341-345 A Case of seronegative HIV-1 infection

Adam M. Spivak; Tim P. Brennan; Karen A. O'Connell; Emily Sydnor; Thomas M. Williams; Robert F. Siliciano; Joel E. Gallant; Joel N. Blankson

doi:10.1086/649822

341-345 A Case of seronegative HIV-1 infection

Adam M. Spivak, Tim P. Brennan, Karen A. O'Connell, Emily Sydnor, Thomas M. Williams, Robert F. Siliciano, Joel E. Gallant, Joel N. Blankson

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Patients infected with human immunodeficiency virus type 1 (HIV-1) typically seroconvert within weeks of primary infection. In rare cases, patients do not develop antibodies against HIV-1 despite demonstrable infection. We describe here a human leukocyte antigen (HLA)-B*5802-positive individual who presented with acquired immune deficiency syndrome despite repeatedly negative HIV-1 antibody screening test results. Phylogenetic analysis of env clones revealed little sequence diversity, and weak HIV-1-specific CD8 ⁺ T cell responses were present to Gag epitopes. The patient seroconverted after immune reconstitution during receipt of highly active antiretroviral therapy. Lack of an antibody response to HIV-1 is rare and appears to be due to a defect in HIV-1-specific immunity rather than infection with attenuated virus.

Original language	English (US)
Pages (from-to)	341-345
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	201
Issue number	3
DOIs	https://doi.org/10.1086/649822
State	Published - Feb 1 2010

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1086/649822

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title = "341-345 A Case of seronegative HIV-1 infection",

abstract = "Patients infected with human immunodeficiency virus type 1 (HIV-1) typically seroconvert within weeks of primary infection. In rare cases, patients do not develop antibodies against HIV-1 despite demonstrable infection. We describe here a human leukocyte antigen (HLA)-B*5802-positive individual who presented with acquired immune deficiency syndrome despite repeatedly negative HIV-1 antibody screening test results. Phylogenetic analysis of env clones revealed little sequence diversity, and weak HIV-1-specific CD8 + T cell responses were present to Gag epitopes. The patient seroconverted after immune reconstitution during receipt of highly active antiretroviral therapy. Lack of an antibody response to HIV-1 is rare and appears to be due to a defect in HIV-1-specific immunity rather than infection with attenuated virus.",

author = "Spivak, {Adam M.} and Brennan, {Tim P.} and O'Connell, {Karen A.} and Emily Sydnor and Williams, {Thomas M.} and Siliciano, {Robert F.} and Gallant, {Joel E.} and Blankson, {Joel N.}",

note = "Funding Information: Received 30 May 2009; accepted 21 August 2009; electronically published 29 December 2009. Potential conflicts of interest: none reported. Presented in part: 2009 Conference on Retroviruses and Opportunistic Infections, Montreal, Canada, 8–11 February 2009 (abstract 410). Financial support: National Institutes of Health (grants R56 AI73185-01A1 and R01 AI080328 to J.N.B.); Howard Hughes Medical Institute (to R.F.S.). Reprints or correspondence: Dr Joel Blankson, Broadway Research Bldg, Rm 880, Johns Hopkins University School of Medicine, 722 N Broadway, Baltimore, MD 21205 (jblanks@ jhmi.edu).",

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AU - Spivak, Adam M.

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AU - Siliciano, Robert F.

AU - Gallant, Joel E.

AU - Blankson, Joel N.

N1 - Funding Information: Received 30 May 2009; accepted 21 August 2009; electronically published 29 December 2009. Potential conflicts of interest: none reported. Presented in part: 2009 Conference on Retroviruses and Opportunistic Infections, Montreal, Canada, 8–11 February 2009 (abstract 410). Financial support: National Institutes of Health (grants R56 AI73185-01A1 and R01 AI080328 to J.N.B.); Howard Hughes Medical Institute (to R.F.S.). Reprints or correspondence: Dr Joel Blankson, Broadway Research Bldg, Rm 880, Johns Hopkins University School of Medicine, 722 N Broadway, Baltimore, MD 21205 (jblanks@ jhmi.edu).

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AB - Patients infected with human immunodeficiency virus type 1 (HIV-1) typically seroconvert within weeks of primary infection. In rare cases, patients do not develop antibodies against HIV-1 despite demonstrable infection. We describe here a human leukocyte antigen (HLA)-B*5802-positive individual who presented with acquired immune deficiency syndrome despite repeatedly negative HIV-1 antibody screening test results. Phylogenetic analysis of env clones revealed little sequence diversity, and weak HIV-1-specific CD8 + T cell responses were present to Gag epitopes. The patient seroconverted after immune reconstitution during receipt of highly active antiretroviral therapy. Lack of an antibody response to HIV-1 is rare and appears to be due to a defect in HIV-1-specific immunity rather than infection with attenuated virus.

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341-345 A Case of seronegative HIV-1 infection

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