TY - JOUR
T1 - 5-fluorouracil for epithelial downgrowth after Descemet stripping automated endothelial keratoplasty
AU - Wong, Ryan K.
AU - Greene, Daniel P.
AU - Shield, David R.
AU - Eberhart, Charles G.
AU - Huang, John J.
AU - Shayegani, Aryan
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013/12
Y1 - 2013/12
N2 - PURPOSE:: To report the use of intracameral 5-fluorouracil (5-FU) to treat epithelial downgrowth after performing a Descemet-stripping automated endothelial keratoplasty (DSAEK). METHODS:: We describe the case of a 79-year-old woman who underwent a DSAEK for pseudophakic Fuchs endothelial corneal dystrophy. The patient required 2 repeat DSAEKs for graft failure and persistent, visually significant interface haze. Six months after the third and most recent DSAEK, the patient was followed up and found to have a visual acuity of 20/100. On examination, the patient continued to have a persistent interface haze. However, the patient also had a cellular anterior chamber reaction despite the administration of frequent topical corticosteroids, and subtle findings of a translucent, membranous growth over the iris. Argon laser photocoagulation of the area resulted in a whitening response, characteristic of epithelial growth. RESULTS:: Epithelial downgrowth was diagnosed, and intracameral 5-FU was administered. One month after the injection was given, the patient's examination results and vision improved to 20/60. Six months after the single injection, the patient had a clear DSAEK graft without interface haze, a quiet chamber, and 20/30 visual acuity. CONCLUSIONS:: Epithelial downgrowth that occurs after performing a DSAEK can be treated successfully using intracameral 5-FU.
AB - PURPOSE:: To report the use of intracameral 5-fluorouracil (5-FU) to treat epithelial downgrowth after performing a Descemet-stripping automated endothelial keratoplasty (DSAEK). METHODS:: We describe the case of a 79-year-old woman who underwent a DSAEK for pseudophakic Fuchs endothelial corneal dystrophy. The patient required 2 repeat DSAEKs for graft failure and persistent, visually significant interface haze. Six months after the third and most recent DSAEK, the patient was followed up and found to have a visual acuity of 20/100. On examination, the patient continued to have a persistent interface haze. However, the patient also had a cellular anterior chamber reaction despite the administration of frequent topical corticosteroids, and subtle findings of a translucent, membranous growth over the iris. Argon laser photocoagulation of the area resulted in a whitening response, characteristic of epithelial growth. RESULTS:: Epithelial downgrowth was diagnosed, and intracameral 5-FU was administered. One month after the injection was given, the patient's examination results and vision improved to 20/60. Six months after the single injection, the patient had a clear DSAEK graft without interface haze, a quiet chamber, and 20/30 visual acuity. CONCLUSIONS:: Epithelial downgrowth that occurs after performing a DSAEK can be treated successfully using intracameral 5-FU.
KW - 5-fluorouracil
KW - Descemet-stripping automated endothelial keratoplasty
KW - epithelial downgrowth/ingrowth
KW - interface haze
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U2 - 10.1097/ICO.0b013e3182a9fc85
DO - 10.1097/ICO.0b013e3182a9fc85
M3 - Article
C2 - 24113368
AN - SCOPUS:84888133872
VL - 32
SP - 1610
EP - 1612
JO - Cornea
JF - Cornea
SN - 0277-3740
IS - 12
ER -