Abstract
Familial expression of inadequate virilization of 46XY siblings is often reported as an isolated anomaly. We recently evaluated two families with 2 siblings who had a 46XY karyotype, ambiguous genitalia or micropenis, facial anomalies and mental retardation. There is no evidence of gonadotropin deficiency, defects of steroidogenesis, or androgen insensitivity. While there was a testosterone response to human chorionic gonadotropin stimulation in all 3 tested, gonadotropin levels were elevated in 2 of the infants suggestive of faulty seminiferous tubules, 1 of whom later had elevated luteinizing hormone levels. These kindreds may represent a new syndrome with either an X-linked recessive or sex-limited autosomal dominant form of inheritance, with partial testicular failure, multiple congenital anomalies, and mental retardation.
Original language | English (US) |
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Pages (from-to) | 207-210 |
Number of pages | 4 |
Journal | Hormone Research |
Volume | 29 |
Issue number | 5-6 |
DOIs | |
State | Published - 1988 |
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology