341-345 A Case of seronegative HIV-1 infection

Adam M. Spivak, Tim P. Brennan, Karen A. O'Connell, Emily Sydnor, Thomas M. Williams, Robert F. Siliciano, Joel E. Gallant, Joel N. Blankson

Research output: Contribution to journalArticlepeer-review


Patients infected with human immunodeficiency virus type 1 (HIV-1) typically seroconvert within weeks of primary infection. In rare cases, patients do not develop antibodies against HIV-1 despite demonstrable infection. We describe here a human leukocyte antigen (HLA)-B*5802-positive individual who presented with acquired immune deficiency syndrome despite repeatedly negative HIV-1 antibody screening test results. Phylogenetic analysis of env clones revealed little sequence diversity, and weak HIV-1-specific CD8 + T cell responses were present to Gag epitopes. The patient seroconverted after immune reconstitution during receipt of highly active antiretroviral therapy. Lack of an antibody response to HIV-1 is rare and appears to be due to a defect in HIV-1-specific immunity rather than infection with attenuated virus.

Original languageEnglish (US)
Pages (from-to)341-345
Number of pages5
JournalJournal of Infectious Diseases
Issue number3
StatePublished - Feb 1 2010

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


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