3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: Synthesis and biological evaluation

Ronghui Lin, Yanhua Lu, Steven K. Wetter, Peter J. Connolly, Ignatius J. Turchi, William V. Murray, Stuart L. Emanuel, Robert H. Gruninger, Angel R. Fuentes-Pesquera, Mary Adams, Niranjan Pandey, Sandra Moreno-Mazza, Steven A. Middleton, Linda K. Jolliffe

Research output: Contribution to journalArticlepeer-review

Abstract

A novel series of 2,6-diamino-3-acylpyridines were designed and synthesized as cyclin-dependent kinase (CDK) inhibitors. The representative compounds 2r and 11 showed potent CDK1 and CDK2 inhibitory activities and inhibited cellular proliferation in HeLa, HCT116, and A375 tumor cells.

Original languageEnglish (US)
Pages (from-to)2221-2224
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number9
DOIs
StatePublished - May 2 2005
Externally publishedYes

Keywords

  • CDK inhibitor
  • Cell proliferation inhibitor
  • Cyclin-dependent kinase inhibitor
  • Synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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