3,4-Methylenedioxyethylamphetamine (MDE), a novel analogue of MDMA, produces long-lasting depletion of serotonin in the rat brain

G. A. Ricaurte, K. F. Finnegan, D. E. Nichols, L. E. DeLanney, I. Irwin, J. W. Langston

Research output: Contribution to journalArticlepeer-review

Abstract

The present study was carried out to asses possible toxic effects of 3,4-methylenedioxyethylamphetamine (MDE) on serotonergic, dopaminergic or noradrenergic neurons in the rat brain. It was found that MDE produced a long-lasting, dose-related depletion of serotonin (5HT). However, even at high dosage, MDE did not reduce the concentration of either dopamine (DA) or norepinephrine (NE) on a long-term basis. When compared to 3,4-methylenedioxymethylamphetamine (MDMA), MDE was approximately one fourth as potent as producing a long-term depletion of 5HT. These results suggest that MDE, like MDMA, may be selectively toxic to central serotonergic neurons.

Original languageEnglish (US)
Pages (from-to)265-268
Number of pages4
JournalEuropean Journal of Pharmacology
Volume137
Issue number2-3
DOIs
StatePublished - Jun 4 1987
Externally publishedYes

Keywords

  • Amphetamines (and analogues)
  • Neurotoxicity
  • Serotonergic neurons

ASJC Scopus subject areas

  • Pharmacology

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