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  • Edward Lakatta
2016

Prognostic significance of mechanical biomarkers derived from pulse wave analysis for predicting long-term cardiovascular mortality in two population-based cohorts

Cheng, H. M., Chuang, S. Y., Wang, J. J., Shih, Y. T., Wang, H. N., Huang, C. J., Huang, J. T., Sung, S. H., Lakatta, E., Yin, F. C. P., Chou, P., Yeh, C. J., Bai, C. H., Pan, W. H. & Chen, C. H., Jul 15 2016, In : International Journal of Cardiology. 215, p. 388-395 8 p.

Research output: Contribution to journalArticle

2018

Positive Feedback Mechanisms among Local Ca Releases, NCX, and ICaL Ignite Pacemaker Action Potentials

Lyashkov, A. E., Beahr, J., Lakatta, E., Yaniv, Y. & Maltsev, V. A., Mar 13 2018, In : Biophysical Journal. 114, 5, p. 1176-1189 14 p.

Research output: Contribution to journalArticle

2016

The Aging Arterial Wall

Wang, M., Monticone, R. E. & Lakatta, E. G., Jan 1 2016, Handbook of the Biology of Aging: Eighth Edition. Elsevier Inc., p. 359-389 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2018

Aldosterone, inactive matrix gla-protein, and large artery stiffness in hypertension

Chirinos, J. A., Sardana, M., Syed, A. A., Koppula, M. R., Varakantam, S., Vasim, I., Oldland, H. G., Phan, T. S., Drummen, N. E. A., Vermeer, C., Townsend, R. R., Akers, S. R., Wei, W., Lakatta, E. & Fedorova, O. V., Jan 1 2018, (Accepted/In press) In : Journal of the American Society of Hypertension.

Research output: Contribution to journalArticle

Adipocytokine correlations with thyroid function and autoimmunity in euthyroid sardinians

Delitala, A. P., Steri, M., Fiorillo, E., Marongiu, M., Lakatta, E., Schlessinger, D. & Cucca, F., Nov 1 2018, In : Cytokine. 111, p. 189-193 5 p.

Research output: Contribution to journalArticle

2017

Longitudinal Association between Serum Uric Acid and Arterial Stiffness: Results from the Baltimore Longitudinal Study of Aging

Canepa, M., Viazzi, F., Strait, J. B., Ameri, P., Pontremoli, R., Brunelli, C., Studenski, S., Ferrucci, L., Lakatta, E. G. & Alghatrif, M., Feb 1 2017, In : Hypertension. 69, 2, p. 228-235 8 p.

Research output: Contribution to journalArticle

2016

A rat carotid balloon injury model to test anti-vascular remodeling therapeutics

Petrasheskaya, N., Tae, H. J., Ahmet, I., Talan, M. I., Lakatta, E. & Lin, L., Sep 19 2016, In : Journal of Visualized Experiments. 2016, 115, e53777.

Research output: Contribution to journalArticle

2019

Age-related changes of the retinal microvasculature

Orlov, N. V., Coletta, C., van Asten, F., Qian, Y., Ding, J., AlGhatrif, M., Lakatta, E., Chew, E., Wong, W., Swaroop, A., Fiorillo, E., Delitala, A., Marongiu, M., Goldberg, I. G. & Schlessinger, D., May 2019, In : PloS one. 14, 5, e0215916.

Research output: Contribution to journalArticle

Open Access

Cardiotonic Steroids Induce Vascular Fibrosis Via Pressure-Independent Mechanism in NaCl-Loaded Diabetic Rats

Fedorova, O. V., Fadeev, A. V., Grigorova, Y. N., Marshall, C. A., Zernetkina, V., Kolodkin, N. I., Agalakova, N. I., Konradi, A. O., Lakatta, E. G. & Bagrov, A. Y., Nov 1 2019, In : Journal of cardiovascular pharmacology. 74, 5, p. 436-442 7 p.

Research output: Contribution to journalArticle

2016

AGE-RAGE signal generates a specific NF-Κ B RelA "barcode" that directs collagen i expression

Peng, Y., Kim, J. M., Park, H. S., Yang, A., Islam, C., Lakatta, E. G. & Lin, L., Jan 5 2016, In : Scientific reports. 6, 18822.

Research output: Contribution to journalArticle

2017

Causal effect of plasminogen activator inhibitor type 1 on coronary heart disease

CHARGE Consortium Hemostatic Factor Working Group, ICBP Consortium & CHARGE Consortium Subclinical Working Group, Jun 1 2017, In : Journal of the American Heart Association. 6, 6, e004918.

Research output: Contribution to journalArticle

Computer algorithms for automated detection and analysis of local Ca2+ releases in spontaneously beating cardiac pacemaker cells

Maltsev, A. V., Parsons, S. P., Kim, M. S., Tsutsui, K., Stern, M. D., Lakatta, E. G., Maltsev, V. A. & Monfredi, O., Jul 2017, In : PloS one. 12, 7, e0179419.

Research output: Contribution to journalArticle

2018

Dual activation of phosphodiesterases 3 and 4 regulates basal spontaneous beating rate of cardiac pacemaker cells: Role of compartmentalization?

Vinogradova, T. M., Kobrinsky, E. & Lakatta, E., Oct 9 2018, In : Frontiers in Physiology. 9, OCT, 1301.

Research output: Contribution to journalReview article

2016

Mouse RAGE variant 4 is a dominant membrane receptor that does not shed to generate soluble RAGE

Peng, Y., Horwitz, N., Lakatta, E. & Lin, L., Sep 1 2016, In : PLoS One. 11, 9, e0153657.

Research output: Contribution to journalArticle

2018

Segment-specific associations between local haemodynamic and imaging markers of early atherosclerosis at the carotid artery: An in vivo human study

Gallo, D., Bijari, P. B., Morbiducci, U., Qiao, Y., Xie, Y., Etesami, M., Habets, D., Lakatta, E. G., Wasserman, B. A. & Steinman, D. A., Oct 1 2018, In : Journal of the Royal Society Interface. 15, 147, 20180352.

Research output: Contribution to journalArticle

2020

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

Ntalla, I., Weng, L. C., Cartwright, J. H., Hall, A. W., Sveinbjornsson, G., Tucker, N. R., Choi, S. H., Chaffin, M. D., Roselli, C., Barnes, M. R., Mifsud, B., Warren, H. R., Hayward, C., Marten, J., Cranley, J. J., Concas, M. P., Gasparini, P., Boutin, T., Kolcic, I., Polasek, O. & 167 others, Rudan, I., Araujo, N. M., Lima-Costa, M. F., Ribeiro, A. L. P., Souza, R. P., Tarazona-Santos, E., Giedraitis, V., Ingelsson, E., Mahajan, A., Morris, A. P., Del Greco M, F., Foco, L., Gögele, M., Hicks, A. A., Cook, J. P., Lind, L., Lindgren, C. M., Sundström, J., Nelson, C. P., Riaz, M. B., Samani, N. J., Sinagra, G., Ulivi, S., Kähönen, M., Mishra, P. P., Mononen, N., Nikus, K., Caulfield, M. J., Dominiczak, A., Padmanabhan, S., Montasser, M. E., O’Connell, J. R., Ryan, K., Shuldiner, A. R., Aeschbacher, S., Conen, D., Risch, L., Thériault, S., Hutri-Kähönen, N., Lehtimäki, T., Lyytikäinen, L. P., Raitakari, O. T., Barnes, C. L. K., Campbell, H., Joshi, P. K., Wilson, J. F., Isaacs, A., Kors, J. A., van Duijn, C. M., Huang, P. L., Gudnason, V., Harris, T. B., Launer, L. J., Smith, A. V., Bottinger, E. P., Loos, R. J. F., Nadkarni, G. N., Preuss, M. H., Correa, A., Mei, H., Wilson, J., Meitinger, T., Müller-Nurasyid, M., Peters, A., Waldenberger, M., Mangino, M., Spector, T. D., Rienstra, M., van de Vegte, Y. J., van der Harst, P., Verweij, N., Kääb, S., Schramm, K., Sinner, M. F., Strauch, K., Cutler, M. J., Fatkin, D., London, B., Olesen, M., Roden, D. M., Benjamin Shoemaker, M., Gustav Smith, J., Biggs, M. L., Bis, J. C., Brody, J. A., Psaty, B. M., Rice, K., Sotoodehnia, N., De Grandi, A., Fuchsberger, C., Pattaro, C., Pramstaller, P. P., Ford, I., Wouter Jukema, J., Macfarlane, P. W., Trompet, S., Dörr, M., Felix, S. B., Völker, U., Weiss, S., Havulinna, A. S., Jula, A., Sääksjärvi, K., Salomaa, V., Guo, X., Heckbert, S. R., Lin, H. J., Rotter, J. I., Taylor, K. D., Yao, J., de Mutsert, R., Maan, A. C., Mook-Kanamori, D. O., Noordam, R., Cucca, F., Ding, J., Lakatta, E. G., Qian, Y., Tarasov, K. V., Levy, D., Lin, H., Newton-Cheh, C. H., Lunetta, K. L., Murray, A. D., Porteous, D. J., Smith, B. H., Stricker, B. H., Uitterlinden, A., van den Berg, M. E., Haessler, J., Jackson, R. D., Kooperberg, C., Peters, U., Reiner, A. P., Whitsel, E. A., Alonso, A., Arking, D. E., Boerwinkle, E., Ehret, G. B., Soliman, E. Z., Avery, C. L., Gogarten, S. M., Kerr, K. F., Laurie, C. C., Seyerle, A. A., Stilp, A., Assa, S., Abdullah Said, M., Yldau van der Ende, M., Lambiase, P. D., Orini, M., Ramirez, J., Van Duijvenboden, S., Arnar, D. O., Gudbjartsson, D. F., Holm, H., Sulem, P., Thorleifsson, G., Thorolfsdottir, R. B., Thorsteinsdottir, U., Benjamin, E. J., Tinker, A., Stefansson, K., Ellinor, P. T., Jamshidi, Y., Lubitz, S. A. & Munroe, P. B., Dec 1 2020, In : Nature communications. 11, 1, 2542.

Research output: Contribution to journalArticle

Open Access
2018

Calorie restriction curbs proinflammation that accompanies arterial aging, preserving a youthful phenotype

Wang, M., Zhang, L., Zhu, W., Zhang, J., Kim, S. H., Wang, Y., Ni, L., Telljohann, R., Monticone, R. E., McGraw, K., Liu, L., de Cabo, R. & Lakatta, E. G., Sep 1 2018, In : Journal of the American Heart Association. 7, 18, e009112.

Research output: Contribution to journalArticle

2016

High short-term blood pressure variability predicts long-term cardiovascular mortality in untreated hypertensives but not in normotensives

Hsu, P. F., Cheng, H. M., Wu, C. H., Sung, S. H., Chuang, S. Y., Lakatta, E., Yin, F. C. P., Chou, P. & Chen, C. H., 2016, In : American Journal of Hypertension. 29, 7, p. 806-813 8 p.

Research output: Contribution to journalArticle

2019

Aging, MicroRNAs, and Heart Failure

Florio, M. C., Magenta, A., Beji, S., Lakatta, E. G. & Capogrossi, M. C., Jan 1 2019, (Accepted/In press) In : Current Problems in Cardiology.

Research output: Contribution to journalArticle

2018

Unique Ca2+-cycling protein abundance and regulation sustains local Ca2+ releases and spontaneous firing of rabbit sinoatrial node cells

Vinogradova, T. M., Sirenko, S. T. & Lakatta, E., Aug 1 2018, In : International Journal of Molecular Sciences. 19, 8, 2173.

Research output: Contribution to journalReview article

2016

The relationship between the metabolic syndrome and arterial wall thickness: A mosaic still to be interpreted

Scuteri, A., Franco, O. H., Völzke, H., Shin, M. H., Kweon, S. S., Rietzschel, E., Ryliškytė, L., Strazhesko, I., Chen, C. H., Lakatta, E. & Nilsson, P. M., Dec 1 2016, In : Atherosclerosis. 255, p. 11-16 6 p.

