. W., Gutmann, D. H., Noushmehr, H., Arachchi, H., Auman, J. T., Balasundaram, M., Balu, S., Barnett, G., Baylin, S., Bell, S., Benz, C., Bir, N., Black, K. L., Bodenheimer, T., Boice, L., Bootwalla, M. S., Bowen, J., Bristow, C. A., Butterfield, Y. S. N., Chen, Q. R., Chin, L., Cho, J., Chuah, E., Chudamani, S., Coetzee, S. G., Cohen, M. L., Colman, H., Couce, M., D'Angelo, F., Davidsen, T., Davis, A., Demchok, J. A., Devine, K., Ding, L., Duell, R., Elder, J. B., Eschbacher, J. M., Fehrenbach, A., Ferguson, M., Frazer, S., Fuller, G., Fulop, J., Gabriel, S. B., Garofano, L., Gastier-Foster, J. M., Gehlenborg, N., Gerken, M., Getz, G., Giannini, C., Gibson, W. J., Hadjipanayis, A., Hayes, D. N., Heiman, D. I., Hermes, B., Hilty, J., Hoadley, K. A., Hoyle, A. P., Huang, M., Jefferys, S. R., Jones, C. D., Jones, S. J. M., Ju, Z., Kastl, A., Kendler, A., Kim, J., Kucherlapati, R., Lai, P. H., Lawrence, M. S., Lee, S., Leraas, K. M., Lichtenberg, T. M., Lin, P., Liu, Y., Liu, J., Ljubimova, J. Y., Lu, Y., Ma, Y., Maglinte, D. T., Mahadeshwar, H. S., Marra, M. A., McGraw, M., McPherson, C., Meng, S., Mieczkowski, P. A., Miller, C. R., Mills, G. B., Moore, R. A., Mose, L. E., Mungall, A. J., Naresh, R., Naska, T., Neder, L., Noble, M. S., Noss, A., O'Neill, B. P., Ostrom, Q. T., Palmer, C., Pantazi, A., Parfenov, M., Park, P. J., Parker, J. S., Perou, C. M., Pierson, C. R., Pihl, T., Protopopov, A., Radenbaugh, A., Ramirez, N. C., Rathmell, W. K., Ren, X., Roach, J., Robertson, A. G., Saksena, G., Schein, J. E., Schumacher, S. E., Seidman, J., Senecal, K., Seth, S., Shen, H., Shi, Y., Shih, J., Shimmel, K., Sicotte, H., Sifri, S., Silva, T., Simons, J. V., Singh, R., Skelly, T., Sloan, A. E., Sofia, H. J., Soloway, M. G., Song, X., Sougnez, C., Souza, C., Staugaitis, S. M., Sun, H., Sun, C., Tan, D., Tang, J., Tang, Y., Thorne, L., Trevisan, F. A., Triche, T., Van Den Berg, D. J., Veluvolu, U., Voet, D., Wan, Y., Wang, Z., Warnick, R., Weinstein, J. N., Weisenberger, D. J., Wilkerson, M. D., Williams, F., Wise, L., Wolinsky, Y., Wu, J., Xu, A. W., Yang, L., Yang, L., Zack, T. I., Zenklusen, J. C., Zhang, J., Zhang, W., Zhang, J., Zmuda, E., Noushmehr, H., Iavarone, A. & Verhaak, R. G. W., Jan 28 2016, In : Cell. 164, 3, p. 550-563 14 p.

