3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: Synthesis and biological evaluation

Ronghui Lin, Yanhua Lu, Steven K. Wetter, Peter J. Connolly, Ignatius J. Turchi, William V. Murray, Stuart L. Emanuel, Robert H. Gruninger, Angel R. Fuentes-Pesquera, Mary Adams, Niranjan Pandey, Sandra Moreno-Mazza, Steven A. Middleton, Linda K. Jolliffe

Research output: Contribution to journalArticle

Abstract

A novel series of 2,6-diamino-3-acylpyridines were designed and synthesized as cyclin-dependent kinase (CDK) inhibitors. The representative compounds 2r and 11 showed potent CDK1 and CDK2 inhibitory activities and inhibited cellular proliferation in HeLa, HCT116, and A375 tumor cells.

Original languageEnglish (US)
Pages (from-to)2221-2224
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number9
DOIs
StatePublished - May 2 2005
Externally publishedYes

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Cyclin-Dependent Kinases
Tumors
Cells
Cell Proliferation
Neoplasms
2,6-diaminopyridine

Keywords

  • CDK inhibitor
  • Cell proliferation inhibitor
  • Cyclin-dependent kinase inhibitor
  • Synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Lin, R., Lu, Y., Wetter, S. K., Connolly, P. J., Turchi, I. J., Murray, W. V., ... Jolliffe, L. K. (2005). 3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: Synthesis and biological evaluation. Bioorganic and Medicinal Chemistry Letters, 15(9), 2221-2224. https://doi.org/10.1016/j.bmcl.2005.03.024

3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors : Synthesis and biological evaluation. / Lin, Ronghui; Lu, Yanhua; Wetter, Steven K.; Connolly, Peter J.; Turchi, Ignatius J.; Murray, William V.; Emanuel, Stuart L.; Gruninger, Robert H.; Fuentes-Pesquera, Angel R.; Adams, Mary; Pandey, Niranjan; Moreno-Mazza, Sandra; Middleton, Steven A.; Jolliffe, Linda K.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 15, No. 9, 02.05.2005, p. 2221-2224.

Research output: Contribution to journalArticle

Lin, R, Lu, Y, Wetter, SK, Connolly, PJ, Turchi, IJ, Murray, WV, Emanuel, SL, Gruninger, RH, Fuentes-Pesquera, AR, Adams, M, Pandey, N, Moreno-Mazza, S, Middleton, SA & Jolliffe, LK 2005, '3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: Synthesis and biological evaluation', Bioorganic and Medicinal Chemistry Letters, vol. 15, no. 9, pp. 2221-2224. https://doi.org/10.1016/j.bmcl.2005.03.024
Lin, Ronghui ; Lu, Yanhua ; Wetter, Steven K. ; Connolly, Peter J. ; Turchi, Ignatius J. ; Murray, William V. ; Emanuel, Stuart L. ; Gruninger, Robert H. ; Fuentes-Pesquera, Angel R. ; Adams, Mary ; Pandey, Niranjan ; Moreno-Mazza, Sandra ; Middleton, Steven A. ; Jolliffe, Linda K. / 3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors : Synthesis and biological evaluation. In: Bioorganic and Medicinal Chemistry Letters. 2005 ; Vol. 15, No. 9. pp. 2221-2224.
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