Research output: Contribution to journalArticle

2017

Arterial Stiffness and Risk of Overall Heart Failure, Heart Failure with Preserved Ejection Fraction, and Heart Failure with Reduced Ejection Fraction: The Health ABC Study (Health, Aging, and Body Composition)

Pandey, A., Khan, H., Newman, A. B., Lakatta, E. G., Forman, D. E., Butler, J. & Berry, J. D., Feb 1 2017, In : Hypertension. 69, 2, p. 267-274 8 p.

Research output: Contribution to journalArticle

2018

The reality of getting old

Lakatta, E., Sep 1 2018, In : Nature Reviews Cardiology. 15, 9, p. 499-500 2 p.

Research output: Contribution to journalComment/debate

2017

Prognostic utility of morning blood pressure surge for 20-year all- cause and cardiovascular mortalities: Results of a community-based study

Cheng, H. M., Wu, C. L., Sung, S. H., Lee, J. C., Kario, K., Chiang, C. E., Huang, C. J., Hsu, P. F., Chuang, S. Y., Lakatta, E. G., Yin, F. C. P., Chou, P. & Chen, C. H., Dec 1 2017, In : Journal of the American Heart Association. 6, 12, e007667.

Research output: Contribution to journalArticle

2018

TGFβ1 reinforces arterial aging in the vascular smooth muscle cell through a long-range regulation of the cytoskeletal stiffness

Zhu, W., Kim, B. C., Wang, M., Huang, J., Isak, A., Bexiga, N. M., Monticone, R., Ha, T., Lakatta, E. & An, S., Dec 1 2018, In : Scientific Reports. 8, 1, 2668.

Research output: Contribution to journalArticle

2016

Ca2 +/calmodulin-activated phosphodiesterase 1A is highly expressed in rabbit cardiac sinoatrial nodal cells and regulates pacemaker function

Lukyanenko, Y. O., Younes, A., Lyashkov, A. E., Tarasov, K. V., Riordon, D. R., Lee, J., Sirenko, S. G., Kobrinsky, E., Ziman, B., Tarasova, Y. S., Juhaszova, M., Sollott, S. J., Graham, D. & Lakatta, E., Sep 1 2016, In : Journal of Molecular and Cellular Cardiology. 98, p. 73-82 10 p.

Research output: Contribution to journalArticle

2017

The Pressure of Aging

AlGhatrif, M., Wang, M., Fedorova, O. V., Bagrov, A. Y. & Lakatta, E., Jan 1 2017, In : Medical Clinics of North America. 101, 1, p. 81-101 21 p.

