25 years of neuroimaging in amyotrophic lateral sclerosis

Bradley R. Foerster, Robert C. Welsh, Eva L. Feldman

Research output: Contribution to journalReview article

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease for which a precise cause has not yet been identified. Standard CT or MRI evaluation does not demonstrate gross structural nervous system changes in ALS, so conventional neuroimaging techniques have provided little insight into the pathophysiology of this disease. Advanced neuroimaging techniques - such as structural MRI, diffusion tensor imaging and proton magnetic resonance spectroscopy - allow evaluation of alterations of the nervous system in ALS. These alterations include focal loss of grey and white matter and reductions in white matter tract integrity, as well as changes in neural networks and in the chemistry, metabolism and receptor distribution in the brain. Given their potential for investigation of both brain structure and function, advanced neuroimaging methods offer important opportunities to improve diagnosis, guide prognosis, and direct future treatment strategies in ALS. In this article, we review the contributions made by various advanced neuroimaging techniques to our understanding of the impact of ALS on different brain regions, and the potential role of such measures in biomarker development.

Original languageEnglish (US)
Pages (from-to)513-524
Number of pages12
JournalNature Reviews Neurology
Volume9
Issue number9
DOIs
StatePublished - Sep 2013
Externally publishedYes

Fingerprint

Amyotrophic Lateral Sclerosis
Neuroimaging
Nervous System
Brain
Motor Neuron Disease
Diffusion Tensor Imaging
Biomarkers
White Matter

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

25 years of neuroimaging in amyotrophic lateral sclerosis. / Foerster, Bradley R.; Welsh, Robert C.; Feldman, Eva L.

In: Nature Reviews Neurology, Vol. 9, No. 9, 09.2013, p. 513-524.

Research output: Contribution to journalReview article

Foerster, Bradley R. ; Welsh, Robert C. ; Feldman, Eva L. / 25 years of neuroimaging in amyotrophic lateral sclerosis. In: Nature Reviews Neurology. 2013 ; Vol. 9, No. 9. pp. 513-524.
@article{f906a47a83c3495f8f1df5779f7daa9d,
title = "25 years of neuroimaging in amyotrophic lateral sclerosis",
abstract = "Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease for which a precise cause has not yet been identified. Standard CT or MRI evaluation does not demonstrate gross structural nervous system changes in ALS, so conventional neuroimaging techniques have provided little insight into the pathophysiology of this disease. Advanced neuroimaging techniques - such as structural MRI, diffusion tensor imaging and proton magnetic resonance spectroscopy - allow evaluation of alterations of the nervous system in ALS. These alterations include focal loss of grey and white matter and reductions in white matter tract integrity, as well as changes in neural networks and in the chemistry, metabolism and receptor distribution in the brain. Given their potential for investigation of both brain structure and function, advanced neuroimaging methods offer important opportunities to improve diagnosis, guide prognosis, and direct future treatment strategies in ALS. In this article, we review the contributions made by various advanced neuroimaging techniques to our understanding of the impact of ALS on different brain regions, and the potential role of such measures in biomarker development.",
author = "Foerster, {Bradley R.} and Welsh, {Robert C.} and Feldman, {Eva L.}",
year = "2013",
month = "9",
doi = "10.1038/nrneurol.2013.153",
language = "English (US)",
volume = "9",
pages = "513--524",
journal = "Nature Reviews Neurology",
issn = "1759-4758",
publisher = "Nature Publishing Group",
number = "9",

}

TY - JOUR

T1 - 25 years of neuroimaging in amyotrophic lateral sclerosis

AU - Foerster, Bradley R.

AU - Welsh, Robert C.

AU - Feldman, Eva L.

PY - 2013/9

Y1 - 2013/9

N2 - Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease for which a precise cause has not yet been identified. Standard CT or MRI evaluation does not demonstrate gross structural nervous system changes in ALS, so conventional neuroimaging techniques have provided little insight into the pathophysiology of this disease. Advanced neuroimaging techniques - such as structural MRI, diffusion tensor imaging and proton magnetic resonance spectroscopy - allow evaluation of alterations of the nervous system in ALS. These alterations include focal loss of grey and white matter and reductions in white matter tract integrity, as well as changes in neural networks and in the chemistry, metabolism and receptor distribution in the brain. Given their potential for investigation of both brain structure and function, advanced neuroimaging methods offer important opportunities to improve diagnosis, guide prognosis, and direct future treatment strategies in ALS. In this article, we review the contributions made by various advanced neuroimaging techniques to our understanding of the impact of ALS on different brain regions, and the potential role of such measures in biomarker development.

AB - Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease for which a precise cause has not yet been identified. Standard CT or MRI evaluation does not demonstrate gross structural nervous system changes in ALS, so conventional neuroimaging techniques have provided little insight into the pathophysiology of this disease. Advanced neuroimaging techniques - such as structural MRI, diffusion tensor imaging and proton magnetic resonance spectroscopy - allow evaluation of alterations of the nervous system in ALS. These alterations include focal loss of grey and white matter and reductions in white matter tract integrity, as well as changes in neural networks and in the chemistry, metabolism and receptor distribution in the brain. Given their potential for investigation of both brain structure and function, advanced neuroimaging methods offer important opportunities to improve diagnosis, guide prognosis, and direct future treatment strategies in ALS. In this article, we review the contributions made by various advanced neuroimaging techniques to our understanding of the impact of ALS on different brain regions, and the potential role of such measures in biomarker development.

UR - http://www.scopus.com/inward/record.url?scp=84883740172&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883740172&partnerID=8YFLogxK

U2 - 10.1038/nrneurol.2013.153

DO - 10.1038/nrneurol.2013.153

M3 - Review article

C2 - 23917850

AN - SCOPUS:84883740172

VL - 9

SP - 513

EP - 524

JO - Nature Reviews Neurology

JF - Nature Reviews Neurology

SN - 1759-4758

IS - 9

ER -