[24] Molecular methods for analysis of genetic polymorphisms: Application to the molecular genetic study of genes encoding β2-adrenoceptor and stimulatory G protein α subunit

Charles W. Emala, Michael A. Levine

    Research output: Contribution to journalArticle

    Abstract

    The ability to screen DNA rapidly for small changes in base sequence has revolutionized the search for genetic basis of disease. These techniques have led to the identification of specific mutations that account for the disease phenotype in syndromes such as Albright hereditary osteodystrophy and McCune-Albright syndrome, and have provided polymorphic markers for candidate gene and positional cloning studies of inherited airway hyperresponsiveness. These and additional techniques will continue to accelerate the discovery of the genetic cause of many human diseases.

    Original languageEnglish (US)
    Pages (from-to)379-400
    Number of pages22
    JournalMethods in Neurosciences
    Volume29
    Issue numberC
    DOIs
    StatePublished - 1996

    Fingerprint

    Protein Subunits
    Genetic Polymorphisms
    GTP-Binding Proteins
    Adrenergic Receptors
    Molecular Biology
    Polyostotic Fibrous Dysplasia
    Inborn Genetic Diseases
    Genes
    Organism Cloning
    Phenotype
    Mutation
    DNA
    Albright's hereditary osteodystrophy

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

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    abstract = "The ability to screen DNA rapidly for small changes in base sequence has revolutionized the search for genetic basis of disease. These techniques have led to the identification of specific mutations that account for the disease phenotype in syndromes such as Albright hereditary osteodystrophy and McCune-Albright syndrome, and have provided polymorphic markers for candidate gene and positional cloning studies of inherited airway hyperresponsiveness. These and additional techniques will continue to accelerate the discovery of the genetic cause of many human diseases.",
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