3H-apomorphine interactions with dopamine receptors in calf brain

Leon Thal, Ian Creese, Solomon H Snyder

Research output: Contribution to journalArticle

Abstract

3H-apomorphine binds to membranes from areas of the corpus striatum and limbic system of calf brain saturable and with a drug specificity indicating that it labels dopamine receptors. In terms of drug specificity, log-logit displacement curve slopes and number of binding sites, 3H-apomorphine interacts with receptors in a manner more like 3H-dopamine than 3H-haloperidol. These properties of 3H-apomorphine binding are those of an apparently "pure" agonist in contrast to the partial agonist effects of apomorphine upon the dopamine-sensitive adenylate cyclase.

Original languageEnglish (US)
Pages (from-to)295-299
Number of pages5
JournalEuropean Journal of Pharmacology
Volume49
Issue number3
DOIs
StatePublished - Jun 1 1978

Fingerprint

Apomorphine
Dopamine Receptors
Brain
Dopamine
Corpus Striatum
Limbic System
Haloperidol
Adenylyl Cyclases
Pharmaceutical Preparations
Binding Sites
Membranes

Keywords

  • H-Apomorphine binding
  • H-Dopamine binding
  • H-Haloperidol binding
  • Dopamine receptor
  • Neuroleptic

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

3H-apomorphine interactions with dopamine receptors in calf brain. / Thal, Leon; Creese, Ian; Snyder, Solomon H.

In: European Journal of Pharmacology, Vol. 49, No. 3, 01.06.1978, p. 295-299.

Research output: Contribution to journalArticle

@article{d0f4f8f8f14942a8961f11c6e4c391c9,
title = "3H-apomorphine interactions with dopamine receptors in calf brain",
abstract = "3H-apomorphine binds to membranes from areas of the corpus striatum and limbic system of calf brain saturable and with a drug specificity indicating that it labels dopamine receptors. In terms of drug specificity, log-logit displacement curve slopes and number of binding sites, 3H-apomorphine interacts with receptors in a manner more like 3H-dopamine than 3H-haloperidol. These properties of 3H-apomorphine binding are those of an apparently {"}pure{"} agonist in contrast to the partial agonist effects of apomorphine upon the dopamine-sensitive adenylate cyclase.",
keywords = "H-Apomorphine binding, H-Dopamine binding, H-Haloperidol binding, Dopamine receptor, Neuroleptic",
author = "Leon Thal and Ian Creese and Snyder, {Solomon H}",
year = "1978",
month = "6",
day = "1",
doi = "10.1016/0014-2999(78)90105-X",
language = "English (US)",
volume = "49",
pages = "295--299",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - 3H-apomorphine interactions with dopamine receptors in calf brain

AU - Thal, Leon

AU - Creese, Ian

AU - Snyder, Solomon H

PY - 1978/6/1

Y1 - 1978/6/1

N2 - 3H-apomorphine binds to membranes from areas of the corpus striatum and limbic system of calf brain saturable and with a drug specificity indicating that it labels dopamine receptors. In terms of drug specificity, log-logit displacement curve slopes and number of binding sites, 3H-apomorphine interacts with receptors in a manner more like 3H-dopamine than 3H-haloperidol. These properties of 3H-apomorphine binding are those of an apparently "pure" agonist in contrast to the partial agonist effects of apomorphine upon the dopamine-sensitive adenylate cyclase.

AB - 3H-apomorphine binds to membranes from areas of the corpus striatum and limbic system of calf brain saturable and with a drug specificity indicating that it labels dopamine receptors. In terms of drug specificity, log-logit displacement curve slopes and number of binding sites, 3H-apomorphine interacts with receptors in a manner more like 3H-dopamine than 3H-haloperidol. These properties of 3H-apomorphine binding are those of an apparently "pure" agonist in contrast to the partial agonist effects of apomorphine upon the dopamine-sensitive adenylate cyclase.

KW - H-Apomorphine binding

KW - H-Dopamine binding

KW - H-Haloperidol binding

KW - Dopamine receptor

KW - Neuroleptic

UR - http://www.scopus.com/inward/record.url?scp=0018200985&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018200985&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(78)90105-X

DO - 10.1016/0014-2999(78)90105-X

M3 - Article

C2 - 658143

AN - SCOPUS:0018200985

VL - 49

SP - 295

EP - 299

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 3

ER -