Research output: Contribution to journalArticle

2018

Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 255-269.e4

Research output: Contribution to journalArticle

Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer cell. 33, 4, p. 721-735.e8

Research output: Contribution to journalArticle

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 297-312.e12

Research output: Contribution to journalArticle

Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 172-180.e3

Research output: Contribution to journalArticle

Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 282-296.e4

Research output: Contribution to journalArticle

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

The Fusion Analysis Working Group & The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 227-238.e3

Research output: Contribution to journalArticle

2017

Combination epigenetic therapy in metastatic colorectal cancer (mCRC) with subcutaneous 5-azacitidine and entinostat; a phase 2 consortium/stand Up 2 cancer study

Azad, N. S., El-Khoueiry, A., Yin, J., Oberg, A. L., Flynn, P., Adkins, D., Sharma, A., Weisenberger, D. J., Brown, T., Medvari, P., Jones, P. A., Easwaran, H., Kamel, I., Bahary, N., Kim, G., Picus, J., Pitot, H. C., Erlichman, C., Donehower, R., Shen, H. & 4 others, Laird, P. W., Piekarz, R., Baylin, S. & Ahuja, N., Jan 1 2017, In : Oncotarget. 8, 21, p. 35326-35338 13 p.

Research output: Contribution to journalArticle

2018

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 194-212.e6

Research output: Contribution to journalArticle

2016

Vitamin C increases viral mimicry induced by 5-aza-2'-deoxycytidine

Liu, M., Ohtani, H., Zhou, W., Ørskov, A. D., Charlet, J., Zhang, Y., Shen, H., Baylin, S. B., Liang, G., Grønbæk, K. & Jones, P. A., Sep 13 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 37, p. 10238-10244 7 p.

Research output: Contribution to journalArticle

2018

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 239-254.e6

Research output: Contribution to journalArticle

Dual inhibition of DNA and histone methyltransferases increases viral mimicry in ovarian cancer cells

Liu, M., Thomas, S. L., DeWitt, A. K., Zhou, W., Madaj, Z. B., Ohtani, H., Baylin, S. B., Liang, G. & Jones, P. A., Oct 15 2018, In : Cancer Research. 78, 20, p. 5754-5760 7 p.

Research output: Contribution to journalArticle

2016

Jacob, Monod, the Lac Operon, and the pajama experiment-gene expression circuitry changing the face of cancer research

Baylin, S. B., Apr 15 2016, In : Cancer Research. 76, 8, p. 2060-2062 3 p.

Research output: Contribution to journalComment/debate

2019

DFMO and 5-azacytidine increase M1 macrophages in the tumor microenvironment of murine ovarian cancer

Travers, M., Brown, S. M., Dunworth, M., Holbert, C. E., Wiehagen, K. R., Bachman, K. E., Foley, J. R., Stone, M. L., Baylin, S. B., Casero, R. A. & Zahnow, C. A., 2019, In : Cancer Research. 79, 13, p. 3445-3454 10 p.

Research output: Contribution to journalArticle

2016

CHAPTER 10: Dosing - When less is more

Pandiyan, K., Jones, P. A. & Baylin, S. B., Jan 1 2016, Privileged Scaffolds in Medicinal Chemistry: Design, Synthesis, Evaluation. Carey, N. (ed.). 48 ed. Royal Society of Chemistry, p. 249-266 18 p. (RSC Drug Discovery Series; vol. 2016-January, no. 48).

Research output: Chapter in Book/Report/Conference proceedingChapter

2018

Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer

Zhang, H., Pandey, S., Travers, M., Sun, H., Morton, G., Madzo, J., Chung, W., Khowsathit, J., Perez-Leal, O., Barrero, C. A., Merali, C., Okamoto, Y., Sato, T., Pan, J., Garriga, J., Bhanu, N. V., Simithy, J., Patel, B., Huang, J., Raynal, N. J. M. & 13 others, Garcia, B. A., Jacobson, M. A., Kadoch, C., Merali, S., Zhang, Y., Childers, W., Abou-Gharbia, M., Karanicolas, J., Baylin, S. B., Zahnow, C., Jelinek, J., Graña, X. & Issa, J. P. J., Nov 15 2018, In : Cell. 175, 5, p. 1244-1258.e26

Research output: Contribution to journalArticle

Diamine oxidase activity in human tumors: Clinical and biologic significance

Baylin, S. B. & Luk, G. D., Jan 1 2018, Structure and Functions of Amine Oxidases. CRC Press, p. 187-194 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2016

Inhibitors of DNA Methylation, Histone Deacetylation, and Histone Demethylation. A Perfect Combination for Cancer Therapy.

