3-deoxy-3-substituted-D-myo-inositol imidazolyl ether lipid phosphates and carbonate as inhibitors of the phosphatidylinositol 3-kinase pathway and cancer cell growth

Youhong Hu; Emmanuelle J. Meuillet; Margareta Berggren; Garth Powis; Alan P. Kozikowski

doi:10.1016/S0960-894X(00)00640-5

3-deoxy-3-substituted-D-myo-inositol imidazolyl ether lipid phosphates and carbonate as inhibitors of the phosphatidylinositol 3-kinase pathway and cancer cell growth

Youhong Hu, Emmanuelle J. Meuillet, Margareta Berggren, Garth Powis, Alan P. Kozikowski

School of Medicine

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

3-Modified D-myo-inositol imidazolyl ether lipid phosphates and a carbonate were synthesized and evaluated as inhibitors of PI3-K and Akt. These data are presented along with IC₅₀ values for the inhibition of the growth of three cancer cell lines.

Original language	English (US)
Pages (from-to)	173-176
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/S0960-894X(00)00640-5
State	Published - Jan 22 2001

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(00)00640-5

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3-deoxy-3-substituted-D-myo-inositol imidazolyl ether lipid phosphates and carbonate as inhibitors of the phosphatidylinositol 3-kinase pathway and cancer cell growth. / Hu, Youhong; Meuillet, Emmanuelle J.; Berggren, Margareta et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 11, No. 2, 22.01.2001, p. 173-176.

Research output: Contribution to journal › Article › peer-review

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abstract = "3-Modified D-myo-inositol imidazolyl ether lipid phosphates and a carbonate were synthesized and evaluated as inhibitors of PI3-K and Akt. These data are presented along with IC50 values for the inhibition of the growth of three cancer cell lines.",

author = "Youhong Hu and Meuillet, {Emmanuelle J.} and Margareta Berggren and Garth Powis and Kozikowski, {Alan P.}",

note = "Funding Information: This work was supported by the National Institutes of Health (Grant No. CA 61015) and the Department of Defense (DAMD 17-93-V-3018). Copyright: Copyright 2007 Elsevier B.V., All rights reserved.",

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AU - Berggren, Margareta

AU - Powis, Garth

AU - Kozikowski, Alan P.

N1 - Funding Information: This work was supported by the National Institutes of Health (Grant No. CA 61015) and the Department of Defense (DAMD 17-93-V-3018). Copyright: Copyright 2007 Elsevier B.V., All rights reserved.

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3-deoxy-3-substituted-D-myo-inositol imidazolyl ether lipid phosphates and carbonate as inhibitors of the phosphatidylinositol 3-kinase pathway and cancer cell growth

Abstract

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