[32P]ATP inhibits the growth of xenografted tumors in nude mice

Yulan Cheng, Srinivasan Senthamizhchelvan, Rachana Agarwal, Gilbert M. Green, Ronnie Mease, George Sgouros, David L. Huso, Martin Gilbert Pomper, Stephen Meltzer, John M. Abraham

Research output: Contribution to journalArticle

Abstract

The search for new therapeutic agents that are effective against cancer has been difficult and expensive. The activity of anticancer candidate agents against human cancer-derived cell lines in immunocompromised mice is an important tool in this search. Because ATP is a naturally occurring small molecule, its radiolabeled form poses many advantages as a potential anticancer therapeutic agent. We previously found that a single, low-dose intravenous injection of [32P] ATP inhibited the growth of xenografted tumors in nude mice for up to several weeks. The current study describes the biodistribution and the results and advantages of multi-dose administration of this potential drug. Future studies should investigate the mechanism involved in the possible use of [32P]ATP as a cytotoxic agent that homes naturally to the tumor microenvironment.

Original languageEnglish (US)
Pages (from-to)1878-1882
Number of pages5
JournalCell cycle (Georgetown, Tex.)
Volume11
Issue number10
DOIs
StatePublished - May 15 2012

Fingerprint

Nude Mice
Adenosine Triphosphate
Antineoplastic Agents
Growth
Neoplasms
Tumor Microenvironment
Cytotoxins
Intravenous Injections
Cell Line
Therapeutics
Pharmaceutical Preparations

Keywords

  • [32P]ATP
  • Mice
  • Tumor inhibition
  • Xenografts

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Developmental Biology
  • Medicine(all)

Cite this

Cheng, Y., Senthamizhchelvan, S., Agarwal, R., Green, G. M., Mease, R., Sgouros, G., ... Abraham, J. M. (2012). [32P]ATP inhibits the growth of xenografted tumors in nude mice. Cell cycle (Georgetown, Tex.), 11(10), 1878-1882. https://doi.org/10.4161/cc.19955

[32P]ATP inhibits the growth of xenografted tumors in nude mice. / Cheng, Yulan; Senthamizhchelvan, Srinivasan; Agarwal, Rachana; Green, Gilbert M.; Mease, Ronnie; Sgouros, George; Huso, David L.; Pomper, Martin Gilbert; Meltzer, Stephen; Abraham, John M.

In: Cell cycle (Georgetown, Tex.), Vol. 11, No. 10, 15.05.2012, p. 1878-1882.

Research output: Contribution to journalArticle

Cheng, Y, Senthamizhchelvan, S, Agarwal, R, Green, GM, Mease, R, Sgouros, G, Huso, DL, Pomper, MG, Meltzer, S & Abraham, JM 2012, '[32P]ATP inhibits the growth of xenografted tumors in nude mice', Cell cycle (Georgetown, Tex.), vol. 11, no. 10, pp. 1878-1882. https://doi.org/10.4161/cc.19955
Cheng, Yulan ; Senthamizhchelvan, Srinivasan ; Agarwal, Rachana ; Green, Gilbert M. ; Mease, Ronnie ; Sgouros, George ; Huso, David L. ; Pomper, Martin Gilbert ; Meltzer, Stephen ; Abraham, John M. / [32P]ATP inhibits the growth of xenografted tumors in nude mice. In: Cell cycle (Georgetown, Tex.). 2012 ; Vol. 11, No. 10. pp. 1878-1882.
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