Abstract
PURPOSE:: To report the use of intracameral 5-fluorouracil (5-FU) to treat epithelial downgrowth after performing a Descemet-stripping automated endothelial keratoplasty (DSAEK). METHODS:: We describe the case of a 79-year-old woman who underwent a DSAEK for pseudophakic Fuchs endothelial corneal dystrophy. The patient required 2 repeat DSAEKs for graft failure and persistent, visually significant interface haze. Six months after the third and most recent DSAEK, the patient was followed up and found to have a visual acuity of 20/100. On examination, the patient continued to have a persistent interface haze. However, the patient also had a cellular anterior chamber reaction despite the administration of frequent topical corticosteroids, and subtle findings of a translucent, membranous growth over the iris. Argon laser photocoagulation of the area resulted in a whitening response, characteristic of epithelial growth. RESULTS:: Epithelial downgrowth was diagnosed, and intracameral 5-FU was administered. One month after the injection was given, the patient's examination results and vision improved to 20/60. Six months after the single injection, the patient had a clear DSAEK graft without interface haze, a quiet chamber, and 20/30 visual acuity. CONCLUSIONS:: Epithelial downgrowth that occurs after performing a DSAEK can be treated successfully using intracameral 5-FU.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1610-1612 |
| Number of pages | 3 |
| Journal | Cornea |
| Volume | 32 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 2013 |
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Keywords
- 5-fluorouracil
- Descemet-stripping automated endothelial keratoplasty
- epithelial downgrowth/ingrowth
- interface haze
ASJC Scopus subject areas
- Ophthalmology
Cite this
5-fluorouracil for epithelial downgrowth after Descemet stripping automated endothelial keratoplasty. / Wong, Ryan K.; Greene, Daniel P.; Shield, David R.; Eberhart, Charles G; Huang, John J.; Shayegani, Aryan.
In: Cornea, Vol. 32, No. 12, 12.2013, p. 1610-1612.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 5-fluorouracil for epithelial downgrowth after Descemet stripping automated endothelial keratoplasty
AU - Wong, Ryan K.
AU - Greene, Daniel P.
AU - Shield, David R.
AU - Eberhart, Charles G
AU - Huang, John J.
AU - Shayegani, Aryan
PY - 2013/12
Y1 - 2013/12
N2 - PURPOSE:: To report the use of intracameral 5-fluorouracil (5-FU) to treat epithelial downgrowth after performing a Descemet-stripping automated endothelial keratoplasty (DSAEK). METHODS:: We describe the case of a 79-year-old woman who underwent a DSAEK for pseudophakic Fuchs endothelial corneal dystrophy. The patient required 2 repeat DSAEKs for graft failure and persistent, visually significant interface haze. Six months after the third and most recent DSAEK, the patient was followed up and found to have a visual acuity of 20/100. On examination, the patient continued to have a persistent interface haze. However, the patient also had a cellular anterior chamber reaction despite the administration of frequent topical corticosteroids, and subtle findings of a translucent, membranous growth over the iris. Argon laser photocoagulation of the area resulted in a whitening response, characteristic of epithelial growth. RESULTS:: Epithelial downgrowth was diagnosed, and intracameral 5-FU was administered. One month after the injection was given, the patient's examination results and vision improved to 20/60. Six months after the single injection, the patient had a clear DSAEK graft without interface haze, a quiet chamber, and 20/30 visual acuity. CONCLUSIONS:: Epithelial downgrowth that occurs after performing a DSAEK can be treated successfully using intracameral 5-FU.
AB - PURPOSE:: To report the use of intracameral 5-fluorouracil (5-FU) to treat epithelial downgrowth after performing a Descemet-stripping automated endothelial keratoplasty (DSAEK). METHODS:: We describe the case of a 79-year-old woman who underwent a DSAEK for pseudophakic Fuchs endothelial corneal dystrophy. The patient required 2 repeat DSAEKs for graft failure and persistent, visually significant interface haze. Six months after the third and most recent DSAEK, the patient was followed up and found to have a visual acuity of 20/100. On examination, the patient continued to have a persistent interface haze. However, the patient also had a cellular anterior chamber reaction despite the administration of frequent topical corticosteroids, and subtle findings of a translucent, membranous growth over the iris. Argon laser photocoagulation of the area resulted in a whitening response, characteristic of epithelial growth. RESULTS:: Epithelial downgrowth was diagnosed, and intracameral 5-FU was administered. One month after the injection was given, the patient's examination results and vision improved to 20/60. Six months after the single injection, the patient had a clear DSAEK graft without interface haze, a quiet chamber, and 20/30 visual acuity. CONCLUSIONS:: Epithelial downgrowth that occurs after performing a DSAEK can be treated successfully using intracameral 5-FU.
KW - 5-fluorouracil
KW - Descemet-stripping automated endothelial keratoplasty
KW - epithelial downgrowth/ingrowth
KW - interface haze
UR - http://www.scopus.com/inward/record.url?scp=84888133872&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84888133872&partnerID=8YFLogxK
U2 - 10.1097/ICO.0b013e3182a9fc85
DO - 10.1097/ICO.0b013e3182a9fc85
M3 - Article
C2 - 24113368
AN - SCOPUS:84888133872
VL - 32
SP - 1610
EP - 1612
JO - Cornea
JF - Cornea
SN - 0277-3740
IS - 12
ER -