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  • Thomas Hartung
2016

Utility of the adverse outcome pathway concept in drug development

Hartung, T., Oct 23 2016, (Accepted/In press) In : Expert Opinion on Drug Metabolism and Toxicology. p. 1-3 3 p.

Research output: Contribution to journalArticle

Evidence-based toxicology

Hoffmann, S., Hartung, T. & Stephens, M. L., Sep 1 2016, Advances in Experimental Medicine and Biology. Springer New York LLC, Vol. 856. p. 231-241 11 p. (Advances in Experimental Medicine and Biology; vol. 856).

Research output: Chapter in Book/Report/Conference proceedingChapter

From big data to predictive analysis from In Vitro systems

Kleensang, A., Maertens, A. & Hartung, T., Nov 30 2016, Regenerative Medicine Technology: On-a-Chip Applications for Disease Modeling, Drug Discovery and Personalized Medicine. CRC Press, p. 85-101 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Detecting the broad spectrum of pyrogens with the human whole-blood monocyte activation test

Hartung, T., Borel, A. & Schmitz, G., Mar 1 2016, In : BioProcess International. 14, 3

Research output: Contribution to journalArticle

2018

Alternative Approaches for Carcinogenicity and Reproductive Toxicity

Corvi, R., Spielmann, H. & Hartung, T., Oct 22 2018, The History of Alternative Test Methods in Toxicology. Elsevier, p. 209-217 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2017

Good cell culture practice for stem cells & stem-cell-derived models

Pamies, D., Bal-Price, A., Simeonov, A., Tagle, D., Allen, D., Gerhold, D., Yin, D., Pistollato, F., Inutsuka, T., Sullivan, K., Stacey, G., Salem, H., Leist, M., Daneshian, M., Vemuri, M. C., Mcfarland, R., Coecke, S., Fitzpatrick, S. C., Lakshmipathy, U., Mack, A. & 6 others, Wang, W. B., Yamazaki, D., Sekino, Y., Kanda, Y., Smirnova, L. & Hartung, T., 2017, In : ALTEX. 34, 1, p. 95-132 38 p.

Research output: Contribution to journalArticle

2016

Characterization of three human cell line models for high-throughput neuronal cytotoxicity screening

Tong, Z. B., Hogberg, H., Kuo, D., Sakamuru, S., Xia, M., Smirnova, L., Hartung, T. & Gerhold, D., 2016, (Accepted/In press) In : Journal of Applied Toxicology.

Research output: Contribution to journalArticle

2019

The effect of chronic vitamin deficiency and long term very low dose exposure to 6 pesticides mixture on neurological outcomes – A real-life risk simulation approach

Tsatsakis, A., Tyshko, N. V., Docea, A. O., Shestakova, S. I., Sidorova, Y. S., Petrov, N. A., Zlatian, O., Mach, M., Hartung, T. & Tutelyan, V. A., Oct 15 2019, In : Toxicology Letters. 315, p. 96-106 11 p.

Research output: Contribution to journalArticle

2017

21st Century Cell Culture for 21st Century Toxicology

Pamies, D. & Hartung, T., Jan 17 2017, In : Chemical Research in Toxicology. 30, 1, p. 43-52 10 p.

Research output: Contribution to journalArticle

Thresholds of toxicological concern - Setting a threshold for testing below which there is little concern

Hartung, T., 2017, In : ALTEX. 34, 3, p. 331-351 21 p.

Research output: Contribution to journalArticle

2018

Rebooting the generally recognized as safe (GRAS) approach for food additive safety in the US

Hartung, T., 2018, In : ALTEX. 35, 1, p. 3-25 23 p.

Research output: Contribution to journalArticle

2016

Food for thought... E-cigarettes and the need and opportunities for alternatives to animal testing

Hartung, T., 2016, In : ALTEX. 33, 3, p. 211-224 14 p.

Research output: Contribution to journalArticle

2017

Corrigendum to "The need for strategic development of safety sciences"

Busquet, F. & Hartung, T., 2017, In : ALTEX. 34, 2, 1 p.

