5-fluorouracil for epithelial downgrowth after Descemet stripping automated endothelial keratoplasty

Ryan K. Wong, Daniel P. Greene, David R. Shield, Charles G. Eberhart, John J. Huang, Aryan Shayegani

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


PURPOSE:: To report the use of intracameral 5-fluorouracil (5-FU) to treat epithelial downgrowth after performing a Descemet-stripping automated endothelial keratoplasty (DSAEK). METHODS:: We describe the case of a 79-year-old woman who underwent a DSAEK for pseudophakic Fuchs endothelial corneal dystrophy. The patient required 2 repeat DSAEKs for graft failure and persistent, visually significant interface haze. Six months after the third and most recent DSAEK, the patient was followed up and found to have a visual acuity of 20/100. On examination, the patient continued to have a persistent interface haze. However, the patient also had a cellular anterior chamber reaction despite the administration of frequent topical corticosteroids, and subtle findings of a translucent, membranous growth over the iris. Argon laser photocoagulation of the area resulted in a whitening response, characteristic of epithelial growth. RESULTS:: Epithelial downgrowth was diagnosed, and intracameral 5-FU was administered. One month after the injection was given, the patient's examination results and vision improved to 20/60. Six months after the single injection, the patient had a clear DSAEK graft without interface haze, a quiet chamber, and 20/30 visual acuity. CONCLUSIONS:: Epithelial downgrowth that occurs after performing a DSAEK can be treated successfully using intracameral 5-FU.

Original languageEnglish (US)
Pages (from-to)1610-1612
Number of pages3
Issue number12
StatePublished - Dec 2013


  • 5-fluorouracil
  • Descemet-stripping automated endothelial keratoplasty
  • epithelial downgrowth/ingrowth
  • interface haze

ASJC Scopus subject areas

  • Ophthalmology


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