47,XYY and 46,XY males with antisocial and/or sex-offending behavior: antiandrogen therapy plus counseling

J. Money, C. Wiedeking, P. Walker, C. Migeon, W. Meyer, D. Borgaonkar

Research output: Contribution to journalArticle


(1) Thirteen males with the 47,XYY genotype and ten with 46,XY were given the androgendepleting (antiandrogenic) steroid, medroxyprogesterone acetate, in combination with a counseling program. (2) Those with the XY genotype were all sex offenders and those with the XYY genotype were antisocial offenders (primarily robbery and destructiveness), with or without sexual offences. (3) The combined treatment program was beneficial in helping sex offenders to regulate their behavior and, in five instances (three XY and two XYY), there was a remission of paraphiliac symptoms. (4) The effect of treatment on aggressive-destructive antisocial behavior was less clear, and was probably due to a placebo-like response.

Original languageEnglish (US)
Pages (from-to)165-178
Number of pages14
Issue number2
StatePublished - 1975


ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Psychiatry and Mental health
  • Biological Psychiatry

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