TY - JOUR
T1 - 3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors
T2 - Synthesis and biological evaluation
AU - Lin, Ronghui
AU - Lu, Yanhua
AU - Wetter, Steven K.
AU - Connolly, Peter J.
AU - Turchi, Ignatius J.
AU - Murray, William V.
AU - Emanuel, Stuart L.
AU - Gruninger, Robert H.
AU - Fuentes-Pesquera, Angel R.
AU - Adams, Mary
AU - Pandey, Niranjan
AU - Moreno-Mazza, Sandra
AU - Middleton, Steven A.
AU - Jolliffe, Linda K.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2005/5/2
Y1 - 2005/5/2
N2 - A novel series of 2,6-diamino-3-acylpyridines were designed and synthesized as cyclin-dependent kinase (CDK) inhibitors. The representative compounds 2r and 11 showed potent CDK1 and CDK2 inhibitory activities and inhibited cellular proliferation in HeLa, HCT116, and A375 tumor cells.
AB - A novel series of 2,6-diamino-3-acylpyridines were designed and synthesized as cyclin-dependent kinase (CDK) inhibitors. The representative compounds 2r and 11 showed potent CDK1 and CDK2 inhibitory activities and inhibited cellular proliferation in HeLa, HCT116, and A375 tumor cells.
KW - CDK inhibitor
KW - Cell proliferation inhibitor
KW - Cyclin-dependent kinase inhibitor
KW - Synthesis
UR - http://www.scopus.com/inward/record.url?scp=20244379731&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20244379731&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2005.03.024
DO - 10.1016/j.bmcl.2005.03.024
M3 - Article
C2 - 15837297
AN - SCOPUS:20244379731
VL - 15
SP - 2221
EP - 2224
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 9
ER -