3D and 4D bioprinting of the myocardium: Current approaches, challenges, and future prospects

Chin Siang Ong, Lucy Nam, Kingsfield Ong, Aravind Krishnan, Chen Yu Huang, Takuma Fukunishi, Narutoshi Hibino

Research output: Contribution to journalReview articlepeer-review

Abstract

3D and 4D bioprinting of the heart are exciting notions in the modern era. However, myocardial bioprinting has proven to be challenging. This review outlines the methods, materials, cell types, issues, challenges, and future prospects in myocardial bioprinting. Advances in 3D bioprinting technology have significantly improved the manufacturing process. While scaffolds have traditionally been utilized, 3D bioprinters, which do not require scaffolds, are increasingly being employed. Improved understanding of the cardiac cellular composition and multiple strategies to tackle the issues of vascularization and viability had led to progress in this field. In vivo studies utilizing small animal models have been promising. 4D bioprinting is a new concept that has potential to advance the field of 3D bioprinting further by incorporating the fourth dimension of time. Clinical translation will require multidisciplinary collaboration to tackle the pertinent issues facing this field.

Original languageEnglish (US)
Article number6497242
JournalBioMed Research International
Volume2018
DOIs
StatePublished - Apr 22 2018

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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