25(OH)D serum levels decline with age earlier in women than in men and less efficiently prevent compensatory hyperparathyroidism in older adults

Dario Maggio, Antonio Cherubini, Fulvio Lauretani, Roberto Cosimo Russo, Benedetta Bartali, Marco Pierandrei, Carmelinda Ruggiero, Maria Carmela Macchiarulo, Ruben Giorgino, Salvatore Minisola, Luigi Ferrucci

Research output: Contribution to journalArticle

Abstract

Background. Although a host of factors are known to influence 25-hydroxyvitamin D [25(OH)D] serum levels, few studies addressed the distinctive sex-specific influence of aging, and the age-specific relationship of parathyroid hormone (PTH) with 25(OH)D. The aims of this research were to evaluate changes of 25(OH)D and PTH levels with age in a large population-based sample of men and women and to test the hypothesis that 25(OH)D serum concentrations needed to offset age-associated hyperparathyroidism are significantly higher in older than in younger persons. Methods. In 1107 participants of the InCHTANTI (Invecchiare in Chianti, i.e., Aging in the Chianti area) study, we collected information on dietary intake, daylight exposure, and disability, and measured renal function and serum 25(OH)D and PTH. Results. In women, the age-related decline of 25(OH)D was already evident shortly after age 50, whereas in men it started only after age 70 and was substantially less steep. Age, daylight exposure, winter season, and disability were independent predictors of low 25(OH)D levels. For any given level of 25(OH)D, PTH levels were progressively and consistently higher in older than in younger participants. Conclusions. These findings suggest that the age-associated fall of serum 25(OH)D starts earlier in women than in men and that higher levels of 25(OH)D are required in older compared to younger persons to avoid the age-associated compensatory hyperparathyroidism.

Original languageEnglish (US)
Pages (from-to)1414-1419
Number of pages6
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume60
Issue number11
StatePublished - Nov 2005
Externally publishedYes

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Hyperparathyroidism
Parathyroid Hormone
Serum
Kidney
Research
Population

ASJC Scopus subject areas

  • Aging

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25(OH)D serum levels decline with age earlier in women than in men and less efficiently prevent compensatory hyperparathyroidism in older adults. / Maggio, Dario; Cherubini, Antonio; Lauretani, Fulvio; Russo, Roberto Cosimo; Bartali, Benedetta; Pierandrei, Marco; Ruggiero, Carmelinda; Macchiarulo, Maria Carmela; Giorgino, Ruben; Minisola, Salvatore; Ferrucci, Luigi.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 60, No. 11, 11.2005, p. 1414-1419.

Research output: Contribution to journalArticle

Maggio, D, Cherubini, A, Lauretani, F, Russo, RC, Bartali, B, Pierandrei, M, Ruggiero, C, Macchiarulo, MC, Giorgino, R, Minisola, S & Ferrucci, L 2005, '25(OH)D serum levels decline with age earlier in women than in men and less efficiently prevent compensatory hyperparathyroidism in older adults', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 60, no. 11, pp. 1414-1419.
Maggio, Dario ; Cherubini, Antonio ; Lauretani, Fulvio ; Russo, Roberto Cosimo ; Bartali, Benedetta ; Pierandrei, Marco ; Ruggiero, Carmelinda ; Macchiarulo, Maria Carmela ; Giorgino, Ruben ; Minisola, Salvatore ; Ferrucci, Luigi. / 25(OH)D serum levels decline with age earlier in women than in men and less efficiently prevent compensatory hyperparathyroidism in older adults. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2005 ; Vol. 60, No. 11. pp. 1414-1419.
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AU - Maggio, Dario

AU - Cherubini, Antonio

AU - Lauretani, Fulvio

AU - Russo, Roberto Cosimo

AU - Bartali, Benedetta

AU - Pierandrei, Marco

AU - Ruggiero, Carmelinda

AU - Macchiarulo, Maria Carmela

AU - Giorgino, Ruben

AU - Minisola, Salvatore

AU - Ferrucci, Luigi

PY - 2005/11

Y1 - 2005/11

N2 - Background. Although a host of factors are known to influence 25-hydroxyvitamin D [25(OH)D] serum levels, few studies addressed the distinctive sex-specific influence of aging, and the age-specific relationship of parathyroid hormone (PTH) with 25(OH)D. The aims of this research were to evaluate changes of 25(OH)D and PTH levels with age in a large population-based sample of men and women and to test the hypothesis that 25(OH)D serum concentrations needed to offset age-associated hyperparathyroidism are significantly higher in older than in younger persons. Methods. In 1107 participants of the InCHTANTI (Invecchiare in Chianti, i.e., Aging in the Chianti area) study, we collected information on dietary intake, daylight exposure, and disability, and measured renal function and serum 25(OH)D and PTH. Results. In women, the age-related decline of 25(OH)D was already evident shortly after age 50, whereas in men it started only after age 70 and was substantially less steep. Age, daylight exposure, winter season, and disability were independent predictors of low 25(OH)D levels. For any given level of 25(OH)D, PTH levels were progressively and consistently higher in older than in younger participants. Conclusions. These findings suggest that the age-associated fall of serum 25(OH)D starts earlier in women than in men and that higher levels of 25(OH)D are required in older compared to younger persons to avoid the age-associated compensatory hyperparathyroidism.

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