Research output: Contribution to journalComment/debate

Open Access
2016

The Mammalian Malonyl-CoA Synthetase ACSF3 Is Required for Mitochondrial Protein Malonylation and Metabolic Efficiency

Bowman, C. E., Rodriguez, S., Selen Alpergin, E. S., Acoba, M. G., Zhao, L., Hartung, T., Claypool, S. M., Watkins, P. A. & Wolfgang, M. J., Nov 10 2016, (Accepted/In press) In : Cell Chemical Biology.

Research output: Contribution to journalArticle

2019

Optimizing drug discovery by investigative toxicology: Current and future trends

Beilmann, M., Boonen, H., Czich, A., Dear, G., Hewitt, P., Mow, T., Newham, P., Oinonen, T., Pognan, F., Roth, A., Valentin, J. P., Van Goethem, F., Weaver, R. J., Birk, B., Boyer, S., Caloni, F., Chen, A. E., Corvi, R., Cronin, M. T. D., Daneshian, M. & 14 others, Ewart, L. C., FitzGerald, R. E., Hamilton, G. A., Hartung, T., Kangas, J. D., Kramer, N. I., Leist, M., Marx, U., Polak, S., Rovida, C., Testai, E., Van de Water, B., Vulto, P. & Steger-Hartmann, T., 2019, In : ALTEX. 36, 2, p. 289-313 25 p.

Research output: Contribution to journalArticle

Open Access
2018

Big-data and machine learning to revamp computational toxicology and its use in risk assessment

Luechtefeld, T., Rowlands, C. & Hartung, T., Jan 1 2018, In : Toxicology Research. 7, 5, p. 732-744 13 p.

Research output: Contribution to journalArticle

2017

From in vivo to in vitro: The medical device testing paradigm shift

Myers, D. K., Goldberg, A. M., Poth, A., Wolf, M. F., Carraway, J., McKim, J., Coleman, K. P., Hutchinson, R., Brown, R., Krug, H. F., Bahinski, A. & Hartung, T., 2017, In : ALTEX. 34, 4, p. 479-500 22 p.

Research output: Contribution to journalArticle

2020

The exposome - a new approach for risk assessment

Sillé, F. C. M., Karakitsios, S., Kleensang, A., Koehler, K., Maertens, A., Miller, G. W., Prasse, C., Quiros-Alcala, L., Ramachandran, G., Rappaport, S. M., Rule, A. M., Sarigiannis, D., Smirnova, L. & Hartung, T., Jan 1 2020, In : ALTEX. 37, 1, p. 3-23 21 p.

Research output: Contribution to journalEditorial

Open Access
2016

Analysis of public oral toxicity data from REACH registrations 2008-2014

Luechtefeld, T., Maertens, A., Russo, D. P., Rovida, C., Zhu, H. & Hartung, T., 2016, In : ALTEX. 33, 2, p. 111-122 12 p.

Research output: Contribution to journalArticle

Toward good read-across practice (GRAP) guidance

Ball, N., Cronin, M. T. D., Shen, J., Blackburn, K., Booth, E. D., Bouhifd, M., Donley, E., Egnash, L., Hastings, C., Juberg, D. R., Kleensang, A., Kleinstreuer, N., Kroese, E. D., Lee, A. C., Luechtefeld, T., Maertens, A., Marty, S., Naciff, J. M., Palmer, J., Pamies, D. & 9 others, Penman, M., Richarz, A. N., Russo, D. P., Stuard, S. B., Patlewicz, G., Van Ravenzwaay, B., Wu, S., Zhu, H. & Hartung, T., 2016, In : ALTEX. 33, 2, p. 149-166 18 p.

Research output: Contribution to journalArticle

2017

The Threshold of Toxicological Concern for prenatal developmental toxicity in rats and rabbits

van Ravenzwaay, B., Jiang, X., Luechtefeld, T. & Hartung, T., Aug 1 2017, In : Regulatory Toxicology and Pharmacology. 88, p. 157-172 16 p.

