55th Bowditch Lecture: Effects of chronic hypoxia on the pulmonary circulation: Role of HIF-1

Research output: Contribution to journalReview article

Abstract

Shimoda LA. 55th Bowditch Lecture: Effects of chronic hypoxia on the pulmonary circulation: role of HIF-1. J Appl Physiol 113: 1343-1352, 2012. First published August 23, 2012; doi:10.1152/japplphysiol.00843.2012.-When exposed to chronic hypoxia (CH), the pulmonary circulation responds with enhanced contraction and vascular remodeling, resulting in elevated pulmonary arterial pressures. Our work has identified CH-induced alterations in the expression and activity of several ion channels and transporters in pulmonary vascular smooth muscle that contribute to the development of hypoxic pulmonary hypertension and uncovered a critical role for the transcription factor hypoxia-inducible factor-1 (HIF-1) in mediating these responses. Current work is focused on the regulation of HIF in the chronically hypoxic lung and evaluation of the potential for pharmacological inhibitors of HIF to prevent, reverse, or slow the progression of pulmonary hypertension.

Original languageEnglish (US)
Pages (from-to)1343-1352
Number of pages10
JournalJournal of applied physiology
Volume113
Issue number9
DOIs
StatePublished - Nov 1 2012

Keywords

  • Chronic hypoxia
  • Hypoxia-inducible factor-1
  • Pulmonary hypertension

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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