Research output: Contribution to journalReview article

2016

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

Ehret, G. B., Ferreira, T., Chasman, D. I., Jackson, A. U., Schmidt, E. M., Johnson, T., Thorleifsson, G., Luan, JA., Donnelly, L. A., Kanoni, S., Petersen, A. K., Pihur, V., Strawbridge, R. J., Shungin, D., Hughes, M. F., Meirelles, O., Kaakinen, M., Bouatia-Naji, N., Kristiansson, K., Shah, S. & 293 others, Kleber, M. E., Guo, X., Lyytikäinen, L. P., Fava, C., Eriksson, N., Nolte, I. M., Magnusson, P. K., Salfati, E. L., Rallidis, L. S., Theusch, E., Smith, A. J. P., Folkersen, L., Witkowska, K., Pers, T. H., Joehanes, R., Kim, S. K., Lataniotis, L., Jansen, R., Johnson, A. D., Warren, H., Kim, Y. J., Zhao, W., Wu, Y., Tayo, B. O., Bochud, M., Absher, D., Adair, L. S., Amin, N., Arking, D. E., Axelsson, T., Baldassarre, D., Balkau, B., Bandinelli, S., Barnes, M. R., Barroso, I., Bevan, S., Bis, J. C., Bjornsdottir, G., Boehnke, M., Boerwinkle, E., Bonnycastle, L. L., Boomsma, D. I., Bornstein, S. R., Brown, M. J., Burnier, M., Cabrera, C. P., Chambers, J. C., Chang, I. S., Cheng, C. Y., Chines, P. S., Chung, R. H., Collins, F. S., Connell, J. M., Döring, A., Dallongeville, J., Danesh, J., De Faire, U., Delgado, G., Dominiczak, A. F., Doney, A. S. F., Drenos, F., Edkins, S., Eicher, J. D., Elosua, R., Enroth, S., Erdmann, J., Eriksson, P., Esko, T., Evangelou, E., Evans, A., Fall, T., Farrall, M., Felix, J. F., Ferrières, J., Ferrucci, L., Fornage, M., Forrester, T., Franceschini, N., Franco, O. H., Franco-Cereceda, A., Fraser, R. M., Ganesh, S. K., Gao, H., Gertow, K., Gianfagna, F., Gigante, B., Giulianini, F., Goel, A., Goodall, A. H., Goodarzi, M. O., Gorski, M., Gräßler, J., Groves, C. J., Gudnason, V., Gyllensten, U., Hallmans, G., Hartikainen, A. L., Hassinen, M., Havulinna, A. S., Hayward, C., Hercberg, S., Herzig, K. H., Hicks, A. A., Hingorani, A. D., Hirschhorn, J. N., Hofman, A., Holmen, J., Holmen, O. L., Hottenga, J. J., Howard, P., Hsiung, C. A., Hunt, S. C., Ikram, M. A., Illig, T., Iribarren, C., Jensen, R. A., Kähönen, M., Kang, H. M., Kathiresan, S., Keating, B. J., Khaw, K. T., Kim, Y. K., Kim, E., Kivimaki, M., Klopp, N., Kolovou, G., Komulainen, P., Kooner, J. S., Kosova, G., Krauss, R. M., Kuh, D., Kutalik, Z., Kuusisto, J., Kvaløy, K., Lakka, T. A., Lee, N. R., Lee, I. T., Lee, W. J., Levy, D., Li, X., Liang, K. W., Lin, H., Lin, L., Lindström, J., Lobbens, S., Männistö, S., Müller, G., Müller-Nurasyid, M., Mach, F., Markus, H. S., Marouli, E., McCarthy, M. I., McKenzie, C. A., Meneton, P., Menni, C., Metspalu, A., Mijatovic, V., Moilanen, L., Montasser, M. E., Morris, A. D., Morrison, A. C., Mulas, A., Nagaraja, R., Narisu, N., Nikus, K., O'Donnell, C. J., O'Reilly, P. F., Ong, K. K., Paccaud, F., Palmer, C. D., Parsa, A., Pedersen, N. L., Penninx, B. W., Perola, M., Peters, A., Poulter, N., Pramstaller, P. P., Psaty, B. M., Quertermous, T., Rao, D. C., Rasheed, A., Rayner, N. W., Renström, F., Rettig, R., Rice, K. M., Roberts, R., Rose, L. M., Rossouw, J., Samani, N. J., Sanna, S., Saramies, J., Schunkert, H., Sebert, S., Sheu, W. H. H., Shin, Y. A., Sim, X., Smit, J. H., Smith, A. V., Sosa, M. X., Spector, T. D., Stančáková, A., Stanton, A. V., Stirrups, K. E., Stringham, H. M., Sundstrom, J., Swift, A. J., Syvänen, A. C., Tai, E. S., Tanaka, T., Tarasov, K. V., Teumer, A., Thorsteinsdottir, U., Tobin, M. D., Tremoli, E., Uitterlinden, A. G., Uusitupa, M., Vaez, A., Vaidya, D., Van Duijn, C. M., Van Iperen, E. P. A., Vasan, R. S., Verwoert, G. C., Virtamo, J., Vitart, V., Voight, B. F., Vollenweider, P., Wagner, A., Wain, L. V., Wareham, N. J., Watkins, H., Weder, A. B., Westra, H. J., Wilks, R., Wilsgaard, T., Wilson, J. F., Wong, T. Y., Yang, T. P., Yao, J., Yengo, L., Zhang, W., Zhao, J. H., Zhu, X., Bovet, P., Cooper, R. S., Mohlke, K. L., Saleheen, D., Lee, J. Y., Elliott, P., Gierman, H. J., Willer, C. J., Franke, L., Hovingh, G. K., Taylor, K. D., Dedoussis, G., Sever, P., Wong, A., Lind, L., Assimes, T. L., Njølstad, I., Schwarz, P. E. H., Langenberg, C., Snieder, H., Caulfield, M. J., Melander, O., Laakso, M., Saltevo, J., Rauramaa, R., Tuomilehto, J., Ingelsson, E., Lehtimäki, T., Hveem, K., Palmas, W., März, W., Kumari, M., Salomaa, V., Chen, Y. D. I., Rotter, J. I., Froguel, P., Jarvelin, M. R., Lakatta, E. G., Kuulasmaa, K., Franks, P. W., Hamsten, A., Wichmann, H. E., Palmer, C. N. A., Stefansson, K., Ridker, P. M., Loos, R. J. F., Chakravarti, A., Deloukas, P., Morris, A. P., Newton-Cheh, C. & Munroe, P. B., Oct 1 2016, In : Nature genetics. 48, 10, p. 1171-1184 14 p.

Research output: Contribution to journalArticle

2018

Antibody to marinobufagenin reverses placenta-induced fibrosis of umbilical arteries in preeclampsia

Fedorova, O. V., Ishkaraeva, V. V., Grigorova, Y. N., Reznik, V. A., Kolodkin, N. I., Zazerskaya, I. E., Zernetkina, V., Agalakova, N. I., Tapilskaya, N. I., Adair, C. D., Lakatta, E. & Bagrov, A. Y., Aug 13 2018, In : International Journal of Molecular Sciences. 19, 8, 2377.

Research output: Contribution to journalArticle

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

the Million Veteran Program, Oct 1 2018, In : Nature genetics. 50, 10, p. 1412-1425 14 p.

Research output: Contribution to journalArticle

2020

The inherent challenges of classifying senescence−−Response

Calimport, S. R. G., Bentley, B. L., Stewart, C. E., Pawelec, G., Scuteri, A., Vinciguerra, M., Slack, C., Chen, D., Harries, L. W., Marchant, G., Alexander Fleming, G., Conboy, M., Antebi, A., Small, G. W., Gil, J., Lakatta, E. G., Richardson, A., Rosen, C., Nikolich, K., Wyss-Coray, T. & 5 others, Steinman, L., Montine, T., de Magalhães, J. P., Campisi, J. & Church, G., May 8 2020, In : Science. 368, 6491, p. 595-596 2 p.

Research output: Contribution to journalLetter

2019

Complexities in cardiovascular rhythmicity: Perspectives on circadian normality, ageing and disease

Monfredi, O. & Lakatta, E. G., Sep 1 2019, In : Cardiovascular research. 115, 11, p. 1576-1595 20 p.

Research output: Contribution to journalArticle

Open Access

To help aging populations, classify organismal senescence

Calimport, S. R. G., Bentley, B. L., Stewart, C. E., Pawelec, G., Scuteri, A., Vinciguerra, M., Slack, C., Chen, D., Harries, L. W., Marchant, G., Alexander Fleming, G., Conboy, M., Antebi, A., Small, G. W., Gil, J., Lakatta, E. G., Richardson, A., Rosen, C., Nikolich, K., Wyss-Coray, T. & 5 others, Steinman, L., Montine, T., de Magalhães, J. P., Campisi, J. & Church, G., Nov 1 2019, In : Science. 366, 6465, p. 576-578 3 p.

Research output: Contribution to journalArticle

2017

Spontaneous, local diastolic subsarcolemmal calcium releases in single, isolated guinea-pig sinoatrial nodal cells

Sirenko, S. G., Yang, D., Maltseva, L. A., Kim, M. S., Lakatta, E. G. & Maltsev, V. A., Sep 2017, In : PloS one. 12, 9, e0185222.

Research output: Contribution to journalArticle

2018

Association of arginine vasopressin with low atrial natriuretic peptide levels, left ventricular remodelling, and outcomes in adults with and without heart failure

Chirinos, J. A., Sardana, M., Oldland, G., Ansari, B., Lee, J., Hussain, A., Mustafa, A., Akers, S. R., Wei, W., Lakatta, E. G. & Fedorova, O. V., Oct 2018, In : ESC Heart Failure. 5, 5, p. 911-919 9 p.

Research output: Contribution to journalArticle

2016

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Pattaro, C., Teumer, A., Gorski, M., Chu, A. Y., Li, M., Mijatovic, V., Garnaas, M., Tin, A., Sorice, R., Li, Y., Taliun, D., Olden, M., Foster, M., Yang, Q., Chen, M. H., Pers, T. H., Johnson, A. D., Ko, Y. A., Fuchsberger, C., Tayo, B. & 678 others, Nalls, M., Feitosa, M. F., Isaacs, A., Dehghan, A., D'Adamo, P., Adeyemo, A., Dieffenbach, A. K., Zonderman, A. B., Nolte, I. M., Van Der Most, P. J., Wright, A. F., Shuldiner, A. R., Morrison, A. C., Hofman, A., Smith, A. V., Dreisbach, A. W., Franke, A., Uitterlinden, A. G., Metspalu, A., Tonjes, A., Lupo, A., Robino, A., Johansson, Å., Demirkan, A., Kollerits, B., Freedman, B. I., Ponte, B., Oostra, B. A., Paulweber, B., Krämer, B. K., Mitchell, B. D., Buckley, B. M., Peralta, C. A., Hayward, C., Helmer, C., Rotimi, C. N., Shaffer, C. M., Müller, C., Sala, C., Van Duijn, C. M., Saint-Pierre, A., Ackermann, D., Shriner, D., Ruggiero, D., Toniolo, D., Lu, Y., Cusi, D., Czamara, D., Ellinghaus, D., Siscovick, D. S., Ruderfer, D., Gieger, C., Grallert, H., Rochtchina, E., Atkinson, E. J., Holliday, E. G., Boerwinkle, E., Salvi, E., Bottinger, E. P., Murgia, F., Rivadeneira, F., Ernst, F., Kronenberg, F., Hu, F. B., Navis, G. J., Curhan, G. C., Ehret, G. B., Homuth, G., Coassin, S., Thun, G. A., Pistis, G., Gambaro, G., Malerba, G., Montgomery, G. W., Eiriksdottir, G., Jacobs, G., Li, G., Wichmann, H. E., Campbell, H., Schmidt, H., Wallaschofski, H., Völzke, H., Brenner, H., Kroemer, H. K., Kramer, H., Lin, H., Leach, I. M., Ford, I., Guessous, I., Rudan, I., Prokopenko, I., Borecki, I., Heid, I. M., Kolcic, I., Persico, I., Jukema, J. W., Wilson, J. F., Felix, J. F., Divers, J., Lambert, J. C., Stafford, J. M., Gaspoz, J. M., Smith, J. A., Faul, J. D., Wang, J. J., Ding, J., Hirschhorn, J. N., Attia, J., Whitfield, J. B., Chalmers, J., Viikari, J., Coresh, J., Denny, J. C., Karjalainen, J., Fernandes, J. K., Endlich, K., Butterbach, K., Keene, K. L., Lohman, K., Portas, L., Launer, L. 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R., Susztak, K., Hamet, P., Tremblay, J., De Boer, I. H., Böger, C. A., Goessling, W., Chasman, D. I., Köttgen, A., Kao, W. H. L. & Fox, C. S., Jan 21 2016, In : Nature communications. 7, 10023.

Research output: Contribution to journalArticle

Camkii-dependent phosphorylation regulates basal cardiac pacemaker function via modulation of local ca2+ releases

Li, Y., Sirenko, S., Riordon, D. R., Yang, D., Spurgeon, H., Lakatta, E. & Vinogradova, T. M., Sep 1 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 311, 3, p. H532-H544

Research output: Contribution to journalArticle

2019

Acclimation to a thermoneutral environment abolishes age-associated alterations in heart rate and heart rate variability in conscious, unrestrained mice

Axsom, J. E., Nanavati, A. P., Rutishauser, C. A., Bonin, J. E., Moen, J. M. & Lakatta, E. G., Jan 1 2019, (Accepted/In press) In : GeroScience.