Research output: Contribution to journalArticle

Systems Toxicology: Real World Applications and Opportunities

Hartung, T., FitzGerald, R. E., Jennings, P., Mirams, G. R., Peitsch, M. C., Rostami-Hodjegan, A., Shah, I., Wilks, M. F. & Sturla, S. J., Apr 17 2017, In : Chemical research in toxicology. 30, 4, p. 870-882 13 p.

Research output: Contribution to journalReview article

2019

A Human iPSC-derived 3D platform using primary brain cancer cells to study drug development and personalized medicine

Plummer, S., Wallace, S., Ball, G., Lloyd, R., Schiapparelli, P., Quiñones-Hinojosa, A., Hartung, T. & Pamies, D., Dec 1 2019, In : Scientific reports. 9, 1, 1407.

Research output: Contribution to journalArticle

2017

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

Skardal, A., Murphy, S. V., Devarasetty, M., Mead, I., Kang, H. W., Seol, Y. J., Zhang, Y. S., Shin, S. R., Zhao, L., Aleman, J., Hall, A. R., Shupe, T. D., Kleensang, A., Dokmeci, M. R., Jin Lee, S., Jackson, J. D., Yoo, J. J., Hartung, T., Khademhosseini, A., Soker, S. & 2 others, Bishop, C. E. & Atala, A., Dec 1 2017, In : Scientific reports. 7, 1, 8837.

Research output: Contribution to journalArticle

2016

Pathway-Based Approaches for Environmental Monitoring and Risk Assessment

Ankley, G., Escher, B., Hartung, T. & Shah, I., Nov 21 2016, In : Chemical research in toxicology. 29, 11, p. 1789-1790 2 p.

Research output: Contribution to journalEditorial

Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer

Elgogary, A., Xu, Q., Poore, B., Alt, J., Zimmermann, S. C., Zhao, L., Fu, J., Chen, B., Xia, S., Liu, Y., Neisser, M., Nguyen, C., Lee, R., Park, J. K., Reyes, J., Hartung, T., Rojas, C., Rais, R., Tsukamoto, T., Semenza, G. L. & 3 others, Hanes, J., Slusher, B. S. & Le, A., Sep 6 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 36, p. E5328-E5336

Research output: Contribution to journalArticle

2019

Long-term effects of chromium on morphological and immunological parameters of Wistar rats

Karaulov, A. V., Renieri, E. A., Smolyagin, A. I., Mikhaylova, I. V., Stadnikov, A. A., Begun, D. N., Tsarouhas, K., Buha Djordjevic, A., Hartung, T. & Tsatsakis, A., Nov 2019, In : Food and Chemical Toxicology. 133, 110748.

Research output: Contribution to journalArticle

2018

Green Toxicology-know early about and avoid toxic product liabilities

Maertens, A. & Hartung, T., Feb 1 2018, In : Toxicological Sciences. 161, 2, p. 285-289 5 p., kfx243.

Research output: Contribution to journalEditorial

2017

From the exposome to mechanistic understanding of chemical-induced adverse effects

Escher, B. I., Hackermüller, J., Polte, T., Scholz, S., Aigner, A., Altenburger, R., Böhme, A., Bopp, S. K., Brack, W., Busch, W., Chadeau-Hyam, M., Covaci, A., Eisenträger, A., Galligan, J. J., Garcia-Reyero, N., Hartung, T., Hein, M., Herberth, G., Jahnke, A., Kleinjans, J. & 16 others, Klüver, N., Krauss, M., Lamoree, M., Lehmann, I., Luckenbach, T., Miller, G. W., Müller, A., Phillips, D. H., Reemtsma, T., Rolle-Kampczyk, U., Schüürmann, G., Schwikowski, B., Tan, Y. M., Trump, S., Walter-Rohde, S. & Wambaugh, J. F., 2017, In : Environment international. 99, p. 97-106 10 p.

Research output: Contribution to journalReview article

2019

Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer

Nguyen, T., Kirsch, B. J., Asaka, R., Nabi, K., Quinones, A., Tan, J., Antonio, M. J., Camelo, F., Li, T., Nguyen, S., Hoang, G., Nguyen, K., Udupa, S., Sazeides, C., Shen, Y. A., Elgogary, A., Reyes, J., Zhao, L., Kleensang, A., Chaichana, K. L. & 7 others, Hartung, T., Betenbaugh, M. J., Marie, S. K., Jung, J. G., Wang, T. L., Gabrielson, E. & Le, A., Apr 9 2019, In : Cell Reports. 27, 2, p. 491-501.e6

Research output: Contribution to journalArticle

Open Access
2017

A primer on systematic reviews in toxicology

Hoffmann, S., de Vries, R. B. M., Stephens, M. L., Beck, N. B., Dirven, H. A. A. M., Fowle, J. R., Goodman, J. E., Hartung, T., Kimber, I., Lalu, M. M., Thayer, K., Whaley, P., Wikoff, D. & Tsaioun, K., May 13 2017, (Accepted/In press) In : Archives of Toxicology. p. 1-25 25 p.

Research output: Contribution to journalArticle

2020

Toxicity testing in the 21st century: progress in the past decade and future perspectives

Krewski, D., Andersen, M. E., Tyshenko, M. G., Krishnan, K., Hartung, T., Boekelheide, K., Wambaugh, J. F., Jones, D., Whelan, M., Thomas, R., Yauk, C., Barton-Maclaren, T. & Cote, I., Jan 1 2020, In : Archives of Toxicology. 94, 1

Research output: Contribution to journalReview article

Open Access
2017

Information-dependent enrichment analysis reveals time-dependent transcriptional regulation of the estrogen pathway of toxicity

Pendse, S. N., Maertens, A., Rosenberg, M., Roy, D., Fasani, R. A., Vantangoli, M. M., Madnick, S. J., Boekelheide, K., Fornace, A. J., Odwin, S. A., Yager, J. D., Hartung, T., Andersen, M. E. & McMullen, P. D., Apr 1 2017, In : Archives of Toxicology. 91, 4, p. 1749-1762 14 p.

Research output: Contribution to journalArticle

2016

Can TTIP improve laboratory animal welfare in safety testing and 3Rs?

Busquet, F., Zurlo, J. & Hartung, T., Jan 1 2016, In : ILAR journal. 57, 3, p. 358-367 10 p.

Research output: Contribution to journalArticle

2018

Toxicity, recovery, and resilience in a 3D dopaminergic neuronal in vitro model exposed to rotenone

Harris, G., Eschment, M., Orozco, S. P., McCaffery, J. M., Maclennan, R., Severin, D., Leist, M., Kleensang, A., Pamies, D., Maertens, A., Hogberg, H. T., Freeman, D., Kirkwood, A., Hartung, T. & Smirnova, L., Aug 1 2018, In : Archives of Toxicology. 92, 8, p. 2587-2606 20 p.

Research output: Contribution to journalArticle

2017

Whole blood cytokine response to local traffic-related particulate matter in peruvian children with and without asthma

Negherbon, J. P., Romero, K., Williams, DA. L., Guerrero-Preston, R., Hartung, T., Scott, A. L., Breysse, P. N., Checkley, W. & Hansel, N. N., Mar 30 2017, In : Frontiers in Pharmacology. 8, MAR, 157.

Research output: Contribution to journalArticle

2018

Machine learning of toxicological big data enables read-across structure activity relationships (RASAR) outperforming animal test reproducibility

Luechtefeld, T., Marsh, D., Rowlands, C. & Hartung, T., Jan 1 2018, In : Toxicological Sciences. 165, 1, p. 198-212 15 p.

Research output: Contribution to journalArticle

2016

Applicability of the Monocyte Activation Test (MAT) for hyperimmune sera in the routine of the quality control laboratory: Comparison with the Rabbit Pyrogen Test (RPT)

da Silva, C. C., Presgrave, O. A. F., Hartung, T., de Moraes, A. M. L. & Delgado, I. F., Apr 1 2016, In : Toxicology in Vitro. 32, p. 70-75 6 p.

