[3H]Clonidine binding to two α-adrenergic sites in rat CNS: Differential effects of 6-hydroxydopamine

David C. U'Prichard, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

[3H]Clonidine binds to two rat CNS α-receptor sites, with KD values of 0.5 nM and 3.0 nM. These sites can be examined in isolation from each other. α-Agonists are more potent at the high affinity site, while the converse is true for α-antagonists. The regional distribution in rat CNS for high affinity and low affinity [3H]clonidine binding is different. In the cerebral cortex, 6-hydroxydopamine (6-OHDA) treatment doubles the number of high affinity sites, but does not affect the number of low affinity sites. Throughout the brain, 6-OHDA treatment increases high affinity binding much more than low affinity binding, except in the pons and medulla, where 6-OHDA did not change high affinity [3H]clonidine binding.

Original languageEnglish (US)
Pages (from-to)237-241
Number of pages5
JournalAdvances in the Biosciences
Volume18
Issue numberC
StatePublished - 1979

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Oxidopamine
Clonidine
Adrenergic Agents
Rats
Brain

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[3H]Clonidine binding to two α-adrenergic sites in rat CNS : Differential effects of 6-hydroxydopamine. / U'Prichard, David C.; Snyder, Solomon H.

In: Advances in the Biosciences, Vol. 18, No. C, 1979, p. 237-241.

Research output: Contribution to journalArticle

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