55th Bowditch Lecture: Effects of chronic hypoxia on the pulmonary circulation: role of HIF-1.

Research output: Contribution to journalArticle

Abstract

When exposed to chronic hypoxia (CH), the pulmonary circulation responds with enhanced contraction and vascular remodeling, resulting in elevated pulmonary arterial pressures. Our work has identified CH-induced alterations in the expression and activity of several ion channels and transporters in pulmonary vascular smooth muscle that contribute to the development of hypoxic pulmonary hypertension and uncovered a critical role for the transcription factor hypoxia-inducible factor-1 (HIF-1) in mediating these responses. Current work is focused on the regulation of HIF in the chronically hypoxic lung and evaluation of the potential for pharmacological inhibitors of HIF to prevent, reverse, or slow the progression of pulmonary hypertension.

Original languageEnglish (US)
Pages (from-to)1343-1352
Number of pages10
JournalJournal of Applied Physiology
Volume113
Issue number9
StatePublished - Nov 2012

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Hypoxia-Inducible Factor 1
Pulmonary Circulation
Pulmonary Hypertension
Lung
Ion Channels
Vascular Smooth Muscle
Arterial Pressure
Transcription Factors
Pharmacology
Hypoxia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

55th Bowditch Lecture : Effects of chronic hypoxia on the pulmonary circulation: role of HIF-1. / Shimoda, Larissa.

In: Journal of Applied Physiology, Vol. 113, No. 9, 11.2012, p. 1343-1352.

Research output: Contribution to journalArticle

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