Research output: Contribution to journalArticle

2017

Dear readers

ALTEX Editorial Team, Board of ALTEX Edition, Jan 1 2017, In : Altex. 34, 4, p. U2

Research output: Contribution to journalEditorial

2016

Editorial

Von Aulock, S., Gruber, F. P., Hartung, T., Hoesli, H. P., Hughes, M. M., Krummenacher, G., Mayr, P., Rauter, C., Zurlo, J. & Daneshian, M., 2016, In : Altex. 33, 4, p. U2

Research output: Contribution to journalEditorial

Making big sense from big data in toxicology by read-across

Hartung, T., 2016, In : Altex. 33, 2, p. 83-93 11 p.

Research output: Contribution to journalArticle

Pathway-Based Approaches for Environmental Monitoring and Risk Assessment

Ankley, G., Escher, B. I., Hartung, T. & Shaw, I., Oct 4 2016, In : Environmental Science and Technology. 50, 19, p. 10295-10296 2 p.

Research output: Contribution to journalComment/debate

2017

Food for thought: The need for strategic development of safety sciences

Busquet, F. & Hartung, T., Jan 1 2017, In : ALTEX. 34, 1, p. 3-21 19 p.

Research output: Contribution to journalArticle

2020

New European Union statistics on laboratory animal use - what really counts!

Busquet, F., Kleensang, A., Rovida, C., Herrmann, K., Leist, M. & Hartung, T., Jan 1 2020, In : ALTEX. 37, 2, p. 167-186 20 p.

Research output: Contribution to journalArticle

Open Access
2018

Perspectives on in vitro to in vivo extrapolations

Hartung, T., Dec 1 2018, In : Applied In Vitro Toxicology. 4, 4, p. 305-316 12 p.

Research output: Contribution to journalReview article

2016

Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

Marx, U., Andersson, T. B., Bahinski, A., Beilmann, M., Beken, S., Cassee, F. R., Cirit, M., Daneshian, M., Fitzpatrick, S., Frey, O., Gaertner, C., Giese, C., Griffith, L., Hartung, T., Heringa, M. B., Hoeng, J., De Jong, W. H., Kojima, H., Kuehnl, J., Leist, M. & 16 others, Luch, A., Maschmeyer, I., Sakharov, D., Sips, A. J. A. M., Steger-Hartmann, T., Tagle, D. A., Tonevitsky, A., Tralau, T., Tsyb, S., Van De Stolpe, A., Vandebriel, R., Vulto, P., Wang, J., Wiest, J., Rodenburg, M. & Roth, A., 2016, In : Altex. 33, 3, p. 272-321 50 p.

Research output: Contribution to journalArticle

2020

Erratum to Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data

Krebs, A., Waldmann, T., Wilks, M. F., Van Vugt-Lussenburg, B. M. A., Van der Burg, B., Terron, A., Steger-Hartmann, T., Ruegg, J., Rovida, C., Pedersen, E., Pallocca, G., Luijten, M., Leite, S. B., Kustermann, S., Kamp, H., Hoeng, J., Hewitt, P., Herzler, M., Hengstler, J. G., Heinonen, T. & 16 others, Hartung, T., Hardy, B., Gantner, F., Fritsche, E., Fant, K., Ezendam, J., Exner, T., Dunkern, T., Dietrich, D. R., Coecke, S., Busquet, F., Braeuning, A., Bondarenko, O., Bennekou, S. H., Beilmann, M. & Leist, M., 2020, In : ALTEX. 37, 1, 1 p.

Research output: Contribution to journalComment/debate

Open Access
2016

Evidence-based absorption, distribution, metabolism, excretion (ADME) and its interplay with alternative toxicity methods

Tsaioun, K., Blaauboer, B. J. & Hartung, T., 2016, In : ALTEX. 33, 4, p. 343-358 16 p.

Research output: Contribution to journalArticle

2018

The Center for Alternatives to Animal Testing in the USA and Europe

Goldberg, A., Leist, M. & Hartung, T., Oct 22 2018, The History of Alternative Test Methods in Toxicology. Elsevier, p. 109-117 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter