3T MR with diffusion tensor imaging and single-voxel spectroscopy in giant axonal neuropathy

Christiana Brenner, Carlos Eduardo Speck-Martins, Luciano Farage, Peter B. Barker

Research output: Contribution to journalArticle

Abstract

Magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), and MR spectroscopy (MRS) data were obtained in a patient with giant axonal neuropathy (GAN) and compared to a control group. Fractional anisotropy (FA) and apparent coefficient diffusion (ADC) data were obtained from specific white matter tracts including the corticospinal tracts (CST), corpus callosum (CC), optic radiations (OR), and middle cerebellar peduncle (MCP). Analysis of the MRS was performed. DTI parameters and MRS results were correlated with the neuropathological findings described for GAN. No significant difference between the FA of the CC of the patient and the control group was found. However, there was a significant difference between the FA of the CST, OR, and MCP of the patient and the control group. The ADC values for all tracts of the patient were significantly increased. N-acetylaspartate to creatine (NAA/Cr) and N-acetylaspartate to choline (NAA-Cho) (choline) metabolite ratios were slightly decreased and choline to creatine (Cho/Cr) and myo-inositol to creatine (Ins/Cr) metabolite ratios were increased in the parietal gray and white matter of the patient as compared to the control group. Cerebellar involvement was less evident. The DTI and MRS findings suggest myelin and axonal damage.

Original languageEnglish (US)
Pages (from-to)236-241
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Volume28
Issue number1
DOIs
StatePublished - Jul 1 2008

Keywords

  • Diffusion tensor imaging
  • Leukoencephalopathy
  • MR spectroscopy
  • MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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