8q24 allelic imbalance and MYC gene copy number in primary prostate cancer

H. Chen, W. Liu, W. Roberts, S. Hooker, H. Fedor, Angelo Michael Demarzo, William B Isaacs, R. A. Kittles

Research output: Contribution to journalArticle

Abstract

Four independent regions within 8q24 near the MYC gene are associated with risk for prostate cancer (Pca). Here, we investigated allelic imbalance (AI) at 8q24 risk variants and MYC gene DNA copy number (CN) in 27 primary Pcas. Heterozygotes were observed in 24 of 27 patients at one or more 8q24 markers and 27% of the loci exhibited AI in tumor DNA. The 8q24 risk alleles were preferentially favored in the tumors. Increased MYC gene CN was observed in 33% of tumors, and the co-existence of increased MYC gene CN with AI at risk loci was observed in 86% (P

Original languageEnglish (US)
Pages (from-to)238-243
Number of pages6
JournalProstate Cancer and Prostatic Diseases
Volume13
Issue number3
DOIs
StatePublished - Sep 2010

Fingerprint

Allelic Imbalance
Gene Dosage
Prostatic Neoplasms
Neoplasms
DNA
Heterozygote
Alleles
Genes

Keywords

  • 8q24
  • Allelic imbalance
  • DNA copy number
  • MYC gene

ASJC Scopus subject areas

  • Oncology
  • Urology
  • Cancer Research

Cite this

8q24 allelic imbalance and MYC gene copy number in primary prostate cancer. / Chen, H.; Liu, W.; Roberts, W.; Hooker, S.; Fedor, H.; Demarzo, Angelo Michael; Isaacs, William B; Kittles, R. A.

In: Prostate Cancer and Prostatic Diseases, Vol. 13, No. 3, 09.2010, p. 238-243.

Research output: Contribution to journalArticle

Chen, H. ; Liu, W. ; Roberts, W. ; Hooker, S. ; Fedor, H. ; Demarzo, Angelo Michael ; Isaacs, William B ; Kittles, R. A. / 8q24 allelic imbalance and MYC gene copy number in primary prostate cancer. In: Prostate Cancer and Prostatic Diseases. 2010 ; Vol. 13, No. 3. pp. 238-243.
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