3-Year Actuarial Biochemical Recurrence-Free Survival Following Laparoscopic Radical Prostatectomy: Experience From a Tertiary Referral Center in the United States

Christian Pavlovich, Bruce Trock, Aaron Sulman, Andrew A. Wagner, Lynda Z. Mettee, Li Ming Su

Research output: Contribution to journalArticle

Abstract

Purpose: We performed a prospective analysis of pathological and oncological outcomes following laparoscopic radical prostatectomy at a medical center in the United States. Materials and Methods: A total of 528 men underwent laparoscopic radical prostatectomy between April 2001 and August 2005. We excluded 4 open surgical conversions (0.8%) and 16 men (3.0%) without followup. The remaining 508 men had a mean preoperative prostate specific antigen of 6.0 ng/ml (range 0.3 to 27) and Gleason score of 6.3 (range 6 to 10). Stage was cT1b in 1 case (0.2%), cT1c in 350 (68.9%), cT2a in 135 (26.6%), cT2b in 21 (4.1%) and cT2c in 1 (0.2%). Of the patients 89% underwent cavernous nerve preservation. Biochemical recurrence was defined and timed at the first prostate specific antigen of 0.2 ng/ml or greater if at repeat testing it remained 0.2 ng/ml or greater. Results: Mean followup was 13.2 months (median 12, range 2 to 52). Pathological stage was pT0N0/Nx in 2 men (0.4%), pT2N0/Nx in 414 (81.5%), pT3aN0/Nx in 72 (14.2%), pT3bN0/Nx in 17 (3.3%) and pT2-3N1 in 3 (0.6%). Positive margin rates increased with higher stage (8.2% in pT2 and 39.3% in pT3 cases, p

Original languageEnglish (US)
Pages (from-to)917-922
Number of pages6
JournalJournal of Urology
Volume179
Issue number3
DOIs
Publication statusPublished - Mar 2008

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Keywords

  • laparoscopy
  • local
  • neoplasm recurrence
  • prostate
  • prostate-specific antigen
  • prostatectomy

ASJC Scopus subject areas

  • Urology

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