3‐dimensional functional imaging of human brain using echo‐shifted FLASH MRI

Jeff H. Duyn; Venhatha S. Mattay; Roy H. Sexton; Geoffrey S. Sobering; Fernando A. Barrios; Guoying Liu; Joseph A. Frank; Daniel R. Weinberger; Chrit T.W. Moonen

doi:10.1002/mrm.1910320123

3‐dimensional functional imaging of human brain using echo‐shifted FLASH MRI

Jeff H. Duyn, Venhatha S. Mattay, Roy H. Sexton, Geoffrey S. Sobering, Fernando A. Barrios, Guoying Liu, Joseph A. Frank, Daniel R. Weinberger, Chrit T.W. Moonen

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

A 3‐dimensional MRI method has been developed for functional mapping of the human brain, based on blood oxygenation level dependent (BOLD) contrast mechanisms. The method uses recently introduced principles of echo‐shifted FLASH to acquire a single 3D data set in 20 s. The technique was tested on a conventional 1.5 Tesla clinical scanner with a standard head coil using visual stimulation with a 8 Hz flashing white light, or a varying checkerboard pattern. Areas of increased signal intensity were identified in the visual cortex, consistent with the known functional organization.

Original language	English (US)
Pages (from-to)	150-155
Number of pages	6
Journal	Magnetic resonance in medicine
Volume	32
Issue number	1
DOIs	https://doi.org/10.1002/mrm.1910320123
State	Published - Jul 1994
Externally published	Yes

Keywords

MR, rapid imaging
brain, MR
brain, function
functional MRI

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1002/mrm.1910320123

Cite this

@article{2ecbc1a9efa649499045401f3020d17d,

title = "3‐dimensional functional imaging of human brain using echo‐shifted FLASH MRI",

abstract = "A 3‐dimensional MRI method has been developed for functional mapping of the human brain, based on blood oxygenation level dependent (BOLD) contrast mechanisms. The method uses recently introduced principles of echo‐shifted FLASH to acquire a single 3D data set in 20 s. The technique was tested on a conventional 1.5 Tesla clinical scanner with a standard head coil using visual stimulation with a 8 Hz flashing white light, or a varying checkerboard pattern. Areas of increased signal intensity were identified in the visual cortex, consistent with the known functional organization.",

keywords = "MR, rapid imaging, brain, MR, brain, function, functional MRI",

author = "Duyn, {Jeff H.} and Mattay, {Venhatha S.} and Sexton, {Roy H.} and Sobering, {Geoffrey S.} and Barrios, {Fernando A.} and Guoying Liu and Frank, {Joseph A.} and Weinberger, {Daniel R.} and Moonen, {Chrit T.W.}",

year = "1994",

month = jul,

doi = "10.1002/mrm.1910320123",

language = "English (US)",

volume = "32",

pages = "150--155",

journal = "Magnetic resonance in medicine",

issn = "0740-3194",

publisher = "John Wiley and Sons Inc.",

number = "1",

}

TY - JOUR

T1 - 3‐dimensional functional imaging of human brain using echo‐shifted FLASH MRI

AU - Duyn, Jeff H.

AU - Mattay, Venhatha S.

AU - Sexton, Roy H.

AU - Sobering, Geoffrey S.

AU - Barrios, Fernando A.

AU - Liu, Guoying

AU - Frank, Joseph A.

AU - Weinberger, Daniel R.

AU - Moonen, Chrit T.W.

PY - 1994/7

Y1 - 1994/7

N2 - A 3‐dimensional MRI method has been developed for functional mapping of the human brain, based on blood oxygenation level dependent (BOLD) contrast mechanisms. The method uses recently introduced principles of echo‐shifted FLASH to acquire a single 3D data set in 20 s. The technique was tested on a conventional 1.5 Tesla clinical scanner with a standard head coil using visual stimulation with a 8 Hz flashing white light, or a varying checkerboard pattern. Areas of increased signal intensity were identified in the visual cortex, consistent with the known functional organization.

AB - A 3‐dimensional MRI method has been developed for functional mapping of the human brain, based on blood oxygenation level dependent (BOLD) contrast mechanisms. The method uses recently introduced principles of echo‐shifted FLASH to acquire a single 3D data set in 20 s. The technique was tested on a conventional 1.5 Tesla clinical scanner with a standard head coil using visual stimulation with a 8 Hz flashing white light, or a varying checkerboard pattern. Areas of increased signal intensity were identified in the visual cortex, consistent with the known functional organization.

KW - MR, rapid imaging

KW - brain, MR

KW - brain, function

KW - functional MRI

UR - http://www.scopus.com/inward/record.url?scp=0028340398&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028340398&partnerID=8YFLogxK

U2 - 10.1002/mrm.1910320123

DO - 10.1002/mrm.1910320123

M3 - Article

C2 - 8084232

AN - SCOPUS:0028340398

SN - 0740-3194

VL - 32

SP - 150

EP - 155

JO - Magnetic resonance in medicine

JF - Magnetic resonance in medicine

IS - 1

ER -

3‐dimensional functional imaging of human brain using echo‐shifted FLASH MRI

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this