Zahnow, C. A., Topper, M., Stone, M., Murray-Stewart, T., Li, H., Baylin, S. B. & Casero, R. A., Jan 1 2016, Advances in Cancer Research, 2016. Fisher, P. B. & Tew, K. D. (eds.). Academic Press Inc., p. 55-111 57 p. (Advances in Cancer Research; vol. 130).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2018

DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk

Xie, W., Kagiampakis, I., Pan, L., Zhang, Y., Murphy, L., Tao, Y., Kong, X., Kang, B., Xia, L., Carvalho, F. L. F., Sen, S., Yen, R-W., Zahnow, C., Ahuja, N., Baylin, S. B. & Easwaran, H., Feb 12 2018, In : Cancer Cell. 33, 2, p. 309-321.e5

Research output: Contribution to journalArticle

An effective epigenetic-PARP inhibitor combination therapy for breast and ovarian cancers independent of BRCA mutations

Pulliam, N., Fang, F., Ozes, A. R., Tang, J., Adewuyi, A., Keer, H., Lyons, J., Baylin, S. B., Matei, D., Nakshatri, H., Rassool, F. V., Miller, K. D. & Nephew, K. P., Jul 1 2018, In : Clinical Cancer Research. 24, 13, p. 3163-3175 13 p.

Research output: Contribution to journalArticle

2016

Genome-wide positioning of bivalent mononucleosomes

Sen, S., Block, K. F., Pasini, A., Baylin, S. B. & Easwaran, H., Sep 15 2016, In : BMC Medical Genomics. 9, 1, 60.

Research output: Contribution to journalArticle

2017

Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single-Step Transformation by KRAS Mutations

Vaz, M., Hwang, S. Y., Kagiampakis, I., Phallen, J., Patil, A., O'Hagan, H. M., Murphy, L., Zahnow, C., Gabrielson, E., Velculescu, V. E., Easwaran, H. & Baylin, S. B., Sep 11 2017, In : Cancer Cell. 32, 3, p. 360-376 17 p.

Research output: Contribution to journalArticle

2016

Targeting the cancer epigenome for therapy

Jones, P. A., Issa, J. P. J. & Baylin, S. B., Oct 1 2016, In : Nature Reviews Genetics. 17, 10, p. 630-641 12 p.

Research output: Contribution to journalReview article

Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma

Linehan, W. M., Spellman, P. T., Ricketts, C. J., Creighton, C. J., Fei, S. S., Davis, C., Wheeler, D. A., Murray, B. A., Schmidt, L., Vocke, C. D., Peto, M., Al Mamun, A. A. M., Shinbrot, E., Sethi, A., Brooks, S., Rathmell, W. K., Brooks, A. N., Hoadley, K. A., Robertson, A. G., Brooks, D. & 208 others, Bowlby, R., Sadeghi, S., Shen, H., Weisenberger, D. J., Bootwalla, M., Baylin, S. B., Laird, P. W., Cherniack, A. D., Saksena, G., Haake, S., Li, J., Liang, H., Lu, Y., Mills, G. B., Akbani, R., Leiserson, M. D. M., Raphael, B. J., Anur, P., Bottaro, D., Albiges, L., Barnabas, N., Choueiri, T. K., Czerniak, B., Godwin, A. K., Hakimi, A. A., Ho, T. H., Hsieh, J., Ittmann, M., Kim, W. Y., Krishnan, B., Merino, M. J., Shaw, K. R. M., Reuter, V. E., Reznik, E., Shelley, C. S., Shuch, B., Signoretti, S., Srinivasan, R., Tamboli, P., Thomas, G., Tickoo, S., Burnett, K., Crain, D., Gardner, J., Lau, K., Mallery, D., Morris, S., Paulauskis, J. D., Penny, R. J., Shelton, C., Shelton, W. T., Sherman, M., Thompson, E., Yena, P., Avedon, M. T., Bowen, J., Gastier-Foster, J. M., Gerken, M., Leraas, K. M., Lichtenberg, T. M., Ramirez, N. C., Santos, T., Wise, L., Zmuda, E., Demchok, J. A., Felau, I., Hutter, C. M., Sheth, M., Sofia, H. J., Tarnuzzer, R., Wang, Z., Yang, L., Zenklusen, J. C., Zhang, J., Ayala, B., Baboud, J., Chudamani, S., Liu, J., Lolla, L., Naresh, R., Pihl, T., Sun, Q., Wan, Y., Wu, Y., Ally, A., Balasundaram, M., Balu, S., Beroukhim, R., Bodenheimer, T., Buhay, C., Butterfield, Y. S. N., Carlsen, R., Carter, S. L., Chao, H., Chuah, E., Clarke, A., Covington, K. R., Dahdouli, M., Dewal, N., Dhalla, N., Doddapaneni, H. V., Drummond, J. A., Gabriel, S. B., Gibbs, R. A., Guin, R., Hale, W., Hawes, A., Hayes, D. N., Holt, R. A., Hoyle, A. P., Jefferys, S. R., Jones, S. J. M., Jones, C. D., Kalra, D., Kovar, C., Lewis, L., Li, J., Ma, Y., Marra, M. A., Mayo, M., Meng, S., Meyerson, M., Mieczkowski, P. A., Moore, R. A., Morton, D., Mose, L. E., Mungall, A. J., Muzny, D., Parker, J. S., Perou, C. M., Roach, J., Schein, J. E., Schumacher, S. E., Shi, Y., Simons, J. V., Sipahimalani, P., Skelly, T., Soloway, M. G., Sougnez, C., Tam, A., Tan, D., Thiessen, N., Veluvolu, U., Wang, M., Wilkerson, M. D., Wong, T., Wu, J., Xi, L., Zhou, J., Bedford, J., Chen, F., Fu, Y., Gerstein, M., Haussler, D., Kasaian, K., Lai, P., Ling, S., Radenbaugh, A., Van Den Berg, D., Weinstein, J. N., Zhu, J., Albert, M., Alexopoulou, I., Andersen, J. J., Auman, J. T., Bartlett, J., Bastacky, S., Bergsten, J., Blute, M. L., Boice, L., Bollag, R. J., Boyd, J., Castle, E., Chen, Y. B., Cheville, J. C., Curley, E., Davies, B., DeVolk, A., Dhir, R., Dike, L., Eckman, J., Engel, J., Harr, J., Hrebinko, R., Huang, M., Huelsenbeck-Dill, L., Iacocca, M., Jacobs, B., Lobis, M., Maranchie, J. K., McMeekin, S., Myers, J., Nelson, J., Parfitt, J., Parwani, A., Petrelli, N., Rabeno, B., Roy, S., Salner, A. L., Slaton, J., Stanton, M., Thompson, R. H., Thorne, L., Tucker, K., Weinberger, P. M., Winemiller, C., Zach, L. A. & Zuna, R., Jan 14 2016, In : New England Journal of Medicine. 374, 2, p. 135-145 11 p.

Research output: Contribution to journalArticle

2018

The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53

Szczepny, A., Carey, K., McKenzie, L., Jayasekara, W. S. N., Rossello, F., Gonzalez-Rajal, A., McCaw, A. S., Popovski, D., Wang, D., Sadler, A. J., Mahar, A., Russell, P. A., Wright, G., McCloy, R. A., Garama, D. J., Gough, D. J., Baylin, S. B., Burgess, A., Cain, J. E. & Watkins, D. N., Apr 1 2018, In : Oncogene. 37, 14, p. 1939-1948 10 p.

Research output: Contribution to journalArticle