Research output: Contribution to journalArticle

Open Access

Monoclonal Antibody to Marinobufagenin Downregulates TGFβ Profibrotic Signaling in Left Ventricle and Kidney and Reduces Tissue Remodeling in Salt-Sensitive Hypertension

Zhang, Y., Wei, W., Shilova, V., Petrashevskaya, N. N., Zernetkina, V. I., Grigorova, Y. N., Marshall, C. A., Fenner, R. C., Lehrmann, E., Wood, W. H., Becker, K. G., Lakatta, E. G., Bagrov, A. Y. & Fedorova, O. V., Oct 15 2019, In : Journal of the American Heart Association. 8, 20, p. e012138

Research output: Contribution to journalArticle

Open Access
2017

Hemodynamic determinants of the short-term blood pressure variability: Differential roles of arterial stiffness and wave reflection

Hsu, P. F., Cheng, H. M., Sung, S. H., Chuang, S. Y., Lakatta, E., Yin, F. C. P., Chou, P. & Chen, C. H., 2017, In : American Journal of Hypertension. 30, 3, p. 256-263 8 p.

Research output: Contribution to journalArticle

2016

Aortic Fibrosis, Induced by High Salt Intake in the Absence of Hypertensive Response, Is Reduced by a Monoclonal Antibody to Marinobufagenin

Grigorova, Y. N., Juhasz, O., Zernetkina, V., Fishbein, K. W., Lakatta, E., Fedorova, O. V. & Bagrov, A. Y., May 1 2016, In : American Journal of Hypertension. 29, 5, p. 641-646 6 p.

Research output: Contribution to journalArticle

Pharmacological Strategies to Retard Cardiovascular Aging

Alfaras, I., Di Germanio, C., Bernier, M., Csiszar, A., Ungvari, Z., Lakatta, E. G. & De Cabo, R., May 13 2016, In : Circulation research. 118, 10, p. 1626-1642 17 p.

Research output: Contribution to journalReview article

2020
Open Access
2017

Lower mitochondrial energy production of the thigh muscles in patients with low-normal ankle-brachial index

AlGhatrif, M., Zane, A., Oberdier, M., Canepa, M., Studenski, S., Simonsick, E., Spencer, R. G., Fishbein, K., Reiter, D., Lakatta, E. G., McDermott, M. M. & Ferrucci, L., Sep 1 2017, In : Journal of the American Heart Association. 6, 9, e006604.

Research output: Contribution to journalArticle

2018

Characteristics of healthy vascular ageing in pooled population-based cohort studies: The global metabolic syndrome and artery research consortium

Metabolic syndrome, Arteries REsearch (MARE) Consortium, 2018, In : Journal of hypertension. 36, 12, p. 2340-2349 10 p.

Research output: Contribution to journalArticle

A coupled-clock system drives the automaticity of human sinoatrial nodal pacemaker cells

Tsutsui, K., Monfredi, O. J., Sirenko-Tagirova, S. G., Maltseva, L. A., Bychkov, R., Kim, M. S., Ziman, B. D., Tarasov, K. V., Tarasova, Y. S., Zhang, J., Wang, M., Maltsev, A. V., Brennan, J. A., Efimov, I. R., Stern, M. D., Maltsev, V. A. & Lakatta, E., Jun 12 2018, In : Science Signaling. 11, 534, eaap7608.

Research output: Contribution to journalArticle

2019

Discoidin domain Receptor 2: A determinant of metabolic syndrome-associated arterial fibrosis in non-human primates

Ushakumary, M. G., Wang, M., Harikrishnan, V., Titus, A. S., Zhang, J., Liu, L., Monticone, R., Wang, Y., Mattison, J. A., De Cabo, R., Lakatta, E. G. & Kailasam, S., 2019, In : PloS one. 14, 12, e0225911.

Research output: Contribution to journalArticle

Open Access
2017

The Systematic Evaluation of Identifying the Infarct Related Artery Utilizing Cardiac Magnetic Resonance in Patients Presenting with ST-Elevation Myocardial Infarction

Hamo, C. E., Klem, I., Rao, S. V., Songco, V., Najjar, S., Lakatta, E., Raman, S. V., Harrington, R. A. & Heitner, J. F., Jan 1 2017, In : PLoS One. 12, 1, e0169108.

Research output: Contribution to journalArticle